Timothy A Graubert

Timothy A Graubert

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Timothy A Graubert

Timothy A Graubert

Publications by authors named "Timothy A Graubert"

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Targeting R-loop-associated ATR response in myelodysplastic syndrome.

Oncotarget 2019 Apr 5;10(27):2581-2582. Epub 2019 Apr 5.

Lee Zou: Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA, USA; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.18632/oncotarget.26851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6498995PMC
April 2019

Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity.

Cell 2019 03 28;176(6):1265-1281.e24. Epub 2019 Feb 28.

Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Ludwig Center at Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674193009
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http://dx.doi.org/10.1016/j.cell.2019.01.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6515904PMC
March 2019

Immune Escape of Relapsed AML Cells after Allogeneic Transplantation.

N Engl J Med 2018 12 31;379(24):2330-2341. Epub 2018 Oct 31.

From the Division of Oncology, Department of Internal Medicine (M.J.C., A.A.P., M.P.R., C.A.M., E.C., N.M.H., L.D.W., J.S.W., S.E.H., D.C.L., M.J.W., P.W., T.J.L., J.F.D.), the McDonnell Genome Institute (A.A.P., C.A.M., M.O., C.C.F., R.S.F., L.D.W., T.J.L.), the Department of Pathology and Immunology (E.J.D., J.E.P.), and the Division of Biostatistics (J.D.B.), Washington University in St. Louis, St. Louis; the Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN (J.M.K.); the Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH (R.K.W.); and the Center for Cancer Research, Massachusetts General Hospital, Boston (T.A.G.).

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http://www.nejm.org/doi/10.1056/NEJMoa1808777
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http://dx.doi.org/10.1056/NEJMoa1808777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322675PMC
December 2018

Mutation Clearance after Transplantation for Myelodysplastic Syndrome.

N Engl J Med 2018 Sep;379(11):1028-1041

From the Department of Pathology and Immunology (E.J.D.), the Department of Medicine, Division of Oncology (M.A.J., C.A.M., N.E., J.S., K.E., J.R., S.E.H., K.B., L.D.W., M.J.C., I.P., J.S.W., G.L.U., D.C.L., J.F.D., P.W., T.J.L., M.J.W.), the McDonnell Genome Institute (G.S.C., C.A.M., H.A., R.S.F., C.C.F., M.O.), the Department of Medicine, Division of Hospital Medicine (R.S.), and Siteman Biostatistics Shared Resource, Siteman Cancer Center (K.T.), Washington University School of Medicine in St. Louis, St. Louis; and Massachusetts General Hospital Cancer Center, Boston (T.A.G.).

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http://www.nejm.org/doi/10.1056/NEJMoa1804714
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http://dx.doi.org/10.1056/NEJMoa1804714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309244PMC
September 2018

Genomics in childhood acute myeloid leukemia comes of age.

Nat Med 2018 01;24(1):7-9

Massachusetts General Hospital Cancer Center, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nm.4469DOI Listing
January 2018

Splicing factor gene mutations in hematologic malignancies.

Blood 2017 03 9;129(10):1260-1269. Epub 2016 Dec 9.

Massachusetts General Hospital Cancer Center, Boston, MA.

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http://dx.doi.org/10.1182/blood-2016-10-692400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345729PMC
March 2017

Functions of Replication Protein A as a Sensor of R Loops and a Regulator of RNaseH1.

Mol Cell 2017 Mar;65(5):832-847.e4

Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2017.01.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507214PMC
March 2017

Case 37-2016. An 86-Year-Old Woman with Leukocytosis and Splenomegaly.

N Engl J Med 2016 12;375(23):2273-2282

From the Departments of Medicine (A.T.F., T.A.G.), Radiology (N.M.K.), and Pathology (R.P.H.), Massachusetts General Hospital, the Department of Pathology, Brigham and Women's Hospital (F.C.K.), and the Departments of Medicine (A.T.F., T.A.G.), Radiology (N.M.K.), and Pathology (F.C.K., R.P.H.), Harvard Medical School - all in Boston.

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http://dx.doi.org/10.1056/NEJMcpc1509539DOI Listing
December 2016

TP53 and Decitabine in Acute Myeloid Leukemia and Myelodysplastic Syndromes.

