Tim Wiltshire

Tim Wiltshire

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Tim Wiltshire

Tim Wiltshire

Publications by authors named "Tim Wiltshire"

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Cost-Effectiveness of Multigene Pharmacogenetic Testing in Patients With Acute Coronary Syndrome After Percutaneous Coronary Intervention.

Value Health 2020 Jan 25;23(1):61-73. Epub 2019 Sep 25.

Division of Pharmacotherapy and Experimental Therapeutics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Center for Pharmacogenomics and Individualized Therapy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1016/j.jval.2019.08.002DOI Listing
January 2020

Synergistic Chemotherapy Drug Response Is a Genetic Trait in Lymphoblastoid Cell Lines.

Front Genet 2019 15;10:829. Epub 2019 Oct 15.

Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, Durham, NC, United States.

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http://dx.doi.org/10.3389/fgene.2019.00829DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804467PMC
October 2019

Characterizing the pharmacogenome using molecular inversion probes for targeted next-generation sequencing.

Pharmacogenomics 2019 09;20(14):1005-1020

Division of Pharmacotherapy & Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.2217/pgs-2019-0057DOI Listing
September 2019

The influence of Neanderthal alleles on cytotoxic response.

PeerJ 2018 23;6:e5691. Epub 2018 Oct 23.

Bioinformatics Research Center, North Carolina State University, Raleigh, NC, United States of America.

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https://peerj.com/articles/5691
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http://dx.doi.org/10.7717/peerj.5691DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202974PMC
October 2018

Challenges and Solutions for Future Pharmacy Practice in the Era of Precision Medicine.

Am J Pharm Educ 2018 08;82(6):6652

Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

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http://dx.doi.org/10.5688/ajpe6652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116878PMC
August 2018

Projected impact of a multigene pharmacogenetic test to optimize medication prescribing in cardiovascular patients.

Pharmacogenomics 2018 06 25;19(9):771-782. Epub 2018 May 25.

Division of Pharmacotherapy & Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.2217/pgs-2018-0049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367721PMC
June 2018

Clinical pharmacogenetics: how do we ensure a favorable future for patients?

Pharmacogenomics 2018 04 5;19(6):553-562. Epub 2018 Apr 5.

Division of Pharmacotherapy & Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.2217/pgs-2017-0192DOI Listing
April 2018

Pharmacogenetic Analysis of the Model-Based Pharmacokinetics of Five Anti-HIV Drugs: How Does This Influence the Effect of Aging?

Clin Transl Sci 2018 03 3;11(2):226-236. Epub 2017 Dec 3.

University of North Carolina Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1111/cts.12525DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866997PMC
March 2018

Precision Dosing: Public Health Need, Proposed Framework, and Anticipated Impact.

Clin Transl Sci 2017 11 10;10(6):443-454. Epub 2017 Aug 10.

Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1111/cts.12490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698804PMC
November 2017

Car8 dorsal root ganglion expression and genetic regulation of analgesic responses are associated with a cis-eQTL in mice.

Mamm Genome 2017 Oct 25;28(9-10):407-415. Epub 2017 May 25.

Department of Pharmacology and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1007/s00335-017-9694-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5693610PMC
October 2017

Advancing precision medicine in healthcare: addressing implementation challenges to increase pharmacogenetic testing in the clinical setting.

Physiol Genomics 2017 Jul 26;49(7):346-354. Epub 2017 May 26.

Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, and Center for Pharmacogenomics and Individualized Therapy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina

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http://www.physiology.org/doi/10.1152/physiolgenomics.00029.
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http://dx.doi.org/10.1152/physiolgenomics.00029.2017DOI Listing
July 2017

Gulp1 is associated with the pharmacokinetics of PEGylated liposomal doxorubicin (PLD) in inbred mouse strains.

Nanomedicine 2016 10 9;12(7):2007-2017. Epub 2016 Jun 9.

Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Carolina Center of Cancer Nanotechnology Excellence, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Center for Pharmacogenomics and Individualized Therapy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address:

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http://dx.doi.org/10.1016/j.nano.2016.05.019DOI Listing
October 2016

Transitioning Pharmacogenomics into the Clinical Setting: Training Future Pharmacists.

Front Pharmacol 2016 8;7:241. Epub 2016 Aug 8.

Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina Chapel Hill, NC, USA.

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http://dx.doi.org/10.3389/fphar.2016.00241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4976536PMC
August 2016

Carbonic anhydrase-8 regulates inflammatory pain by inhibiting the ITPR1-cytosolic free calcium pathway.

