Timm Schroeder

Timm Schroeder

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Timm Schroeder

Publications by authors named "Timm Schroeder"

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Fate Distribution and Regulatory Role of Human Mesenchymal Stromal Cells in Engineered Hematopoietic Bone Organs.

iScience 2019 Sep 7;19:504-513. Epub 2019 Aug 7.

Department of Biosystems Science and Engineering (D-BSSE), ETH Zurich, Mattenstrasse 26, 4058 Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.isci.2019.08.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710718PMC
September 2019

Clustering of samples with a tree-shaped dependence structure, with an application to microscopic time lapse imaging.

Bioinformatics 2019 Jul;35(13):2291-2299

Department of medicine, Institute of Medical Statistics and Computational Biology, University Hospital Cologne, Cologne, Germany.

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http://dx.doi.org/10.1093/bioinformatics/bty939DOI Listing
July 2019

Erratum to "Engineered humanized bone organs maintain human hematopoiesis in vivo": [Experimental Hematology 61 (2018) 45-51].

Exp Hematol 2019 Apr 26;72:72. Epub 2019 Jan 26.

Hematology, University Hospital Zurich and University of Zurich, Zurich, Switzerland; International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan.

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http://dx.doi.org/10.1016/j.exphem.2019.01.007DOI Listing
April 2019

Understanding cell fate control by continuous single-cell quantification.

Blood 2019 Mar 6;133(13):1406-1414. Epub 2019 Feb 6.

Department of Biosystems Science and Engineering, Eidgenössische Technische Hochschule Zurich, Basel, Switzerland.

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http://dx.doi.org/10.1182/blood-2018-09-835397DOI Listing
March 2019

OVOL1 Influences the Determination and Expansion of iPSC Reprogramming Intermediates.

Stem Cell Reports 2019 Feb 10;12(2):319-332. Epub 2019 Jan 10.

Department of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan; Hakubi Center for Advanced Research, Kyoto University, Kyoto 606-8501, Japan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22136711183052
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http://dx.doi.org/10.1016/j.stemcr.2018.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372973PMC
February 2019

Automated Microfluidic System for Dynamic Stimulation and Tracking of Single Cells.

Anal Chem 2018 09 30;90(18):10695-10700. Epub 2018 Jul 30.

Department of Biosystems Science and Engineering , ETH Zurich, Mattenstrasse 26 4058 Basel , Switzerland.

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http://pubs.acs.org/doi/10.1021/acs.analchem.8b00312
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http://dx.doi.org/10.1021/acs.analchem.8b00312DOI Listing
September 2018

Inductive and Selective Effects of GSK3 and MEK Inhibition on Nanog Heterogeneity in Embryonic Stem Cells.

Stem Cell Reports 2018 07 17;11(1):58-69. Epub 2018 May 17.

Department of Biosystems Science and Engineering, ETH Zurich, 4058 Basel, Switzerland; Research Unit Stem Cell Dynamics, Helmholtz Zentrum München, 85764 Neuherberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2018.04.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6066909PMC
July 2018

Lineage marker synchrony in hematopoietic genealogies refutes the PU.1/GATA1 toggle switch paradigm.

Nat Commun 2018 07 12;9(1):2697. Epub 2018 Jul 12.

Institute of Computational Biology, Helmholtz Zentrum München, 85764, Neuherberg, Germany.

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http://dx.doi.org/10.1038/s41467-018-05037-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043612PMC
July 2018

In vitro biomimetic engineering of a human hematopoietic niche with functional properties.

Proc Natl Acad Sci U S A 2018 06 4;115(25):E5688-E5695. Epub 2018 Jun 4.

Tissue Engineering, Department of Biomedicine, University Hospital Basel, University of Basel, 4031 Basel, Switzerland;

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http://dx.doi.org/10.1073/pnas.1805440115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016789PMC
June 2018

Engineered humanized bone organs maintain human hematopoiesis in vivo.

Exp Hematol 2018 05 9;61:45-51.e5. Epub 2018 Feb 9.

Hematology, University Hospital Zurich and University of Zurich, Zurich, Switzerland; International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2018.01.004DOI Listing
May 2018

Mouse and human HSPC immobilization in liquid culture by CD43- or CD44-antibody coating.

