Timothy E McGraw

Timothy E McGraw

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Timothy E McGraw

Timothy E McGraw

Publications by authors named "Timothy E McGraw"

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Thirty sweet years of GLUT4.

J Biol Chem 2019 07 7;294(30):11369-11381. Epub 2019 Jun 7.

Charles Perkins Centre, School of Life and Environmental Sciences, Sydney Medical School, University of Sydney, Camperdown, New South Wales 2050, Australia

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http://dx.doi.org/10.1074/jbc.REV119.008351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6663870PMC
July 2019

Methodological Issues in Studying PAHSA Biology: Masking PAHSA Effects.

Cell Metab 2018 10 20;28(4):543-546. Epub 2018 Sep 20.

Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2018.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6542592PMC
October 2018

Biochemical and cellular properties of insulin receptor signalling.

Nat Rev Mol Cell Biol 2018 Jan 4;19(1):31-44. Epub 2017 Oct 4.

Columbia University College of Physicians & Surgeons, Department of Medicine, New York, New York 10032, USA.

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http://dx.doi.org/10.1038/nrm.2017.89DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5894887PMC
January 2018

Downregulation of a GPCR by β-Arrestin2-Mediated Switch from an Endosomal to a TGN Recycling Pathway.

Cell Rep 2016 12;17(11):2966-2978

Department of Biochemistry, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA; Department of Cardiothoracic Surgery, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.11.050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161243PMC
December 2016

Adenovirus Protein E4-ORF1 Activation of PI3 Kinase Reveals Differential Regulation of Downstream Effector Pathways in Adipocytes.

Cell Rep 2016 12;17(12):3305-3318

Department of Biochemistry, Weill Cornell Medicine, New York, NY 10065, USA; Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY 10065, USA; Lung Cancer Program, Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.11.082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5193245PMC
December 2016

SEC16A is a RAB10 effector required for insulin-stimulated GLUT4 trafficking in adipocytes.

J Cell Biol 2016 07 27;214(1):61-76. Epub 2016 Jun 27.

Department of Biochemistry, Weill Cornell Medical College, New York, NY 10065 Department of Cardiothoracic Surgery, Weill Cornell Medical College, New York, NY 10065

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http://dx.doi.org/10.1083/jcb.201509052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932369PMC
July 2016

The Microenvironment of Lung Cancer and Therapeutic Implications.

Adv Exp Med Biol 2016 ;890:75-110

Department of Radiation Oncology, New York University School of Medicine, 566 First Avenue, New York, NY, 10016, USA.

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http://dx.doi.org/10.1007/978-3-319-24932-2_5DOI Listing
May 2016

Altered Plasma Profile of Antioxidant Proteins as an Early Correlate of Pancreatic β Cell Dysfunction.

J Biol Chem 2016 Apr 25;291(18):9648-56. Epub 2016 Feb 25.

From the Department of Medicine and Berrie Diabetes Center, Columbia University College of Physicians and Surgeons, New York, New York 10032 and

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http://dx.doi.org/10.1074/jbc.M115.702183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850302PMC
April 2016

Development of a new model system to dissect isoform specific Akt signalling in adipocytes.

Biochem J 2015 Jun 9;468(3):425-34. Epub 2015 Apr 9.

Biochemistry Department, Weill Cornell Medical College, 1300 York Avenue, Room W-320, New York, NY 10065, U.S.A.

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http://dx.doi.org/10.1042/BJ20150191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604748PMC
June 2015

Anorexia and impaired glucose metabolism in mice with hypothalamic ablation of Glut4 neurons.

Diabetes 2015 Feb 3;64(2):405-17. Epub 2014 Sep 3.

Department of Medicine and Naomi Berrie Diabetes Center, Columbia University College of Physicians and Surgeons, New York, NY

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http://dx.doi.org/10.2337/db14-0752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303970PMC
February 2015

A naturally occurring GIP receptor variant undergoes enhanced agonist-induced desensitization, which impairs GIP control of adipose insulin sensitivity.

Mol Cell Biol 2014 Oct 21;34(19):3618-29. Epub 2014 Jul 21.

Department of Biochemistry, Weill Medical College of Cornell University, New York, New York, USA Department of Cardiothoracic Surgery, Weill Medical College of Cornell University, New York, New York, USA

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http://dx.doi.org/10.1128/MCB.00256-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187723PMC
October 2014

Reciprocal regulation of endocytosis and metabolism.

Cold Spring Harb Perspect Biol 2014 Jul 1;6(7):a016964. Epub 2014 Jul 1.

Program in Cell Biology, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.

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http://dx.doi.org/10.1101/cshperspect.a016964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067987PMC
July 2014

Specialized sorting of GLUT4 and its recruitment to the cell surface are independently regulated by distinct Rabs.

Mol Biol Cell 2013 Aug 26;24(16):2544-57. Epub 2013 Jun 26.

Department of Biochemistry, Weill Cornell Medical College, Cornell University, New York, NY 10065, USA.

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http://dx.doi.org/10.1091/mbc.E13-02-0103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744946PMC
August 2013

Ratio of positron emission tomography uptake to tumor size in surgically resected non-small cell lung cancer.

