Timothy A Chan

Timothy A Chan

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Timothy A Chan

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Evolutionary divergence of HLA class I genotype impacts efficacy of cancer immunotherapy.

Nat Med 2019 Nov 7;25(11):1715-1720. Epub 2019 Nov 7.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1038/s41591-019-0639-4DOI Listing
November 2019

APOBEC mutagenesis is tightly linked to the immune landscape and immunotherapy biomarkers in head and neck squamous cell carcinoma.

Oral Oncol 2019 Sep 30;96:140-147. Epub 2019 Jul 30.

Cancer Immunology Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA, United States; Department of Otolaryngology-Head and Neck Surgery, University of Pittsburgh, Pittsburgh, PA, United States. Electronic address:

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http://dx.doi.org/10.1016/j.oraloncology.2019.07.020DOI Listing
September 2019

The good, the bad, and the ugly: hyperprogression in cancer patients following immune checkpoint therapy.

Genome Med 2019 07 24;11(1):43. Epub 2019 Jul 24.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1186/s13073-019-0661-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6651948PMC
July 2019

Tumor mutational burden as a predictive biomarker for checkpoint inhibitor immunotherapy.

Hum Vaccin Immunother 2019 Jul 30:1-4. Epub 2019 Jul 30.

a Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center , New York , NY , USA.

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http://dx.doi.org/10.1080/21645515.2019.1631136DOI Listing
July 2019

Immunomodulatory and immunotherapeutic implications of tobacco smoking in squamous cell carcinomas and normal airway epithelium.

Oncotarget 2019 Jun 11;10(39):3835-3839. Epub 2019 Jun 11.

Immunogenomics Precision Oncology Platform, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.18632/oncotarget.26982DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6570474PMC
June 2019

High-dose radiation therapy is needed for intracranial control and long-term survival in patients with non-seminomatous germ cell tumor brain metastases.

J Neurooncol 2019 May 15;142(3):523-528. Epub 2019 Feb 15.

Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY, 10065, USA.

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http://dx.doi.org/10.1007/s11060-019-03123-0DOI Listing
May 2019

Lung Cancer Evolution: What's Immunity Got to Do with It?

Cancer Cell 2019 May;35(5):711-713

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Immunogenomics and Precision Oncology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Radiation Oncology, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.04.009DOI Listing
May 2019

The evolving landscape of biomarkers for checkpoint inhibitor immunotherapy.

Nat Rev Cancer 2019 03;19(3):133-150

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1038/s41568-019-0116-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6705396PMC
March 2019

G-quadruplex DNA drives genomic instability and represents a targetable molecular abnormality in ATRX-deficient malignant glioma.

Nat Commun 2019 02 26;10(1):943. Epub 2019 Feb 26.

Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1038/s41467-019-08905-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391399PMC
February 2019

Tobacco Smoking-Associated Alterations in the Immune Microenvironment of Squamous Cell Carcinomas.

J Natl Cancer Inst 2018 12;110(12):1386-1392

Immunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer Center, New York, NY.

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http://dx.doi.org/10.1093/jnci/djy060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292793PMC
December 2018

The hallmarks of successful anticancer immunotherapy.

Sci Transl Med 2018 09;10(459)

Departamento de Biología Funcional, Área de Inmunología, Universidad de Oviedo, Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), 33006 Oviedo, Spain.

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http://dx.doi.org/10.1126/scitranslmed.aat7807DOI Listing
September 2018

Update on Tumor Neoantigens and Their Utility: Why It Is Good to Be Different.

Trends Immunol 2018 07 8;39(7):536-548. Epub 2018 May 8.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Immunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.it.2018.04.005DOI Listing
July 2018

Phosphatidylinositol-3-Kinase Mutations Are Associated With Increased Local Failure in Brain Metastases Treated With Radiation.

Int J Radiat Oncol Biol Phys 2018 07 29;101(4):833-844. Epub 2018 Mar 29.

Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York. Electronic address:

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http://dx.doi.org/10.1016/j.ijrobp.2018.03.032DOI Listing
July 2018

Multicenter Phase IB Trial of Carboxyamidotriazole Orotate and Temozolomide for Recurrent and Newly Diagnosed Glioblastoma and Other Anaplastic Gliomas.

J Clin Oncol 2018 06 23;36(17):1702-1709. Epub 2018 Apr 23.

Antonio Omuro, University of Miami, Miami, FL; Kathryn Beal, Robert J. Young, Thomas J. Kaley, Lisa M. DeAngelis, Mariza Daras, Igor T. Gavrilovic, Ingo Mellinghoff, Eli L. Diamond, Andrew McKeown, Malbora Manne, Andrew Caterfino, Krishna Patel, Philip Gutin, Viviane Tabar, Debyani Chakravarty, Timothy A. Chan, Cameron W. Brennan, and Elena Pentsova, Memorial Sloan Kettering Cancer Center; Rashida A. Karmali, Tactical Therapeutics, Inc, New York; Katharine McNeill, Montefiore Medical Center, Bronx, NY; Alissa Thomas, University of Vermont, Burlington, VT; Xuling Lin, National Neuroscience Institute, Singapore; Robert Terziev, University Hospital, Zurich, Switzerland; Linda Bavisotto, Porta Clinica PLLC, Seattle, WA; Greg Gorman, Samford University McWhorter School of Pharmacy, Birmingham, AL; Michael Lamson, Nuventra Pharma Sciences, Durham, NC; and Elizabeth Garrett-Mayer, Medical University of South Carolina, Charleston, SC.

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http://ascopubs.org/doi/10.1200/JCO.2017.76.9992
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http://dx.doi.org/10.1200/JCO.2017.76.9992DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993168PMC
June 2018

ImmunoMap: A Bioinformatics Tool for T-cell Repertoire Analysis.

Cancer Immunol Res 2018 02 20;6(2):151-162. Epub 2017 Dec 20.

Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1158/2326-6066.CIR-17-0114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478441PMC
February 2018

Tumor and Microenvironment Evolution during Immunotherapy with Nivolumab.

Cell 2017 Nov 12;171(4):934-949.e16. Epub 2017 Oct 12.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Immunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674173112
Publisher Site
http://dx.doi.org/10.1016/j.cell.2017.09.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685550PMC
November 2017

NF-κB c-Rel Is Crucial for the Regulatory T Cell Immune Checkpoint in Cancer.

Cell 2017 Sep;170(6):1096-1108.e13

Department of Microbiology & Immunology, College of Physicians & Surgeons, Columbia University, New York, NY 10032, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633372PMC
September 2017

Stratification of Pancreatic Ductal Adenocarcinoma: Combinatorial Genetic, Stromal, and Immunologic Markers.

Clin Cancer Res 2017 Aug 27;23(15):4429-4440. Epub 2017 Mar 27.

McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, Texas.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-0162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5951386PMC
August 2017

An Integrated Systems Biology Approach Identifies TRIM25 as a Key Determinant of Breast Cancer Metastasis.

Cell Rep 2017 08;20(7):1623-1640

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Brain Tumor Center, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Cellular and Developmental Biology, Weill Cornell Medical College, New York, NY, USA; Immunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.07.052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985663PMC
August 2017

Dissecting microsatellite instability in colorectal cancer: one size does not fit all.

Genome Med 2017 05 24;9(1):45. Epub 2017 May 24.

Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.

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http://dx.doi.org/10.1186/s13073-017-0438-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442871PMC
May 2017

Pan-Cancer Analysis Links PARK2 to BCL-XL-Dependent Control of Apoptosis.

Neoplasia 2017 02 27;19(2):75-83. Epub 2016 Dec 27.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Weill Cornell College of Medicine, New York, NY, USA; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Immunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neo.2016.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5198112PMC
February 2017

PLK1 inhibition enhances temozolomide efficacy in IDH1 mutant gliomas.

