Timothy F Osborne

Timothy F Osborne

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Timothy F Osborne

Timothy F Osborne

Publications by authors named "Timothy F Osborne"

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Estrogen-related receptor γ controls sterol regulatory element-binding protein-1c expression and alcoholic fatty liver.

Biochim Biophys Acta Mol Cell Biol Lipids 2019 Aug 31;1864(12):158521. Epub 2019 Aug 31.

National Creative Research Initiatives Center for Nuclear Receptor Signals, Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University, Gwangju 61186, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2019.158521DOI Listing
August 2019

SREBP-1a-stimulated lipid synthesis is required for macrophage phagocytosis downstream of TLR4-directed mTORC1.

Proc Natl Acad Sci U S A 2018 12 10;115(52):E12228-E12234. Epub 2018 Dec 10.

Institute for Fundamental Biomedical Research, Johns Hopkins University School of Medicine, St. Petersburg, FL 33701;

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http://dx.doi.org/10.1073/pnas.1813458115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310840PMC
December 2018

T1R2 receptor-mediated glucose sensing in the upper intestine potentiates glucose absorption through activation of local regulatory pathways.

Mol Metab 2018 11 27;17:98-111. Epub 2018 Aug 27.

Center for Metabolic Origins of Disease, Sanford Burnham Prebys Medical Discovery Institute, Orlando, FL, USA; Translational Research Institute for Metabolism and Diabetes, Florida Hospital, Orlando, FL, USA; Department of Biological Chemistry and Pharmacology, College of Medicine, The Ohio State University, Columbus, OH, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22128778183049
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http://dx.doi.org/10.1016/j.molmet.2018.08.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197762PMC
November 2018

Differential open chromatin profile and transcriptomic signature define depot-specific human subcutaneous preadipocytes: primary outcomes.

Clin Epigenetics 2018 11 26;10(1):148. Epub 2018 Nov 26.

Translational Research Institute for Metabolism and Diabetes, Florida Hospital, 301 E. Princeton Street, Orlando, FL, 32804, USA.

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https://clinicalepigeneticsjournal.biomedcentral.com/article
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http://dx.doi.org/10.1186/s13148-018-0582-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258289PMC
November 2018

Skeletal muscle overexpression of nicotinamide phosphoribosyl transferase in mice coupled with voluntary exercise augments exercise endurance.

Mol Metab 2018 01 6;7:1-11. Epub 2017 Nov 6.

Sanford-Burnham-Prebys Medical Discovery Institute, Orlando, FL, USA; Pennington Biomedical Research Center, Baton Rouge, LA, USA; Translational Research Institute for Metabolism and Diabetes, Orlando, FL, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2017.10.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784330PMC
January 2018

Hepatocyte ABCA1 Deletion Impairs Liver Insulin Signaling and Lipogenesis.

Cell Rep 2017 06;19(10):2116-2129

Section on Molecular Medicine, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.05.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5512440PMC
June 2017

miRNA and cholesterol homeostasis.

Biochim Biophys Acta 2016 12 15;1861(12 Pt B):2041-2046. Epub 2016 Jan 15.

Integrative Metabolism Program, Sanford.Burnham.Prebys Medical Discovery Institute, Orlando, FL, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2016.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980302PMC
December 2016

SREBP-2/PNPLA8 axis improves non-alcoholic fatty liver disease through activation of autophagy.

Sci Rep 2016 10 21;6:35732. Epub 2016 Oct 21.

School of Life Sciences, Ulsan National Institute of Science and Technology (UNIST), UNIST-gil 50, Ulsan, 44919, Korea.

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http://dx.doi.org/10.1038/srep35732DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5073315PMC
October 2016

SETDB2 Links Glucocorticoid to Lipid Metabolism through Insig2a Regulation.

Cell Metab 2016 09 25;24(3):474-484. Epub 2016 Aug 25.

Sanford Burnham Prebys Medical Discovery Institute, 6400 Sanger Road, Orlando, FL 32827, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.07.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023502PMC
September 2016

SREBP-2-deficient and hypomorphic mice reveal roles for SREBP-2 in embryonic development and SREBP-1c expression.

J Lipid Res 2016 Mar 18;57(3):410-21. Epub 2015 Dec 18.

Departments of Human Genetics David Geffen School of Medicine at the University of California, Los Angeles, CA 90095 Medicine, David Geffen School of Medicine at the University of California, Los Angeles, CA 90095 Molecular Biology Institute, University of California, Los Angeles, CA 90095

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http://www.jlr.org/content/early/2015/12/18/jlr.M064022.full
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http://www.jlr.org/content/57/3/410.full.pdf
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http://www.jlr.org/lookup/doi/10.1194/jlr.M064022
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http://dx.doi.org/10.1194/jlr.M064022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766990PMC
March 2016

H3K4/H3K9me3 Bivalent Chromatin Domains Targeted by Lineage-Specific DNA Methylation Pauses Adipocyte Differentiation.

Mol Cell 2015 Nov;60(4):584-96

Division of Metabolic Medicine, The University of Tokyo, 4-6-1, Komaba, Meguro-ku, Tokyo 153-8904, Japan; The Translational Systems Biology and Medicine Initiative (TSBMI), Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, Tokyo 113-8655, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2015.10.025DOI Listing
November 2015

JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis.

