Timothy A Thornton

Timothy A Thornton

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Timothy A Thornton

Timothy A Thornton

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Genetic association testing using the GENESIS R/Bioconductor package.

Bioinformatics 2019 Jul 22. Epub 2019 Jul 22.

Department of Biostatistics, University of Washington, Seattle, WA, USA.

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http://dx.doi.org/10.1093/bioinformatics/btz567DOI Listing
July 2019

Genetic analyses of diverse populations improves discovery for complex traits.

Nature 2019 Jun 19;570(7762):514-518. Epub 2019 Jun 19.

Division of Public Health Science, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

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http://dx.doi.org/10.1038/s41586-019-1310-4DOI Listing
June 2019

Accuracy of Gene Expression Prediction From Genotype Data With PrediXcan Varies Across and Within Continental Populations.

Front Genet 2019 3;10:261. Epub 2019 Apr 3.

Department of Biostatistics, University of Washington, Seattle, WA, United States.

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http://dx.doi.org/10.3389/fgene.2019.00261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456650PMC
April 2019

Genome-wide Significance Thresholds for Admixture Mapping Studies.

Am J Hum Genet 2019 Mar 14;104(3):454-465. Epub 2019 Feb 14.

Department of Biostatistics, University of Washington, Seattle, WA 98195, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00029297193000
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http://dx.doi.org/10.1016/j.ajhg.2019.01.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407497PMC
March 2019

Generalizing polygenic risk scores from Europeans to Hispanics/Latinos.

Genet Epidemiol 2019 02 15;43(1):50-62. Epub 2018 Oct 15.

Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, Massachusetts.

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http://doi.wiley.com/10.1002/gepi.22166
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http://dx.doi.org/10.1002/gepi.22166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330129PMC
February 2019

Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation.

Authors:
Joshua C Bis Xueqiu Jian Brian W Kunkle Yuning Chen Kara L Hamilton-Nelson William S Bush William J Salerno Daniel Lancour Yiyi Ma Alan E Renton Edoardo Marcora John J Farrell Yi Zhao Liming Qu Shahzad Ahmad Najaf Amin Philippe Amouyel Gary W Beecham Jennifer E Below Dominique Campion Camille Charbonnier Jaeyoon Chung Paul K Crane Carlos Cruchaga L Adrienne Cupples Jean-François Dartigues Stéphanie Debette Jean-François Deleuze Lucinda Fulton Stacey B Gabriel Emmanuelle Genin Richard A Gibbs Alison Goate Benjamin Grenier-Boley Namrata Gupta Jonathan L Haines Aki S Havulinna Seppo Helisalmi Mikko Hiltunen Daniel P Howrigan M Arfan Ikram Jaakko Kaprio Jan Konrad Amanda Kuzma Eric S Lander Mark Lathrop Terho Lehtimäki Honghuang Lin Kari Mattila Richard Mayeux Donna M Muzny Waleed Nasser Benjamin Neale Kwangsik Nho Gaël Nicolas Devanshi Patel Margaret A Pericak-Vance Markus Perola Bruce M Psaty Olivier Quenez Farid Rajabli Richard Redon Christiane Reitz Anne M Remes Veikko Salomaa Chloe Sarnowski Helena Schmidt Michael Schmidt Reinhold Schmidt Hilkka Soininen Timothy A Thornton Giuseppe Tosto Christophe Tzourio Sven J van der Lee Cornelia M van Duijn Badri Vardarajan Weixin Wang Ellen Wijsman Richard K Wilson Daniela Witten Kim C Worley Xiaoling Zhang Celine Bellenguez Jean-Charles Lambert Mitja I Kurki Aarno Palotie Mark Daly Eric Boerwinkle Kathryn L Lunetta Anita L Destefano Josée Dupuis Eden R Martin Gerard D Schellenberg Sudha Seshadri Adam C Naj Myriam Fornage Lindsay A Farrer

Mol Psychiatry 2018 Aug 14. Epub 2018 Aug 14.

