Publications by authors named "Timothy C Tan"

76Publications

The Role of Multi-modality Imaging in the Diagnosis of Cardiac Amyloidosis: A Focused Update.

Front Cardiovasc Med 2020 30;7:590557. Epub 2020 Oct 30.

Department of Cardiology, Blacktown Hospital, Sydney, NSW, Australia.

View Article and Find Full Text PDF
October 2020

Does vascular endothelial dysfunction play a role in physical frailty and sarcopenia? A systematic review.

Age Ageing 2020 Nov 6. Epub 2020 Nov 6.

Department of Cardiology, Blacktown Hospital, Western Sydney Local Health District, Sydney, Australia.

View Article and Find Full Text PDF
November 2020

Association of influenza infection and vaccination with cardiac biomarkers and left ventricular ejection fraction in patients with acute myocardial infarction.

Int J Cardiol Heart Vasc 2020 Dec 13;31:100648. Epub 2020 Oct 13.

Biosecurity Program, Kirby Institute, University of New South Wales, Sydney, NSW, 2052, Australia.

View Article and Find Full Text PDF
December 2020

Incidence and treatment of arrhythmias secondary to coronavirus infection in humans: A systematic review.

Eur J Clin Invest 2020 Oct 12:e13428. Epub 2020 Oct 12.

Department of Cardiology, Blacktown Hospital, Sydney, NSW, Australia.

View Article and Find Full Text PDF
October 2020

Left ventricular aneurysm: a rare complication of an acute myocardial infarction in the modern era.

Oxf Med Case Reports 2020 Sep 22;2020(9):omaa080. Epub 2020 Sep 22.

Department of Cardiology, Blacktown Hospital, Blacktown, New South Wales 2148, Australia.

View Article and Find Full Text PDF
September 2020

Characterisation of recent trends in cardiovascular risk factors in young and middle-aged patients with ischaemic stroke and/or transient ischaemic attack.

J Neurol Sci 2020 Nov 2;418:117115. Epub 2020 Sep 2.

Department of Cardiology, Blacktown Hospital, Sydney, NSW 2148, Australia; School of Public Health and Community Medicine, University of New South Wales, Sydney, NSW 2052, Australia.

View Article and Find Full Text PDF
November 2020

Drivers of hospitalization in atrial fibrillation: A contemporary review.

Heart Rhythm 2020 Nov 19;17(11):1991-1999. Epub 2020 Jun 19.

Department of Cardiology, Blacktown Hospital, Sydney, New South Wales, Australia; School of Public Health and Community Medicine, University of New South Wales, Sydney, New South Wales, Australia. Electronic address:

View Article and Find Full Text PDF
November 2020

The role of multimodality imaging in the diagnosis of left ventricular noncompaction.

Eur J Clin Invest 2020 Sep 14;50(9):e13254. Epub 2020 May 14.

Department of Cardiology, Westmead Hospital, Sydney, NSW, Australia.

View Article and Find Full Text PDF
September 2020

Pulmonary Artery Systolic Pressure Response to Exercise in Patients with Rheumatic Mitral Stenosis: Determinants and Prognostic Value.

J Am Soc Echocardiogr 2020 May 29;33(5):550-558. Epub 2020 Feb 29.

Postgraduate Course of Infectious Diseases and Tropical Medicine, School of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil; Hospital das Clinicas, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil. Electronic address:

View Article and Find Full Text PDF
May 2020

Impairment of left atrial function and cryptogenic stroke: Potential insights in the pathophysiology of stroke in the young.

Int J Cardiol Heart Vasc 2020 Feb 26;26:100454. Epub 2019 Dec 26.

Department of Cardiology, Blacktown Hospital, Blacktown Road, Blacktown, NSW 2148, Australia.

View Article and Find Full Text PDF
February 2020

Cost-benefit analysis of a national influenza vaccination program in preventing hospitalisation costs in Australian adults aged 50-64 years old.

Vaccine 2019 09 28;37(40):5979-5985. Epub 2019 Aug 28.