Nat Commun 2015 May 7;6:7052. Epub 2015 May 7.

1] Division of Metabolic Medicine, Research Center for Advanced Science and Technology (RCAST), The University of Tokyo, Tokyo 153-8904, Japan [2] The Translational Systems Biology and Medicine Initiative, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, University of Tokyo, Tokyo 113-8655, Japan.

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http://dx.doi.org/10.1038/ncomms8052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432656PMC
May 2015

Lipid-cell cycle nexus: SREBP regulates microRNAs targeting Fbxw7.

Cell Cycle 2014 13;13(3):339-40. Epub 2013 Dec 13.

Metabolic Signaling and Disease Program and Diabetes and Obesity Center; Sanford-Burnham Medical Research Institute; Orlando, FL USA.

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http://dx.doi.org/10.4161/cc.27509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956523PMC
January 2015

Partitioning circadian transcription by SIRT6 leads to segregated control of cellular metabolism.

Cell 2014 Jul;158(3):659-72

Center for Epigenetics and Metabolism, University of California, Irvine, Irvine, CA 92697, USA; Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA; Institute for Genomics and Bioinformatics, University of California, Irvine, Irvine, CA 92697, USA; INSERM U904, Sprague Hall, University of California, Irvine, Irvine, CA 92697, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674140088
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http://dx.doi.org/10.1016/j.cell.2014.06.050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472354PMC
July 2014

Response to Gerlic et al.

Cell Metab 2014 Mar;19(3):346-7

Metabolic Disease Program, Sanford-Burnham Medical Research Institute, Orlando, FL 32827, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2014.02.016DOI Listing
March 2014

An SREBP-responsive microRNA operon contributes to a regulatory loop for intracellular lipid homeostasis.

Cell Metab 2013 Jul;18(1):51-61

Metabolic Signaling and Disease Program and Diabetes and Obesity Center, Sanford-Burnham Medical Research Institute, Orlando, Florida 32827, USA.

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http://dx.doi.org/10.1016/j.cmet.2013.06.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3740797PMC
July 2013

Genome-wide analysis of FoxO1 binding in hepatic chromatin: potential involvement of FoxO1 in linking retinoid signaling to hepatic gluconeogenesis.

Nucleic Acids Res 2012 Dec 12;40(22):11499-509. Epub 2012 Oct 12.

Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA.

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http://dx.doi.org/10.1093/nar/gks932DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526316PMC
December 2012

Protection from bacterial-toxin-induced apoptosis in macrophages requires the lipogenic transcription factor sterol regulatory element binding protein 1a.

Mol Cell Biol 2012 Jun 9;32(12):2196-202. Epub 2012 Apr 9.

Department of Physiology, Keimyung University School of Medicine, Dalseo-Gu, Daegu, South Korea.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.06294-11
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http://dx.doi.org/10.1128/MCB.06294-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3372266PMC
June 2012

Guidelines for the use and interpretation of assays for monitoring autophagy.