Blood 2018 03 16;131(13):1425-1429. Epub 2018 Feb 16.

Department of Biosystems Science and Engineering, Eidgenössische Technische Hochschule Zurich, Basel, Switzerland; and.

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http://dx.doi.org/10.1182/blood-2017-07-794131DOI Listing
March 2018

Engineering Human Bone Marrow Proxies.

Cell Stem Cell 2018 03;22(3):298-301

Department of Biosystems Science and Engineering, ETH Zurich, CH-4058 Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2018.01.002DOI Listing
March 2018

On the statistical analysis of single cell lineage trees.

J Theor Biol 2018 02 5;439:160-165. Epub 2017 Dec 5.

Department of Biosystems Science & Engineering (D-BSSE) Mattenstrasse 26, Basel 4058, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.jtbi.2017.11.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5764708PMC
February 2018

Multicolor quantitative confocal imaging cytometry.

Nat Methods 2018 01 13;15(1):39-46. Epub 2017 Nov 13.

Department of Biosystems Science and Engineering, ETH Zürich, Basel, Switzerland.

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http://dx.doi.org/10.1038/nmeth.4503DOI Listing
January 2018

Specific Phospholipids Regulate the Acquisition of Neuronal and Astroglial Identities in Post-Mitotic Cells.

Sci Rep 2018 01 11;8(1):460. Epub 2018 Jan 11.

Instituto de Biología Molecular y Celular de Rosario (IBR, CONICET) Ocampo y Esmeralda, Predio CONICET and Departamento de Ciencias Biológicas, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, 2000, Rosario, Argentina.

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http://dx.doi.org/10.1038/s41598-017-18700-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765016PMC
January 2018

Three-dimensional map of nonhematopoietic bone and bone-marrow cells and molecules.

Nat Biotechnol 2017 Dec 13;35(12):1202-1210. Epub 2017 Nov 13.

Department of Biosystems Science and Engineering, ETH Zürich, Basel, Switzerland.

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http://dx.doi.org/10.1038/nbt.4006DOI Listing
December 2017

Illuminating stem cell transcription factor dynamics: long-term single-cell imaging of fluorescent protein fusions.

Curr Opin Cell Biol 2017 12 22;49:77-83. Epub 2017 Dec 22.

Department of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, 4058 Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.ceb.2017.12.006DOI Listing
December 2017

Live Imaging Followed by Single Cell Tracking to Monitor Cell Biology and the Lineage Progression of Multiple Neural Populations.

J Vis Exp 2017 12 16(130). Epub 2017 Dec 16.

Biochemistry and Molecular Biology Department, Faculty of Veterinary medicine, Complutense University; University Institute for Neurochemistry Research (IUIN); Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC);

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http://dx.doi.org/10.3791/56291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755616PMC
December 2017

fastER: a user-friendly tool for ultrafast and robust cell segmentation in large-scale microscopy.

Bioinformatics 2017 Jul;33(13):2020-2028

Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.

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http://dx.doi.org/10.1093/bioinformatics/btx107DOI Listing
July 2017

Lineage Reprogramming of Astroglial Cells from Different Origins into Distinct Neuronal Subtypes.

Stem Cell Reports 2017 07 8;9(1):162-176. Epub 2017 Jun 8.

Brain Institute, Federal University of Rio Grande do Norte, Natal 59056-450, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2017.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511102PMC
July 2017

A BaSiC tool for background and shading correction of optical microscopy images.

Nat Commun 2017 06 8;8:14836. Epub 2017 Jun 8.

Department of Computer Science, Chair of Computer Aided Medical Procedure, Technische Universität München, Boltzmannstr. 3, Garching 85748, Germany.

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http://dx.doi.org/10.1038/ncomms14836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472168PMC
June 2017

Vitamin A-Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy.

Cell 2017 May 4;169(5):807-823.e19. Epub 2017 May 4.

Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, 69120 Heidelberg, Germany; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), 69120 Heidelberg, Germany; German Cancer Consortium (DKTK), 69120 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.04.018DOI Listing
May 2017

Prospective identification of hematopoietic lineage choice by deep learning.

Nat Methods 2017 Apr 20;14(4):403-406. Epub 2017 Feb 20.

