Timothy A McKinsey

Timothy A McKinsey

UNVERIFIED PROFILE

Are you Timothy A McKinsey?   Register this Author

Register author
Timothy A McKinsey

Timothy A McKinsey

Publications by authors named "Timothy A McKinsey"

Are you Timothy A McKinsey?   Register this Author

100Publications

2207Reads

50Profile Views

Site-specific acetyl-mimetic modification of cardiac troponin I modulates myofilament relaxation and calcium sensitivity.

J Mol Cell Cardiol 2020 Feb 22;139:135-147. Epub 2020 Jan 22.

Division of Cardiology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United States of America. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yjmcc.2020.01.007DOI Listing
February 2020

Defining decreased protein succinylation of failing human cardiac myofibrils in ischemic cardiomyopathy.

J Mol Cell Cardiol 2020 Jan 10;138:304-317. Epub 2019 Dec 10.

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yjmcc.2019.11.159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058372PMC
January 2020

Dynamic Chromatin Targeting of BRD4 Stimulates Cardiac Fibroblast Activation.

Circ Res 2019 Sep 14;125(7):662-677. Epub 2019 Aug 14.

From the Department of Medicine, Division of Cardiology (M.S.S., R.A.B., M.B.F., A.S.R., B.Y.E., K.A.K., M.A.C., K.S., M.P.Y.L., T.A.M.), University of Colorado Anschutz Medical Campus, Aurora.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCRESAHA.119.315125DOI Listing
September 2019

HDAC5 catalytic activity suppresses cardiomyocyte oxidative stress and NRF2 target gene expression.

J Biol Chem 2019 05 8;294(21):8640-8652. Epub 2019 Apr 8.

From the Department of Medicine, Division of Cardiology and Consortium for Fibrosis Research & Translation and

View Article

Download full-text PDF

Source
http://www.jbc.org/lookup/doi/10.1074/jbc.RA118.007006
Publisher Site
http://dx.doi.org/10.1074/jbc.RA118.007006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544848PMC
May 2019

Epigenetic therapies in heart failure.

J Mol Cell Cardiol 2019 05 13;130:197-204. Epub 2019 Apr 13.

Gladstone Institutes, San Francisco, CA, United States of America; Division of Cardiology, Department of Medicine, University of California San Francisco School of Medicine, San Francisco, CA, United States of America; Cardiometabolic Disorders, Amgen, South San Francisco, CA, United States of America. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00222828193006
Publisher Site
http://dx.doi.org/10.1016/j.yjmcc.2019.04.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6850768PMC
May 2019

The Fibrosis Across Organs Symposium: A Roadmap for Future Research Priorities.

Am J Med Sci 2019 05;357(5):405-410

National Jewish Health, Denver, Colorado; University of Colorado Anschutz Medical Campus and Consortium for Fibrosis Research & Translation, Denver, Colorado.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.amjms.2019.02.014DOI Listing
May 2019

Gold Nanoparticle-Functionalized Reverse Thermal Gel for Tissue Engineering Applications.

ACS Appl Mater Interfaces 2019 May 7;11(20):18671-18680. Epub 2019 May 7.

Department of Medicine, Division of Cardiology , University of Colorado Anschutz Medical Campus , 12700 E. 19th Avenue, Bldg. P15 , Aurora , Colorado 80045 , United States.

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/10.1021/acsami.9b00666
Publisher Site
http://dx.doi.org/10.1021/acsami.9b00666DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764451PMC
May 2019

Putting the Heat on Cardiac Fibrosis: Hsp20 Regulates Myocyte-To-Fibroblast Crosstalk.

JACC Basic Transl Sci 2019 Apr 29;4(2):200-203. Epub 2019 Apr 29.

Department of Medicine, Division of Cardiology and Consortium for Fibrosis Research & Translation, University of Colorado, Aurora, Colorado.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jacbts.2019.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488747PMC
April 2019

Epigenomic regulation of heart failure: integrating histone marks, long noncoding RNAs, and chromatin architecture.

F1000Res 2018 29;7. Epub 2018 Oct 29.

Departments of Anesthesiology, Medicine, and Physiology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.