Departments of Biostatistics, Boston University School of Public Health, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41380-018-0112-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375806PMC
August 2018

Hepatic Abundance and Activity of Androgen- and Drug-Metabolizing Enzyme UGT2B17 Are Associated with Genotype, Age, and Sex.

Drug Metab Dispos 2018 06 30;46(6):888-896. Epub 2018 Mar 30.

Departments of Pharmaceutics (D.K.B., A.B., H.Z., K.G.C., A.M., B.P.), Genome Sciences (S.L., D.A.N.), Biostatistics (T.A.T.), and Medicine (J.K.A.), University of Washington, Seattle, Washington; Division of Pediatric Pharmacology and Medical Toxicology, Department of Pediatrics, Children's Mercy Hospitals and Clinics, Kansas City, Missouri (A.G., R.E.P., R.G., J.S.L.); Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee (A.S.C., E.G.S.); and Section of Genomic Pediatrics, Department of Pediatrics, and Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, Wisconsin (U.B.)

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http://dx.doi.org/10.1124/dmd.118.080952DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938891PMC
June 2018

Polymorphic Human Sulfotransferase 2A1 Mediates the Formation of 25-Hydroxyvitamin D-3--Sulfate, a Major Circulating Vitamin D Metabolite in Humans.

Drug Metab Dispos 2018 04 17;46(4):367-379. Epub 2018 Jan 17.

Departments of Pharmaceutics (T.W., Z.W., B.D.C., M.S., K.G.C., C.G., B.P., Al.C., J.C., Q.M., K.E.T.), Medicine and Kidney Research Institute (I.H.d.B.), and Biostatistics (T.A.T.), University of Washington, Seattle, Washington; Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., South San Francisco, California (Z.W.); Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., Cambridge, Massachusetts (R.S.F.); St. Jude Children's Research Hospital, Memphis, Tennessee (Am.C., E.G.S.); and Heartland Assays LLC, Ames, Iowa (R.L.H.)

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http://dx.doi.org/10.1124/dmd.117.078428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829543PMC
April 2018

Powerful Genetic Association Analysis for Common or Rare Variants with High-Dimensional Structured Traits.

Genetics 2017 08 22;206(4):1779-1790. Epub 2017 Jun 22.

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109

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http://dx.doi.org/10.1534/genetics.116.199646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560787PMC
August 2017

Erratum: Genetic loci associated with heart rate variability and their effects on cardiac disease risk.

