Publications by authors named "Timo Gaiser"

100Publications

Molecular characterization of ulcerative colitis-associated colorectal carcinomas.

Mod Pathol 2020 Dec 14. Epub 2020 Dec 14.

Institute of Pathology, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

View Article and Find Full Text PDF
December 2020

Newly established gastrointestinal cancer cell lines retain the genomic and immunophenotypic landscape of their parental cancers.

Sci Rep 2020 10 21;10(1):17895. Epub 2020 Oct 21.

Institute of Pathology, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.

View Article and Find Full Text PDF
October 2020

Clinical responses to PD-1 inhibition and their molecular characterization in six patients with mismatch repair-deficient metastatic cancer of the digestive system.

J Cancer Res Clin Oncol 2020 Aug 9. Epub 2020 Aug 9.

Department of Medicine III, Medical Faculty Mannheim, University Medical Center Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.

View Article and Find Full Text PDF
August 2020

Cancer-Associated Mutations in Normal Colorectal Mucosa Adjacent to Sporadic Neoplasia.

Clin Transl Gastroenterol 2020 Jul;11(7):e00212

1Department Medicine II, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; 2German Cancer Research Center (DKFZ), Division Signaling and Functional Genomics and Department of Cell and Molecular Biology, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany; 3Central Interdisciplinary Endoscopy (ZIE), University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; 4Institute of Pathology, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; 5German Cancer Consortium (DKTK), Heidelberg, Germany.

View Article and Find Full Text PDF
July 2020

Interaction between CIEDs and modern radiotherapy techniques: Flattening filter free-VMAT, dose-rate effects, scatter radiation, and neutron-generating energies.

Radiother Oncol 2020 Nov 20;152:196-202. Epub 2020 Jan 20.

First Department of Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Germany; DZHK (German Centre for Cardiovascular Research) partner site, Mannheim, Germany.

View Article and Find Full Text PDF
November 2020

Visualisation of HER2 homodimers in single cells from HER2 overexpressing primary formalin fixed paraffin embedded tumour tissue.

Mol Med 2019 08 28;25(1):42. Epub 2019 Aug 28.

INM - Leibniz Institute for New Materials, Campus D2-2, 66123, Saarbrücken, Germany.

View Article and Find Full Text PDF
August 2019

Metastasis of pulmonary adenocarcinoma to the palatine tonsil.

Mol Clin Oncol 2019 Feb 27;10(2):231-234. Epub 2018 Nov 27.

Department of Otorhinolaryngology Head and Neck Surgery, University Hospital Mannheim, Medical Faculty Mannheim, University Heidelberg, D-68167 Mannheim, Germany.

View Article and Find Full Text PDF
February 2019

Clinical Presentation of Gastrointestinal Stromal Tumors.

Visc Med 2018 Oct 13;34(5):335-340. Epub 2018 Oct 13.

Division of Surgical Oncology, Mannheim University Medical Center, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.

View Article and Find Full Text PDF
October 2018

Single-cell genetic analysis of clonal dynamics in colorectal adenomas indicates CDX2 gain as a predictor of recurrence.

Int J Cancer 2019 04 11;144(7):1561-1573. Epub 2018 Dec 11.

Institute of Pathology, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

View Article and Find Full Text PDF
April 2019

Automatic evaluation of tumor budding in immunohistochemically stained colorectal carcinomas and correlation to clinical outcome.

Diagn Pathol 2018 Aug 28;13(1):64. Epub 2018 Aug 28.

Institute of Pathology, University Medical Centre Mannheim, University of Heidelberg, 68167, Mannheim, Germany.

View Article and Find Full Text PDF
August 2018

Impact of adjuvant chemotherapy on patients with ypT0-2 ypN0 rectal cancer after neoadjuvant chemoradiation: a cohort study from a tertiary referral hospital.

World J Surg Oncol 2018 Aug 2;16(1):156. Epub 2018 Aug 2.