Institute of Computational Biology, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany.

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http://dx.doi.org/10.1038/nmeth.4182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376497PMC
April 2017

Hoxa9 and Meis1 Cooperatively Induce Addiction to Syk Signaling by Suppressing miR-146a in Acute Myeloid Leukemia.

Cancer Cell 2017 04;31(4):549-562.e11

Department of Medicine II, Hematology/Oncology, Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany; Department of Haematology, University of Cambridge, Hills Road, Cambridge CB2 0XY, UK; Cambridge Institute for Medical Research, Wellcome Trust/MRC Stem Cell Institute, Cambridge CB2 0XY, UK; German Cancer Research Center and German Cancer Consortium, 69120 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389883PMC
April 2017

CSF-1-induced Src signaling can instruct monocytic lineage choice.

Blood 2017 03 3;129(12):1691-1701. Epub 2017 Feb 3.

Research Unit Stem Cell Dynamics, Helmholtz Center Munich-German Research Center for Environmental Health, Neuherberg, Germany.

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http://dx.doi.org/10.1182/blood-2016-05-714329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364337PMC
March 2017

Nanog dynamics in single embryonic stem cells.

Cell Cycle 2016 ;15(6):770-1

a Department of Biosystems Science and Engineering, ETH Zurich , Basel , Switzerland.

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http://dx.doi.org/10.1080/15384101.2015.1137711DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845949PMC
December 2016

Challenges in long-term imaging and quantification of single-cell dynamics.

Nat Biotechnol 2016 Nov;34(11):1137-1144

Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.

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http://dx.doi.org/10.1038/nbt.3713DOI Listing
November 2016

Continuous single cell imaging reveals sequential steps of plasmacytoid dendritic cell development from common dendritic cell progenitors.

Sci Rep 2016 11 28;6:37462. Epub 2016 Nov 28.

Institute for Immunology, Biomedical Center, Ludwig-Maximilians-University Munich, Großhaderner Str. 9, 82152 Martinsried, Germany.

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http://dx.doi.org/10.1038/srep37462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5124969PMC
November 2016

Identification of factors promoting ex vivo maintenance of mouse hematopoietic stem cells by long-term single-cell quantification.

Blood 2016 09 30;128(9):1181-92. Epub 2016 Jun 30.

Research Unit Stem Cell Dynamics, Helmholtz Center Munich-German Research Center for Environmental Health (GmbH), Neuherberg, Germany; Department of Biosystems Science and Engineering, Eidgenössische Technische Hochschule Zurich, Basel, Switzerland;

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http://dx.doi.org/10.1182/blood-2016-03-705590DOI Listing
September 2016

Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal.

Nat Cell Biol 2016 06 25;18(6):607-18. Epub 2016 Apr 25.

The Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Department of Medicine, Division of Hematology/Oncology, University of California San Francisco, San Francisco, California 94143, USA.

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http://dx.doi.org/10.1038/ncb3346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884136PMC
June 2016

DNA-damage response gene GADD45A induces differentiation in hematopoietic stem cells without inhibiting cell cycle or survival.

Stem Cells 2016 Mar 26;34(3):699-710. Epub 2016 Jan 26.

LOEWE Center for Cell and Gene Therapy and Department of Medicine, Hematology/Oncology, Goethe University Frankfurt, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1002/stem.2282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832267PMC
March 2016

Identification and Successful Negotiation of a Metabolic Checkpoint in Direct Neuronal Reprogramming.

Cell Stem Cell 2016 Mar 31;18(3):396-409. Epub 2015 Dec 31.

Physiological Genomics, Biomedical Center Ludwig-Maximilians-University Munich, 80336 Munich, Germany; Institute for Stem Cell Research, Helmholtz Center Munich, 85764 Neuherberg, Germany; Excellence Cluster of Systems Neurology (SYNERGY), 80336 Munich, Germany. Electronic address:

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http://www.cell.com/cell-stem-cell/pdf/S1934-5909(15)00548-2
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http://linkinghub.elsevier.com/retrieve/pii/S193459091500548
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http://dx.doi.org/10.1016/j.stem.2015.12.003DOI Listing
March 2016

Seamless Combination of Fluorescence-Activated Cell Sorting and Hanging-Drop Networks for Individual Handling and Culturing of Stem Cells and Microtissue Spheroids.