PLoS One 2015 3;10(3):e0118273. Epub 2015 Mar 3.

Department of Anesthesiology, Perioperative Medicine and Pain Management, University of Miami Miller School of Medicine, Miami, Florida, United States of America; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, United States of America; John T Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, Florida, United States of America; Bruce W. Carter Miami Veterans Healthcare System, Miami, Florida, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0118273PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4347988PMC
January 2016

Mst1 directs Myosin IIa partitioning of low and higher affinity integrins during T cell migration.

PLoS One 2014 18;9(8):e105561. Epub 2014 Aug 18.

Department of Pathology and Immunology, Washington University, St. Louis, Missouri, United States of America; Departments of Pathology and Microbiology & Immunology, The Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0105561PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136924PMC
December 2015

Molecular genetic mechanisms of allelic specific regulation of murine Comt expression.

Pain 2015 Oct;156(10):1965-77

aCenter for Pain Research and Innovation, University of North Carolina, Chapel Hill, NC, USA bNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA cThe Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC, Canada dDepartment of Oral Biology, School of Dentistry, University of North Carolina, Chapel Hill, NC, USA eDepartment of Psychiatry, University of North Carolina, Chapel Hill, NC, USA fPharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA gDepartment of Psychology, McGill University, Montreal, QC, Canada hDepartment of Psychology, University of Toronto Mississauga, Mississauga, ON, Canada.

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http://dx.doi.org/10.1097/j.pain.0000000000000258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4579042PMC
October 2015

Immune cell-based screening assay for response to anticancer agents: applications in pharmacogenomics.

Pharmgenomics Pers Med 2015 26;8:81-98. Epub 2015 Feb 26.

Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA ; Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina, Chapel Hill, NC, USA.

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http://dx.doi.org/10.2147/PGPM.S73312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397719PMC
April 2015

Identifying genes that mediate anthracyline toxicity in immune cells.

Front Pharmacol 2015 15;6:62. Epub 2015 Apr 15.

Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina Chapel Hill, NC, USA ; Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina Chapel Hill, NC, USA.

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http://journal.frontiersin.org/article/10.3389/fphar.2015.00
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http://dx.doi.org/10.3389/fphar.2015.00062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4398020PMC
April 2015

A cellular genetics approach identifies gene-drug interactions and pinpoints drug toxicity pathway nodes.

Front Genet 2014 29;5:272. Epub 2014 Aug 29.

Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy at the University of North Carolina at Chapel Hill Chapel Hill, NC, USA.

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http://dx.doi.org/10.3389/fgene.2014.00272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148776PMC
September 2014

Genome-wide association mapping of acute lung injury in neonatal inbred mice.

FASEB J 2014 Jun 26;28(6):2538-50. Epub 2014 Feb 26.

Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, U.S. National Institutes of Health, Research Triangle Park, North Carolina, USA;

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http://dx.doi.org/10.1096/fj.13-247221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4021442PMC
June 2014

In vitro and in vivo mouse models for pharmacogenetic studies.

Methods Mol Biol 2013 ;1015:263-78

Division of Pharmacotherapy and Experimental Therapeutics, Institute for Pharmacogenomics and Individualized Therapy, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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http://link.springer.com/10.1007/978-1-62703-435-7_17
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http://dx.doi.org/10.1007/978-1-62703-435-7_17DOI Listing
February 2014

Characterization of Highper, an ENU-induced mouse mutant with abnormal psychostimulant and stress responses.

Psychopharmacology (Berl) 2013 Jan 5;225(2):407-19. Epub 2012 Sep 5.

Department of Psychiatry, University of North Carolina, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1007/s00213-012-2827-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536991PMC
January 2013

Genetic dissection of the Canq1 locus governing variation in extent of the collateral circulation.

PLoS One 2012 6;7(3):e31910. Epub 2012 Mar 6.

Department of Physiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0031910PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3295810PMC
August 2012

Evaluating genetic markers and neurobiochemical analytes for fluoxetine response using a panel of mouse inbred strains.

Psychopharmacology (Berl) 2012 May 24;221(2):297-315. Epub 2011 Nov 24.

Division of Pharmacotherapy and Experimental Therapeutics, University of North Carolina at Chapel Hill, Genetic Medicine Building, 120 Mason Farm Road, Chapel Hill, NC 27599, USA.

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http://link.springer.com/10.1007/s00213-011-2574-z
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http://dx.doi.org/10.1007/s00213-011-2574-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3337404PMC
May 2012

Relax, you won't feel the pain.

Nat Neurosci 2011 Nov 23;14(12):1496-7. Epub 2011 Nov 23.