Biosecurity Program, The Kirby Institute, Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia; College of Public Affairs and Community Solutions, Arizona State University, Phoenix, AZ 85004, USA.

View Article and Find Full Text PDF
September 2019

Impact of left atrial compliance improvement on functional status after percutaneous mitral valvuloplasty.

Catheter Cardiovasc Interv 2019 01 23;93(1):156-163. Epub 2018 Sep 23.

Postgraduate Course of Infectious Diseases and Tropical Medicine, School of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.

View Article and Find Full Text PDF
January 2019

Proteomic profiling of skeletal and cardiac muscle in cancer cachexia: alterations in sarcomeric and mitochondrial protein expression.

Oncotarget 2018 Apr 24;9(31):22001-22022. Epub 2018 Apr 24.

Mechanisms of Disease and Translational Research, School of Medical Sciences, Faculty of Medicine, UNSW Sydney, New South Wales, Australia.

View Article and Find Full Text PDF
April 2018

Acute Leukemia is Associated with Cardiac Alterations before Chemotherapy.

J Am Soc Echocardiogr 2017 Nov 15;30(11):1111-1118. Epub 2017 Sep 15.

Cardiac Ultrasound Laboratory, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; Cardiac Ultrasound Laboratory, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

View Article and Find Full Text PDF
November 2017

Clinical features and prognosis of patients with isolated severe aortic stenosis and valve area less than 1.0 cm.

Heart 2018 02 16;104(3):222-229. Epub 2017 Aug 16.

Division of Cardiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

View Article and Find Full Text PDF
February 2018

Impact of percutaneous mitral valvuloplasty on left ventricular function in patients with mitral stenosis assessed by 3D echocardiography.

Int J Cardiol 2017 Dec 23;248:280-285. Epub 2017 Jun 23.

Post-Graduate Program in Infectious Diseases and Tropical Medicine, School of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil; School of Medicine and Hospital das Clínicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil. Electronic address:

View Article and Find Full Text PDF
December 2017

Three-Dimensional Field Optimization Method: Clinical Validation of a Novel Color Doppler Method for Quantifying Mitral Regurgitation.

J Am Soc Echocardiogr 2016 10 9;29(10):926-934. Epub 2016 Jul 9.

Cardiac Ultrasound Laboratory, Division of Cardiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts. Electronic address:

View Article and Find Full Text PDF
October 2016

Myocardial Viability: From Proof of Concept to Clinical Practice.

Cardiol Res Pract 2016 29;2016:1020818. Epub 2016 May 29.

Department of Cardiology, Blacktown Hospital, Blacktown Road, Blacktown NSW 2148, Australia; Western Sydney University, Richmond, NSW, Australia.

View Article and Find Full Text PDF
June 2016

Update on percutaneous mitral commissurotomy.

Heart 2016 Apr 7;102(7):500-7. Epub 2016 Jan 7.

Cardiac Ultrasound Lab, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

View Article and Find Full Text PDF
April 2016

Standard transthoracic echocardiography and transesophageal echocardiography views of mitral pathology that every surgeon should know.

Ann Cardiothorac Surg 2015 Sep;4(5):449-60

Cardiac Ultrasound Laboratory, Division of Cardiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

View Article and Find Full Text PDF
September 2015

Risk Prediction in Aortic Valve Replacement: Incremental Value of the Preoperative Echocardiogram.

J Am Heart Assoc 2015 Oct 26;4(10):e002129. Epub 2015 Oct 26.

Massachusetts General Hospital, Harvard Medical School, Boston, MA (T.C.T., A.W.F., P.M., M.C.N., L.M.R., D.M.S., M.H.P., J.A.) Jewish General Hospital, McGill University, Montreal, Quebec, Canada (A.C.T., L.G.R., J.A.) Centre for Clinical Epidemiology, Lady Davis Institute, Montreal, Quebec, Canada (J.A.).

View Article and Find Full Text PDF
October 2015

Cardiac and skeletal muscles show molecularly distinct responses to cancer cachexia.

Physiol Genomics 2015 Dec 22;47(12):588-99. Epub 2015 Sep 22.