Anal Chem 2016 Jan 6;88(2):1222-9. Epub 2016 Jan 6.

ETH Zurich , Department of Biosystems Science and Engineering, Bio Engineering Laboratory, Mattenstrasse 26, CH-4058 Basel, Switzerland.

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http://dx.doi.org/10.1021/acs.analchem.5b03513DOI Listing
January 2016

Ectopic expression of Msx2 in mammalian myotubes recapitulates aspects of amphibian muscle dedifferentiation.

Stem Cell Res 2015 Nov 30;15(3):542-553. Epub 2015 Sep 30.

Department of Biosystems Science and Engineering, ETH Zürich, Mattenstrasse 26, Basel 4058, Switzerland; Faculty of Science, University of Basel, Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2015.09.012DOI Listing
November 2015

STAT5-regulated microRNA-193b controls haematopoietic stem and progenitor cell expansion by modulating cytokine receptor signalling.

Nat Commun 2015 Nov 25;6:8928. Epub 2015 Nov 25.

LOEWE Center for Cell and Gene Therapy and Department of Medicine, Hematology/Oncology, Goethe University Frankfurt, Theodor-Stern-Kai 7, Frankfurt 60590, Germany.

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http://dx.doi.org/10.1038/ncomms9928DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674773PMC
November 2015

Inflammation-Induced Emergency Megakaryopoiesis Driven by Hematopoietic Stem Cell-like Megakaryocyte Progenitors.

Cell Stem Cell 2015 Oct 20;17(4):422-34. Epub 2015 Aug 20.

Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), 69120 Heidelberg, Germany; Division of Stem Cells and Cancer, Hematopoietic Stem Cells and Stress Group, Deutsches Krebsforschungszentrum (DKFZ), 69120 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2015.07.007DOI Listing
October 2015

Network plasticity of pluripotency transcription factors in embryonic stem cells.

Nat Cell Biol 2015 Oct 21;17(10):1235-46. Epub 2015 Sep 21.

Research Unit Stem Cell Dynamics, Helmholtz Zentrum München-German Research Center for Environmental Health, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany.

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http://dx.doi.org/10.1038/ncb3237DOI Listing
October 2015

Factor graph analysis of live cell-imaging data reveals mechanisms of cell fate decisions.

Bioinformatics 2015 Jun 31;31(11):1816-23. Epub 2015 Jan 31.

Gene Center, Department of Chemistry and Biochemistry, Ludwig-Maximilians-University München, Germany, Max-Planck-Institute for Plant Breeding Research, Cologne, Germany Department of Biology, Albertus-Magnus University, Cologne, Germany, Institute for Medical Informatics and Biometry, Faculty of Medicine Carl Gustav Carus, TU Dresden, Germany, Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany and Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland Gene Center, Department of Chemistry and Biochemistry, Ludwig-Maximilians-University München, Germany, Max-Planck-Institute for Plant Breeding Research, Cologne, Germany Department of Biology, Albertus-Magnus University, Cologne, Germany, Institute for Medical Informatics and Biometry, Faculty of Medicine Carl Gustav Carus, TU Dresden, Germany, Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany and Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland Gene Center, Department of Chemistry and Biochemistry, Ludwig-Maximilians-University München, Germany, Max-Planck-Institute for Plant Breeding Research, Cologne, Germany Department of Biology, Albertus-Magnus University, Cologne, Germany, Institute for Medical Informatics and Biometry, Faculty of Medicine Carl Gustav Carus, TU Dresden, Germany, Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany and Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.

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http://dx.doi.org/10.1093/bioinformatics/btv040DOI Listing
June 2015

Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells.

Nature 2015 Apr 18;520(7548):549-52. Epub 2015 Feb 18.

1] Heidelberg Institute for Stem Cell Technology and Experimental Medicine gGmbH (HI-STEM), 69120 Heidelberg, Germany [2] Deutsches Krebsforschungszentrum (DKFZ), Division of Stem Cells and Cancer, Experimental Hematology Group, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1038/nature14131DOI Listing
April 2015

Marker-free detection of progenitor cell differentiation by analysis of Brownian motion in micro-wells.