Authors:
Ilja M Nolte M Loretto Munoz Vinicius Tragante Azmeraw T Amare Rick Jansen Ahmad Vaez Benedikt von der Heyde Christy L Avery Joshua C Bis Bram Dierckx Jenny van Dongen Stephanie M Gogarten Philippe Goyette Jussi Hernesniemi Ville Huikari Shih-Jen Hwang Deepali Jaju Kathleen F Kerr Alexander Kluttig Bouwe P Krijthe Jitender Kumar Sander W van der Laan Leo-Pekka Lyytikäinen Adam X Maihofer Arpi Minassian Peter J van der Most Martina Müller-Nurasyid Michel Nivard Erika Salvi James D Stewart Julian F Thayer Niek Verweij Andrew Wong Delilah Zabaneh Mohammad H Zafarmand Abdel Abdellaoui Sulayma Albarwani Christine Albert Alvaro Alonso Foram Ashar Juha Auvinen Tomas Axelsson Dewleen G Baker Paul I W de Bakker Matteo Barcella Riad Bayoumi Rob J Bieringa Dorret Boomsma Gabrielle Boucher Annie R Britton Ingrid Christophersen Andrea Dietrich George B Ehret Patrick T Ellinor Markku Eskola Janine F Felix John S Floras Oscar H Franco Peter Friberg Maaike G J Gademan Mark A Geyer Vilmantas Giedraitis Catharina A Hartman Daiane Hemerich Albert Hofman Jouke-Jan Hottenga Heikki Huikuri Nina Hutri-Kähönen Xavier Jouven Juhani Junttila Markus Juonala Antti M Kiviniemi Jan A Kors Meena Kumari Tatiana Kuznetsova Cathy C Laurie Joop D Lefrandt Yong Li Yun Li Duanping Liao Marian C Limacher Henry J Lin Cecilia M Lindgren Steven A Lubitz Anubha Mahajan Barbara McKnight Henriette Meyer Zu Schwabedissen Yuri Milaneschi Nina Mononen Andrew P Morris Mike A Nalls Gerjan Navis Melanie Neijts Kjell Nikus Kari E North Daniel T O'Connor Johan Ormel Siegfried Perz Annette Peters Bruce M Psaty Olli T Raitakari Victoria B Risbrough Moritz F Sinner David Siscovick Johannes H Smit Nicholas L Smith Elsayed Z Soliman Nona Sotoodehnia Jan A Staessen Phyllis K Stein Adrienne M Stilp Katarzyna Stolarz-Skrzypek Konstantin Strauch Johan Sundström Cees A Swenne Ann-Christine Syvänen Jean-Claude Tardif Kent D Taylor Alexander Teumer Timothy A Thornton Lesley E Tinker André G Uitterlinden Jessica van Setten Andreas Voss Melanie Waldenberger Kirk C Wilhelmsen Gonneke Willemsen Quenna Wong Zhu-Ming Zhang Alan B Zonderman Daniele Cusi Michele K Evans Halina K Greiser Pim van der Harst Mohammad Hassan Erik Ingelsson Marjo-Riitta Järvelin Stefan Kääb Mika Kähönen Mika Kivimaki Charles Kooperberg Diana Kuh Terho Lehtimäki Lars Lind Caroline M Nievergelt Chris J O'Donnell Albertine J Oldehinkel Brenda Penninx Alexander P Reiner Harriëtte Riese Arie M van Roon John D Rioux Jerome I Rotter Tamar Sofer Bruno H Stricker Henning Tiemeier Tanja G M Vrijkotte Folkert W Asselbergs Bianca J J M Brundel Susan R Heckbert Eric A Whitsel Marcel den Hoed Harold Snieder Eco J C de Geus

Nat Commun 2017 08 2;8:16140. Epub 2017 Aug 2.

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http://dx.doi.org/10.1038/ncomms16140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543301PMC
August 2017

Genetic loci associated with heart rate variability and their effects on cardiac disease risk.