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http://dx.doi.org/10.1038/nn.2987DOI Listing
November 2011

Genetic dissection of a key reproductive barrier between nascent species of house mice.

Genetics 2011 Sep 12;189(1):289-304. Epub 2011 Jul 12.

Laboratory of Genetics, University of Wisconsin, Madison, Wisconsin 53706-1580, USA.

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http://www.genetics.org/lookup/doi/10.1534/genetics.111.1291
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http://dx.doi.org/10.1534/genetics.111.129171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176122PMC
September 2011

Extensive recombination rate variation in the house mouse species complex inferred from genetic linkage maps.

Genome Res 2011 Jan 26;21(1):114-25. Epub 2010 Oct 26.

Laboratory of Genetics, University of Wisconsin, Madison, Wisconsin 53706, USA.

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http://genome.cshlp.org/cgi/doi/10.1101/gr.111252.110
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http://dx.doi.org/10.1101/gr.111252.110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012918PMC
January 2011

Genetic architecture of voluntary exercise in an advanced intercross line of mice.

Physiol Genomics 2010 Jul 13;42(2):190-200. Epub 2010 Apr 13.

Department of Genetics, University of North Carolina at Chapel Hill, 120 Mason Farm Rd., Chapel Hill, NC 27599-7264, USA.

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http://dx.doi.org/10.1152/physiolgenomics.00028.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3032284PMC
July 2010

Quantitative trait locus and haplotype mapping in closely related inbred strains identifies a locus for open field behavior.

Mamm Genome 2010 Jun 15;21(5-6):231-46. Epub 2010 May 15.

Department of Psychiatry, University of North Carolina, 120 Mason Farm Road, Chapel Hill, NC 27599, USA.

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http://link.springer.com/10.1007/s00335-010-9260-z
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http://dx.doi.org/10.1007/s00335-010-9260-zDOI Listing
June 2010

Genetical genomics: spotlight on QTL hotspots.

PLoS Genet 2008 Oct 24;4(10):e1000232. Epub 2008 Oct 24.

Groningen Bioinformatics Centre, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Kerklaan 30, Haren, The Netherlands.

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http://dx.doi.org/10.1371/journal.pgen.1000232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2563687PMC
October 2008

Expression analysis of G Protein-Coupled Receptors in mouse macrophages.

Immunome Res 2008 Apr 29;4. Epub 2008 Apr 29.

Cooperative Research Centre for Chronic Inflammatory Diseases and Special Research Centre for Functional and Applied Genomics, Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, 4072, Australia.

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http://www.immunome-research.com/content/4/1/5
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http://dx.doi.org/10.1186/1745-7580-4-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2394514PMC
April 2008

The Modifier of hemostasis (Mh) locus on chromosome 4 controls in vivo hemostasis of Gp6-/- mice.

Blood 2008 Feb 8;111(3):1266-73. Epub 2007 Nov 8.

Roon Research Center for Arteriosclerosis and Thrombosis, Division of Experimental Hemostasis and Thrombosis, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1182/blood-2007-09-111369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2214743PMC
February 2008

Databases of free expression.

Mamm Genome 2006 Dec 1;17(12):1141-6. Epub 2006 Dec 1.

Genomics Institute of Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, USA.

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http://dx.doi.org/10.1007/s00335-006-0043-5DOI Listing
December 2006

A mutant mouse with a highly specific contextual fear-conditioning deficit found in an N-ethyl-N-nitrosourea (ENU) mutagenesis screen.

Learn Mem 2006 Mar-Apr;13(2):143-9

Institute for Childhood and Neglected Diseases, Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1101/lm.98606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1409825PMC
June 2006

Comparative analysis of haplotype association mapping algorithms.

BMC Bioinformatics 2006 Feb 9;7:61. Epub 2006 Feb 9.

Genomics Institute of the Novartis Research Foundation, San Diego, USA.

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http://dx.doi.org/10.1186/1471-2105-7-61DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1409800PMC
February 2006

Marked interindividual variability in the response to selective inhibitors of cyclooxygenase-2.

Gastroenterology 2006 Jan;130(1):55-64

The Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6084, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S001650850502011
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http://dx.doi.org/10.1053/j.gastro.2005.10.002DOI Listing
January 2006

Can we find the genes involved in complex traits?

Genome Biol 2004 22;5(10):347. Epub 2004 Sep 22.

Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, USA.

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http://dx.doi.org/10.1186/gb-2004-5-10-347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC545590PMC
July 2005

Genome-wide linkage identifies novel modifier loci of aganglionosis in the Sox10Dom model of Hirschsprung disease.

