Timothy Hla

Timothy Hla

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Timothy Hla

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Endothelial sphingosine 1-phosphate receptors promote vascular normalization and antitumor therapy.

Proc Natl Acad Sci U S A 2020 Feb 27;117(6):3157-3166. Epub 2020 Jan 27.

Vascular Biology Program, Boston Children's Hospital, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.1906246117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7022165PMC
February 2020

Sphingosine 1-Phosphate Receptor Signaling Establishes AP-1 Gradients to Allow for Retinal Endothelial Cell Specialization.

Dev Cell 2020 Feb 6. Epub 2020 Feb 6.

Vascular Biology Program, Boston Children's Hospital, Department of Surgery, Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Dana-Farber Cancer Institute, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2020.01.016DOI Listing
February 2020

TLR4 (Toll-Like Receptor 4)-Dependent Signaling Drives Extracellular Catabolism of LDL (Low-Density Lipoprotein) Aggregates.

Arterioscler Thromb Vasc Biol 2020 Jan 10;40(1):86-102. Epub 2019 Oct 10.

From the Department of Biochemistry, Weill Cornell Medical College, New York, NY (R.K.S., A.S.H., A.A., V.C.B.-L., I.G., H.F.C., F.R.M.).

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http://dx.doi.org/10.1161/ATVBAHA.119.313200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928397PMC
January 2020

Sphingosine kinases protect murine embryonic stem cells from sphingosine-induced cell cycle arrest.

Stem Cells 2020 Jan 9. Epub 2020 Jan 9.

Department of Surgery, Weill Cornell Medicine, New York, New York.

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http://dx.doi.org/10.1002/stem.3145DOI Listing
January 2020

Myeloid sphingosine-1-phosphate receptor 1 is important for CNS autoimmunity and neuroinflammation.

J Autoimmun 2019 Dec 12;105:102290. Epub 2019 Jun 12.

Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jaut.2019.06.001DOI Listing
December 2019

Post-transcriptional regulation of Nrf2-mRNA by the mRNA-binding proteins HuR and AUF1.

FASEB J 2019 Dec 1;33(12):14636-14652. Epub 2019 Nov 1.

Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland.

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http://dx.doi.org/10.1096/fj.201901930RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6993928PMC
December 2019

Identification of ApoA4 as a sphingosine 1-phosphate chaperone in ApoM- and albumin-deficient mice.

J Lipid Res 2019 Nov 28;60(11):1912-1921. Epub 2019 Aug 28.

Vascular Biology Program, Boston Children's Hospital, Department of Surgery, Harvard Medical School, Boston, MA 02115

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http://dx.doi.org/10.1194/jlr.RA119000277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6824498PMC
November 2019

Sphingosine 1-phosphate: Lipid signaling in pathology and therapy.

Science 2019 10;366(6463)

Vascular Biology Program, Boston Children's Hospital and Department of Surgery, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/science.aar5551DOI Listing
October 2019

Sphingosine 1-phosphate and inflammation.

Int Immunol 2019 08;31(9):617-625

Vascular Biology Program, Boston Children's Hospital, Department of Surgery, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1093/intimm/dxz037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939830PMC
August 2019

Sphingosine 1-phosphate receptor 1 regulates cell-surface localization of membrane proteins in endothelial cells.

Biochim Biophys Acta Gen Subj 2019 06 4;1863(6):1079-1087. Epub 2019 Apr 4.

The Affiliated Kangning Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325007, China; The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, China; School of Mental Health, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China; The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325015, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03044165193007
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http://dx.doi.org/10.1016/j.bbagen.2019.04.001DOI Listing
June 2019

Bioactive lysolipids in cancer and angiogenesis.

Pharmacol Ther 2019 01 23;193:91-98. Epub 2018 Jul 23.