Department of Surgery, University Hospital Mannheim, Medical Faculty Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.

View Article and Find Full Text PDF
August 2018

Dynamics of Genome Alterations in Crohn's Disease-Associated Colorectal Carcinogenesis.

Clin Cancer Res 2018 10 2;24(20):4997-5011. Epub 2018 Jul 2.

Institute of Pathology, Medical Faculty Mannheim, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany.

View Article and Find Full Text PDF
October 2018

Loss of Chromosome 18q11.2-q12.1 Is Predictive for Survival in Patients With Metastatic Colorectal Cancer Treated With Bevacizumab.

J Clin Oncol 2018 07 24;36(20):2052-2060. Epub 2018 May 24.

Erik van Dijk, Hedde D. Biesma, Martijn Cordes, Maarten Neerincx, Paul P. Eijk, Henk M.W. Verheul, Nicole C.T. van Grieken, and Bauke Ylstra, Vrije Universiteit Medical Center; Gerrit A. Meijer, Netherlands Cancer Institute; Cornelis J.A. Punt, Academic Medical Center, Amsterdam; Miriam Koopman, University Medical Center Utrecht, Utrecht, the Netherlands; Dominiek Smeets and Diether Lambrechts, KU Leuven, Leuven, Belgium; Sudipto Das, Orna Bacon, Jochen H.M. Prehn, Bryan T. Hennessey, Darran P. O'Connor, and Annette T. Byrne, Royal College of Surgeons in Ireland; Verena Murphy, Cancer Trials Ireland; Anna Barat, Deborah A. McNamara, and Elaine W. Kay, Beaumont Hospital; Bozena Fender and William M. Gallagher, OncoMark Ltd; Rut Klinger and William M. Gallagher, University College Dublin, Dublin, United Kingdom; Johannes Betge, Timo Gaiser, and Matthias P.A. Ebert, University Hospital Mannheim, Mannheim, Germany; and Fotios Loupakis, Veneto Institute of Oncology IOV-IRCCS Padua, Italy.

View Article and Find Full Text PDF
July 2018

gene amplification is a rare event in atypical fibroxanthoma and pleomorphic dermal sarcoma.

Oncotarget 2018 Apr 20;9(30):21182-21189. Epub 2018 Apr 20.

Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, Mannheim, Germany.

View Article and Find Full Text PDF
April 2018

Merkel cell carcinoma expresses the immunoregulatory ligand CD200 and induces immunosuppressive macrophages and regulatory T cells.

Oncoimmunology 2018;7(5):e1426517. Epub 2018 Feb 8.

Dermatology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, USA.

View Article and Find Full Text PDF
February 2018

Pringle maneuver increases the risk of anastomotic leakage after colonic resection in rats.

HPB (Oxford) 2018 05 4;20(5):392-397. Epub 2018 Jan 4.

Department of General, Visceral and Transplantation Surgery, Johannes Gutenberg University Hospital Mainz, Mainz, Germany. Electronic address:

View Article and Find Full Text PDF
May 2018

Loss of epithelial cell adhesion molecule (EpCAM) in infiltrative basal cell carcinoma.

Int J Clin Exp Pathol 2018 1;11(1):406-412. Epub 2018 Jan 1.

Institute of Pathology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg Mannheim, Germany.

View Article and Find Full Text PDF
January 2018

[Good remission under HER2 blockade in an advanced carcinoma of the oesophagogastric junction with only focal HER2 overexpression].

Z Gastroenterol 2017 Sep 8;55(9):866-871. Epub 2017 Aug 8.

III. Medizinische Klinik, Universitätsmedizin Mannheim, Mannheim, Germany.

View Article and Find Full Text PDF
September 2017

P53-induced miR-30e-5p inhibits colorectal cancer invasion and metastasis by targeting ITGA6 and ITGB1.

Int J Cancer 2017 11 24;141(9):1879-1890. Epub 2017 Jul 24.

Department of Experimental Surgery-Cancer Metastasis, Medical Faculty Mannheim, University of Heidelberg, Germany.