Oncotarget 2017 Feb;8(9):15827-15837

Department of Internal Medicine, Division of Hematology/Oncology, University of Cincinnati, Cincinnati, OH, USA.

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http://dx.doi.org/10.18632/oncotarget.15015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362526PMC
February 2017

Recurrent SERPINB3 and SERPINB4 mutations in patients who respond to anti-CTLA4 immunotherapy.

Nat Genet 2016 11 26;48(11):1327-1329. Epub 2016 Sep 26.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

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http://dx.doi.org/10.1038/ng.3677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553281PMC
November 2016

The role of neoantigens in response to immune checkpoint blockade.

Int Immunol 2016 08 5;28(8):411-9. Epub 2016 Apr 5.

Department of Radiation Oncology, Human Oncology and Pathogenesis Program and

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http://dx.doi.org/10.1093/intimm/dxw019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986233PMC
August 2016

Personalized Oncology Meets Immunology: The Path toward Precision Immunotherapy.

Cancer Discov 2016 07 22;6(7):703-13. Epub 2016 Apr 22.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York. Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.

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http://dx.doi.org/10.1158/2159-8290.CD-16-0146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930745PMC
July 2016

Loss-of-Function PTPRD Mutations Lead to Increased STAT3 Activation and Sensitivity to STAT3 Inhibition in Head and Neck Cancer.

PLoS One 2015 12;10(8):e0135750. Epub 2015 Aug 12.

Department of Otolaryngology, University of California San Francisco, San Francisco, CA, United States of America, 94143.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0135750PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534317PMC
May 2016

Corticosteroids compromise survival in glioblastoma.

Brain 2016 05 28;139(Pt 5):1458-71. Epub 2016 Mar 28.

2 Department of Neurosciences at the Cleveland Clinic Lerner Research Institute, Cleveland, Ohio, 44195, USA 3 Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA, USA

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http://brain.oxfordjournals.org/content/brain/early/2016/03/
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http://pdfs.journals.lww.com/neurosurgery/2016/10000/Do_Cort
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http://dx.doi.org/10.1093/brain/aww046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006251PMC
May 2016

Integrated Genomics for Pinpointing Survival Loci within Arm-Level Somatic Copy Number Alterations.

Cancer Cell 2016 05;29(5):737-750

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Brain Tumor Center, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Cellular and Developmental Biology, Weill Cornell Medical College, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.03.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864611PMC
May 2016

Regularized quantile regression under heterogeneous sparsity with application to quantitative genetic traits.

Comput Stat Data Anal 2016 Mar 24;95:222-239. Epub 2015 Oct 24.

Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

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http://dx.doi.org/10.1016/j.csda.2015.10.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5267342PMC
March 2016

Cancer Neoantigens and Applications for Immunotherapy.

Clin Cancer Res 2016 Feb 29;22(4):807-12. Epub 2015 Oct 29.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York. Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.

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http://clincancerres.aacrjournals.org/content/early/2015/10/
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http://clincancerres.aacrjournals.org/content/22/4/807.full.
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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
Publisher Site
http://dx.doi.org/10.1158/1078-0432.CCR-14-3175DOI Listing
February 2016

Immunotherapy and Oncogenic Pathways: The PTEN Connection.

Cancer Discov 2016 Feb;6(2):128-9

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York. Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.

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http://dx.doi.org/10.1158/2159-8290.CD-15-1501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746001PMC
February 2016

Genomic profile, smoking, and response to anti-PD-1 therapy in non-small cell lung carcinoma.

Mol Cell Oncol 2016 Jan 26;3(1):e1048929. Epub 2015 May 26.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center , New York, NY.

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http://dx.doi.org/10.1080/23723556.2015.1048929DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845184PMC
January 2016

Genetic Basis for Clinical Response to CTLA-4 Blockade in Melanoma.