View Article

Download full-text PDF

Source
https://f1000research.com/articles/7-1713/v1
Publisher Site
http://dx.doi.org/10.12688/f1000research.15797.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206605PMC
March 2019

Epigenetics in Cardiac Fibrosis: Emphasis on Inflammation and Fibroblast Activation.

JACC Basic Transl Sci 2018 Oct 12;3(5):704-715. Epub 2018 Nov 12.

Department of Medicine, Division of Cardiology and Consortium for Fibrosis Research & Translation, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S2452302X183012
Publisher Site
http://dx.doi.org/10.1016/j.jacbts.2018.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234501PMC
October 2018

Class I HDACs control a JIP1-dependent pathway for kinesin-microtubule binding in cardiomyocytes.

J Mol Cell Cardiol 2017 11 5;112:74-82. Epub 2017 Sep 5.

Department of Medicine, Division of Cardiology, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA; Department of Pharmacology, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA; Consortium for Fibrosis Research & Translation, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yjmcc.2017.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5845792PMC
November 2017

DUSP5 functions as a feedback regulator of TNFα-induced ERK1/2 dephosphorylation and inflammatory gene expression in adipocytes.

Sci Rep 2017 10 10;7(1):12879. Epub 2017 Oct 10.

University of Nevada, Department of Agriculture, Nutrition, and Veterinary Sciences, Reno, Reno, Nevada, 89557, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-017-12861-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5635013PMC
October 2017

p38α: A Profibrotic Signaling Nexus.

Circulation 2017 08;136(6):562-565

From Department of Medicine, Division of Cardiology and Consortium for Fibrosis Research & Translation, University of Colorado Anschutz Medical Campus, Aurora.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCULATIONAHA.117.028957DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709048PMC
August 2017

BRD4 inhibition for the treatment of pathological organ fibrosis.

F1000Res 2017 28;6. Epub 2017 Jun 28.

Department of Medicine, Division of Cardiology and Consortium for Fibrosis Research & Translation, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.

View Article

Download full-text PDF

Source
https://f1000research.com/articles/6-1015/v1
Publisher Site
http://dx.doi.org/10.12688/f1000research.11339.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5497817PMC
June 2017

Overlapping and Divergent Actions of Structurally Distinct Histone Deacetylase Inhibitors in Cardiac Fibroblasts.

J Pharmacol Exp Ther 2017 04 7;361(1):140-150. Epub 2017 Feb 7.

Division of Cardiology and Consortium for Fibrosis Research and Translation, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado (K.B.S., M.S.S., W.W.B., T.A.M.); Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical, Sciences, University of Colorado Denver, Aurora, Colorado (M.F.W.); Stanley Center for Psychiatric Research, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts (F.F.W., E.B.H.); Department of Cancer Biology, Fox Chase Cancer Center, Philadelphia, Pennsylvania (Y.-M.K., A.J.A.); and Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts (T.M.G., J.M.H.)

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/jpet.116.237701DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363768PMC
April 2017

Tryptophan hydroxylase 1 Inhibition Impacts Pulmonary Vascular Remodeling in Two Rat Models of Pulmonary Hypertension.

J Pharmacol Exp Ther 2017 Feb 7;360(2):267-279. Epub 2016 Dec 7.

Karos Pharmaceuticals, New Haven, Connecticut (R.J.A, P.-A.B, Q.Z, J.D., D.R.G., S.D.L., V.P.); INSERM UMR_S 999, Le Plessis-Robinson, France (M.H., C.G.), Université Paris-Sud, Université Paris-Saclay, Le Kremlin-Bicêtre, France (M.H., C.G.); Service de Pneumologie, Hôpital Bicêtre, Assistance Publique Hôpitaux de Paris, Le Kremlin-Bicêtre, France (M.H.); Division of Cardiology and Consortium for Fibrosis Research and Translation, Department of Medicine, University of Colorado Denver, Aurora, Colorado (M.A.C., T.A.M.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/jpet.116.237933DOI Listing
February 2017

Imaging cardiac SCN5A using the novel F-18 radiotracer radiocaine.

Sci Rep 2017 02 16;7:42136. Epub 2017 Feb 16.

