Timothy A Vickers

Timothy A Vickers

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Timothy A Vickers

Timothy A Vickers

Publications by authors named "Timothy A Vickers"

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Golgi-endosome transport mediated by M6PR facilitates release of antisense oligonucleotides from endosomes.

Nucleic Acids Res 2020 Feb;48(3):1372-1391

Core Antisense Research, Ionis Pharmaceuticals, Inc. Carlsbad, CA 92104, USA.

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http://dx.doi.org/10.1093/nar/gkz1171DOI Listing
February 2020

Kinetic and subcellular analysis of PS-ASO/protein interactions with P54nrb and RNase H1.

Nucleic Acids Res 2019 Nov;47(20):10865-10880

Department of Core Antisense Research, Ionis Pharmaceuticals, Inc., Carlsbad, CA, USA.

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http://dx.doi.org/10.1093/nar/gkz771DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6846478PMC
November 2019

mRNA levels can be reduced by antisense oligonucleotides via no-go decay pathway.

Nucleic Acids Res 2019 07;47(13):6900-6916

Department of Core Antisense Research, Ionis Pharmaceutics, Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA.

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http://dx.doi.org/10.1093/nar/gkz500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6649848PMC
July 2019

Development of a Quantitative BRET Affinity Assay for Nucleic Acid-Protein Interactions.

PLoS One 2016 29;11(8):e0161930. Epub 2016 Aug 29.

Department of Core Antisense Research, Ionis Pharmaceuticals, Inc., 2855 Gazelle Court, Carlsbad, CA, 92010, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0161930PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003356PMC
August 2017

Cellular uptake and trafficking of antisense oligonucleotides.

Nat Biotechnol 2017 Mar 27;35(3):230-237. Epub 2017 Feb 27.

Department of Core Antisense Research, Ionis Pharmaceuticals, Inc., Carlsbad, California, USA.

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http://dx.doi.org/10.1038/nbt.3779DOI Listing
March 2017

Translation efficiency of mRNAs is increased by antisense oligonucleotides targeting upstream open reading frames.

Nat Biotechnol 2016 08 11;34(8):875-80. Epub 2016 Jul 11.

Department of Core Antisense Research, Ionis Pharmaceuticals, Inc., Carlsbad, California, USA.

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http://www.nature.com/articles/nbt.3589
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http://dx.doi.org/10.1038/nbt.3589DOI Listing
August 2016

Targeting of repeated sequences unique to a gene results in significant increases in antisense oligonucleotide potency.

PLoS One 2014 15;9(10):e110615. Epub 2014 Oct 15.

Department of Core Antisense Research, ISIS Pharmaceuticals, Inc., Carlsbad, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0110615PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198294PMC
December 2015

The rates of the major steps in the molecular mechanism of RNase H1-dependent antisense oligonucleotide induced degradation of RNA.

Nucleic Acids Res 2015 Oct 17;43(18):8955-63. Epub 2015 Sep 17.

Department of Core Antisense Research, ISIS Pharmaceuticals, Inc. 2855 Gazelle Court, Carlsbad, CA 92010, USA.

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http://dx.doi.org/10.1093/nar/gkv920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605327PMC
October 2015

Antisense oligonucleotides capable of promoting specific target mRNA reduction via competing RNase H1-dependent and independent mechanisms.

PLoS One 2014 9;9(10):e108625. Epub 2014 Oct 9.

Department of Core Antisense Research, ISIS Pharmaceuticals, Inc., Carlsbad, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0108625PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191969PMC
June 2015

siRNAs targeted to certain polyadenylation sites promote specific, RISC-independent degradation of messenger RNAs.

Nucleic Acids Res 2012 Jul 15;40(13):6223-34. Epub 2012 Mar 15.

Department of Core Antisense Research, ISIS Pharmaceuticals, Inc. 2855 Gazelle Court, Carlsbad, CA 92010, USA.

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http://dx.doi.org/10.1093/nar/gks239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401429PMC
July 2012

U1 adaptors result in reduction of multiple pre-mRNA species principally by sequestering U1snRNP.

Nucleic Acids Res 2011 May 16;39(10):e71. Epub 2011 Mar 16.

Department of Core Antisense Research, ISIS Pharmaceuticals, Inc, 1896 Rutherford Road, Carlsbad, CA 92008, USA.

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http://dx.doi.org/10.1093/nar/gkr150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3105408PMC
May 2011

Efficient and specific knockdown of small non-coding RNAs in mammalian cells and in mice.

Nucleic Acids Res 2011 Feb 9;39(3):e13. Epub 2010 Nov 9.

Department of Core Antisense Research, ISIS Pharmaceuticals, Inc. 1896 Rutherford Rd. Carlsbad, CA 92008, USA.

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http://dx.doi.org/10.1093/nar/gkq1121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035437PMC
February 2011

Antisense masking of an hnRNP A1/A2 intronic splicing silencer corrects SMN2 splicing in transgenic mice.

Am J Hum Genet 2008 Apr 27;82(4):834-48. Epub 2008 Mar 27.

Cold Spring Harbor Laboratory, PO Box 100, Cold Spring Harbor, NY 11724, USA.

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http://dx.doi.org/10.1016/j.ajhg.2008.01.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2427210PMC
April 2008

Reduced levels of Ago2 expression result in increased siRNA competition in mammalian cells.

Nucleic Acids Res 2007 28;35(19):6598-610. Epub 2007 Sep 28.

Isis Pharmaceuticals. 1896 Rutherford Road, Carlsbad, CA 92008, USA.

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http://dx.doi.org/10.1093/nar/gkm663DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2095815PMC
December 2007

Prelamin A and lamin A appear to be dispensable in the nuclear lamina.

J Clin Invest 2006 Mar;116(3):743-52

Department of Medicine/Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.

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http://dx.doi.org/10.1172/JCI27125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1386109PMC
March 2006

Modification of MyD88 mRNA splicing and inhibition of IL-1beta signaling in cell culture and in mice with a 2'-O-methoxyethyl-modified oligonucleotide.

J Immunol 2006 Mar;176(6):3652-61

Department of Functional Genomics, Isis Pharmaceuticals, 1896 Rutherfored Road, Carlsbad, CA 92008, USA.

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http://dx.doi.org/10.4049/jimmunol.176.6.3652DOI Listing
March 2006

Efficient reduction of target RNAs by small interfering RNA and RNase H-dependent antisense agents. A comparative analysis.

J Biol Chem 2003 Feb 23;278(9):7108-18. Epub 2002 Dec 23.

GeneTrove Division and Antisense Core Research Department, Isis Pharmaceuticals, Inc., Carlsbad, California 92008, USA.

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http://dx.doi.org/10.1074/jbc.M210326200DOI Listing
February 2003

The catalytic domain of RNase E shows inherent 3' to 5' directionality in cleavage site selection.

Proc Natl Acad Sci U S A 2002 Nov 4;99(23):14746-51. Epub 2002 Nov 4.

Department of Genetics, Stanford University School of Medicine, CA 94305USA-5120, USA.

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http://dx.doi.org/10.1073/pnas.202590899DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC137490PMC
November 2002