Authors:
Ilja M Nolte M Loretto Munoz Vinicius Tragante Azmeraw T Amare Rick Jansen Ahmad Vaez Benedikt von der Heyde Christy L Avery Joshua C Bis Bram Dierckx Jenny van Dongen Stephanie M Gogarten Philippe Goyette Jussi Hernesniemi Ville Huikari Shih-Jen Hwang Deepali Jaju Kathleen F Kerr Alexander Kluttig Bouwe P Krijthe Jitender Kumar Sander W van der Laan Leo-Pekka Lyytikäinen Adam X Maihofer Arpi Minassian Peter J van der Most Martina Müller-Nurasyid Michel Nivard Erika Salvi James D Stewart Julian F Thayer Niek Verweij Andrew Wong Delilah Zabaneh Mohammad H Zafarmand Abdel Abdellaoui Sulayma Albarwani Christine Albert Alvaro Alonso Foram Ashar Juha Auvinen Tomas Axelsson Dewleen G Baker Paul I W de Bakker Matteo Barcella Riad Bayoumi Rob J Bieringa Dorret Boomsma Gabrielle Boucher Annie R Britton Ingrid Christophersen Andrea Dietrich George B Ehret Patrick T Ellinor Markku Eskola Janine F Felix John S Floras Oscar H Franco Peter Friberg Maaike G J Gademan Mark A Geyer Vilmantas Giedraitis Catharina A Hartman Daiane Hemerich Albert Hofman Jouke-Jan Hottenga Heikki Huikuri Nina Hutri-Kähönen Xavier Jouven Juhani Junttila Markus Juonala Antti M Kiviniemi Jan A Kors Meena Kumari Tatiana Kuznetsova Cathy C Laurie Joop D Lefrandt Yong Li Yun Li Duanping Liao Marian C Limacher Henry J Lin Cecilia M Lindgren Steven A Lubitz Anubha Mahajan Barbara McKnight Henriette Meyer Zu Schwabedissen Yuri Milaneschi Nina Mononen Andrew P Morris Mike A Nalls Gerjan Navis Melanie Neijts Kjell Nikus Kari E North Daniel T O'Connor Johan Ormel Siegfried Perz Annette Peters Bruce M Psaty Olli T Raitakari Victoria B Risbrough Moritz F Sinner David Siscovick Johannes H Smit Nicholas L Smith Elsayed Z Soliman Nona Sotoodehnia Jan A Staessen Phyllis K Stein Adrienne M Stilp Katarzyna Stolarz-Skrzypek Konstantin Strauch Johan Sundström Cees A Swenne Ann-Christine Syvänen Jean-Claude Tardif Kent D Taylor Alexander Teumer Timothy A Thornton Lesley E Tinker André G Uitterlinden Jessica van Setten Andreas Voss Melanie Waldenberger Kirk C Wilhelmsen Gonneke Willemsen Quenna Wong Zhu-Ming Zhang Alan B Zonderman Daniele Cusi Michele K Evans Halina K Greiser Pim van der Harst Mohammad Hassan Erik Ingelsson Marjo-Riitta Järvelin Stefan Kääb Mika Kähönen Mika Kivimaki Charles Kooperberg Diana Kuh Terho Lehtimäki Lars Lind Caroline M Nievergelt Chris J O'Donnell Albertine J Oldehinkel Brenda Penninx Alexander P Reiner Harriëtte Riese Arie M van Roon John D Rioux Jerome I Rotter Tamar Sofer Bruno H Stricker Henning Tiemeier Tanja G M Vrijkotte Folkert W Asselbergs Bianca J J M Brundel Susan R Heckbert Eric A Whitsel Marcel den Hoed Harold Snieder Eco J C de Geus

Nat Commun 2017 06 14;8:15805. Epub 2017 Jun 14.

Department of Biological Psychology, Behavioral and Movement Sciences, VU University, Amsterdam 1081 BT, The Netherlands.

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http://dx.doi.org/10.1038/ncomms15805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474732PMC
June 2017

A genome-wide interaction analysis of tricyclic/tetracyclic antidepressants and RR and QT intervals: a pharmacogenomics study from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.

J Med Genet 2017 05 30;54(5):313-323. Epub 2016 Dec 30.

Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1136/jmedgenet-2016-104112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406254PMC
May 2017

Inflammatory Bowel Disease (IBD) pharmacotherapy and the risk of serious infection: a systematic review and network meta-analysis.

BMC Gastroenterol 2017 Apr 14;17(1):52. Epub 2017 Apr 14.

Department of Health Services, School of Public Health, University of Washington, 1959 NE Pacific Street, Magnuson Health Sciences Center, Room H-680, Box 357660, Seattle, WA, USA.

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http://dx.doi.org/10.1186/s12876-017-0602-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391579PMC
April 2017

Identity-by-descent estimation with population- and pedigree-based imputation in admixed family data.

BMC Proc 2016 18;10(Suppl 7):295-301. Epub 2016 Oct 18.

Department of Biostatistics, University of Washington, Seattle, WA USA ; Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA USA ; Department of Genome Sciences, University of Washington, Seattle, WA USA.

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http://dx.doi.org/10.1186/s12919-016-0046-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133511PMC
October 2016

Detecting Heterogeneity in Population Structure Across the Genome in Admixed Populations.