Harvard Medical School, Massachusetts General Hospital, Martinos Center for Biomedical Imaging, 149 13th Street, 02129 Charlestown, MA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep42136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5311962PMC
February 2017

Histone deacetylase 3 regulates the inflammatory gene expression programme of rheumatoid arthritis fibroblast-like synoviocytes.

Ann Rheum Dis 2017 Jan 25;76(1):277-285. Epub 2016 Jul 25.

Department of Experimental Immunology and Department of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/annrheumdis-2015-209064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264225PMC
January 2017

The potential of targeting epigenetic regulators for the treatment of fibrotic cardiac diseases.

Future Med Chem 2016 09 24;8(13):1533-6. Epub 2016 Aug 24.

Department of Medicine, Division of Cardiology & Consortium for Fibrosis Research & Translation, University of Colorado - Anschutz Medical Campus, 12700 East 19th Avenue, Aurora, CO 80045-0508, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4155/fmc-2016-0144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558550PMC
September 2016

Discovery of novel small molecule inhibitors of cardiac hypertrophy using high throughput, high content imaging.

J Mol Cell Cardiol 2016 08 27;97:106-13. Epub 2016 Apr 27.

Department of Medicine, Division of Cardiology, University of Colorado, Anschutz Medical Campus, United States; Department of Medicine, Consortium for Fibrosis Research and Translation, University of Colorado, Anschutz Medical Campus, United States. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yjmcc.2016.04.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5002372PMC
August 2016

Myofibril growth during cardiac hypertrophy is regulated through dual phosphorylation and acetylation of the actin capping protein CapZ.

Cell Signal 2016 08 13;28(8):1015-24. Epub 2016 May 13.

Department of Physiology and Biophysics, University of Illinois at Chicago, College of Medicine, Chicago, IL 60612-7342, United States; Department of Physiology & Biophysics, Center for Cardiovascular Research, University of Illinois at Chicago, Chicago, IL 60612-7342, United States. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cellsig.2016.05.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987081PMC
August 2016

Signal-Dependent Recruitment of BRD4 to Cardiomyocyte Super-Enhancers Is Suppressed by a MicroRNA.

Cell Rep 2016 08 14;16(5):1366-1378. Epub 2016 Jul 14.

Division of Cardiology, Department of Medicine, University of Colorado Denver, Aurora, CO 80045, USA; Medical Scientist Training Program, University of Colorado Denver, Aurora, CO 80045, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2016.06.074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972677PMC
August 2016

Epigenetic regulation of cardiac fibrosis.

J Mol Cell Cardiol 2016 Mar 12;92:206-13. Epub 2016 Feb 12.

Department of Medicine, Division of Cardiology and Center for Fibrosis Research and Translation, University of Colorado Denver, 12700 E. 19th Ave, Aurora, CO 80045-0508, United States. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yjmcc.2016.02.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987078PMC
March 2016

Nuclear PTEN functions as an essential regulator of SRF-dependent transcription to control smooth muscle differentiation.

Nat Commun 2016 Mar 4;7:10830. Epub 2016 Mar 4.

Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado, Anschutz Medical Campus, 12700 East 19th Avenue, C281, Research Complex 2, Room 7101, Aurora, Colorado 80045, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms10830DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411712PMC
March 2016

Inflammatory cytokines epigenetically regulate rheumatoid arthritis fibroblast-like synoviocyte activation by suppressing HDAC5 expression.

Ann Rheum Dis 2016 Feb 1;75(2):430-8. Epub 2014 Dec 1.

Department of Experimental Immunology and Department of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/annrheumdis-2014-205635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336378PMC
February 2016

High-efficiency reprogramming of fibroblasts into cardiomyocytes requires suppression of pro-fibrotic signalling.

Nat Commun 2015 Sep 10;6:8243. Epub 2015 Sep 10.

Division of Cardiology, Department of Medicine, University of Colorado School of Medicine, 12700 E. 19th Avenue, B139, Aurora, Colorado 80045, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms9243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4579788PMC
September 2015

TNAP: a new player in cardiac fibrosis? Focus on "Tissue-nonspecific alkaline phosphatase as a target of sFRP2 in cardiac fibroblasts".