Inflammation and Infection Research Centre, University of New South Wales Australia, New South Wales, Australia; Department of Pathology, School of Medical Sciences, Faculty of Medicine, University of New South Wales Australia, New South Wales, Australia;

View Article and Find Full Text PDF
December 2015

Author's Reply.

J Am Soc Echocardiogr 2015 Sep;28(9):1129-30

Cardiac Ultrasound Laboratory and Division of Cardiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.

View Article and Find Full Text PDF
September 2015

Differential left ventricular outflow tract remodeling and dynamics in aortic stenosis.

J Am Soc Echocardiogr 2015 Nov 22;28(11):1259-66. Epub 2015 Aug 22.

Division of Cardiology, Cardiac Ultrasound Laboratory, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts. Electronic address:

View Article and Find Full Text PDF
November 2015

Anthracycline-Induced Cardiomyopathy in Adults.

Compr Physiol 2015 Jul;5(3):1517-40

Cardiac Ultrasound Laboratory, Division of Cardiology, Massachusetts General Hospital, Boston, Massachusetts, USA.

View Article and Find Full Text PDF
July 2015

Major Cardiac Events and the Value of Echocardiographic Evaluation in Patients Receiving Anthracycline-Based Chemotherapy.

Am J Cardiol 2015 Aug 14;116(3):442-6. Epub 2015 May 14.

Cardiac Ultrasound Laboratory, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; Cardio-Oncology Program, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address:

View Article and Find Full Text PDF
August 2015

Echocardiographic and Hemodynamic Predictors of Survival in Precapillary Pulmonary Hypertension: Seven-Year Follow-Up.

Circ Cardiovasc Imaging 2015 Jun;8(6)

From the Department of Cardiology, Hammersmith Hospital, Imperial College London, United Kingdom (J.G., T.C., B.C.F.S., D.D., P.N.); Department of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston (M.C.P.N., T.C.T.); and National Pulmonary Hypertension Service, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom (I.Z.C., J.S.R.G.).

View Article and Find Full Text PDF
June 2015

Ventilatory inefficiency in patients with rheumatic mitral stenosis.

Int J Cardiol 2015 Aug 8;193:36-8. Epub 2015 May 8.

Post-Graduate Program in Infectious Diseases and Tropical Medicine, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil. Electronic address:

View Article and Find Full Text PDF
August 2015

Fetal Mammalian Heart Generates a Robust Compensatory Response to Cell Loss.

Circulation 2015 Jul 20;132(2):109-21. Epub 2015 May 20.

From Stanford Cardiovascular Institute (A.C.S., K.R., K.P., A.S., A.F.X., G.L., S.M.W.), Division of Cardiovascular Medicine, Department of Medicine (A.C.S., S.M.W.), Department of Pathology (R.G.), Institute for Stem Cell Biology and Regenerative Medicine (S.M.W.), and Child Health Research Institute (S.M.W.), Stanford University School of Medicine, CA; and Division of Cardiology, Department of Medicine (A.C.S., K.R., D.P., A.R., T.C.T., M.C.E., R.F., K.D.R., M.S.-C., I.J.D.) and Department of Pathology (M.K.S.), Massachusetts General Hospital, Boston.

View Article and Find Full Text PDF
July 2015

Peri-operative assessment of right heart function: role of echocardiography.

Eur J Clin Invest 2015 Jul;45(7):755-66

Department of Anesthesia, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

View Article and Find Full Text PDF
July 2015

Echocardiographic parameters of left ventricular size and function as predictors of symptomatic heart failure in patients with a left ventricular ejection fraction of 50-59% treated with anthracyclines.

Eur Heart J Cardiovasc Imaging 2015 Sep 29;16(9):977-84. Epub 2015 Apr 29.

Cardiac Ultrasound Laboratory, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA

View Article and Find Full Text PDF
September 2015

Endoplasmic Reticulum Stress, Calcium Dysregulation and Altered Protein Translation: Intersection of Processes That Contribute to Cancer Cachexia Induced Skeletal Muscle Wasting.