Vascular Biology Program, Boston Children's Hospital, Department of Surgery, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, United States. Electronic address:

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http://dx.doi.org/10.1016/j.pharmthera.2018.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309747PMC
January 2019

Lipid Mediators, M2 Macrophages, and Pathological Neovascularization.

Trends Mol Med 2018 12 15;24(12):977-978. Epub 2018 Nov 15.

Vascular Biology Program, Boston Children's Hospital and Department of Surgery, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S14714914183018
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http://dx.doi.org/10.1016/j.molmed.2018.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6876743PMC
December 2018

A dark side to omega-3 fatty acids.

Nature 2017 Dec;552(7684):180-181

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http://dx.doi.org/10.1038/d41586-017-07678-8DOI Listing
December 2017

Bioluminescence imaging of G protein-coupled receptor activation in living mice.

Nat Commun 2017 10 27;8(1):1163. Epub 2017 Oct 27.

Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1038/s41467-017-01340-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660082PMC
October 2017

S1PR1 (Sphingosine-1-Phosphate Receptor 1) Signaling Regulates Blood Flow and Pressure.

Hypertension 2017 08 12;70(2):426-434. Epub 2017 Jun 12.

From the Department of Pathology and Laboratory Medicine, Center for Vascular Biology, Weill Cornell Medicine, New York (A.C., A.G., E.D., C.L., Y.Z., T.H., A.D.L.); and Department of Pharmacy, Faculty of Pharmacy, University of Naples "Federico II", Naples, Italy (A.G.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.117.09088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531041PMC
August 2017

Lymphatic endothelial S1P promotes mitochondrial function and survival in naive T cells.

Nature 2017 06 24;546(7656):158-161. Epub 2017 May 24.

Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA.

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http://dx.doi.org/10.1038/nature22352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683179PMC
June 2017

Quality Versus Quantity: Making HDL Great Again.

Arterioscler Thromb Vasc Biol 2017 06;37(6):1018-1019

From the Vascular Biology Program, Boston Children's Hospital, MA (S.G., T.H.); and Department of Surgery, Harvard Medical School, Boston, MA (S.G., T.H.).

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http://dx.doi.org/10.1161/ATVBAHA.117.309441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498076PMC
June 2017

Vascular and Immunobiology of the Circulatory Sphingosine 1-Phosphate Gradient.

Annu Rev Physiol 2017 02 21;79:67-91. Epub 2016 Oct 21.

Vascular Biology Program, Department of Surgery, Harvard Medical School and Boston Children's Hospital, Boston, Massachusetts 02115; email: ,

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http://dx.doi.org/10.1146/annurev-physiol-021014-071635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500220PMC
February 2017

Platelet and Erythrocyte Sources of S1P Are Redundant for Vascular Development and Homeostasis, but Both Rendered Essential After Plasma S1P Depletion in Anaphylactic Shock.

Circ Res 2016 Sep 31;119(8):e110-26. Epub 2016 Aug 31.

From the INSERM U970, Paris Cardiovascular Research Centre, 75015 Paris, France (S.L.G., B.M., L.C., V.B., S.M.L.G., N.Z., J.R., P.-L.T., E.C.); Université Sorbonne Paris Cité, Paris, France (S.L.G., B.M., B. Decouture, L.C., P.B., V.B., S.M.L.G., B. Dizier, N.Z., J.R., P.G., P.-L.T., C.B.-L., B.H.-T.-N., E.C.); AP-HP, Hôpital Bicêtre, Service de Biochimie, 94275 Le Kremlin Bicêtre, France (P.T.); Lip(Sys)2-Biochimie appliquée, Université Paris-Sud, Université Paris-Saclay, 92290 Châtenay-Malabry, France (P.T.); INSERM U1140, Faculté de Pharmacie, 75006 Paris, France (B. Decouture, B. Dizier, P.G., C.B.-L.); Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University, New York (Y.X., T.H.); AP-HP, Hôpital Lariboisière, Physiologie Clinique-Explorations-Fonctionnelles, INSERM U965, 75010, Paris, France (P.B.); Australian Centre for Blood Diseases & Department of Clinical Haematology, Monash University, Melbourne, Australia (J.R.H.); AP-HP, Hôpital Européen Georges Pompidou, Service d'Hématologie Biologique, Paris, France (P.G.); Department of Molecular and Cellular Neuroscience, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA (J.C.); Cardiovascular Research Institute, University of California, San Francisco (S.R.C.); and INSERM U698, 75018 Paris, France (B.H.-T.-N.).