Am J Physiol Cell Physiol 2015 Aug 24;309(3):C137-8. Epub 2015 Jun 24.

Department of Medicine, Division of Cardiology, University of Colorado Denver, Aurora, Colorado

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajpcell.00167.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4525085PMC
August 2015

Non-sirtuin histone deacetylases in the control of cardiac aging.

J Mol Cell Cardiol 2015 Jun 16;83:14-20. Epub 2015 Mar 16.

Department of Medicine, Division of Cardiology, University of Colorado, Denver, 12700 E. 19th Ave Aurora, CO 80045-0508, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yjmcc.2015.03.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459895PMC
June 2015

Transgenic over-expression of YY1 induces pathologic cardiac hypertrophy in a sex-specific manner.

Biochem Biophys Res Commun 2015 Jun 29;462(2):131-7. Epub 2015 Apr 29.

Division of Cardiology, University of Colorado School of Medicine, Aurora, CO, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2015.04.106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449792PMC
June 2015

Novel Interaction of Class IIb Histone Deacetylase 6 (HDAC6) with Class IIa HDAC9 Controls Gonadotropin Releasing Hormone (GnRH) Neuronal Cell Survival and Movement.

J Biol Chem 2015 May 14;290(22):14045-56. Epub 2015 Apr 14.

From the Division of Endocrinology, Metabolism, and Diabetes and Research Service Veterans Affairs Medical Center, Denver, Colorado 80220, and

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M115.640482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447976PMC
May 2015

Acetyl-lysine erasers and readers in the control of pulmonary hypertension and right ventricular hypertrophy.

Biochem Cell Biol 2015 Apr 16;93(2):149-57. Epub 2014 Dec 16.

Department of Medicine, Division of Cardiology, University of Colorado Denver, 12700 E. 19th Ave, Aurora, CO 80045-0508, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1139/bcb-2014-0119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975937PMC
April 2015

Promiscuous actions of small molecule inhibitors of the protein kinase D-class IIa HDAC axis in striated muscle.

FEBS Lett 2015 Apr 25;589(10):1080-8. Epub 2015 Mar 25.

Department of Medicine, Division of Cardiology, University of Colorado Denver, Aurora, CO, United States. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.febslet.2015.03.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4410688PMC
April 2015

AKT network of genes and impaired myocardial contractility during murine acute Chagasic myocarditis.

Am J Trop Med Hyg 2015 Mar 12;92(3):523-9. Epub 2015 Jan 12.

Division of Infectious Diseases and Departments of Medicine and Immunology, University of Colorado, Denver, Colorado; Department of Epidemiology, Colorado School of Public Health, Denver, Colorado; Department of Pathology, Denver Health, Denver, Colorado.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4269/ajtmh.14-0433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350542PMC
March 2015

Emerging roles for histone deacetylases in pulmonary hypertension and right ventricular remodeling (2013 Grover Conference series).

Pulm Circ 2015 Mar;5(1):63-72

Department of Medicine, Division of Cardiology, University of Colorado Denver, Aurora, Colorado, USA.

View Article

Download full-text PDF

Source
http://journals.sagepub.com/doi/10.1086/679700
Publisher Site
http://dx.doi.org/10.1086/679700DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405717PMC
March 2015

Diet and sex modify exercise and cardiac adaptation in the mouse.

Am J Physiol Heart Circ Physiol 2015 Jan 14;308(2):H135-45. Epub 2014 Nov 14.

Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajpheart.00532.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338936PMC
January 2015

Class I HDAC inhibition stimulates cardiac protein SUMOylation through a post-translational mechanism.

Cell Signal 2014 Dec 16;26(12):2912-20. Epub 2014 Sep 16.

Department of Medicine, Division of Cardiology, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA; Department of Pharmacology, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cellsig.2014.09.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4252807PMC
December 2014

Tubulin hyperacetylation is adaptive in cardiac proteotoxicity by promoting autophagy.

Proc Natl Acad Sci U S A 2014 Dec 17;111(48):E5178-86. Epub 2014 Nov 17.