N Engl J Med 2015 Nov;373(20):1984

Memorial Sloan Kettering Cancer Center, New York, NY

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http://dx.doi.org/10.1056/NEJMc1508163DOI Listing
November 2015

Genetics and immunology: reinvigorated.

Oncoimmunology 2015 Oct 14;4(10):e1029705. Epub 2015 Apr 14.

Human Oncology and Pathogenesis Program; Memorial Sloan-Kettering Cancer Center ; New York, NY USA.

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http://dx.doi.org/10.1080/2162402X.2015.1029705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589040PMC
October 2015

Molecular mechanisms orchestrating cyclin stability.

Cell Cycle 2014 ;13(16):2487-8

a Human Oncology and Pathogenesis Program; Memorial Sloan Kettering Cancer Center ; New York , NY USA.

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http://dx.doi.org/10.4161/15384101.2014.946376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4614406PMC
August 2015

Stereotactic radiosurgery for melanoma brain metastases in patients receiving ipilimumab: safety profile and efficacy of combined treatment.

Int J Radiat Oncol Biol Phys 2015 Jun 5;92(2):368-75. Epub 2015 Mar 5.

Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York. Electronic address:

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http://dx.doi.org/10.1016/j.ijrobp.2015.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4955924PMC
June 2015

Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas.

Authors:
Daniel J Brat Roel G W Verhaak Kenneth D Aldape W K Alfred Yung Sofie R Salama Lee A D Cooper Esther Rheinbay C Ryan Miller Mark Vitucci Olena Morozova A Gordon Robertson Houtan Noushmehr Peter W Laird Andrew D Cherniack Rehan Akbani Jason T Huse Giovanni Ciriello Laila M Poisson Jill S Barnholtz-Sloan Mitchel S Berger Cameron Brennan Rivka R Colen Howard Colman Adam E Flanders Caterina Giannini Mia Grifford Antonio Iavarone Rajan Jain Isaac Joseph Jaegil Kim Katayoon Kasaian Tom Mikkelsen Bradley A Murray Brian Patrick O'Neill Lior Pachter Donald W Parsons Carrie Sougnez Erik P Sulman Scott R Vandenberg Erwin G Van Meir Andreas von Deimling Hailei Zhang Daniel Crain Kevin Lau David Mallery Scott Morris Joseph Paulauskis Robert Penny Troy Shelton Mark Sherman Peggy Yena Aaron Black Jay Bowen Katie Dicostanzo Julie Gastier-Foster Kristen M Leraas Tara M Lichtenberg Christopher R Pierson Nilsa C Ramirez Cynthia Taylor Stephanie Weaver Lisa Wise Erik Zmuda Tanja Davidsen John A Demchok Greg Eley Martin L Ferguson Carolyn M Hutter Kenna R Mills Shaw Bradley A Ozenberger Margi Sheth Heidi J Sofia Roy Tarnuzzer Zhining Wang Liming Yang Jean Claude Zenklusen Brenda Ayala Julien Baboud Sudha Chudamani Mark A Jensen Jia Liu Todd Pihl Rohini Raman Yunhu Wan Ye Wu Adrian Ally J Todd Auman Miruna Balasundaram Saianand Balu Stephen B Baylin Rameen Beroukhim Moiz S Bootwalla Reanne Bowlby Christopher A Bristow Denise Brooks Yaron Butterfield Rebecca Carlsen Scott Carter Lynda Chin Andy Chu Eric Chuah Kristian Cibulskis Amanda Clarke