View Article and Find Full Text PDF
November 2017

Langerhans and Merkel: a nervous epidermal dispute.

Virchows Arch 2018 02 16;472(2):281-284. Epub 2017 Jun 16.

Institute of Pathology, University Medical Center Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.

View Article and Find Full Text PDF
February 2018

Identification of a characteristic vascular belt zone in human colorectal cancer.

PLoS One 2017 2;12(3):e0171378. Epub 2017 Mar 2.

Institute of Pathology, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany.

View Article and Find Full Text PDF
August 2017

Multiple behavioral factors are associated with occurrence of large, flat colorectal polyps.

Int J Colorectal Dis 2017 Apr 28;32(4):575-582. Epub 2016 Nov 28.

Department of Internal Medicine II, Medical Faculty Mannheim, Heidelberg University, Universitätsmedizin Mannheim, Theodor-Kutzer Ufer 1-3, D-68167, Mannheim, Germany.

View Article and Find Full Text PDF
April 2017

Differential expression of cancer stem cell markers in cutaneous and systemic lymphoma.

Exp Dermatol 2016 07 26;25(7):561-3. Epub 2016 Apr 26.

Department of Dermatology, Venereology and Allergy, University Medical Center Mannheim, Ruprecht-Karls-University of Heidelberg, Mannheim, Germany.

View Article and Find Full Text PDF
July 2016

Multi-class texture analysis in colorectal cancer histology.

Sci Rep 2016 06 16;6:27988. Epub 2016 Jun 16.

Institute of Computer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

View Article and Find Full Text PDF
June 2016

MAP kinase pathway gene copy alterations in NRAS/BRAF wild-type advanced melanoma.

Int J Cancer 2016 May 11;138(9):2257-62. Epub 2016 Jan 11.

Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany.

View Article and Find Full Text PDF
May 2016

Transcriptome profiling of LGR5 positive colorectal cancer cells.

Genom Data 2014 Dec 14;2:212-5. Epub 2014 Jun 14.

Institute of Pathology, University Medical Center Mannheim, Germany.

View Article and Find Full Text PDF
December 2014

Amplicon sequencing of colorectal cancer: variant calling in frozen and formalin-fixed samples.

PLoS One 2015 26;10(5):e0127146. Epub 2015 May 26.

Division of Signaling and Functional Genomics, German Cancer Research Center (DKFZ) and Department of Cell and Molecular Biology, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.

View Article and Find Full Text PDF
April 2016

Abdominopelvic actinomycosis in three different locations with invasion of the abdominal wall and ureteric obstruction: An uncommon presentation.

Int J Surg Case Rep 2015 12;12:48-51. Epub 2015 May 12.

Department of Surgery, University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University, Germany. Electronic address:

View Article and Find Full Text PDF
June 2015

Case report: Intraductal tubulopapillary neoplasm of the pancreas with unique clear cell phenotype.

Diagn Pathol 2014 Jan 20;9:11. Epub 2014 Jan 20.

Institute of Pathology, University Medical Center Mannheim, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany.

View Article and Find Full Text PDF
January 2014

LGR5 positivity defines stem-like cells in colorectal cancer.

Carcinogenesis 2014 Apr 26;35(4):849-58. Epub 2013 Nov 26.

Section of Cancer Genomics, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

View Article and Find Full Text PDF
April 2014

Mast cell sarcoma mimicking metastatic colon carcinoma.

Ann Hematol 2014 Jun 19;93(6):1067-9. Epub 2013 Oct 19.

III. Medizinische Klinik, Universitätsmedizin Mannheim, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.

View Article and Find Full Text PDF
June 2014

Deficiency of caveolin-1 in Apc(min/+) mice promotes colorectal tumorigenesis.

Carcinogenesis 2013 Sep 2;34(9):2109-18. Epub 2013 May 2.

Department of Internal Medicine II, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, D-68167 Mannheim, Germany.