Integr Biol (Camb) 2015 Feb;7(2):178-83

Faculty of Physics and Center for NanoScience, Ludwig-Maximilians-University, Munich, Germany.

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http://dx.doi.org/10.1039/c4ib00158cDOI Listing
February 2015

Instruction of hematopoietic lineage choice by cytokine signaling.

Exp Cell Res 2014 Dec 18;329(2):207-13. Epub 2014 Jul 18.

Department of Biosystems Science and Engineering (D-BSSE), ETH Zurich, Mattenstrasse 26, 4058 Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.yexcr.2014.07.011DOI Listing
December 2014

Quantitative single-cell approaches to stem cell research.

Cell Stem Cell 2014 Nov 6;15(5):546-58. Epub 2014 Nov 6.

Department of Biosystems Science and Engineering, ETH Zurich, 4058 Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2014.10.015DOI Listing
November 2014

Single-cell technologies sharpen up mammalian stem cell research.

Nat Cell Biol 2014 Oct;16(10):919-27

Department of Biosystems Science and Engineering, ETH Zurich, 4058 Basel, Switzerland.

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http://dx.doi.org/10.1038/ncb3042DOI Listing
October 2014

Prdm6 is essential for cardiovascular development in vivo.

PLoS One 2013 21;8(11):e81833. Epub 2013 Nov 21.

Institut für Klinische Chemie und Pathobiochemie, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany ; German Cancer Consortium (DKTK), Heidelberg, Germany ; German Cancer Research Center (DKFZ), Heidelberg, Germany ; Laboratory of Signaling in the Immune System, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0081833PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836774PMC
August 2014

Circulation-independent differentiation pathway from extraembryonic mesoderm toward hematopoietic stem cells via hemogenic angioblasts.

Cell Rep 2014 Jul 26;8(1):31-9. Epub 2014 Jun 26.

Laboratory of Stem Cell Biology, Center for Developmental Biology, RIKEN Kobe, 2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe 650-0047, Japan.

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http://dx.doi.org/10.1016/j.celrep.2014.05.055DOI Listing
July 2014

Cytokine-regulated GADD45G induces differentiation and lineage selection in hematopoietic stem cells.

Stem Cell Reports 2014 Jul 19;3(1):34-43. Epub 2014 Jun 19.

LOEWE Center for Cell and Gene Therapy and Department for Hematology/Oncology, Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany ; Georg-Speyer-Haus, Paul-Ehrlich-Strasse 42-44, 60596 Frankfurt am Main, Germany ; German Cancer Consortium (DKTK), Heidelberg, Germany ; German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.stemcr.2014.05.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110750PMC
July 2014

Human Pancreatic Cancer-Associated Stellate Cells Remain Activated after in vivo Chemoradiation.

Front Oncol 2014 9;4:102. Epub 2014 May 9.

Lombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University , Washington, DC , USA ; Division of Hematology/Oncology, Department of Medicine, Georgetown University , Washington, DC , USA.

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http://dx.doi.org/10.3389/fonc.2014.00102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023027PMC
May 2014

HSC-explorer: a curated database for hematopoietic stem cells.

PLoS One 2013 30;8(7):e70348. Epub 2013 Jul 30.

Institute for Bioinformatics and Systems Biology (IBIS), Helmholtz Zentrum München - German Research Center for Environmental Health (GmbH), Neuherberg, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0070348PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728102PMC
April 2014

C/EBPα is required for long-term self-renewal and lineage priming of hematopoietic stem cells and for the maintenance of epigenetic configurations in multipotent progenitors.

PLoS Genet 2014 Jan 9;10(1):e1004079. Epub 2014 Jan 9.

The Finsen Laboratory, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark ; Biotech Research and Innovation Center (BRIC), University of Copenhagen, Copenhagen, Denmark ; Danish Stem Cell Centre (DanStem) Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark ; The Bioinformatic Centre, Department of Biology, Faculty of Natural Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1371/journal.pgen.1004079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3886906PMC
January 2014

Leveraging cross-species transcription factor binding site patterns: from diabetes risk loci to disease mechanisms.