Authors:
Daniel J Klionsky Fabio C Abdalla Hagai Abeliovich Robert T Abraham Abraham Acevedo-Arozena Khosrow Adeli Lotta Agholme Maria Agnello Patrizia Agostinis Julio A Aguirre-Ghiso Hyung Jun Ahn Ouardia Ait-Mohamed Slimane Ait-Si-Ali Takahiko Akematsu Shizuo Akira Hesham M Al-Younes Munir A Al-Zeer Matthew L Albert Roger L Albin Javier Alegre-Abarrategui Maria Francesca Aleo Mehrdad Alirezaei Alexandru Almasan Maylin Almonte-Becerril Atsuo Amano Ravi Amaravadi Shoba Amarnath Amal O Amer Nathalie Andrieu-Abadie Vellareddy Anantharam David K Ann Shailendra Anoopkumar-Dukie Hiroshi Aoki Nadezda Apostolova Giuseppe Arancia John P Aris Katsuhiko Asanuma Nana Y O Asare Hisashi Ashida Valerie Askanas David S Askew Patrick Auberger Misuzu Baba Steven K Backues Eric H Baehrecke Ben A Bahr Xue-Yuan Bai Yannick Bailly Robert Baiocchi Giulia Baldini Walter Balduini Andrea Ballabio Bruce A Bamber Edward T W Bampton Gábor Bánhegyi Clinton R Bartholomew Diane C Bassham Robert C Bast Henri Batoko Boon-Huat Bay Isabelle Beau Daniel M Béchet Thomas J Begley Christian Behl Christian Behrends Soumeya Bekri Bryan Bellaire Linda J Bendall Luca Benetti Laura Berliocchi Henri Bernardi Francesca Bernassola Sébastien Besteiro Ingrid Bhatia-Kissova Xiaoning Bi Martine Biard-Piechaczyk Janice S Blum Lawrence H Boise Paolo Bonaldo David L Boone Beat C Bornhauser Karina R Bortoluci Ioannis Bossis Frédéric Bost Jean-Pierre Bourquin Patricia Boya Michaël Boyer-Guittaut Peter V Bozhkov Nathan R Brady Claudio Brancolini Andreas Brech Jay E Brenman Ana Brennand Emery H Bresnick Patrick Brest Dave Bridges Molly L Bristol Paul S Brookes Eric J Brown John H Brumell Nicola Brunetti-Pierri Ulf T Brunk Dennis E Bulman Scott J Bultman Geert Bultynck Lena F Burbulla Wilfried Bursch Jonathan P Butchar Wanda Buzgariu Sergio P Bydlowski Ken Cadwell Monika Cahová Dongsheng Cai Jiyang Cai Qian Cai Bruno Calabretta Javier Calvo-Garrido Nadine Camougrand Michelangelo Campanella Jenny Campos-Salinas Eleonora Candi Lizhi Cao Allan B Caplan Simon R Carding Sandra M Cardoso Jennifer S Carew Cathleen R Carlin Virginie Carmignac Leticia A M Carneiro Serena Carra Rosario A Caruso Giorgio Casari Caty Casas Roberta Castino Eduardo Cebollero Francesco Cecconi Jean Celli Hassan Chaachouay Han-Jung Chae Chee-Yin Chai David C Chan Edmond Y Chan Raymond Chuen-Chung Chang Chi-Ming Che Ching-Chow Chen Guang-Chao Chen Guo-Qiang Chen Min Chen Quan Chen Steve S-L Chen WenLi Chen Xi Chen Xiangmei Chen Xiequn Chen Ye-Guang Chen Yingyu Chen Yongqiang Chen Yu-Jen Chen Zhixiang Chen Alan Cheng Christopher H K Cheng Yan Cheng Heesun Cheong Jae-Ho Cheong Sara Cherry Russ Chess-Williams Zelda H Cheung Eric Chevet Hui-Ling Chiang Roberto Chiarelli Tomoki Chiba Lih-Shen Chin Shih-Hwa Chiou Francis V Chisari Chi Hin Cho Dong-Hyung Cho Augustine M K Choi DooSeok Choi Kyeong Sook Choi Mary E Choi Salem Chouaib Divaker Choubey Vinay Choubey Charleen T Chu Tsung-Hsien Chuang Sheau-Huei Chueh Taehoon Chun Yong-Joon Chwae Mee-Len Chye Roberto Ciarcia Maria R Ciriolo Michael J Clague Robert S B Clark Peter G H Clarke Robert Clarke Patrice Codogno Hilary A Coller María I Colombo Sergio Comincini Maria Condello Fabrizio Condorelli Mark R Cookson Graham H Coombs Isabelle Coppens Ramon Corbalan Pascale Cossart Paola Costelli Safia Costes Ana Coto-Montes Eduardo Couve Fraser P Coxon James M Cregg José L Crespo Marianne J Cronjé Ana Maria Cuervo Joseph J Cullen Mark J Czaja Marcello D'Amelio Arlette Darfeuille-Michaud Lester M Davids Faith E Davies Massimo De Felici John F de Groot Cornelis A M de Haan Luisa De Martino Angelo De Milito Vincenzo De Tata Jayanta Debnath Alexei Degterev Benjamin Dehay Lea M D Delbridge Francesca Demarchi Yi Zhen Deng Jörn Dengjel Paul Dent Donna Denton Vojo Deretic Shyamal D Desai Rodney J Devenish Mario Di Gioacchino Gilbert Di Paolo Chiara Di Pietro Guillermo Díaz-Araya Inés Díaz-Laviada Maria T Diaz-Meco