Curr Drug Targets 2016 ;17(10):1140-6

School of Medical Sciences, Faculty of Medicine, Rm 420 Wallace Wurth East Building, UNSW Australia, 2052 NSW, Australia.

View Article and Find Full Text PDF
August 2017

Time Trends of Left Ventricular Ejection Fraction and Myocardial Deformation Indices in a Cohort of Women with Breast Cancer Treated with Anthracyclines, Taxanes, and Trastuzumab.

J Am Soc Echocardiogr 2015 May 13;28(5):509-14. Epub 2015 Mar 13.

Cardiac Ultrasound Laboratory and Division of Cardiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts. Electronic address:

View Article and Find Full Text PDF
May 2015

Assessment of the source of ischemic cerebrovascular events in patients with Chagas disease.

Int J Cardiol 2014 Oct 6;176(3):1352-4. Epub 2014 Aug 6.

Post-Graduate Program in Infectious Diseases and Tropical Medicine, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil. Electronic address:

View Article and Find Full Text PDF
October 2014

Echocardiography of the mitral valve.

Prog Cardiovasc Dis 2014 Jul-Aug;57(1):55-73. Epub 2014 May 21.

Cardiac Ultrasound Laboratory, Massachusetts General Hospital, Boston, MA, USA. Electronic address:

View Article and Find Full Text PDF
October 2014

Left atrium and the imaging of atrial fibrosis: catch it if you can!

Eur J Clin Invest 2014 Sep;44(9):872-81

Department of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

View Article and Find Full Text PDF
September 2014

The role of vitamin D in skeletal and cardiac muscle function.

Front Physiol 2014 16;5:145. Epub 2014 Apr 16.

Inflammation and Infection Research Centre, School of Medical Sciences, Faculty of Medicine, UNSW Australia Kensington, NSW, Australia ; Cardiac Ultrasound Laboratory, Department of Cardiology, Massachusetts General Hospital Boston, MA, USA.

View Article and Find Full Text PDF
April 2014

Echocardiography of a woman after valve intervention.

Heart 2014 Oct 3;100(19):1497, 1561. Epub 2014 Apr 3.

Hospital das Clinicas, School of Medicine of the Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.

View Article and Find Full Text PDF
October 2014

Ly-6Chigh monocytes depend on Nr4a1 to balance both inflammatory and reparative phases in the infarcted myocardium.

Circ Res 2014 May 13;114(10):1611-22. Epub 2014 Mar 13.

From the Center for Systems Biology (I.H., L.M.S.G., C.W., B.G.C., Y.I., M.N., R.W., F.K.S.) and Department of Cardiology (T.C.T., M.S.-C.), Massachusetts General Hospital, Boston; Department of Gastroenterology, Hepatology, and Infectious Diseases, University of Duesseldorf, Duesseldorf, Germany (T.A.W.H.); Department of Medicine (R.L.) and Cardiovascular Division, Department of Medicine (P.L.), Brigham and Women's Hospital, Boston, MA; Department of Cardiology and Angiology I, University Heart Center Freiburg, Freiburg, Germany (A.Z.); Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology, CA (C.C.H.); and Department of Systems Biology, Harvard Medical School, Boston, MA (R.W.).

View Article and Find Full Text PDF
May 2014

Cardiac complications of chemotherapy: role of imaging.

Curr Treat Options Cardiovasc Med 2014 Apr;16(4):296

Cardiac Ultrasound Laboratory, Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA,

View Article and Find Full Text PDF
April 2014

The echo score revisited: Impact of incorporating commissural morphology and leaflet displacement to the prediction of outcome for patients undergoing percutaneous mitral valvuloplasty.

Circulation 2014 Feb 26;129(8):886-95. Epub 2013 Nov 26.

Cardiac Ultrasound Lab, Massachusetts General Hospital, Harvard Medical School, Boston, MA (M.C.P.N., T.C.T., M.D.H., A.E.W., J.H.); School of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil (M.C.P.N.); Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA (S.E., R.d.L., R.M., I.C.-G., I.I., I.F.P.); and Massachusetts General Hospital Biostatistics Center, Harvard Medical School, Boston, MA (H.Z.).