N Engl J Med 2016 11;375(21):2023-2036

the Department of Internal Medicine, Division of Oncology (J.S.W., L.D.W., G.L.U., A.G., M.H.T., I.P., R.R., T.A.F., K.E.S.-G., R.V., S.T.O., C.N.A., A.F.C., M.A.S., M.A.J., S.E.H., K.L., M.R.J., M.J.W., P.W., D.C.L., J.F.D., T.J.L.), and the Division of Biostatistics (J.D.B.), and the Department of Pathology and Immunology (E.J.D., B.T., Y.-S.L.), Washington University School of Medicine, and McDonnell Genome Institute, Washington University in St. Louis (A.A.P., C.A.M., C.C.F., M.O., R.S.F., R.K.W., L.D.W., T.J.L.) - both in St. Louis; the Departments of Internal Medicine (A.H., N.K., M.J.S., W.S.) and Pharmacy (R.W.K.), University of Chicago, Chicago; and the Department of Internal Medicine (T.A.G.), Massachusetts General Hospital, Boston.

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http://dx.doi.org/10.1056/NEJMoa1605949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5217532PMC
November 2016

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice.

Authors:
Elizabeth C Townsend Mark A Murakami Alexandra Christodoulou Amanda L Christie Johannes Köster Tiffany A DeSouza Elizabeth A Morgan Scott P Kallgren Huiyun Liu Shuo-Chieh Wu Olivia Plana Joan Montero Kristen E Stevenson Prakash Rao Raga Vadhi Michael Andreeff Philippe Armand Karen K Ballen Patrizia Barzaghi-Rinaudo Sarah Cahill Rachael A Clark Vesselina G Cooke Matthew S Davids Daniel J DeAngelo David M Dorfman Hilary Eaton Benjamin L Ebert Julia Etchin Brant Firestone David C Fisher Arnold S Freedman Ilene A Galinsky Hui Gao Jacqueline S Garcia Francine Garnache-Ottou Timothy A Graubert Alejandro Gutierrez Ensar Halilovic Marian H Harris Zachary T Herbert Steven M Horwitz Giorgio Inghirami Andrew M Intlekofer Moriko Ito Shai Izraeli Eric D Jacobsen Caron A Jacobson Sébastien Jeay Irmela Jeremias Michelle A Kelliher Raphael Koch Marina Konopleva Nadja Kopp Steven M Kornblau Andrew L Kung Thomas S Kupper Nicole R LeBoeuf Ann S LaCasce Emma Lees Loretta S Li A Thomas Look Masato Murakami Markus Muschen Donna Neuberg Samuel Y Ng Oreofe O Odejide Stuart H Orkin Rachel R Paquette Andrew E Place Justine E Roderick Jeremy A Ryan Stephen E Sallan Brent Shoji Lewis B Silverman Robert J Soiffer David P Steensma Kimberly Stegmaier Richard M Stone Jerome Tamburini Aaron R Thorner Paul van Hummelen Martha Wadleigh Marion Wiesmann Andrew P Weng Jens U Wuerthner David A Williams Bruce M Wollison Andrew A Lane Anthony Letai Monica M Bertagnolli Jerome Ritz Myles Brown Henry Long Jon C Aster Margaret A Shipp James D Griffin David M Weinstock

Cancer Cell 2016 07 11;30(1):183. Epub 2016 Jul 11.

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http://dx.doi.org/10.1016/j.ccell.2016.06.008DOI Listing
July 2016

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice.

Authors:
Elizabeth C Townsend Mark A Murakami Alexandra Christodoulou Amanda L Christie Johannes Köster Tiffany A DeSouza Elizabeth A Morgan Scott P Kallgren Huiyun Liu Shuo-Chieh Wu Olivia Plana Joan Montero Kristen E Stevenson Prakash Rao Raga Vadhi Michael Andreeff Philippe Armand Karen K Ballen Patrizia Barzaghi-Rinaudo Sarah Cahill Rachael A Clark Vesselina G Cooke Matthew S Davids Daniel J DeAngelo David M Dorfman Hilary Eaton Benjamin L Ebert Julia Etchin Brant Firestone David C Fisher Arnold S Freedman Ilene A Galinsky Hui Gao Jacqueline S Garcia Francine Garnache-Ottou Timothy A Graubert Alejandro Gutierrez Ensar Halilovic Marian H Harris Zachary T Herbert Steven M Horwitz Giorgio Inghirami Andrew M Intlekofer Moriko Ito Shai Izraeli Eric D Jacobsen Caron A Jacobson Sébastien Jeay Irmela Jeremias Michelle A Kelliher Raphael Koch Marina Konopleva Nadja Kopp Steven M Kornblau Andrew L Kung Thomas S Kupper Nicole R LeBoeuf Ann S LaCasce Emma Lees Loretta S Li A Thomas Look Masato Murakami Markus Muschen Donna Neuberg Samuel Y Ng Oreofe O Odejide Stuart H Orkin Rachel R Paquette Andrew E Place Justine E Roderick Jeremy A Ryan Stephen E Sallan Brent Shoji Lewis B Silverman Robert J Soiffer David P Steensma Kimberly Stegmaier Richard M Stone Jerome Tamburini Aaron R Thorner Paul van Hummelen Martha Wadleigh Marion Wiesmann Andrew P Weng Jens U Wuerthner David A Williams Bruce M Wollison Andrew A Lane Anthony Letai Monica M Bertagnolli Jerome Ritz Myles Brown Henry Long Jon C Aster Margaret A Shipp James D Griffin David M Weinstock

Cancer Cell 2016 04;29(4):574-586

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, 450 Brookline Avenue, Dana 510B, MA 02215, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.03.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5177991PMC
April 2016

Integrated analysis of germline and somatic variants in ovarian cancer.