Javier Diaz-Nido Ivan Dikic Savithramma P Dinesh-Kumar Wen-Xing Ding Clark W Distelhorst Abhinav Diwan Mojgan Djavaheri-Mergny Svetlana Dokudovskaya Zheng Dong Frank C Dorsey Victor Dosenko James J Dowling Stephen Doxsey Marlène Dreux Mark E Drew Qiuhong Duan Michel A Duchosal Karen Duff Isabelle Dugail Madeleine Durbeej Michael Duszenko Charles L Edelstein Aimee L Edinger Gustavo Egea Ludwig Eichinger N Tony Eissa Suhendan Ekmekcioglu Wafik S El-Deiry Zvulun Elazar Mohamed Elgendy Lisa M Ellerby Kai Er Eng Anna-Mart Engelbrecht Simone Engelender Jekaterina Erenpreisa Ricardo Escalante Audrey Esclatine Eeva-Liisa Eskelinen Lucile Espert Virginia Espina Huizhou Fan Jia Fan Qi-Wen Fan Zhen Fan Shengyun Fang Yongqi Fang Manolis Fanto Alessandro Fanzani Thomas Farkas Jean-Claude Farré Mathias Faure Marcus Fechheimer Carl G Feng Jian Feng Qili Feng Youji Feng László Fésüs Ralph Feuer Maria E Figueiredo-Pereira Gian Maria Fimia Diane C Fingar Steven Finkbeiner Toren Finkel Kim D Finley Filomena Fiorito Edward A Fisher Paul B Fisher Marc Flajolet Maria L Florez-McClure Salvatore Florio Edward A Fon Francesco Fornai Franco Fortunato Rati Fotedar Daniel H Fowler Howard S Fox Rodrigo Franco Lisa B Frankel Marc Fransen José M Fuentes Juan Fueyo Jun Fujii Kozo Fujisaki Eriko Fujita Mitsunori Fukuda Ruth H Furukawa Matthias Gaestel Philippe Gailly Malgorzata Gajewska Brigitte Galliot Vincent Galy Subramaniam Ganesh Barry Ganetzky Ian G Ganley Fen-Biao Gao George F Gao Jinming Gao Lorena Garcia Guillermo Garcia-Manero Mikel Garcia-Marcos Marjan Garmyn Andrei L Gartel Evelina Gatti Mathias Gautel Thomas R Gawriluk Matthew E Gegg Jiefei Geng Marc Germain Jason E Gestwicki David A Gewirtz Saeid Ghavami Pradipta Ghosh Anna M Giammarioli Alexandra N Giatromanolaki Spencer B Gibson Robert W Gilkerson Michael L Ginger Henry N Ginsberg Jakub Golab Michael S Goligorsky Pierre Golstein Candelaria Gomez-Manzano Ebru Goncu Céline Gongora Claudio D Gonzalez Ramon Gonzalez Cristina González-Estévez Rosa Ana González-Polo Elena Gonzalez-Rey Nikolai V Gorbunov Sharon Gorski Sandro Goruppi Roberta A Gottlieb Devrim Gozuacik Giovanna Elvira Granato Gary D Grant Kim N Green Aleš Gregorc Frédéric Gros Charles Grose Thomas W Grunt Philippe Gual Jun-Lin Guan Kun-Liang Guan Sylvie M Guichard Anna S Gukovskaya Ilya Gukovsky Jan Gunst Asa B Gustafsson Andrew J Halayko Amber N Hale Sandra K Halonen Maho Hamasaki Feng Han Ting Han Michael K Hancock Malene Hansen Hisashi Harada Masaru Harada Stefan E Hardt J Wade Harper Adrian L Harris James Harris Steven D Harris Makoto Hashimoto Jeffrey A Haspel Shin-ichiro Hayashi Lori A Hazelhurst Congcong He You-Wen He Marie-Joseé Hébert Kim A Heidenreich Miep H Helfrich Gudmundur V Helgason Elizabeth P Henske Brian Herman Paul K Herman Claudio Hetz Sabine Hilfiker Joseph A Hill Lynne J Hocking Paul Hofman Thomas G Hofmann Jörg Höhfeld Tessa L Holyoake Ming-Huang Hong David A Hood Gökhan S Hotamisligil Ewout J Houwerzijl Maria Høyer-Hansen Bingren Hu Chien-An A Hu Hong-Ming Hu Ya Hua Canhua Huang Ju Huang Shengbing Huang Wei-Pang Huang Tobias B Huber Won-Ki Huh Tai-Ho Hung Ted R Hupp Gang Min Hur James B Hurley Sabah N A Hussain Patrick J Hussey Jung Jin Hwang Seungmin Hwang Atsuhiro Ichihara Shirin Ilkhanizadeh Ken Inoki Takeshi Into Valentina Iovane Juan L Iovanna Nancy Y Ip Yoshitaka Isaka Hiroyuki Ishida Ciro Isidoro Ken-ichi Isobe Akiko Iwasaki Marta Izquierdo Yotaro Izumi Panu M Jaakkola Marja Jäättelä George R Jackson William T Jackson Bassam Janji Marina Jendrach Ju-Hong Jeon Eui-Bae Jeung Hong Jiang Hongchi Jiang Jean X Jiang Ming Jiang Qing Jiang Xuejun Jiang Xuejun Jiang Alberto Jiménez Meiyan Jin Shengkan Jin Cheol O Joe Terje Johansen Daniel E Johnson Gail V W Johnson Nicola L Jones Bertrand Joseph Suresh K Joseph Annie M Joubert Gábor Juhász Lucienne Juillerat-Jeanneret Chang Hwa Jung Yong-Keun Jung Kai Kaarniranta Allen Kaasik Tomohiro