Genetics 2016 Sep 20;204(1):43-56. Epub 2016 Jul 20.

Department of Biostatistics, University of Washington, Seattle, Washington 98195

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http://www.genetics.org/lookup/doi/10.1534/genetics.115.1841
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http://dx.doi.org/10.1534/genetics.115.184184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012403PMC
September 2016

Worldwide Incidence of Colorectal Cancer, Leukemia, and Lymphoma in Inflammatory Bowel Disease: An Updated Systematic Review and Meta-Analysis.

Gastroenterol Res Pract 2016 16;2016:1632439. Epub 2016 May 16.

Division of Gastroenterology, Department of Medicine, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1155/2016/1632439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884856PMC
June 2016

Model-free Estimation of Recent Genetic Relatedness.

Am J Hum Genet 2016 Jan;98(1):127-48

Department of Biostatistics, University of Washington, Seattle, WA 98195, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2015.11.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4716688PMC
January 2016

Robust inference of population structure for ancestry prediction and correction of stratification in the presence of relatedness.

Genet Epidemiol 2015 May 23;39(4):276-93. Epub 2015 Mar 23.

Department of Biostatistics, University of Washington, Seattle, Washington, 98195, United States of America.

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http://dx.doi.org/10.1002/gepi.21896DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836868PMC
May 2015

Genome-wide association study identifies peanut allergy-specific loci and evidence of epigenetic mediation in US children.

Nat Commun 2015 Feb 24;6:6304. Epub 2015 Feb 24.

1] Department of Population, Family and Reproductive Health, Center on the Early Life Origins of Disease, Johns Hopkins University Bloomberg School of Public Health, 615 North Wolfe Street, E4132, Baltimore, Maryland 21205, USA [2] Division of General Pediatrics and Adolescent Medicine, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.

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http://dx.doi.org/10.1038/ncomms7304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340086PMC
February 2015

Statistical methods for genome-wide and sequencing association studies of complex traits in related samples.

Curr Protoc Hum Genet 2015 Jan 20;84:1.28.1-9. Epub 2015 Jan 20.

Department of Biostatistics, University of Washington, Seattle, Washington.

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http://dx.doi.org/10.1002/0471142905.hg0128s84DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4327940PMC
January 2015

Genome-wide association and admixture analysis of glaucoma in the Women's Health Initiative.

Hum Mol Genet 2014 Dec 15;23(24):6634-43. Epub 2014 Jul 15.

Department of Epidemiology and Biostatistics and Institute for Human Genetics, University of California San Francisco, San Francisco, CA 94143, USA, Division of Research, Kaiser Permanente, Oakland, CA 94612, USA.

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http://dx.doi.org/10.1093/hmg/ddu364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4240199PMC
December 2014

Local and global ancestry inference and applications to genetic association analysis for admixed populations.

Genet Epidemiol 2014 Sep;38 Suppl 1:S5-S12

Department of Biostatistics, University of Washington, Seattle, Washington, United States of America.

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http://doi.wiley.com/10.1002/gepi.21819
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http://dx.doi.org/10.1002/gepi.21819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339867PMC
September 2014

Dissecting vancomycin-intermediate resistance in staphylococcus aureus using genome-wide association.

Genome Biol Evol 2014 Apr 30;6(5):1174-85. Epub 2014 Apr 30.

Division of Infectious Diseases, Department of Medicine, Emory University School of MedicineDepartment of Human Genetics, Emory University School of Medicine

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http://dx.doi.org/10.1093/gbe/evu092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040999PMC
April 2014

Adiponectin pathway polymorphisms and risk of breast cancer in African Americans and Hispanics in the Women's Health Initiative.

Breast Cancer Res Treat 2013 Jun 30;139(2):461-8. Epub 2013 Apr 30.

Division Hematology/Oncology, Department of Medicine, Northwestern University, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1007/s10549-013-2546-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3773607PMC
June 2013