Cell 2014 Jan;156(1-2):343-58

Chair of Nutritional Medicine, Technische Universität München, Else Kröner-Fresenius-Center for Nutritional Medicine, 85350 Freising-Weihenstephan, Germany; Nutritional Medicine Unit, ZIEL-Research Center for Nutrition and Food Sciences, Technische Universität München, 85350 Freising-Weihenstephan, Germany; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany; Clinical Cooperation Group Nutrigenomics and Type 2 Diabetes, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany and Technische Universität München, 85350 Freising-Weihenstephan, Germany; Institute of Experimental Genetics, Helmholtz Zentrum München, Neuherberg 85764, Germany. Electronic address:

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http://www.cell.com/cms/attachment/2021778258/2041667086/mmc
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http://linkinghub.elsevier.com/retrieve/pii/S009286741301535
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http://dx.doi.org/10.1016/j.cell.2013.10.058DOI Listing
January 2014

Incomplete cytokinesis and re-fusion of small mononucleated Hodgkin cells lead to giant multinucleated Reed-Sternberg cells.

Proc Natl Acad Sci U S A 2013 Dec 3;110(51):20729-34. Epub 2013 Dec 3.

Dr. Senckenberg Institute of Pathology and Department of Hematology/Oncology, LOEWE Center for Cell and Gene Therapy, Goethe-University, 60590 Frankfurt am Main, Germany.

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http://dx.doi.org/10.1073/pnas.1312509110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870723PMC
December 2013

Probing cellular processes by long-term live imaging--historic problems and current solutions.

J Cell Sci 2013 Sep 13;126(Pt 17):3805-15. Epub 2013 Aug 13.

ETH Zurich, Department of Biosystems Science and Engineering, 4058 Basel, Switzerland.

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September 2013

Oligodendrogliogenic and neurogenic adult subependymal zone neural stem cells constitute distinct lineages and exhibit differential responsiveness to Wnt signalling.

Nat Cell Biol 2013 Jun 5;15(6):602-13. Epub 2013 May 5.

Department of Physiological Genomics, Institute of Physiology, Ludwig-Maximilians University Munich, Munich, Germany.

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http://dx.doi.org/10.1038/ncb2736DOI Listing
June 2013

Heterogeneity of sister cell fates.

Authors:
Timm Schroeder

Nat Rev Mol Cell Biol 2013 Jun;14(6):327

Department of Biosystems Science and Engineering, Eidgenössische Technische Hochschule Zürich, 4058 Basel, Switzerland.

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http://dx.doi.org/10.1038/nrm3594DOI Listing
June 2013

Hematopoiesis.

Cold Spring Harb Perspect Biol 2012 Dec 1;4(12). Epub 2012 Dec 1.

Georg-Speyer-Haus, Institute for Biomedical Research, Frankfurt (Main), Germany.

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http://dx.doi.org/10.1101/cshperspect.a008250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504436PMC
December 2012

Multi-scale modeling of GMP differentiation based on single-cell genealogies.

FEBS J 2012 Sep 3;279(18):3488-500. Epub 2012 Jul 3.

Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg-Munich, Germany.

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http://dx.doi.org/10.1111/j.1742-4658.2012.08664.xDOI Listing
September 2012

Molecular live cell bioimaging in stem cell research.

Ann N Y Acad Sci 2012 Aug;1266:18-27

Research Unit Stem Cell Dynamics, Helmholtz Center Munich-German Research Center for Environmental Health, Neuherberg, Germany.

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http://dx.doi.org/10.1111/j.1749-6632.2012.06560.xDOI Listing
August 2012

Advances in tracking hematopoiesis at the single-cell level.

Curr Opin Hematol 2012 Jul;19(4):243-9

Research Unit Stem Cell Dynamics, Helmholtz Center Munich - German Research Center for Environmental Health, Neuherberg, Germany.

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http://dx.doi.org/10.1097/MOH.0b013e32835421deDOI Listing
July 2012

Stem cell powwow in Squaw Valley.

Development 2012 Jul;139(14):2457-61

MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, 5 Little France Drive, Edinburgh EH16 4UU, UK.

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http://dx.doi.org/10.1242/dev.079475DOI Listing
July 2012

Hierarchical differentiation of myeloid progenitors is encoded in the transcription factor network.