Kabuta Motoni Kadowaki Katarina Kagedal Yoshiaki Kamada Vitaliy O Kaminskyy Harm H Kampinga Hiromitsu Kanamori Chanhee Kang Khong Bee Kang Kwang Il Kang Rui Kang Yoon-A Kang Tomotake Kanki Thirumala-Devi Kanneganti Haruo Kanno Anumantha G Kanthasamy Arthi Kanthasamy Vassiliki Karantza Gur P Kaushal Susmita Kaushik Yoshinori Kawazoe Po-Yuan Ke John H Kehrl Ameeta Kelekar Claus Kerkhoff David H Kessel Hany Khalil Jan A K W Kiel Amy A Kiger Akio Kihara Deok Ryong Kim Do-Hyung Kim Dong-Hou Kim Eun-Kyoung Kim Hyung-Ryong Kim Jae-Sung Kim Jeong Hun Kim Jin Cheon Kim John K Kim Peter K Kim Seong Who Kim Yong-Sun Kim Yonghyun Kim Adi Kimchi Alec C Kimmelman Jason S King Timothy J Kinsella Vladimir Kirkin Lorrie A Kirshenbaum Katsuhiko Kitamoto Kaio Kitazato Ludger Klein Walter T Klimecki Jochen Klucken Erwin Knecht Ben C B Ko Jan C Koch Hiroshi Koga Jae-Young Koh Young Ho Koh Masato Koike Masaaki Komatsu Eiki Kominami Hee Jeong Kong Wei-Jia Kong Viktor I Korolchuk Yaichiro Kotake Michael I Koukourakis Juan B Kouri Flores Attila L Kovács Claudine Kraft Dimitri Krainc Helmut Krämer Carole Kretz-Remy Anna M Krichevsky Guido Kroemer Rejko Krüger Oleg Krut Nicholas T Ktistakis Chia-Yi Kuan Roza Kucharczyk Ashok Kumar Raj Kumar Sharad Kumar Mondira Kundu Hsing-Jien Kung Tino Kurz Ho Jeong Kwon Albert R La Spada Frank Lafont Trond Lamark Jacques Landry Jon D Lane Pierre Lapaquette Jocelyn F Laporte Lajos László Sergio Lavandero Josée N Lavoie Robert Layfield Pedro A Lazo Weidong Le Laurent Le Cam Daniel J Ledbetter Alvin J X Lee Byung-Wan Lee Gyun Min Lee Jongdae Lee Ju-Hyun Lee Michael Lee Myung-Shik Lee Sug Hyung Lee Christiaan Leeuwenburgh Patrick Legembre Renaud Legouis Michael Lehmann Huan-Yao Lei Qun-Ying Lei David A Leib José Leiro John J Lemasters Antoinette Lemoine Maciej S Lesniak Dina Lev Victor V Levenson Beth Levine Efrat Levy Faqiang Li Jun-Lin Li Lian Li Sheng Li Weijie Li Xue-Jun Li Yan-bo Li Yi-Ping Li Chengyu Liang Qiangrong Liang Yung-Feng Liao Pawel P Liberski Andrew Lieberman Hyunjung J Lim Kah-Leong Lim Kyu Lim Chiou-Feng Lin Fu-Cheng Lin Jian Lin Jiandie D Lin Kui Lin Wan-Wan Lin Weei-Chin Lin Yi-Ling Lin Rafael Linden Paul Lingor Jennifer Lippincott-Schwartz Michael P Lisanti Paloma B Liton Bo Liu Chun-Feng Liu Kaiyu Liu Leyuan Liu Qiong A Liu Wei Liu Young-Chau Liu Yule Liu Richard A Lockshin Chun-Nam Lok Sagar Lonial Benjamin Loos Gabriel Lopez-Berestein Carlos López-Otín Laura Lossi Michael T Lotze Peter Lőw Binfeng Lu Bingwei Lu Bo Lu Zhen Lu Frédéric Luciano Nicholas W Lukacs Anders H Lund Melinda A Lynch-Day Yong Ma Fernando Macian Jeff P MacKeigan Kay F Macleod Frank Madeo Luigi Maiuri Maria Chiara Maiuri Davide Malagoli May Christine V Malicdan Walter Malorni Na Man Eva-Maria Mandelkow Stéphen Manon Irena Manov Kai Mao Xiang Mao Zixu Mao Philippe Marambaud Daniela Marazziti Yves L Marcel Katie Marchbank Piero Marchetti Stefan J Marciniak Mateus Marcondes Mohsen Mardi Gabriella Marfe Guillermo Mariño Maria Markaki Mark R Marten Seamus J Martin Camille Martinand-Mari Wim Martinet Marta Martinez-Vicente Matilde Masini Paola Matarrese Saburo Matsuo Raffaele Matteoni Andreas Mayer Nathalie M Mazure David J McConkey Melanie J McConnell Catherine McDermott Christine McDonald Gerald M McInerney Sharon L McKenna BethAnn McLaughlin Pamela J McLean Christopher R McMaster G Angus McQuibban Alfred J Meijer Miriam H Meisler Alicia Meléndez Thomas J Melia Gerry Melino Maria A Mena Javier A Menendez Rubem F S Menna-Barreto Manoj B Menon Fiona M Menzies Carol A Mercer Adalberto Merighi Diane E Merry Stefania Meschini Christian G Meyer Thomas F Meyer Chao-Yu Miao Jun-Ying Miao Paul A M Michels Carine Michiels Dalibor Mijaljica Ana Milojkovic Saverio Minucci Clelia Miracco Cindy K Miranti Ioannis Mitroulis Keisuke Miyazawa Noboru Mizushima Baharia Mograbi Simin Mohseni Xavier Molero Bertrand Mollereau Faustino Mollinedo Takashi Momoi Iryna Monastyrska