Hum Mol Genet 2005 Jun 20;14(11):1549-58. Epub 2005 Apr 20.

Division of Genetic Medicine, Department of Medicine, Vanderbilt University School of Medicine, 529 Light Hall, 2215 Garland Avenue, Nashville, TN 37232-0275, USA.

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http://academic.oup.com/hmg/article/14/11/1549/605506/Genome
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http://dx.doi.org/10.1093/hmg/ddi163DOI Listing
June 2005

Uncovering regulatory pathways that affect hematopoietic stem cell function using 'genetical genomics'.

Nat Genet 2005 Mar 13;37(3):225-32. Epub 2005 Feb 13.

Department of Stem Cell Biology, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, the Netherlands.

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http://dx.doi.org/10.1038/ng1497DOI Listing
March 2005

c-Myb and p300 regulate hematopoietic stem cell proliferation and differentiation.

Dev Cell 2005 Feb;8(2):153-66

Genomics Institute of the Novartis Research Foundation, San Diego, California 92121, USA.

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http://dx.doi.org/10.1016/j.devcel.2004.12.015DOI Listing
February 2005

The Collaborative Cross, a community resource for the genetic analysis of complex traits.

Authors:
Gary A Churchill David C Airey Hooman Allayee Joe M Angel Alan D Attie Jackson Beatty William D Beavis John K Belknap Beth Bennett Wade Berrettini Andre Bleich Molly Bogue Karl W Broman Kari J Buck Ed Buckler Margit Burmeister Elissa J Chesler James M Cheverud Steven Clapcote Melloni N Cook Roger D Cox John C Crabbe Wim E Crusio Ariel Darvasi Christian F Deschepper R W Doerge Charles R Farber Jiri Forejt Daniel Gaile Steven J Garlow Hartmut Geiger Howard Gershenfeld Terry Gordon Jing Gu Weikuan Gu Gerald de Haan Nancy L Hayes Craig Heller Heinz Himmelbauer Robert Hitzemann Kent Hunter Hui-Chen Hsu Fuad A Iraqi Boris Ivandic Howard J Jacob Ritsert C Jansen Karl J Jepsen Dabney K Johnson Thomas E Johnson Gerd Kempermann Christina Kendziorski Malak Kotb R Frank Kooy Bastien Llamas Frank Lammert Jean-Michel Lassalle Pedro R Lowenstein Lu Lu Aldons Lusis Kenneth F Manly Ralph Marcucio Doug Matthews Juan F Medrano Darla R Miller Guy Mittleman Beverly A Mock Jeffrey S Mogil Xavier Montagutelli Grant Morahan David G Morris Richard Mott Joseph H Nadeau Hiroki Nagase Richard S Nowakowski Bruce F O'Hara Alexander V Osadchuk Grier P Page Beverly Paigen Kenneth Paigen Abraham A Palmer Huei-Ju Pan Leena Peltonen-Palotie Jeremy Peirce Daniel Pomp Michal Pravenec Daniel R Prows Zhonghua Qi Roger H Reeves John Roder Glenn D Rosen Eric E Schadt Leonard C Schalkwyk Ze'ev Seltzer Kazuhiro Shimomura Siming Shou Mikko J Sillanpää Linda D Siracusa Hans-Willem Snoeck Jimmy L Spearow Karen Svenson Lisa M Tarantino David Threadgill Linda A Toth William Valdar Fernando Pardo-Manuel de Villena Craig Warden Steve Whatley Robert W Williams Tim Wiltshire Nengjun Yi Dabao Zhang Min Zhang Fei Zou

Nat Genet 2004 Nov;36(11):1133-7

The Jackson Laboratory, 600 Main Street Bar Harbor, Maine 04609, USA.

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http://dx.doi.org/10.1038/ng1104-1133DOI Listing
November 2004

Inositol (1,4,5) trisphosphate 3 kinase B controls positive selection of T cells and modulates Erk activity.

Proc Natl Acad Sci U S A 2004 Apr 2;101(15):5604-9. Epub 2004 Apr 2.

Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, USA.

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http://dx.doi.org/10.1073/pnas.0306907101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC397439PMC
April 2004

Melanopsin is required for non-image-forming photic responses in blind mice.

Science 2003 Jul 26;301(5632):525-7. Epub 2003 Jun 26.

Genomics Institute of the Novartis Research Foundation, 10675 John J. Hopkins Drive, San Diego, CA 92121, USA.

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http://dx.doi.org/10.1126/science.1086179DOI Listing
July 2003