View Article and Find Full Text PDF
February 2014

Impaired coronary flow reserve in patients with indeterminate form of Chagas' disease.

Echocardiography 2014 15;31(1):67-73. Epub 2013 Sep 15.

Post-Graduate Program in Infectious Diseases and Tropical Medicine, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil.

View Article and Find Full Text PDF
August 2014

Impact of net atrioventricular compliance on clinical outcome in mitral stenosis.

Circ Cardiovasc Imaging 2013 Nov 4;6(6):1001-8. Epub 2013 Oct 4.

School of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.

View Article and Find Full Text PDF
November 2013

The impact of right ventricular stroke work on B-type natriuretic peptide levels in patients with mitral stenosis undergoing percutaneous mitral valvuloplasty.

J Interv Cardiol 2013 Oct 24;26(5):501-8. Epub 2013 Jul 24.

Post-Graduate Program in Infectious Diseases and Tropical Medicine, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.

View Article and Find Full Text PDF
October 2013

Echocardiography in mitral valve disease. Preface.

Cardiol Clin 2013 May;31(2):ix-x

Echocardiography, Massachusetts General Hospital, Harvard Medical School, Cardiac Ultrasound Laboratory, YAW 5E, 55 Fruit Street, Boston, MA 02114-2696, USA.

View Article and Find Full Text PDF
May 2013

Value of right ventricular strain in predicting functional capacity in patients with mitral stenosis.

Int J Cardiol 2013 Oct 4;168(3):2927-30. Epub 2013 May 4.

Post-Graduate Program in Infectious Diseases and Tropical Medicine, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.

View Article and Find Full Text PDF
October 2013

Differential left ventricular remodelling and longitudinal function distinguishes low flow from normal-flow preserved ejection fraction low-gradient severe aortic stenosis.

Eur Heart J 2013 Jul 26;34(25):1906-14. Epub 2013 Mar 26.

Division of Cardiology, Cardiac Ultrasound Laboratory, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA.

View Article and Find Full Text PDF
July 2013

Assessing the Cardiac Toxicity of Chemotherapeutic Agents: Role of Echocardiography.

Curr Cardiovasc Imaging Rep 2012 Dec;5(6):403-409

Cardiac Ultrasound Laboratory, Division of Cardiology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.

View Article and Find Full Text PDF
December 2012

Cardiac magnetic resonance imaging of rapid VCAM-1 up-regulation in myocardial ischemia-reperfusion injury.

Eur Biophys J 2013 Jan 28;42(1):61-70. Epub 2012 Sep 28.

North Shore Heart Research Group, Kolling Institute, University of Sydney, Sydney, NSW, Australia.

View Article and Find Full Text PDF
January 2013

Cardiac electronic implantable devices in the treatment of heart failure.

Heart Lung Circ 2012 Jun;21(6-7):338-51

Department of Cardiology, Westmead Hospital, Corner of Hawkesbury Road and Darcy Road, Westmead, NSW 2145, Australia.

View Article and Find Full Text PDF
June 2012

Early exercise stress testing is safe after primary percutaneous coronary intervention.

Eur Heart J Acute Cardiovasc Care 2012 Jun;1(2):153-7

Department of Cardiology, Westmead Hospital, Westmead, Australia ; The University of Sydney, Australia.

View Article and Find Full Text PDF
June 2012

Disruption of MEF2C signaling and loss of sarcomeric and mitochondrial integrity in cancer-induced skeletal muscle wasting.

Aging (Albany NY) 2012 Feb;4(2):133-43

Inflammation and Infection Research Centre, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, NSW, 2052, Australia.

View Article and Find Full Text PDF
February 2012

Synapsin I-associated phosphatidylinositol 3-kinase mediates synaptic vesicle delivery to the readily releasable pool.

J Biol Chem 2003 Aug 16;278(31):29065-71. Epub 2003 May 16.

Cell Signalling Unit, Children's Medical Research Institute, Locked Bag 23, Wentworthville 2145, NSW, Australia.

View Article and Find Full Text PDF
August 2003