Martha M Monick Mervyn J Monteiro Michael N Moore Rodrigo Mora Kevin Moreau Paula I Moreira Yuji Moriyasu Jorge Moscat Serge Mostowy Jeremy C Mottram Tomasz Motyl Charbel E-H Moussa Sylke Müller Sylviane Muller Karl Münger Christian Münz Leon O Murphy Maureen E Murphy Antonio Musarò Indira Mysorekar Eiichiro Nagata Kazuhiro Nagata Aimable Nahimana Usha Nair Toshiyuki Nakagawa Kiichi Nakahira Hiroyasu Nakano Hitoshi Nakatogawa Meera Nanjundan Naweed I Naqvi Derek P Narendra Masashi Narita Miguel Navarro Steffan T Nawrocki Taras Y Nazarko Andriy Nemchenko Mihai G Netea Thomas P Neufeld Paul A Ney Ioannis P Nezis Huu Phuc Nguyen Daotai Nie Ichizo Nishino Corey Nislow Ralph A Nixon Takeshi Noda Angelika A Noegel Anna Nogalska Satoru Noguchi Lucia Notterpek Ivana Novak Tomoyoshi Nozaki Nobuyuki Nukina Thorsten Nürnberger Beat Nyfeler Keisuke Obara Terry D Oberley Salvatore Oddo Michinaga Ogawa Toya Ohashi Koji Okamoto Nancy L Oleinick F Javier Oliver Laura J Olsen Stefan Olsson Onya Opota Timothy F Osborne Gary K Ostrander Kinya Otsu Jing-hsiung James Ou Mireille Ouimet Michael Overholtzer Bulent Ozpolat Paolo Paganetti Ugo Pagnini Nicolas Pallet Glen E Palmer Camilla Palumbo Tianhong Pan Theocharis Panaretakis Udai Bhan Pandey Zuzana Papackova Issidora Papassideri Irmgard Paris Junsoo Park Ohkmae K Park Jan B Parys Katherine R Parzych Susann Patschan Cam Patterson Sophie Pattingre John M Pawelek Jianxin Peng David H Perlmutter Ida Perrotta George Perry Shazib Pervaiz Matthias Peter Godefridus J Peters Morten Petersen Goran Petrovski James M Phang Mauro Piacentini Philippe Pierre Valérie Pierrefite-Carle Gérard Pierron Ronit Pinkas-Kramarski Antonio Piras Natik Piri Leonidas C Platanias Stefanie Pöggeler Marc Poirot Angelo Poletti Christian Poüs Mercedes Pozuelo-Rubio Mette Prætorius-Ibba Anil Prasad Mark Prescott Muriel Priault Nathalie Produit-Zengaffinen Ann Progulske-Fox Tassula Proikas-Cezanne Serge Przedborski Karin Przyklenk Rosa Puertollano Julien Puyal Shu-Bing Qian Liang Qin Zheng-Hong Qin Susan E Quaggin Nina Raben Hannah Rabinowich Simon W Rabkin Irfan Rahman Abdelhaq Rami Georg Ramm Glenn Randall Felix Randow V Ashutosh Rao Jeffrey C Rathmell Brinda Ravikumar Swapan K Ray Bruce H Reed John C Reed Fulvio Reggiori Anne Régnier-Vigouroux Andreas S Reichert John J Reiners Russel J Reiter Jun Ren José L Revuelta Christopher J Rhodes Konstantinos Ritis Elizete Rizzo Jeffrey Robbins Michel Roberge Hernan Roca Maria C Roccheri Stephane Rocchi H Peter Rodemann Santiago Rodríguez de Córdoba Bärbel Rohrer Igor B Roninson Kirill Rosen Magdalena M Rost-Roszkowska Mustapha Rouis Kasper M A Rouschop Francesca Rovetta Brian P Rubin David C Rubinsztein Klaus Ruckdeschel Edmund B Rucker Assaf Rudich Emil Rudolf Nelson Ruiz-Opazo Rossella Russo Tor Erik Rusten Kevin M Ryan Stefan W Ryter David M Sabatini Junichi Sadoshima Tapas Saha Tatsuya Saitoh Hiroshi Sakagami Yasuyoshi Sakai Ghasem Hoseini Salekdeh Paolo Salomoni Paul M Salvaterra Guy Salvesen Rosa Salvioli Anthony M J Sanchez José A Sánchez-Alcázar Ricardo Sánchez-Prieto Marco Sandri Uma Sankar Poonam Sansanwal Laura Santambrogio Shweta Saran Sovan Sarkar Minnie Sarwal Chihiro Sasakawa Ausra 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Yoshikawa Tamotsu Yoshimori Kohki Yoshimoto Ho Jin You Richard J Youle Anas Younes Li Yu Long Yu Seong-Woon Yu Wai Haung Yu Zhi-Min Yuan Zhenyu Yue Cheol-Heui Yun Michisuke Yuzaki Olga Zabirnyk Elaine Silva-Zacarin David Zacks Eldad Zacksenhaus Nadia Zaffaroni Zahra Zakeri Herbert J Zeh Scott O Zeitlin Hong Zhang Hui-Ling Zhang Jianhua Zhang Jing-Pu Zhang Lin Zhang Long Zhang Ming-Yong Zhang Xu Dong Zhang Mantong Zhao Yi-Fang Zhao Ying Zhao Zhizhuang J Zhao Xiaoxiang Zheng Boris Zhivotovsky Qing Zhong Cong-Zhao Zhou Changlian Zhu Wei-Guo Zhu Xiao-Feng Zhu Xiongwei Zhu Yuangang Zhu Teresa Zoladek Wei-Xing Zong Antonio Zorzano Jürgen Zschocke Brian Zuckerbraun