Nat Commun 2014 ;5:3156

1] The Genome Institute, Washington University, St. Louis, Missouri 63108, USA [2] Department of Genetics, Washington University, St. Louis, Missouri 63108, USA [3] Siteman Cancer Center, Washington University, St. Louis, Missouri 63108, USA [4] Department of Medicine, Washington University, St. Louis, Missouri 63108, USA.

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http://dx.doi.org/10.1038/ncomms4156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4025965PMC
March 2016

New molecular abnormalities and clonal architecture in AML: from reciprocal translocations to whole-genome sequencing.

Am Soc Clin Oncol Educ Book 2014 :e334-40

From the Massachusetts General Hospital, Boston, MA.

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http://dx.doi.org/10.14694/EdBook_AM.2014.34.e334DOI Listing
December 2015

A call to action for acute lymphoblastic leukemia.

N Engl J Med 2014 Sep;371(11):1064-6

From the Massachusetts General Hospital Cancer Center, Boston.

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http://dx.doi.org/10.1056/NEJMe1407477DOI Listing
September 2014

Pathogenic variants for Mendelian and complex traits in exomes of 6,517 European and African Americans: implications for the return of incidental results.

Am J Hum Genet 2014 Aug 31;95(2):183-93. Epub 2014 Jul 31.

Department of Pediatrics, University of Washington, Seattle, WA 98195, USA; Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00029297140031
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http://dx.doi.org/10.1016/j.ajhg.2014.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4129409PMC
August 2014

SciClone: inferring clonal architecture and tracking the spatial and temporal patterns of tumor evolution.

PLoS Comput Biol 2014 Aug 7;10(8):e1003665. Epub 2014 Aug 7.

The Genome Institute, Washington University, St. Louis, Missouri, United States of America; Department of Internal Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, Missouri, United States of America; Department of Genetics, Washington University, St. Louis, Missouri, United States of America; Siteman Cancer Center, Barnes-Jewish Hospital, Washington University School of Medicine, St. Louis, Missouri, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1003665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125065PMC
August 2014

Clonal architecture of secondary acute myeloid leukemia defined by single-cell sequencing.

PLoS Genet 2014 Jul 10;10(7):e1004462. Epub 2014 Jul 10.

Department of Internal Medicine, Division of Oncology, Washington University, St. Louis, Missouri, United States of America; Siteman Cancer Center, Washington University, St. Louis, Missouri, United States of America; Department of Pathology and Immunology, Washington University, St. Louis, Missouri, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1004462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091781PMC
July 2014

Functional heterogeneity of genetically defined subclones in acute myeloid leukemia.

Cancer Cell 2014 Mar 6;25(3):379-92. Epub 2014 Mar 6.

The Genome Institute, Washington University, St. Louis, MO 63110, USA; Division of Oncology, Section of Stem Cell Biology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccr.2014.01.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983786PMC
March 2014

Genomics of acute myeloid leukemia.

Cancer J 2011 Nov-Dec;17(6):487-91

Division of Oncology, Department of Internal Medicine, Washington University, St Louis, MO, USA.

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http://dx.doi.org/10.1097/PPO.0b013e31823c5652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3240851PMC
June 2012

Integrated genomics of susceptibility to alkylator-induced leukemia in mice.

BMC Genomics 2010 Nov 17;11:638. Epub 2010 Nov 17.

Department of Internal Medicine, Division of Oncology, Stem Cell Biology Section, Washington University, St Louis, MO, USA.

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http://dx.doi.org/10.1186/1471-2164-11-638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018144PMC
November 2010

Murine models of human acute myeloid leukemia.

Cancer Treat Res 2010 ;145:183-96

Washington University School of Medicine, St. Louis, MO, USA.

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http://dx.doi.org/10.1007/978-0-387-69259-3_11DOI Listing
October 2010

Therapy related acute myeloid leukemia in breast cancer survivors, a population-based study.

Breast Cancer Res Treat 2009 Dec 26;118(3):593-8. Epub 2009 Mar 26.

