Publications by authors named "Timothy He"

16Publications

A highly potent CD73 biparatopic antibody blocks organization of the enzyme active site through dual mechanisms.

Authors:
James E Stefano Dana M Lord Yanfeng Zhou Julie Jaworski Joern Hopke Tara Travaline Ningning Zhang Karen Wong Amanda Lennon Timothy He Eva Bric-Furlong Cornishia Cherrie Tristan Magnay Elisabeth Remy William Brondyk Huawei Qiu Katarina Radošević

J Biol Chem 2020 Dec 29;295(52):18379-18389. Epub 2020 Oct 29.

Biologics Research, Sanofi R&D Framingham, Massachusetts, USA.

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December 2020

Dependence on the Pyrimidine Biosynthetic Enzyme DHODH Is a Synthetic Lethal Vulnerability in Mutant KRAS-Driven Cancers.

Authors:
Malvika Koundinya Judith Sudhalter Albane Courjaud Bruno Lionne Gaetan Touyer Luc Bonnet Isabelle Menguy Isabelle Schreiber Christelle Perrault Stephanie Vougier Brigitte Benhamou Bailin Zhang Timothy He Qiang Gao Patricia Gee Daniel Simard M Paola Castaldi Ronald Tomlinson Stephan Reiling Matthieu Barrague Richard Newcombe Hui Cao Yanjun Wang Fangxian Sun Joshua Murtie Mark Munson Eric Yang David Harper Monsif Bouaboula Jack Pollard Claudine Grepin Carlos Garcia-Echeverria Hong Cheng Francisco Adrian Christopher Winter Stuart Licht Ivan Cornella-Taracido Rosalia Arrebola Aaron Morris

Cell Chem Biol 2018 06 5;25(6):705-717.e11. Epub 2018 Apr 5.

Cancer Biology, Oncology Division, Sanofi, Cambridge, MA 02138, USA. Electronic address:

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June 2018

A Robust Multiplex Mass Spectrometric Assay for Screening Small-Molecule Inhibitors of CD73 with Diverse Inhibition Modalities.

Authors:
Jessica McManus Timothy He Julie-Ann Gavigan Ghislaine Marchand Stephanie Vougier Olivier Bedel Paul Ferrari Rosalia Arrebola Timothy Gillespy Richard C Gregory Stuart Licht Hong Cheng Bailin Zhang Gejing Deng

SLAS Discov 2018 03 16;23(3):264-273. Epub 2018 Jan 16.

1 Translational Sciences, Sanofi, Cambridge, MA, USA.

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March 2018

Glutaminase is essential for the growth of triple-negative breast cancer cells with a deregulated glutamine metabolism pathway and its suppression synergizes with mTOR inhibition.

Authors:
Michael Lampa Heike Arlt Timothy He Beatriz Ospina Jason Reeves Bailin Zhang Joshua Murtie Gejing Deng Claude Barberis Dietmar Hoffmann Hong Cheng Jack Pollard Christopher Winter Victoria Richon Carlos Garcia-Escheverria Francisco Adrian Dmitri Wiederschain Lakshmi Srinivasan

PLoS One 2017 26;12(9):e0185092. Epub 2017 Sep 26.

Oncology, Sanofi, Cambridge, MA, United States of America.

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October 2017

Extreme Vulnerability of IDH1 Mutant Cancers to NAD+ Depletion.

Authors:
Kensuke Tateishi Hiroaki Wakimoto A John Iafrate Shota Tanaka Franziska Loebel Nina Lelic Dmitri Wiederschain Olivier Bedel Gejing Deng Bailin Zhang Timothy He Xu Shi Robert E Gerszten Yiyun Zhang Jing-Ruey J Yeh William T Curry Dan Zhao Sudhandra Sundaram Fares Nigim Mara V A Koerner Quan Ho David E Fisher Elisabeth M Roider Lajos V Kemeny Yardena Samuels Keith T Flaherty Tracy T Batchelor Andrew S Chi Daniel P Cahill

Cancer Cell 2015 Dec;28(6):773-784

Department of Neurosurgery, Translational Neuro-Oncology Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. Electronic address:

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December 2015

Discovery and Pharmacology of a Novel Class of Diacylglycerol Acyltransferase 2 Inhibitors.

Authors:
Jason E Imbriglio Dong-Ming Shen Rui Liang Ken Marby Ming You Hye Won Youm Zhe Feng Clare London Yusheng Xiong Jim Tata Andreas Verras Margarita Garcia-Calvo Xuelei Song George H Addona Dave G McLaren Timothy He Beth Murphy Dan E Metzger Gino Salituro Diana Deckman Qing Chen Xiaoling Jin Steven J Stout Sheng-Ping Wang Larissa Wilsie Oksana Palyha Seongah Han Brian K Hubbard Stephen F Previs Shirly Pinto Andrew Taggart

J Med Chem 2015 Dec 20;58(23):9345-53. Epub 2015 Nov 20.

Department of Discovery Chemistry, ‡Chemistry Modeling, and Informatics, §In Vitro Pharmacology, ∥In Vivo Pharmacology, ⊥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, #Basic Pharmaceutical Sciences, and ○Atherosclerosis, Merck & Co., Inc. , 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.

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December 2015

Selective blockade of the hydrolysis of the endocannabinoid 2-arachidonoylglycerol impairs learning and memory performance while producing antinociceptive activity in rodents.