View Article and Find Full Text PDF
September 2013

Chromothripsis and focal copy number alterations determine poor outcome in malignant melanoma.

Cancer Res 2013 Mar 27;73(5):1454-60. Epub 2012 Dec 27.

Genetics Branch, Center for Cancer Research, National Cancer Institute/NIH, Bethesda, Maryland 20892, USA.

View Article and Find Full Text PDF
March 2013

Molecular patterns in the evolution of serrated lesion of the colorectum.

Int J Cancer 2013 Apr 17;132(8):1800-10. Epub 2012 Oct 17.

Section of Cancer Genomics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

View Article and Find Full Text PDF
April 2013

Case report: A unique pediatric case of a primary CD8 expressing ALK-1 positive anaplastic large cell lymphoma of skeletal muscle.

Diagn Pathol 2012 Apr 12;7:38. Epub 2012 Apr 12.

Institute of Pathology, Medical Faculty Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany.

View Article and Find Full Text PDF
April 2012

A recurrent fusion gene in high-grade endometrial stromal sarcoma: a new tool for diagnosis and therapy?

Genome Med 2012 19;4(3):20. Epub 2012 Mar 19.

Department of Pathology, University Medicine Mannheim, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany.

View Article and Find Full Text PDF
May 2014

A new whole genome amplification method for studying clonal evolution patterns in malignant colorectal polyps.

Genes Chromosomes Cancer 2012 May 15;51(5):490-500. Epub 2012 Feb 15.

Section of Cancer Genomics, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

View Article and Find Full Text PDF
May 2012

Automated analysis of protein expression and gene amplification within the same cells of paraffin-embedded tumour tissue.

Cell Oncol (Dordr) 2011 Aug 9;34(4):337-42. Epub 2011 Jun 9.

Section of Cancer Genomics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

View Article and Find Full Text PDF
August 2011

Automated analysis of protein expression and gene amplification within the same cells of paraffin-embedded tumour tissue.

Anal Cell Pathol (Amst) 2010 ;33(2):105-12

Section of Cancer Genomics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

View Article and Find Full Text PDF
February 2011

Outcome and prognostic factors of desmoplastic medulloblastoma treated within a multidisciplinary treatment concept.

BMC Cancer 2010 Aug 23;10:450. Epub 2010 Aug 23.

Department of Radiation Oncology, University Hospital of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany.

View Article and Find Full Text PDF
August 2010

A rare pediatric case of a thymic cytotoxic and lymphoblastic T/NK cell lymphoma.

Int J Clin Exp Pathol 2010 Mar 20;3(4):437-42. Epub 2010 Mar 20.

Section of Cancer Genomics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

View Article and Find Full Text PDF
March 2010

COX-2 expression in malignant melanoma: a novel prognostic marker?

Melanoma Res 2009 Feb;19(1):8-16

Department of Dermatology, University of Heidelberg, Vossstrasse 2, Heidelberg 69115, Germany.

View Article and Find Full Text PDF
February 2009

Daidzein overcomes TRAIL-resistance in malignant glioma cells by modulating the expression of the intrinsic apoptotic inhibitor, bcl-2.

Neurosci Lett 2009 May 14;454(3):223-8. Epub 2009 Mar 14.

Department of Neuropathology, University Hospital Heidelberg, Im Neuenheimer Feld 220, 69120 Heidelberg, Germany.

View Article and Find Full Text PDF
May 2009

p53-mediated inhibition of angiogenesis in diffuse low-grade astrocytomas.

Neurochem Int 2009 Jun 6;54(7):458-63. Epub 2009 Feb 6.

Department of Neuropathology, University Hospital Heidelberg, Im Neuenheimer Feld 220, 69120 Heidelberg, Germany.

View Article and Find Full Text PDF
June 2009

The XIAP inhibitor Embelin enhances TRAIL-mediated apoptosis in malignant glioma cells by down-regulation of the short isoform of FLIP.

