Publications by authors named "Timothy He"

16Publications

Discovery and Pharmacology of a Novel Class of Diacylglycerol Acyltransferase 2 Inhibitors.

J Med Chem 2015 Dec 20;58(23):9345-53. Epub 2015 Nov 20.

Department of Discovery Chemistry, ‡Chemistry Modeling, and Informatics, §In Vitro Pharmacology, ∥In Vivo Pharmacology, ⊥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, #Basic Pharmaceutical Sciences, and ○Atherosclerosis, Merck & Co., Inc. , 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.

View Article and Find Full Text PDF
December 2015

Towards prediction of in vivo intestinal absorption using a 96-well Caco-2 assay.

J Pharm Sci 2010 Jul;99(7):3246-65

Metabolism and Pharmacokinetics Platform, Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.

View Article and Find Full Text PDF
July 2010

Folate deficiency induces genomic uracil misincorporation and hypomethylation but does not increase DNA point mutations.

Gastroenterology 2009 Jan 9;136(1):227-235.e3. Epub 2008 Oct 9.

Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA.

View Article and Find Full Text PDF
January 2009

Evaluation of fluorescence- and mass spectrometry-based CYP inhibition assays for use in drug discovery.

J Biomol Screen 2008 Jun 12;13(5):343-53. Epub 2008 May 12.

ADME Profiling Cambridge, Metabolism and Pharmacokinetics, Global Discovery Chemistry, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts 02139, USA.

View Article and Find Full Text PDF
June 2008

Dnmt3b promotes tumorigenesis in vivo by gene-specific de novo methylation and transcriptional silencing.

Genes Dev 2007 Dec;21(23):3110-22

Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA.

View Article and Find Full Text PDF
December 2007

Complete inactivation of DNMT1 leads to mitotic catastrophe in human cancer cells.

Nat Genet 2007 Mar 18;39(3):391-6. Epub 2007 Feb 18.

Epigenetics Program, Novartis Institutes for Biomedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.

View Article and Find Full Text PDF
March 2007

Metabolism of pyrene by two clam species, Mya arenaria and Protothaca staminea.

Chemosphere 2002 Oct;49(3):315-22

Department of Chemistry, University of British Columbia, Vancouver, Canada.

View Article and Find Full Text PDF
October 2002