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064286PMC
http://dx.doi.org/10.1161/CIRCRESAHA.116.308929DOI Listing
September 2016

Impaired endothelial barrier function in apolipoprotein M-deficient mice is dependent on sphingosine-1-phosphate receptor 1.

FASEB J 2016 06 8;30(6):2351-9. Epub 2016 Mar 8.

Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark; Department of Biomedical Sciences University of Copenhagen, Copenhagen, Denmark;

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http://dx.doi.org/10.1096/fj.201500064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871798PMC
June 2016

Antitumor Activity of a Novel Sphingosine-1-Phosphate 2 Antagonist, AB1, in Neuroblastoma.

J Pharmacol Exp Ther 2015 Sep 23;354(3):261-8. Epub 2015 Jun 23.

Center for Vascular Biology, University of Connecticut Health Center, Farmington, Connecticut (M.-H.L., L.H.S., F.F.); Arroyo Biosciences, LLC, Princeton, New Jersey (R.S.); Department of Urology and Surgery, Connecticut Children's Medical Center, Hartford, Connecticut (M.H., F.F.); TCG Life Sciences Limited, Hinjewadi, Pune, India (S.J.); Chem-Master International Inc., Stony Brook, New York (E.S.); and Department of Pathology and Laboratory Medicine, Center for Vascular Biology, Weill Medical College of Cornell University, New York, New York (T.H.)

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http://jpet.aspetjournals.org/content/354/3/261.full.pdf
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http://jpet.aspetjournals.org/cgi/doi/10.1124/jpet.115.22451
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http://dx.doi.org/10.1124/jpet.115.224519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538871PMC
September 2015

Nogo-B regulates endothelial sphingolipid homeostasis to control vascular function and blood pressure.

Nat Med 2015 Sep 24;21(9):1028-1037. Epub 2015 Aug 24.

Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University, New York, New York, USA.

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http://dx.doi.org/10.1038/nm.3934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4692717PMC
September 2015

Maternal or zygotic sphingosine kinase is required to regulate zebrafish cardiogenesis.

Dev Dyn 2015 Aug 6;244(8):948-54. Epub 2015 Jul 6.

Department of Surgery, Weill Cornell Medical College, Cornell University, New York, New York, 10065.

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http://dx.doi.org/10.1002/dvdy.24288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520754PMC
August 2015

HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P1 to limit vascular inflammation.

Sci Signal 2015 Aug 11;8(389):ra79. Epub 2015 Aug 11.

Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University, New York, NY 10065, USA.

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http://dx.doi.org/10.1126/scisignal.aaa2581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768813PMC
August 2015

HDL-bound sphingosine-1-phosphate restrains lymphopoiesis and neuroinflammation.

Nature 2015 Jul 8;523(7560):342-6. Epub 2015 Jun 8.

1] Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, New York 10065, USA [2] Brain and Mind Research Institute, Weill Medical College of Cornell University, New York, New York 10065, USA.

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http://dx.doi.org/10.1038/nature14462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506268PMC
July 2015

Individual variation of human S1P₁ coding sequence leads to heterogeneity in receptor function and drug interactions.

J Lipid Res 2014 Dec 7;55(12):2665-75. Epub 2014 Oct 7.

Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University, New York, NY 10065.