Simon G Coetzee Noreen Dhalla Tim Fennell Sheila Fisher Stacey Gabriel Gad Getz Richard Gibbs Ranabir Guin Angela Hadjipanayis D Neil Hayes Toshinori Hinoue Katherine Hoadley Robert A Holt Alan P Hoyle Stuart R Jefferys Steven Jones Corbin D Jones Raju Kucherlapati Phillip H Lai Eric Lander Semin Lee Lee Lichtenstein Yussanne Ma Dennis T Maglinte Harshad S Mahadeshwar Marco A Marra Michael Mayo Shaowu Meng Matthew L Meyerson Piotr A Mieczkowski Richard A Moore Lisle E Mose Andrew J Mungall Angeliki Pantazi Michael Parfenov Peter J Park Joel S Parker Charles M Perou Alexei Protopopov Xiaojia Ren Jeffrey Roach Thaís S Sabedot Jacqueline Schein Steven E Schumacher Jonathan G Seidman Sahil Seth Hui Shen Janae V Simons Payal Sipahimalani Matthew G Soloway Xingzhi Song Huandong Sun Barbara Tabak Angela Tam Donghui Tan Jiabin Tang Nina Thiessen Timothy Triche David J Van Den Berg Umadevi Veluvolu Scot Waring Daniel J Weisenberger Matthew D Wilkerson Tina Wong Junyuan Wu Liu Xi Andrew W Xu Lixing Yang Travis I Zack Jianhua Zhang B Arman Aksoy Harindra Arachchi Chris Benz Brady Bernard Daniel Carlin Juok Cho Daniel DiCara Scott Frazer Gregory N Fuller JianJiong Gao Nils Gehlenborg David Haussler David I Heiman Lisa Iype Anders Jacobsen Zhenlin Ju Sol Katzman Hoon Kim Theo Knijnenburg Richard Bailey Kreisberg Michael S Lawrence William Lee Kalle Leinonen Pei Lin Shiyun Ling Wenbin Liu Yingchun Liu Yuexin Liu Yiling Lu Gordon Mills Sam Ng Michael S Noble Evan Paull Arvind Rao Sheila Reynolds Gordon Saksena Zack Sanborn Chris Sander Nikolaus Schultz Yasin Senbabaoglu Ronglai Shen Ilya Shmulevich Rileen Sinha Josh Stuart S Onur Sumer Yichao Sun Natalie Tasman Barry S Taylor Doug Voet Nils Weinhold John N Weinstein Da Yang Kosuke Yoshihara Siyuan Zheng Wei Zhang Lihua Zou Ty Abel Sara Sadeghi Mark L Cohen Jenny Eschbacher Eyas M Hattab Aditya Raghunathan Matthew J Schniederjan Dina Aziz Gene Barnett Wendi Barrett Darell D Bigner Lori Boice Cathy Brewer Chiara Calatozzolo Benito Campos Carlos Gilberto Carlotti Timothy A Chan Lucia Cuppini Erin Curley Stefania Cuzzubbo Karen Devine Francesco DiMeco Rebecca Duell J Bradley Elder Ashley Fehrenbach Gaetano Finocchiaro William Friedman Jordonna Fulop Johanna Gardner Beth Hermes Christel Herold-Mende Christine Jungk Ady Kendler Norman L Lehman Eric Lipp Ouida Liu Randy Mandt Mary McGraw Roger Mclendon Christopher McPherson Luciano Neder Phuong Nguyen Ardene Noss Raffaele Nunziata Quinn T Ostrom Cheryl Palmer Alessandro Perin Bianca Pollo Alexander Potapov Olga Potapova W Kimryn Rathmell Daniil Rotin Lisa Scarpace Cathy Schilero Kelly Senecal Kristen Shimmel Vsevolod Shurkhay Suzanne Sifri Rosy Singh Andrew E Sloan Kathy Smolenski Susan M Staugaitis Ruth Steele Leigh Thorne Daniela P C Tirapelli Andreas Unterberg Mahitha Vallurupalli Yun Wang Ronald Warnick Felicia Williams Yingli Wolinsky Sue Bell Mara Rosenberg Chip Stewart Franklin Huang Jonna L Grimsby Amie J Radenbaugh Jianan Zhang
June 2015

Therapeutic targeting of tumor suppressor genes.