Authors:
Guy Griebel Philippe Pichat Sandra Beeské Thibaud Leroy Nicolas Redon Agnès Jacquet Dominique Françon Lionel Bert Luc Even Mati Lopez-Grancha Tatiana Tolstykh Fangxian Sun Qunyan Yu Scott Brittain Heike Arlt Timothy He Bailin Zhang Dmitri Wiederschain Thomas Bertrand Jacques Houtmann Alexey Rak François Vallée Nadine Michot Franck Augé Véronique Menet Olivier E Bergis Pascal George Patrick Avenet Vincent Mikol Michel Didier Johanna Escoubet

Sci Rep 2015 Jan 6;5:7642. Epub 2015 Jan 6.

Exploratory Unit, Montpellier, France.

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January 2015

Selective inhibition of mutant isocitrate dehydrogenase 1 (IDH1) via disruption of a metal binding network by an allosteric small molecule.

Authors:
Gejing Deng Junqing Shen Ming Yin Jessica McManus Magali Mathieu Patricia Gee Timothy He Chaomei Shi Olivier Bedel Larry R McLean Frank Le-Strat Ying Zhang Jean-Pierre Marquette Qiang Gao Bailin Zhang Alexey Rak Dietmar Hoffmann Eamonn Rooney Aurelie Vassort Walter Englaro Yi Li Vinod Patel Francisco Adrian Stefan Gross Dmitri Wiederschain Hong Cheng Stuart Licht

J Biol Chem 2015 Jan 12;290(2):762-74. Epub 2014 Nov 12.

From Division of Oncology Drug Discovery and Preclinical Development, Sanofi, Cambridge, Massachusetts 02139.

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January 2015

Small molecule activation of lecithin cholesterol acyltransferase modulates lipoprotein metabolism in mice and hamsters.

Authors:
Zhu Chen Sheng-ping Wang Mihajlo L Krsmanovic Jose Castro-Perez Karen Gagen Vivienne Mendoza Ray Rosa Vinit Shah Timothy He Steve J Stout Neil S Geoghagen Sang H Lee David G McLaren Liangsu Wang Thomas P Roddy Andrew S Plump Brian K Hubbard Christopher J Sinz Douglas G Johns

Metabolism 2012 Apr 14;61(4):470-81. Epub 2011 Oct 14.

Cardiovascular Diseases, Merck Research Laboratories, Rahway, NJ 07065, USA.

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April 2012

The use of stable-isotopically labeled oleic acid to interrogate lipid assembly in vivo: assessing pharmacological effects in preclinical species.

Authors:
David G McLaren Timothy He Sheng-Ping Wang Vivienne Mendoza Raymond Rosa Karen Gagen Gowri Bhat Kithsiri Herath Paul L Miller Sloan Stribling Andrew Taggart Jason Imbriglio Jinqi Liu Dunlu Chen Shirly Pinto James M Balkovec Robert J Devita Donald J Marsh Jose M Castro-Perez Alison Strack Douglas G Johns Stephen F Previs Brian K Hubbard Thomas P Roddy

J Lipid Res 2011 Jun 17;52(6):1150-61. Epub 2011 Mar 17.

Merck Research Laboratories, Merck & Co., Inc. Rahway, NJ, USA.

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June 2011

Towards prediction of in vivo intestinal absorption using a 96-well Caco-2 assay.

Authors:
Suzanne Skolnik Xuena Lin Jianling Wang Xiao-Hui Chen Timothy He Bailin Zhang

J Pharm Sci 2010 Jul;99(7):3246-65

Metabolism and Pharmacokinetics Platform, Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.

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July 2010

Folate deficiency induces genomic uracil misincorporation and hypomethylation but does not increase DNA point mutations.

Authors:
Heinz G Linhart Aron Troen George W Bell Erika Cantu Wei-Hsun Chao Eva Moran Eveline Steine Timothy He Rudolf Jaenisch

Gastroenterology 2009 Jan 9;136(1):227-235.e3. Epub 2008 Oct 9.

Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA.

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January 2009

Evaluation of fluorescence- and mass spectrometry-based CYP inhibition assays for use in drug discovery.

Authors:
Leslie Bell Shari Bickford Phong Hung Nguyen Jianling Wang Timothy He Bailin Zhang Yannick Friche Alfred Zimmerlin Laszlo Urban Dejan Bojanic

J Biomol Screen 2008 Jun 12;13(5):343-53. Epub 2008 May 12.

ADME Profiling Cambridge, Metabolism and Pharmacokinetics, Global Discovery Chemistry, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts 02139, USA.

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June 2008

Dnmt3b promotes tumorigenesis in vivo by gene-specific de novo methylation and transcriptional silencing.

Authors:
Heinz G Linhart Haijiang Lin Yasuhiro Yamada Eva Moran Eveline J Steine Sumita Gokhale Grace Lo Erika Cantu Mathias Ehrich Timothy He Alex Meissner Rudolf Jaenisch

Genes Dev 2007 Dec;21(23):3110-22

Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA.

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December 2007

Complete inactivation of DNMT1 leads to mitotic catastrophe in human cancer cells.

Authors:
Taiping Chen Sarah Hevi Frédérique Gay Naomi Tsujimoto Timothy He Bailin Zhang Yoshihide Ueda En Li

Nat Genet 2007 Mar 18;39(3):391-6. Epub 2007 Feb 18.

Epigenetics Program, Novartis Institutes for Biomedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.

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March 2007

Metabolism of pyrene by two clam species, Mya arenaria and Protothaca staminea.

Authors:
Christopher D Simpson William R Cullen Timothy Y T He Michael Ikonomou Kenneth J Reimer

Chemosphere 2002 Oct;49(3):315-22

Department of Chemistry, University of British Columbia, Vancouver, Canada.

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October 2002