Ann Thorac Surg 2013 Feb 20;95(2):397-403; discussion 404. Epub 2012 Sep 20.

Division of Thoracic Surgery, New York Presbyterian Hospital, Weill Cornell Medical College, New York, New York 10021, USA.

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http://ac.els-cdn.com/S0003497512016505/1-s2.0-S000349751201
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http://linkinghub.elsevier.com/retrieve/pii/S000349751201650
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http://dx.doi.org/10.1016/j.athoracsur.2012.07.038DOI Listing
February 2013

TNF-α up-regulates protein level and cell surface expression of the leptin receptor by stimulating its export via a PKC-dependent mechanism.

Endocrinology 2012 Dec 15;153(12):5821-33. Epub 2012 Oct 15.

Division of Molecular Genetics, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA.

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http://dx.doi.org/10.1210/en.2012-1510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3512064PMC
December 2012

Hyperinsulinemia leads to uncoupled insulin regulation of the GLUT4 glucose transporter and the FoxO1 transcription factor.

Proc Natl Acad Sci U S A 2011 Jun 6;108(25):10162-7. Epub 2011 Jun 6.

Biochemistry Department, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1019268108
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http://dx.doi.org/10.1073/pnas.1019268108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3121842PMC
June 2011

Rosiglitazone, PPARγ, and type 2 diabetes.

N Engl J Med 2010 Dec;363(27):2667-9

Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, USA.

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http://dx.doi.org/10.1056/NEJMcibr1012075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3733169PMC
December 2010

Stem cells: Metabolism regulates differentiation.

Nat Chem Biol 2010 Mar;6(3):176-177

Timothy E. McGraw is in the Department of Biochemistry, New York, New York, USA.

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http://www.nature.com/articles/nchembio.324
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http://dx.doi.org/10.1038/nchembio.324DOI Listing
March 2010

Metabolic surgery: the role of the gastrointestinal tract in diabetes mellitus.

Nat Rev Endocrinol 2010 Feb;6(2):102-9

Section of Gastrointestinal Metabolic Surgery, Department of Surgery, Weill Cornell Medical College/New York Presbyterian Hospital, 525 East 68th Street, P-714, New York, NY 10065, USA.

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http://dx.doi.org/10.1038/nrendo.2009.268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2999518PMC
February 2010

The Akt kinases: isoform specificity in metabolism and cancer.

Cell Cycle 2009 Aug 23;8(16):2502-8. Epub 2009 Aug 23.

Department of Biochemistry, Weill Cornell Medical College, New York, NY 10065, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997486PMC
http://dx.doi.org/10.4161/cc.8.16.9335DOI Listing
August 2009

Insulin-modulated Akt subcellular localization determines Akt isoform-specific signaling.

Proc Natl Acad Sci U S A 2009 Apr 16;106(17):7004-9. Epub 2009 Apr 16.

Department of Biochemistry, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USA.

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http://dx.doi.org/10.1073/pnas.0901933106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2678468PMC
April 2009

Use of quantitative immunofluorescence microscopy to study intracellular trafficking: studies of the GLUT4 glucose transporter.

Methods Mol Biol 2008 ;457:347-66

Department of Biochemistry, Weill Medical College of Cornell University, New York, NY, USA.

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http://dx.doi.org/10.1007/978-1-59745-261-8_26DOI Listing
January 2009

Molecular mechanisms controlling GLUT4 intracellular retention.

Mol Biol Cell 2008 Aug 11;19(8):3477-87. Epub 2008 Jun 11.

Department of Biochemistry, Weill Cornell Medical College, New York, NY 10065, USA.

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http://dx.doi.org/10.1091/mbc.e08-03-0236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2488284PMC
August 2008

The CB1 endocannabinoid system modulates adipocyte insulin sensitivity.

Obesity (Silver Spring) 2008 Aug 12;16(8):1727-34. Epub 2008 Jun 12.

Department of Pediatrics, Weill Cornell Medical College, New York, NY, USA.

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http://dx.doi.org/10.1038/oby.2008.309DOI Listing
August 2008

Insulin regulates leptin secretion from 3T3-L1 adipocytes by a PI 3 kinase independent mechanism.

Exp Cell Res 2008 Jul 12;314(11-12):2249-56. Epub 2008 Apr 12.

Department of Molecular Genetics, The Rockefeller University, New York, NY 10021, USA.

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http://dx.doi.org/10.1016/j.yexcr.2008.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997521PMC
July 2008

GLUT4 is internalized by a cholesterol-dependent nystatin-sensitive mechanism inhibited by insulin.

EMBO J 2006 Dec 30;25(24):5648-58. Epub 2006 Nov 30.

Department of Biochemistry, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA.

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http://dx.doi.org/10.1038/sj.emboj.7601462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1698906PMC
December 2006

Insulin signaling diverges into Akt-dependent and -independent signals to regulate the recruitment/docking and the fusion of GLUT4 vesicles to the plasma membrane.

Mol Biol Cell 2006 Oct 16;17(10):4484-93. Epub 2006 Aug 16.