Division of Oncology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8007, Saint Louis, MO 63110, USA.

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http://link.springer.com/10.1007/s10549-009-0376-3
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http://dx.doi.org/10.1007/s10549-009-0376-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400139PMC
December 2009

The impact of copy number variation on local gene expression in mouse hematopoietic stem and progenitor cells.

Nat Genet 2009 Apr 8;41(4):430-7. Epub 2009 Mar 8.

Department of Internal Medicine, Division of Oncology, Stem Cell Biology Section, Washington University, St Louis, MO, USA.

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http://www.nature.com/articles/ng.350
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http://dx.doi.org/10.1038/ng.350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2728431PMC
April 2009

Quantitative trait loci associated with susceptibility to therapy-related acute murine promyelocytic leukemia in hCG-PML/RARA transgenic mice.

Blood 2008 Aug 13;112(4):1434-42. Epub 2008 Jun 13.

Department of Internal Medicine, Division of Oncology, Stem Cell Biology Section, Washington University School of Medicine, St Louis, MO 63110, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2008-01-13
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http://dx.doi.org/10.1182/blood-2008-01-132084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2515115PMC
August 2008

wuHMM: a robust algorithm to detect DNA copy number variation using long oligonucleotide microarray data.

Nucleic Acids Res 2008 Apr 11;36(7):e41. Epub 2008 Mar 11.

Department of Internal Medicine and Department of Genetics, Division of Oncology, Stem Cell Biology Section, Washington University, St Louis, MO, USA.

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http://dx.doi.org/10.1093/nar/gkn110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2367727PMC
April 2008

A high-resolution map of segmental DNA copy number variation in the mouse genome.

PLoS Genet 2007 Jan 22;3(1):e3. Epub 2006 Nov 22.

Department of Medicine, Division of Oncology, Stem Cell Biology Section, Washington University, St. Louis, Missouri, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.0030003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1761046PMC
January 2007

Pharmacogenetics of alkylator-associated acute myeloid leukemia.

Pharmacogenomics 2006 Jul;7(5):719-29

Washington University School of Medicine, Division of Oncology, Stem Cell Biology Section, Campus Box 8007, 660 South Euclid Avenue, St Louis, MO 63110, USA.

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https://www.futuremedicine.com/doi/10.2217/14622416.7.5.719
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http://dx.doi.org/10.2217/14622416.7.5.719DOI Listing
July 2006

Roles of Sca-1 in hematopoietic stem/progenitor cell function.

Exp Hematol 2005 Jul;33(7):836-43

Department of Immunology, Baylor College of Medicine, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.exphem.2005.04.001DOI Listing
July 2005

Dominant negative effects of the AML1/ETO fusion oncoprotein.

Cell Cycle 2005 Jan 19;4(1):33-6. Epub 2005 Jan 19.

Department of Internal Medicine, Division of Oncology, Stem Cell Biology Section, Washington University, St. Louis, Missourie, USA.

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http://dx.doi.org/10.4161/cc.4.1.1399DOI Listing
January 2005

Stem cell expression of the AML1/ETO fusion protein induces a myeloproliferative disorder in mice.

Proc Natl Acad Sci U S A 2004 Oct 11;101(42):15184-9. Epub 2004 Oct 11.

Stem Cell Biology Section, Division of Oncology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0400751101
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http://dx.doi.org/10.1073/pnas.0400751101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC524043PMC
October 2004

Recruitment of bone marrow-derived endothelial cells to sites of pancreatic beta-cell injury.

Diabetes 2004 Jan;53(1):91-8

Department of Internal Medicine, Division of Oncology, Stem Cell Biology Section, Washington University, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.2337/diabetes.53.1.91DOI Listing
January 2004

A mouse-based strategy for cyclophosphamide pharmacogenomic discovery.

J Appl Physiol (1985) 2003 Oct;95(4):1352-60

Washington Univ. School of Medicine, Dept. of Medicine, Campus Box 8069, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1152/japplphysiol.00214.2003DOI Listing
October 2003

Enhanced green fluorescent protein targeted to the Sca-1 (Ly-6A) locus in transgenic mice results in efficient marking of hematopoietic stem cells in vivo.

Exp Hematol 2003 Feb;31(2):159-67

Department of Internal Medicine, Division of Oncology, Stem Cell Biology Section, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/s0301-472x(02)01021-4DOI Listing
February 2003

Sca-1(pos) cells in the mouse mammary gland represent an enriched progenitor cell population.

Dev Biol 2002 May;245(1):42-56

Program in Cell and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77035, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S001216060290625
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http://dx.doi.org/10.1006/dbio.2002.0625DOI Listing
May 2002