Autophagy 2012 Apr;8(4):445-544

Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.

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http://dx.doi.org/10.4161/auto.19496DOI Listing
April 2012

SREBPs: metabolic integrators in physiology and metabolism.

Trends Endocrinol Metab 2012 Feb 7;23(2):65-72. Epub 2011 Dec 7.

Korea Food Research Institute, Seongnam, 463-746, Republic of Korea.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3273665PMC
February 2012

Sterols for Oxygen: The Metabolic Burden of Microbial SREBP.

Mol Cell 2011 Oct;44(2):172-4

Metabolic Signaling and Disease Program, Obesity and Diabetes Center, Sanford Burnham Medical Research Institute, Orlando, FL 32827, USA.

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October 2011

Gut bitter taste receptor signalling induces ABCB1 through a mechanism involving CCK.

Biochem J 2011 Aug;438(1):33-7

Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319131PMC
August 2011

Genome-wide localization of SREBP-2 in hepatic chromatin predicts a role in autophagy.

Cell Metab 2011 Apr;13(4):367-375

Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA 92697, USA; Metabolic Signaling and Disease Program, Sanford-Burnham Medical Research Institute, Orlando, FL 32827, USA. Electronic address:

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April 2011

Liver x receptors in atherosclerosis and inflammation.

Circ Res 2011 Apr;108(8):996-1001

Metabolic Signaling and Disease Program, Diabetes and Obesity Research Center, Sanford-Burnham Medical Research Institute, Lake Nona, Orlando, FL, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082200PMC
April 2011

Genome-wide interrogation of hepatic FXR reveals an asymmetric IR-1 motif and synergy with LRH-1.

Nucleic Acids Res 2010 Oct 18;38(18):6007-17. Epub 2010 May 18.

Department of Molecular Biology and Biochemistry, Institute for Genomics and Bioinformatics, University of California, Irvine, CA 92697, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952856PMC
October 2010

Activation of the farnesoid X receptor provides protection against acetaminophen-induced hepatic toxicity.

Mol Endocrinol 2010 Aug 23;24(8):1626-36. Epub 2010 Jun 23.

Department of Biological Chemistry, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California 90095, USA.

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August 2010

A feed-forward loop amplifies nutritional regulation of PNPLA3.

Proc Natl Acad Sci U S A 2010 Apr 12;107(17):7892-7. Epub 2010 Apr 12.

Departments of Molecular Genetics and Internal Medicine, The Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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April 2010

Regulation of steroid 5-alpha reductase type 2 (Srd5a2) by sterol regulatory element binding proteins and statin.

Exp Cell Res 2009 Nov 3;315(18):3133-9. Epub 2009 Jun 3.

Department of Molecular Biology and Biochemistry, 3244 McGaugh Hall, University of California, UC Irvine, Irvine, CA 92697-3900, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124118PMC
November 2009

Evolutionary conservation and adaptation in the mechanism that regulates SREBP action: what a long, strange tRIP it's been.

Genes Dev 2009 Nov;23(22):2578-91

Department of Molecular Biology and Biochemistry, University of California at Irvine, Irvine, California 92697, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779761PMC
November 2009

Sterol regulatory element binding protein 1a regulates hepatic fatty acid partitioning by activating acetyl coenzyme A carboxylase 2.

Mol Cell Biol 2009 Sep 29;29(17):4864-72. Epub 2009 Jun 29.

Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697-3900, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2725716PMC
September 2009

Genome-wide analysis of SREBP-1 binding in mouse liver chromatin reveals a preference for promoter proximal binding to a new motif.

Proc Natl Acad Sci U S A 2009 Aug 4;106(33):13765-9. Epub 2009 Aug 4.

Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA.

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August 2009

FGF15/FGFR4 integrates growth factor signaling with hepatic bile acid metabolism and insulin action.

J Biol Chem 2009 Apr 23;284(17):11110-20. Epub 2009 Feb 23.

Department of Molecular Biology and Biochemistry, School of Biological Sciences and Center for Diabetes Research and Treatment, University of California, Irvine, California 92697-3900, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670116PMC
April 2009

COUP-TFII acts downstream of Wnt/beta-catenin signal to silence PPARgamma gene expression and repress adipogenesis.

Proc Natl Acad Sci U S A 2009 Apr 23;106(14):5819-24. Epub 2009 Mar 23.

Laboratory of Systems Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo, 4-6-1, Komaba, Meguro-ku, Tokyo 153-8904, Japan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667001PMC
April 2009

SREBP-2 regulates gut peptide secretion through intestinal bitter taste receptor signaling in mice.

J Clin Invest 2008 Nov 9;118(11):3693-700. Epub 2008 Oct 9.

Department of Molecular Biology and Biochemistry, University of California, Irvine, California, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2564613PMC
November 2008

Proto-oncogene FBI-1 (Pokemon) and SREBP-1 synergistically activate transcription of fatty-acid synthase gene (FASN).

J Biol Chem 2008 Oct 5;283(43):29341-54. Epub 2008 Aug 5.