Cancer 2015 May 29;121(9):1357-68. Epub 2014 Dec 29.

Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.

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http://dx.doi.org/10.1002/cncr.29140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526158PMC
May 2015

Remodeling of the methylation landscape in breast cancer metastasis.

PLoS One 2014 1;9(8):e103896. Epub 2014 Aug 1.

Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America; Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0103896PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118917PMC
April 2015

Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer.

Science 2015 Apr 12;348(6230):124-8. Epub 2015 Mar 12.

Weill Cornell Medical College, New York, NY, 10065, USA. Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1126/science.aaa1348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993154PMC
April 2015

Immunogenic peptide discovery in cancer genomes.

Curr Opin Genet Dev 2015 Feb 12;30:7-16. Epub 2015 Jan 12.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, United States; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, United States. Electronic address:

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http://dx.doi.org/10.1016/j.gde.2014.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657809PMC
February 2015

Genetic basis for clinical response to CTLA-4 blockade.

N Engl J Med 2015 02;372(8):783

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http://dx.doi.org/10.1056/NEJMc1415938DOI Listing
February 2015

Ipilimumab and whole brain radiation therapy for melanoma brain metastases.

J Neurooncol 2015 Jan 2;121(1):159-65. Epub 2014 Oct 2.

Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY, 10065, USA.

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http://dx.doi.org/10.1007/s11060-014-1617-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4955922PMC
January 2015

Genetic basis for clinical response to CTLA-4 blockade in melanoma.

N Engl J Med 2014 Dec 19;371(23):2189-2199. Epub 2014 Nov 19.

Department of Medicine (A.S., T.M., M.A.P., J.D.W.), Human Oncology and Pathogenesis Program (A.S., V.M., A.D., L.A.W., K.K., T.A.C.), Swim across America-Ludwig Collaborative Research Laboratory (T.M., Y.L., C.E., C.L., J.D.W.), Department of Radiation Oncology (T.A.C.), Department of Pathology (T.J.H.), and Immunology Program, Ludwig Center for Cancer Immunotherapy (J.Y., P.W., T.S.H., J.D.W.), Memorial Sloan Kettering Cancer Center; Weill Cornell Medical College (A.S., M.A.P., J.D.W., T.A.C.); and Department of Mathematics, Columbia University (C.B.) - all in New York; the Department of Molecular and Medical Pharmacology (J.M.Z., A.R.) and the Department of Medicine, Division of Hematology-Oncology, Jonsson Comprehensive Cancer Center (A.R.), University of California, Los Angeles, Los Angeles; and Bristol-Myers Squibb, Princeton, NJ (C.T.H., L.W.).

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http://dx.doi.org/10.1056/NEJMoa1406498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315319PMC
December 2014

Survival of patients treated with radiation therapy for anaplastic astrocytoma.

Radiol Oncol 2014 Dec 5;48(4):381-6. Epub 2014 Nov 5.

Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.2478/raon-2014-0019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230558PMC
December 2014

Cancer: Antitumour immunity gets a boost.

Nature 2014 Nov;515(7528):496-8

Department of Radiation Oncology and the Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center.

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http://dx.doi.org/10.1038/515496aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6592276PMC
November 2014

Unraveling the molecular genetics of head and neck cancer through genome-wide approaches.

Genes Dis 2014 Sep;1(1):75-86

Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA ; Department of Human Oncology and Pathogenesis, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1016/j.gendis.2014.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310010PMC
September 2014

Deletion of Ptprd and Cdkn2a cooperate to accelerate tumorigenesis.

Oncotarget 2014 Aug;5(16):6976-82

Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA; Dept. of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York, USA; Brain Tumor Center, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.

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http://www.oncotarget.com/fulltext/2106
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196177PMC
http://dx.doi.org/10.18632/oncotarget.2106DOI Listing
August 2014