Publications

Hepatocyte ABCA1 Deletion Impairs Liver Insulin Signaling and Lipogenesis.
Cell Rep 2017 Jun;19(10):2116-2129
Section on Molecular Medicine, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA. Electronic address:

Inhibition of sweet chemosensory receptors alters insulin responses during glucose ingestion in healthy adults: a randomized crossover interventional study.
Am J Clin Nutr 2017 Apr 1;105(4):1001-1009. Epub 2017 Mar 1.
Center for Metabolic Origins of Disease, Sanford Burnham Prebys Medical Discovery Institute, Orlando, FL;

SREBP-2-deficient and hypomorphic mice reveal roles for SREBP-2 in embryonic development and SREBP-1c expression.
J Lipid Res 2016 Mar 18;57(3):410-21. Epub 2015 Dec 18.
Departments of Human Genetics David Geffen School of Medicine at the University of California, Los Angeles, CA 90095 Medicine, David Geffen School of Medicine at the University of California, Los Angeles, CA 90095 Molecular Biology Institute, University of California, Los Angeles, CA 90095

H3K4/H3K9me3 Bivalent Chromatin Domains Targeted by Lineage-Specific DNA Methylation Pauses Adipocyte Differentiation.
Mol Cell 2015 Nov;60(4):584-96
Division of Metabolic Medicine, The University of Tokyo, 4-6-1, Komaba, Meguro-ku, Tokyo 153-8904, Japan; The Translational Systems Biology and Medicine Initiative (TSBMI), Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, Tokyo 113-8655, Japan. Electronic address:

JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis.
Nat Commun 2015 May 7;6:7052. Epub 2015 May 7.
1] Division of Metabolic Medicine, Research Center for Advanced Science and Technology (RCAST), The University of Tokyo, Tokyo 153-8904, Japan [2] The Translational Systems Biology and Medicine Initiative, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, University of Tokyo, Tokyo 113-8655, Japan.

The FBXL10/KDM2B scaffolding protein associates with novel polycomb repressive complex-1 to regulate adipogenesis.
J Biol Chem 2015 Feb 22;290(7):4163-77. Epub 2014 Dec 22.
From the Division of Metabolic Medicine, the Translational Systems Biology and Medicine Initiative Center for Disease Biology and Integrative Medicine, University of Tokyo, Tokyo 153-8904, Japan,

Partitioning circadian transcription by SIRT6 leads to segregated control of cellular metabolism.
Cell 2014 Jul;158(3):659-72
Center for Epigenetics and Metabolism, University of California, Irvine, Irvine, CA 92697, USA; Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA; Institute for Genomics and Bioinformatics, University of California, Irvine, Irvine, CA 92697, USA; INSERM U904, Sprague Hall, University of California, Irvine, Irvine, CA 92697, USA. Electronic address:


Guidelines for the use and interpretation of assays for monitoring autophagy.
Autophagy 2012 Apr;8(4):445-544
Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.



COUP-TFII acts downstream of Wnt/beta-catenin signal to silence PPARgamma gene expression and repress adipogenesis.
Proc Natl Acad Sci U S A 2009 Apr 23;106(14):5819-24. Epub 2009 Mar 23.
Laboratory of Systems Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo, 4-6-1, Komaba, Meguro-ku, Tokyo 153-8904, Japan.

Proto-oncogene FBI-1 (Pokemon) and SREBP-1 synergistically activate transcription of fatty-acid synthase gene (FASN).
J Biol Chem 2008 Oct 5;283(43):29341-54. Epub 2008 Aug 5.
Department of Biochemistry and Molecular Biology, Brain Korea 21 Project for Medical Science, Institute of Genetic Science, Yonsei University School of Medicine, 134, ShinChon-Dong, SeoDaeMoon-Ku, Seoul 120-752, Korea.

Selective binding of sterol regulatory element-binding protein isoforms and co-regulatory proteins to promoters for lipid metabolic genes in liver.
J Biol Chem 2008 Jun 15;283(23):15628-37. Epub 2008 Apr 15.
Department of Molecular Biology and Biochemistry, School of Biological Sciences and Center for Diabetes Research and Treatment, University of California, Irvine, California 92697-3900, USA.


Parasympathetic response in chick myocytes and mouse heart is controlled by SREBP.
J Clin Invest 2008 Jan;118(1):259-71
Molecular Cardiology Research Institute, Department of Medicine, Tufts-New England Medical Center and Tufts University School of Medicine, Boston, Massachusetts 02111, USA.




Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors.
J Biol Chem 2002 Mar 14;277(13):11019-25. Epub 2002 Jan 14.
Department of Pathology and Laboratory Medicine, the Howard Hughes Medical Institute, University of California, Los Angeles, California 90095, USA.

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