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http://dx.doi.org/10.1194/jlr.P054163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4242458PMC
December 2014

ELAVL1 regulates alternative splicing of eIF4E transporter to promote postnatal angiogenesis.

Proc Natl Acad Sci U S A 2014 Dec 24;111(51):18309-14. Epub 2014 Nov 24.

Center for Vascular Biology, Department of Pathology and Laboratory Medicine, and

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http://dx.doi.org/10.1073/pnas.1412172111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280608PMC
December 2014

ELAVL1 modulates transcriptome-wide miRNA binding in murine macrophages.

Cell Rep 2014 Dec 18;9(6):2330-43. Epub 2014 Dec 18.

Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.11.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277505PMC
December 2014

C16:0-ceramide signals insulin resistance.

Cell Metab 2014 Nov 4;20(5):703-705. Epub 2014 Nov 4.

Laboratory of Signal Transduction, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2014.10.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393079PMC
November 2014

Cardiac and vascular effects of fingolimod: mechanistic basis and clinical implications.

Am Heart J 2014 Nov 11;168(5):632-44. Epub 2014 Jul 11.

Novartis Pharma AG, Basel, Switzerland.

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http://dx.doi.org/10.1016/j.ahj.2014.06.028DOI Listing
November 2014

The BCL6 RD2 domain governs commitment of activated B cells to form germinal centers.

Cell Rep 2014 Sep 28;8(5):1497-508. Epub 2014 Aug 28.

Division of Hematology and Oncology, Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.07.059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163070PMC
September 2014

An update on the biology of sphingosine 1-phosphate receptors.

J Lipid Res 2014 Aug 23;55(8):1596-608. Epub 2014 Jan 23.

Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10065.

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http://www.jlr.org/lookup/doi/10.1194/jlr.R046300
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http://dx.doi.org/10.1194/jlr.R046300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109755PMC
August 2014

Induction of chemokine (C-C motif) ligand 2 by sphingosine-1-phosphate signaling in neuroblastoma.

J Pediatr Surg 2014 Aug 16;49(8):1286-91. Epub 2014 May 16.

Center for Vascular Biology, University of Connecticut Health Center, Farmington, CT 06030; Department of Urology and Surgery, Connecticut Children's Medical Center, Hartford, CT 06106. Electronic address:

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http://dx.doi.org/10.1016/j.jpedsurg.2014.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122984PMC
August 2014

Sphingosine-1-phosphate receptor 1 signalling in T cells: trafficking and beyond.

Immunology 2014 Jul;142(3):347-53

Graduate Program in Immunology, Division of Medical Sciences, Harvard Medical School, Boston, MA, USA.

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http://doi.wiley.com/10.1111/imm.12272
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http://dx.doi.org/10.1111/imm.12272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4080950PMC
July 2014

S1P control of endothelial integrity.

Curr Top Microbiol Immunol 2014 ;378:85-105

Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University, New York, NY, 10165, USA.

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http://link.springer.com/10.1007/978-3-319-05879-5_4
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http://dx.doi.org/10.1007/978-3-319-05879-5_4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4240614PMC
July 2014

Treatment with the immunomodulator FTY720 (fingolimod) significantly reduces renal inflammation in murine unilateral ureteral obstruction.

J Urol 2014 May 26;191(5 Suppl):1508-16. Epub 2014 Mar 26.

Center for Vascular Biology, University of Connecticut Health Center, Farmington, Connecticut; Department of Urology, Connecticut Children's Medical Center, Hartford, Connecticut. Electronic address:

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http://dx.doi.org/10.1016/j.juro.2013.10.072DOI Listing
May 2014

Post-transcriptional gene regulation by HuR and microRNAs in angiogenesis.

Curr Opin Hematol 2014 May;21(3):235-40

Department of Pathology and Laboratory Medicine, Center for Vascular Biology, Weill Cornell Medical College, Cornell University, New York, New York, USA.