PLoS One 2011 10;6(8):e22649. Epub 2011 Aug 10.

Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München, München, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154193PMC
December 2011

The role of Pax6 in regulating the orientation and mode of cell division of progenitors in the mouse cerebral cortex.

Development 2011 Dec 26;138(23):5067-78. Epub 2011 Oct 26.

Institute for Stem Cell Research, Helmholtz Zentrum München German Research Center for Environmental Health, Ingolstädter Landstr. 1, 85764 Neuherberg/Munich, Germany.

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December 2011

Using an adherent cell culture of the mouse subependymal zone to study the behavior of adult neural stem cells on a single-cell level.

Nat Protoc 2011 Nov 3;6(12):1847-59. Epub 2011 Nov 3.

Department of Physiological Genomics, Institute of Physiology, Ludwig-Maximilians University Munich, Germany.

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http://dx.doi.org/10.1038/nprot.2011.404DOI Listing
November 2011

Functionally defined substates within the human embryonic stem cell compartment.

Stem Cell Res 2011 Sep 11;7(2):145-53. Epub 2011 May 11.

Centre for Stem Cell Biology, Department of Biomedical Science, University of Sheffield, UK.

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http://dx.doi.org/10.1016/j.scr.2011.04.006DOI Listing
September 2011

Multi-type branching models to describe cell differentiation programs.

J Theor Biol 2011 May 17;277(1):7-18. Epub 2011 Feb 17.

Graduate School of Biomedical Engineering, University of New South Wales, Sydney 2052, Australia.

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http://dx.doi.org/10.1016/j.jtbi.2011.02.006DOI Listing
May 2011

Long-term single-cell imaging of mammalian stem cells.

Authors:
Timm Schroeder

Nat Methods 2011 Apr 30;8(4 Suppl):S30-5. Epub 2011 Mar 30.

Institute of Stem Cell Research, Helmholtz Zentrum Munich-German Research Center for Environmental Health GmbH, Neuherberg, Germany.

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http://dx.doi.org/10.1038/nmeth.1577DOI Listing
April 2011

Continuous live imaging of adult neural stem cell division and lineage progression in vitro.

Development 2011 Mar;138(6):1057-68

Instituto do Cérebro, Universidade Federal do Rio Grande do Norte, 59072-970 Natal, Brazil.

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http://dx.doi.org/10.1242/dev.061663DOI Listing
March 2011

Generation of subtype-specific neurons from postnatal astroglia of the mouse cerebral cortex.

Nat Protoc 2011 Feb 3;6(2):214-28. Epub 2011 Feb 3.

Department of Physiological Genomics, Institute of Physiology, Ludwig-Maximilians University Munich, Munich, Germany.

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http://www.nature.com/articles/nprot.2010.188
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http://dx.doi.org/10.1038/nprot.2010.188DOI Listing
February 2011

The electronic crystal ball: predicting cell fate from time-lapse data.

Authors:
Timm Schroeder

Nat Methods 2010 Mar;7(3):190-1

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March 2010

Hematopoietic stem cell heterogeneity: subtypes, not unpredictable behavior.

Authors:
Timm Schroeder

Cell Stem Cell 2010 Mar;6(3):203-7

Helmholtz Center Munich, Institute of Stem Cell Research, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany.

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http://dx.doi.org/10.1016/j.stem.2010.02.006DOI Listing
March 2010

Instruction of lineage choice by hematopoietic cytokines.

Cell Cycle 2009 Dec 5;8(24):4019-20. Epub 2009 Dec 5.

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http://dx.doi.org/10.4161/cc.8.24.10261DOI Listing
December 2009

The transcription factors STAT5A/B regulate GM-CSF-mediated granulopoiesis.

Blood 2009 Nov 24;114(21):4721-8. Epub 2009 Sep 24.

Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH), Bethesda, MD, USA.

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http://dx.doi.org/10.1182/blood-2009-04-216390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2780307PMC
November 2009

Analyzing cell fate control by cytokines through continuous single cell biochemistry.

J Cell Biochem 2009 Oct;108(2):343-52

Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, 85764 Neuherberg, Germany.

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http://dx.doi.org/10.1002/jcb.22273DOI Listing
October 2009