Department of Biochemistry, Weill Medical College of Cornell University, New York, NY 10021, USA.

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http://www.molbiolcell.org/doi/10.1091/mbc.e06-07-0585
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http://dx.doi.org/10.1091/mbc.e06-07-0585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1635362PMC
October 2006

GLUT4 distribution between the plasma membrane and the intracellular compartments is maintained by an insulin-modulated bipartite dynamic mechanism.

J Biol Chem 2006 Jan 2;281(1):484-90. Epub 2005 Nov 2.

Department of Biochemistry, Weill Cornell Medical College, New York, New York 10013, USA.

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http://dx.doi.org/10.1074/jbc.M505944200DOI Listing
January 2006

Full intracellular retention of GLUT4 requires AS160 Rab GTPase activating protein.

Cell Metab 2005 Oct;2(4):263-72

Department of Biochemistry, Weill-Cornell Medical School, New York, New York 10021, USA.

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http://dx.doi.org/10.1016/j.cmet.2005.09.005DOI Listing
October 2005

Insulin stimulation of GLUT4 exocytosis, but not its inhibition of endocytosis, is dependent on RabGAP AS160.

Mol Biol Cell 2004 Oct 14;15(10):4406-15. Epub 2004 Jul 14.

Department of Biochemistry, Weill Medical College of Cornell University, New York, NY 10021, USA.

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http://www.molbiolcell.org/doi/10.1091/mbc.e04-04-0333
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http://dx.doi.org/10.1091/mbc.e04-04-0333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC519136PMC
October 2004

The transcription factor CCAAT/enhancer-binding protein alpha is required for the intracellular retention of GLUT4.

J Biol Chem 2004 Oct 23;279(40):41468-76. Epub 2004 Jul 23.

Department of Biochemistry, Weill Medical College of Cornell University, New York, New York 10021, USA.

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http://www.jbc.org/cgi/doi/10.1074/jbc.M405088200
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http://dx.doi.org/10.1074/jbc.M405088200DOI Listing
October 2004

Syntaxin-6 SNARE involvement in secretory and endocytic pathways of cultured pancreatic beta-cells.

Mol Biol Cell 2004 Apr 23;15(4):1690-701. Epub 2004 Jan 23.

Division of Endocrinology and Department of Developmental/Molecular Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

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http://dx.doi.org/10.1091/mbc.e03-08-0554DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC379267PMC
April 2004

GLUT4 is retained by an intracellular cycle of vesicle formation and fusion with endosomes.

Mol Biol Cell 2004 Feb 31;15(2):870-82. Epub 2003 Oct 31.

Department of Biochemistry, and Program in Biochemistry and Structural Biology, Weill Medical College of Cornell University, New York, New York 10021, USA.

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http://www.molbiolcell.org/doi/10.1091/mbc.e03-07-0517
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http://dx.doi.org/10.1091/mbc.e03-07-0517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC329400PMC
February 2004

Endocytic recycling.

Nat Rev Mol Cell Biol 2004 Feb;5(2):121-32

Department of Biochemistry, Weill Medical College of Cornell University, 1300 York Avenue, New York, New York 10021, USA.

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http://www.nature.com/articles/nrm1315
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http://dx.doi.org/10.1038/nrm1315DOI Listing
February 2004

Targeted chemical disruption of clathrin function in living cells.

Mol Biol Cell 2003 Nov 7;14(11):4437-47. Epub 2003 Aug 7.

Department of Biochemistry, Weill Medical College of Cornell University, New York, New York 10021, USA.

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http://dx.doi.org/10.1091/mbc.e03-04-0230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC266763PMC
November 2003

Evidence for the interaction of the hereditary haemochromatosis protein, HFE, with the transferrin receptor in endocytic compartments.

Biochem J 2003 Jul;373(Pt 1):145-53

Department of Cell and Developmental Biology, L215, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239-3098, USA.

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http://biochemj.org/lookup/doi/10.1042/bj20030202
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http://dx.doi.org/10.1042/BJ20030202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1223471PMC
July 2003

The epithelial-specific adaptor AP1B mediates post-endocytic recycling to the basolateral membrane.

Nat Cell Biol 2002 Aug;4(8):605-9

Dyson Vision Research Institute, Weill Medical College of Cornell University, 1300 York Ave., New York, NY 10021, USA.

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http://dx.doi.org/10.1038/ncb827DOI Listing
August 2002

GLUT4 retention in adipocytes requires two intracellular insulin-regulated transport steps.

Mol Biol Cell 2002 Jul;13(7):2421-35

Department of Biochemistry, Biophysics and Molecular Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA.

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http://dx.doi.org/10.1091/mbc.e02-02-0071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC117324PMC
July 2002

Vesicular and non-vesicular sterol transport in living cells. The endocytic recycling compartment is a major sterol storage organelle.

J Biol Chem 2002 Jan 26;277(1):609-17. Epub 2001 Oct 26.

Department of Biochemistry, Weill Medical College of Cornell University, New York, New York 10021, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M108861200
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http://dx.doi.org/10.1074/jbc.M108861200DOI Listing
January 2002