The Heart Institute, Department of Pediatrics, Division of Molecular Cardiovascular Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229; and

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1415589111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260547PMC
December 2014

BET-ting on chromatin-based therapeutics for heart failure.

J Mol Cell Cardiol 2014 Sep 14;74:98-102. Epub 2014 May 14.

Department of Medicine, Division of Cardiology, University of Colorado Denver, Aurora, CO 80045, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yjmcc.2014.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4115033PMC
September 2014

Endoplasmic reticulum stress effector CCAAT/enhancer-binding protein homologous protein (CHOP) regulates chronic kidney disease-induced vascular calcification.

J Am Heart Assoc 2014 Jun 24;3(3):e000949. Epub 2014 Jun 24.

Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, CO (S.M.A., M.M., A.L.K., S.J.S., R.M., K.J., J.K., M.C., M.L., M.M.) Division of Endocrinology, Diabetes and Metabolism, University of Colorado Denver, Aurora, CO (M.M.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/JAHA.114.000949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309099PMC
June 2014

Targeting cardiac fibroblasts to treat fibrosis of the heart: focus on HDACs.

J Mol Cell Cardiol 2014 May 11;70:100-7. Epub 2014 Mar 11.

Department of Medicine, Division of Cardiology, University of Colorado Denver, 12700 E. 19th Ave., Aurora, CO 80045-0508, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yjmcc.2014.02.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4080911PMC
May 2014

MicroRNA-124 controls the proliferative, migratory, and inflammatory phenotype of pulmonary vascular fibroblasts.

Circ Res 2014 Jan 11;114(1):67-78. Epub 2013 Oct 11.

From the Department of Pediatrics (D.W., H.Z., M.L., M.G.F., A.R.F., B.A.K., M.E.Y., M.A.F.), Department of Medicine (T.A.M., C.C.S.), Department of Medicine and Pediatrics (K.R.S.), Department of Medicine (N.W.M.), Department of Lung Development and Remodeling (S.S.P., S.V., W.S.), Department of Medicine (H.Z.), University of Colorado Anschutz Medical Campus, Aurora, CO; University of Cambridge, Cambridge, United Kingdom (N.W.M.); Addenbrooke's & Papworth Hospitals, Cambridge, United Kingdom (N.W.M.); Max-Planck-Institute for Heart and Lung Research; University of Giessen and Marburg Lung Center, Bad Nauheim, Germany (S.S.P., S.V., W.S.); and Shengjing Hospital of China Medical University, Shenyang, China (H.Z.).

View Article

Download full-text PDF

Source
http://circres.ahajournals.org/content/early/2013/10/11/CIRC
Web Search
http://circres.ahajournals.org/lookup/doi/10.1161/CIRCRESAHA
Publisher Site
http://dx.doi.org/10.1161/CIRCRESAHA.114.301633DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117588PMC
January 2014

Estrogen regulates histone deacetylases to prevent cardiac hypertrophy.

Mol Biol Cell 2013 Dec 23;24(24):3805-18. Epub 2013 Oct 23.

Division of Endocrinology, Department of Medicine, University of California, Irvine, Irvine, CA 92717 Department of Veterans Affairs Medical Center, Long Beach, CA 90822 GTx, Inc., Memphis, TN 38163 Division of Cardiology, Department of Medicine, University of Colorado, Aurora, CO 80045.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1091/mbc.E13-08-0444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861078PMC
December 2013

BET acetyl-lysine binding proteins control pathological cardiac hypertrophy.

J Mol Cell Cardiol 2013 Oct 9;63:175-9. Epub 2013 Aug 9.

Department of Medicine, Division of Cardiology, University of Colorado Denver, Aurora, CO, USA; Department of Pharmacology, University of Colorado Denver, Aurora, CO, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yjmcc.2013.07.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4089995PMC
October 2013

Roles of histone deacetylation and AMP kinase in regulation of cardiomyocyte PGC-1α gene expression in hypoxia.

Am J Physiol Cell Physiol 2013 Jun 20;304(11):C1064-72. Epub 2013 Mar 20.