Department of Biochemistry and Molecular Biology, Brain Korea 21 Project for Medical Science, Institute of Genetic Science, Yonsei University School of Medicine, 134, ShinChon-Dong, SeoDaeMoon-Ku, Seoul 120-752, Korea.

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October 2008

Selective binding of sterol regulatory element-binding protein isoforms and co-regulatory proteins to promoters for lipid metabolic genes in liver.

J Biol Chem 2008 Jun 15;283(23):15628-37. Epub 2008 Apr 15.

Department of Molecular Biology and Biochemistry, School of Biological Sciences and Center for Diabetes Research and Treatment, University of California, Irvine, California 92697-3900, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2414284PMC
June 2008

Peroxisome proliferator-activated receptor-gamma coactivator-1alpha activation of CYP7A1 during food restriction and diabetes is still inhibited by small heterodimer partner.

J Biol Chem 2008 May 2;283(22):15089-96. Epub 2008 Apr 2.

Department of Molecular Biology and Biochemistry, School of Biological Sciences, Center for Diabetes Research and Treatment, University of California, Irvine, CA 92697-3900, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2397466PMC
May 2008

Parasympathetic response in chick myocytes and mouse heart is controlled by SREBP.

J Clin Invest 2008 Jan;118(1):259-71

Molecular Cardiology Research Institute, Department of Medicine, Tufts-New England Medical Center and Tufts University School of Medicine, Boston, Massachusetts 02111, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2104475PMC
January 2008

A key role for orphan nuclear receptor liver receptor homologue-1 in activation of fatty acid synthase promoter by liver X receptor.

J Biol Chem 2007 Jul 22;282(28):20164-71. Epub 2007 May 22.

Department of Molecular Biology and Biochemistry, School of Biological Sciences and Center for Diabetes Research and Treatment, University of California, Irvine, CA 92697-3900, USA.

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July 2007

Regulation of the sodium/sulfate co-transporter by farnesoid X receptor alpha.

J Biol Chem 2007 Jul 1;282(30):21653-61. Epub 2007 Jun 1.

Department of Biological Chemistry, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.

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July 2007

Coordinated control of bile acids and lipogenesis through FXR-dependent regulation of fatty acid synthase.

J Lipid Res 2006 Dec 6;47(12):2754-61. Epub 2006 Sep 6.

Department of Molecular Biology and Biochemistry, University of California, Irvine, CA, USA.

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December 2006

A simple promoter containing two Sp1 sites controls the expression of sterol-regulatory-element-binding protein 1a (SREBP-1a).

Biochem J 2005 Feb;386(Pt 1):161-8

Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697-3900, USA.

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http://dx.doi.org/10.1042/BJ20041514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1134778PMC
February 2005

Activation domains from both monomers contribute to transcriptional stimulation by sterol regulatory element-binding protein dimers.

J Biol Chem 2005 Feb 17;280(5):3338-45. Epub 2004 Nov 17.

Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697-3900, USA.

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February 2005

Soy isoflavones affect sterol regulatory element binding proteins (SREBPs) and SREBP-regulated genes in HepG2 cells.

J Nutr 2004 Nov;134(11):2942-7

Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, USA.

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November 2004

Selective association of sterol regulatory element-binding protein isoforms with target promoters in vivo.

J Biol Chem 2004 Sep 25;279(36):37360-7. Epub 2004 Jun 25.

Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697-3900, USA.

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September 2004

Selective coactivator interactions in gene activation by SREBP-1a and -1c.

Mol Cell Biol 2004 Sep;24(18):8288-300

Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA 92612-3900, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC515064PMC
September 2004

PGC-1alpha activates CYP7A1 and bile acid biosynthesis.

J Biol Chem 2003 Dec 30;278(50):50047-52. Epub 2003 Sep 30.

Department of Molecular Biology and Biochemistry, University of California, Irvine California 92697-3900, USA.

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December 2003

Thyroid hormone regulation and cholesterol metabolism are connected through Sterol Regulatory Element-Binding Protein-2 (SREBP-2).

J Biol Chem 2003 Sep 26;278(36):34114-8. Epub 2003 Jun 26.

Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697-3900, USA.

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September 2003

A role for cyclic AMP response element-binding protein (CREB) but not the highly similar ATF-2 protein in sterol regulation of the promoter for 3-hydroxy-3-methylglutaryl coenzyme A reductase.

J Biol Chem 2002 Sep 10;277(37):33901-5. Epub 2002 Jul 10.

Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697-3900, USA.

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September 2002

Role of sterol regulatory element binding proteins in the regulation of Galpha(i2) expression in cultured atrial cells.

Circ Res 2002 Jul;91(1):32-7

Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass 02115, USA.

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July 2002

Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors.

J Biol Chem 2002 Mar 14;277(13):11019-25. Epub 2002 Jan 14.

Department of Pathology and Laboratory Medicine, the Howard Hughes Medical Institute, University of California, Los Angeles, California 90095, USA.

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March 2002

NF-Y involvement in the polyunsaturated fat inhibition of fatty acid synthase gene transcription.

Biochem Biophys Res Commun 2002 Feb;290(4):1295-9

Division of Nutritional Sciences, University of Texas, Austin 78712, USA.

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February 2002