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http://dx.doi.org/10.1097/MOH.0000000000000040DOI Listing
May 2014

Elavl1a regulates zebrafish erythropoiesis via posttranscriptional control of gata1.

Blood 2014 Feb 14;123(9):1384-92. Epub 2014 Jan 14.

Center for Vascular Biology, Department of Pathology and Laboratory Medicine, and.

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http://dx.doi.org/10.1182/blood-2013-09-526962DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938149PMC
February 2014

Sphingosine 1-phosphate signalling.

Development 2014 Jan;141(1):5-9

Weill Cornell Medical College, Cornell University, New York, NY 10065, USA.

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http://dx.doi.org/10.1242/dev.094805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865745PMC
January 2014

Defective sphingosine 1-phosphate receptor 1 (S1P1) phosphorylation exacerbates TH17-mediated autoimmune neuroinflammation.

Nat Immunol 2013 Nov 29;14(11):1166-72. Epub 2013 Sep 29.

1] Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA. [2] Graduate Program in Immunology, Division of Medical Sciences, Harvard Medical School, Boston, Massachusetts, USA. [3].

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http://dx.doi.org/10.1038/ni.2730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014310PMC
November 2013

Genetic deletion of microsomal prostaglandin E synthase-1 suppresses mouse mammary tumor growth and angiogenesis.

Prostaglandins Other Lipid Mediat 2013 Oct 25;106:99-105. Epub 2013 Apr 25.

Department of Cell & Developmental Biology and Weill Cornell Cancer Center, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10988823130002
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http://dx.doi.org/10.1016/j.prostaglandins.2013.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3830707PMC
October 2013

FTY720 inhibits tumor growth and enhances the tumor-suppressive effect of topotecan in neuroblastoma by interfering with the sphingolipid signaling pathway.

Pediatr Blood Cancer 2013 Sep 23;60(9):1418-23. Epub 2013 May 23.

University of Connecticut Health Center, Center for Vascular Biology, Farmington, Connecticut, USA.

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http://doi.wiley.com/10.1002/pbc.24564
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http://dx.doi.org/10.1002/pbc.24564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751174PMC
September 2013

Regulation of a vascular plexus by gata4 is mediated in zebrafish through the chemokine sdf1a.

PLoS One 2012 3;7(10):e46844. Epub 2012 Oct 3.

Department of Surgery, Weill Cornell Medical College, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0046844PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463525PMC
May 2013

Antagonistic function of the RNA-binding protein HuR and miR-200b in post-transcriptional regulation of vascular endothelial growth factor-A expression and angiogenesis.

J Biol Chem 2013 Feb 6;288(7):4908-21. Epub 2012 Dec 6.

Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University, New York, New York 10065, USA.

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http://dx.doi.org/10.1074/jbc.M112.423871DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3576095PMC
February 2013

Sphingosine 1-phosphate receptor signaling regulates proper embryonic vascular patterning.

J Biol Chem 2013 Jan 10;288(4):2143-56. Epub 2012 Dec 10.

Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University, New York, New York 10021, USA.

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http://dx.doi.org/10.1074/jbc.M112.427344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554887PMC
January 2013

Assessment of sphingosine-1-phosphate activity in biological samples by receptor internalization and adherens junction formation.

Methods Mol Biol 2012 ;874:69-76

Laboratory Medicine, Department of Pathology, Center for Vascular Biology, Weill Cornell Medical College, Cornell University, New York, NY, USA.

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http://link.springer.com/10.1007/978-1-61779-800-9_6
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http://dx.doi.org/10.1007/978-1-61779-800-9_6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614356PMC
November 2012

S1P and the birth of platelets.

J Exp Med 2012 Nov;209(12):2137-40

Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University, New York, NY 10065, USA.

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http://dx.doi.org/10.1084/jem.20122284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501358PMC
November 2012

Sphingolipid signaling in metabolic disorders.