Institute of Cardiovascular Sciences, St. Boniface General Hospital Research Centre and Department of Physiology, University of Manitoba, Winnipeg, Manitoba, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajpcell.00262.2012DOI Listing
June 2013

Hypoxia alters ocular drug transporter expression and activity in rat and calf models: implications for drug delivery.

Mol Pharm 2013 Jun 22;10(6):2350-61. Epub 2013 May 22.

Pharmaceutical Sciences and Ophthalmology, University of Colorado, Anschutz Medical Campus, Aurora, Colorado 80045, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/mp3007133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973437PMC
June 2013

Signal-dependent repression of DUSP5 by class I HDACs controls nuclear ERK activity and cardiomyocyte hypertrophy.

Proc Natl Acad Sci U S A 2013 Jun 29;110(24):9806-11. Epub 2013 May 29.

Division of Cardiology, Department of Medicine, University of Colorado Denver, Aurora, CO 80045, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1301509110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683796PMC
June 2013

Therapeutic potential for HDAC inhibitors in the heart.

Annu Rev Pharmacol Toxicol 2012 26;52:303-19. Epub 2011 Sep 26.

Department of Medicine, Division of Cardiology, University of Colorado Denver, Aurora, Colorado 80045-0508, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1146/annurev-pharmtox-010611-134712DOI Listing
May 2012

The biology and therapeutic implications of HDACs in the heart.

Handb Exp Pharmacol 2011 ;206:57-78

Department of Medicine, Division of Cardiology, University of Colorado Denver, Aurora, CO 80045-0508, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-3-642-21631-2_4DOI Listing
November 2011

Isoform-selective HDAC inhibitors: closing in on translational medicine for the heart.

J Mol Cell Cardiol 2011 Oct 23;51(4):491-6. Epub 2010 Nov 23.

Department of Medicine, Division of Cardiology, University of Colorado Denver, 12700 E. 19th Ave, Aurora, CO 80045-0508, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yjmcc.2010.11.009DOI Listing
October 2011

Targeting inflammation in heart failure with histone deacetylase inhibitors.

Mol Med 2011 May-Jun;17(5-6):434-41. Epub 2011 Jan 20.

Department of Medicine, Division of Cardiology, University of Colorado Denver, Aurora, Colorado 80045-0508, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2119/molmed.2011.00022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3105143PMC
October 2011

Cardiac HDAC6 catalytic activity is induced in response to chronic hypertension.

J Mol Cell Cardiol 2011 Jul 23;51(1):41-50. Epub 2011 Apr 23.

Department of Medicine, Division of Cardiology, University of Colorado Denver, Aurora, CO, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yjmcc.2011.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113526PMC
July 2011

β-Adrenergic receptor stimulation and activation of protein kinase A protect against α1-adrenergic-mediated phosphorylation of protein kinase D and histone deacetylase 5.

J Card Fail 2011 Jul 22;17(7):592-600. Epub 2011 Apr 22.

Division of Cardiology, School of Medicine, University of Colorado Denver, Health Sciences Center Campus, Aurora, Colorado 80045, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cardfail.2011.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128428PMC
July 2011

A novel protein kinase C target site in protein kinase D is phosphorylated in response to signals for cardiac hypertrophy.

Biochem Biophys Res Commun 2011 Jul 25;411(2):335-41. Epub 2011 Jun 25.

Department of Biology, Gilead Sciences, Palo Alto, CA 94304, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2011.06.143DOI Listing
July 2011

Protein acetylation in the cardiorenal axis: the promise of histone deacetylase inhibitors.

Circ Res 2010 Feb;106(2):272-84

Gilead Colorado Inc, 3333 Walnut St, Boulder, CO 80301, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCRESAHA.109.209338DOI Listing
February 2010

Targeting histone deacetylases for heart failure.

Expert Opin Ther Targets 2009 Jul;13(7):767-84

Gilead Colorado, Inc., 3333 Walnut Street, Boulder, Colorado 80301, USA.

View Article

Download full-text PDF

Source
http://www.tandfonline.com/doi/full/10.1517/1472822090293916
Publisher Site
http://dx.doi.org/10.1517/14728220902939161DOI Listing
July 2009

YY1 protects cardiac myocytes from pathologic hypertrophy by interacting with HDAC5.