Neurochem Int 2009 Nov 4;55(6):423-30. Epub 2009 May 4.

Department of Neuropathology, University Hospital Heidelberg, Im Neuenheimer Feld 220, 69120 Heidelberg, Germany.

View Article and Find Full Text PDF
November 2009

Myricetin sensitizes malignant glioma cells to TRAIL-mediated apoptosis by down-regulation of the short isoform of FLIP and bcl-2.

Cancer Lett 2009 Oct 26;283(2):230-8. Epub 2009 Apr 26.

Department of Neuropathology, University Hospital Heidelberg, Im Neuenheimer Feld 220, 69120 Heidelberg, Germany.

View Article and Find Full Text PDF
October 2009

Genistein enhances proteasomal degradation of the short isoform of FLIP in malignant glioma cells and thereby augments TRAIL-mediated apoptosis.

Neurosci Lett 2009 Apr 13;453(2):92-7. Epub 2009 Feb 13.

Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.

View Article and Find Full Text PDF
April 2009

Stem-cell-like glioma cells are resistant to TRAIL/Apo2L and exhibit down-regulation of caspase-8 by promoter methylation.

Acta Neuropathol 2009 Apr 12;117(4):445-56. Epub 2009 Feb 12.

Department of Neuropathology, University Hospital Heidelberg, Im Neuenheimer Feld 220, 69120, Heidelberg, Germany.

View Article and Find Full Text PDF
April 2009

17-AAG sensitized malignant glioma cells to death-receptor mediated apoptosis.

Neurobiol Dis 2009 Feb 10;33(2):243-9. Epub 2008 Nov 10.

Department of Neuropathology, University Hospital Heidelberg, Im Neuenheimer Feld 220, 69120 Heidelberg, Germany.

View Article and Find Full Text PDF
February 2009

Light chain multiple myeloma with cutaneous AL amyloidosis.

J Dtsch Dermatol Ges 2008 Sep 9;6(9):744-5. Epub 2008 Apr 9.

Department of Dermatology, Clinic Kassel, Germany.

View Article and Find Full Text PDF
September 2008

Tyramide signal amplification: an enhanced method for immunohistochemistry on methyl-methacrylate-embedded bone marrow trephine sections.

Acta Haematol 2007 29;117(2):122-7. Epub 2006 Nov 29.

Institute of Pathology, Klinikum Kassel, Kassel, Germany.

View Article and Find Full Text PDF
March 2007

Receptors for luteinizing hormone releasing hormone (LHRH) expressed in human non-Hodgkin's lymphomas can be targeted for therapy with the cytotoxic LHRH analogue AN-207.

Eur J Cancer 2005 Sep;41(14):2196-202

Endocrine, Polypeptide and Cancer Institute, Veterans Affairs Medical Center, 1601 Perdido St., New Orleans, LA 70112-1262, USA.

View Article and Find Full Text PDF
September 2005

Receptors for luteinizing hormone releasing hormone expressed on human renal cell carcinomas can be used for targeted chemotherapy with cytotoxic luteinizing hormone releasing hormone analogues.

Clin Cancer Res 2005 Aug;11(15):5549-57

Endocrine, Polypeptide and Cancer Institute, Veterans Affairs Medical Center, Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana 70112-1262, USA.

View Article and Find Full Text PDF
August 2005

cDNA arrays: gene expression profiles of Hodgkin's disease and anaplastic large cell lymphoma cell lines.

Pathol Int 2002 Sep;52(9):578-85

Department of Pathology, German Consultation and Reference Center for Lymphomas, Medical University of Luebeck, Luebeck, Germany.

View Article and Find Full Text PDF
September 2002

Gene profiling in anaplastic large-cell lymphoma-derived cell lines with cDNA expression arrays.

J Hematother Stem Cell Res 2002 Apr;11(2):423-8

Department of Pathology, Medical University of Luebeck, 23538 Luebeck, Germany.

View Article and Find Full Text PDF
April 2002