Cell Metab 2012 Oct 13;16(4):420-34. Epub 2012 Sep 13.

Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.cmet.2012.06.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466368PMC
October 2012

Flow-regulated endothelial S1P receptor-1 signaling sustains vascular development.

Dev Cell 2012 Sep;23(3):600-10

Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.devcel.2012.07.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443394PMC
September 2012

Sphingosine 1-phosphate in coagulation and inflammation.

Semin Immunopathol 2012 Jan 31;34(1):73-91. Epub 2011 Jul 31.

Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University, New York, NY 10065, USA.

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http://dx.doi.org/10.1007/s00281-011-0287-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237867PMC
January 2012

SnapShot: Bioactive lysophospholipids.

Cell 2012 Jan;148(1-2):378-378.e2

Division of Cell Biology, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.cell.2012.01.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3645273PMC
January 2012

Gene regulation by RNA binding proteins and microRNAs in angiogenesis.

Trends Mol Med 2011 Nov 29;17(11):650-8. Epub 2011 Jul 29.

Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University, New York, NY 10065, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S147149141100122
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http://dx.doi.org/10.1016/j.molmed.2011.06.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625859PMC
November 2011

Regulation of mammalian physiology, development, and disease by the sphingosine 1-phosphate and lysophosphatidic acid receptors.

Chem Rev 2011 Oct 22;111(10):6299-320. Epub 2011 Sep 22.

Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, New York 10065, USA.

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http://dx.doi.org/10.1021/cr200273uDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216694PMC
October 2011

Sphingolipid modulation of angiogenic factor expression in neuroblastoma.

Cancer Prev Res (Phila) 2011 Aug 16;4(8):1325-32. Epub 2011 May 16.

Center for Vascular Biology, University of Connecticut Health Center, Farmington, CT, USA.

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http://dx.doi.org/10.1158/1940-6207.CAPR-11-0017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152210PMC
August 2011

Engagement of S1P₁-degradative mechanisms leads to vascular leak in mice.

J Clin Invest 2011 Jun 9;121(6):2290-300. Epub 2011 May 9.

Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University, New York, New York 10065, USA.

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http://dx.doi.org/10.1172/JCI45403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3104755PMC
June 2011

Sphingosine 1-phosphate (S1P): Physiology and the effects of S1P receptor modulation.

Neurology 2011 Feb;76(8 Suppl 3):S3-8

Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Cornell University, New York, NY 10065, USA.

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http://www.neurology.org/cgi/doi/10.1212/WNL.0b013e31820d5ec
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http://dx.doi.org/10.1212/WNL.0b013e31820d5ec1DOI Listing
February 2011

Sphingosine-1-phosphate receptor-2 function in myeloid cells regulates vascular inflammation and atherosclerosis.

Arterioscler Thromb Vasc Biol 2011 Jan 14;31(1):81-5. Epub 2010 Oct 14.

Department of Pathology and Laboratory Medicine, Weill Cornell Medical College of Cornell University, New York, NY 10065, USA.

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http://dx.doi.org/10.1161/ATVBAHA.110.213496DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3013369PMC
January 2011

International Union of Basic and Clinical Pharmacology. LXXVIII. Lysophospholipid receptor nomenclature.

Pharmacol Rev 2010 Dec;62(4):579-87

Department of Molecular Biology, The Scripps Research Institute, 10550 N. Torrey Pines Rd., La Jolla, CA 92037, USA.

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http://pharmrev.aspetjournals.org/cgi/doi/10.1124/pr.110.003
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http://dx.doi.org/10.1124/pr.110.003111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993255PMC
December 2010

Sphingosine interaction with acidic leucine-rich nuclear phosphoprotein-32A (ANP32A) regulates PP2A activity and cyclooxygenase (COX)-2 expression in human endothelial cells.

J Biol Chem 2010 Aug 17;285(35):26825-31. Epub 2010 Jun 17.

Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University, Center for Vascular Biology, New York, New York 10065, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M110.147058
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http://dx.doi.org/10.1074/jbc.M110.147058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2930681PMC
August 2010

Cell-surface residence of sphingosine 1-phosphate receptor 1 on lymphocytes determines lymphocyte egress kinetics.

J Exp Med 2010 Jul 28;207(7):1475-83. Epub 2010 Jun 28.

Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University, New York, NY 10065, USA.

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http://dx.doi.org/10.1084/jem.20091343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901064PMC
July 2010

Inhibitory role of sphingosine 1-phosphate receptor 2 in macrophage recruitment during inflammation.

J Immunol 2010 Feb 30;184(3):1475-83. Epub 2009 Dec 30.

Department of Cell Biology, Center for Vascular Biology, University of Connecticut Health Center, Farmington, CT 06030, USA.

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http://dx.doi.org/10.4049/jimmunol.0901586DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068864PMC
February 2010

Ramping up RANTES in the acute response to arterial injury.

J Clin Invest 2010 Jan 28;120(1):90-2. Epub 2009 Dec 28.

Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10065, USA.

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http://www.jci.org/articles/view/41738
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http://dx.doi.org/10.1172/JCI41738DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2798704PMC
January 2010

Essential role of the RNA-binding protein HuR in progenitor cell survival in mice.

J Clin Invest 2009 Dec 2;119(12):3530-43. Epub 2009 Nov 2.

Center for Vascular Biology, University of Connecticut Health Center, Farmington, Connecticut, USA.

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http://dx.doi.org/10.1172/JCI38263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2786787PMC
December 2009

Regulation of vascular physiology and pathology by the S1P2 receptor subtype.

Cardiovasc Res 2009 May 15;82(2):221-8. Epub 2009 Mar 15.

Center for Vascular Biology, University of Connecticut Health Center, Farmington, CT 06030-3501, USA.

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https://academic.oup.com/cardiovascres/article-lookup/doi/10
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http://dx.doi.org/10.1093/cvr/cvp088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2721650PMC
May 2009

Lysophospholipid receptors in vertebrate development, physiology, and pathology.

J Lipid Res 2009 Apr 8;50 Suppl:S293-8. Epub 2008 Dec 8.

Center for Vascular Biology, University of Connecticut Health Center, Farmington, CT 06030, USA.

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http://dx.doi.org/10.1194/jlr.R800047-JLR200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2674736PMC
April 2009

PPARdelta is pro-tumorigenic in a mouse model of COX-2-induced mammary cancer.

Prostaglandins Other Lipid Mediat 2009 Apr 24;88(3-4):97-100. Epub 2008 Dec 24.

Center for Vascular Biology, University of Connecticut Health Center, Farmington, CT 06030-3501, United States.

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http://dx.doi.org/10.1016/j.prostaglandins.2008.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662999PMC
April 2009

S1P/S1P1 signaling stimulates cell migration and invasion in Wilms tumor.

Cancer Lett 2009 Apr 7;276(2):171-9. Epub 2009 Jan 7.

Center for Vascular Biology, University of Connecticut Health Center, Farmington, CT 06030, USA.

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http://dx.doi.org/10.1016/j.canlet.2008.11.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943759PMC
April 2009

S1P/S1P2 signaling induces cyclooxygenase-2 expression in Wilms tumor.

J Urol 2009 Mar 20;181(3):1347-52. Epub 2009 Jan 20.

Center for Vascular Biology, University of Connecticut Health Center, Farmington, Connecticut, USA.

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http://dx.doi.org/10.1016/j.juro.2008.10.140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132875PMC
March 2009

Cell biology. The ABCs of lipophile transport.

Science 2009 Feb;323(5916):883-4

Center for Vascular Biology, University of Connecticut Health Center, Farmington, CT 06030, USA.

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http://dx.doi.org/10.1126/science.1170009DOI Listing
February 2009