Mol Biol Cell 2008 Oct 16;19(10):4141-53. Epub 2008 Jul 16.

Division of Cardiology, School of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1091/mbc.e07-12-1217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2555926PMC
October 2008

Protein kinase D1 stimulates MEF2 activity in skeletal muscle and enhances muscle performance.

Mol Cell Biol 2008 Jun 31;28(11):3600-9. Epub 2008 Mar 31.

Department of Molecular Biology, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd., Dallas, TX 75390, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/MCB.00189-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2423294PMC
June 2008

Histone deacetylase 5 acquires calcium/calmodulin-dependent kinase II responsiveness by oligomerization with histone deacetylase 4.

Mol Cell Biol 2008 May 10;28(10):3437-45. Epub 2008 Mar 10.

Department of Molecular Biology, UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9148, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/MCB.01611-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2423150PMC
May 2008

Angiotensin II stimulates protein kinase D-dependent histone deacetylase 5 phosphorylation and nuclear export leading to vascular smooth muscle cell hypertrophy.

Arterioscler Thromb Vasc Biol 2007 Nov 6;27(11):2355-62. Epub 2007 Sep 6.

Cardiovascular Research Institute and Department of Medicine, University of Rochester School of Medicine, NY 14642, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/ATVBAHA.107.151704DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259271PMC
November 2007

Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli.

Neuron 2007 Nov;56(3):517-29

Department of Psychiatry and Basic Neuroscience, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9070, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuron.2007.09.032DOI Listing
November 2007

Small-molecule therapies for cardiac hypertrophy: moving beneath the cell surface.

Nat Rev Drug Discov 2007 Aug;6(8):617-35

Gilead Colorado, Inc., 7575 West 103rd Avenue, Westminster, Colorado 80021, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrd2193DOI Listing
August 2007

Derepression of pathological cardiac genes by members of the CaM kinase superfamily.

Cardiovasc Res 2007 Mar 5;73(4):667-77. Epub 2006 Dec 5.

Myogen, Inc./Gilead Colorado, Inc., 7575 West 103rd Ave., Westminster, Colorado 80021, USA.

View Article

Download full-text PDF

Source
https://academic.oup.com/cardiovascres/article-lookup/doi/10
Publisher Site
http://dx.doi.org/10.1016/j.cardiores.2006.11.036DOI Listing
March 2007

Control of cardiac hypertrophy and heart failure by histone acetylation/deacetylation.

Novartis Found Symp 2006 ;274:3-12; discussion 13-9, 152-5, 272-6

Myogen, Inc., 757 W. 103rd Ave., Westminster, CO 80021, USA.

View Article

Download full-text PDF

Source
January 2007

Protein kinase D directly phosphorylates histone deacetylase 5 via a random sequential kinetic mechanism.

Arch Biochem Biophys 2006 Jun 9;450(2):141-8. Epub 2006 Mar 9.

Research and Development, Myogen, Inc., 7575 West 103(rd) Ave., Westminster, CO 80021, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.abb.2006.02.014DOI Listing
June 2006

Essential role for protein kinase D family kinases in the regulation of class II histone deacetylases in B lymphocytes.

Mol Cell Biol 2006 Feb;26(4):1569-77

Division of Cell Biology and Immunology, School of Life Sciences, University of Dundee, Scotland, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/MCB.26.4.1569-1577.2006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1367196PMC
February 2006

Protein kinase D1 phosphorylates HDAC7 and induces its nuclear export after T-cell receptor activation.

J Biol Chem 2005 Apr 28;280(14):13762-70. Epub 2004 Dec 28.

Gladstone Institute of Virology and Immunology, University of California, San Francisco, California 94158, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M413396200DOI Listing
April 2005

Toward transcriptional therapies for the failing heart: chemical screens to modulate genes.

J Clin Invest 2005 Mar;115(3):538-46

Myogen Inc., Westminster, Colorado 80021, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/JCI24144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1052006PMC
March 2005

Histone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart development.

Mol Cell Biol 2004 Oct;24(19):8467-76

Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd., Dallas, TX 75390-9148, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/MCB.24.19.8467-8476.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC516756PMC
October 2004