Tim U Krohne

Tim U Krohne

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Tim U Krohne

Tim U Krohne

Publications by authors named "Tim U Krohne"

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Optical coherence tomography angiography (OCT-A) in an animal model of laser-induced choroidal neovascularization.

Exp Eye Res 2019 Jul 16;184:162-171. Epub 2019 Apr 16.

Department of Ophthalmology, University of Bonn, Bonn, Germany.

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http://dx.doi.org/10.1016/j.exer.2019.04.002DOI Listing
July 2019

The long dystrophin gene product Dp427 modulates retinal function and vascular morphology in response to age and retinal ischemia.

Neurochem Int 2019 Jun 11;129:104489. Epub 2019 Jun 11.

Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuint.2019.104489DOI Listing
June 2019

Correction to: Visual impairment and blindness in institutionalized elderly in Germany.

Graefes Arch Clin Exp Ophthalmol 2019 05;257(5):1057

Department of Ophthalmology, University of Bonn, Ernst-Abbe-Str. 2, D-53127, Bonn, Germany.

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http://dx.doi.org/10.1007/s00417-019-04277-3DOI Listing
May 2019

Efficacy of novel selective NLRP3 inhibitors in human and murine retinal pigment epithelial cells.

J Mol Med (Berl) 2019 Apr 10;97(4):523-532. Epub 2019 Feb 10.

Department of Ophthalmology, University of Bonn, Ernst-Abbe-Str. 2, Bonn, 53127, Germany.

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http://dx.doi.org/10.1007/s00109-019-01753-5DOI Listing
April 2019

Retinal Hemorrhages in Shaken Baby Syndrome.

J Pediatr 2019 Apr;207:256

Department of Ophthalmology, University of Bonn, Bonn, Germany.

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http://dx.doi.org/10.1016/j.jpeds.2018.12.054DOI Listing
April 2019

Visual impairment and blindness in institutionalized elderly in Germany.

Graefes Arch Clin Exp Ophthalmol 2019 Feb 27;257(2):363-370. Epub 2018 Nov 27.

Department of Ophthalmology, University of Bonn, Ernst-Abbe-Str. 2, D-53127, Bonn, Germany.

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http://dx.doi.org/10.1007/s00417-018-4196-1DOI Listing
February 2019

Modulation of three key innate immune pathways for the most common retinal degenerative diseases.

EMBO Mol Med 2018 10;10(10)

Laboratory for Experimental Immunology of the Eye, Department of Ophthalmology, University of Cologne, Cologne, Germany

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http://dx.doi.org/10.15252/emmm.201708259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180304PMC
October 2018

LONGITUDINAL CHANGE OF OUTER NUCLEAR LAYER AFTER RETINAL PIGMENT EPITHELIAL TEAR SECONDARY TO AGE-RELATED MACULAR DEGENERATION.

Retina 2018 07;38(7):1331-1337

Department of Ophthalmology, University of Bonn, Bonn, Germany.

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http://dx.doi.org/10.1097/IAE.0000000000001688DOI Listing
July 2018

Retinal Injury Following Laser Pointer Exposure.

Dtsch Arztebl Int 2017 12;114(49):831-837

Department of Ophthalmology, University of Bonn, Bonn, Germany; Oxford Eye Hospital and Nuffield Laboratory of Ophthalmology, Department of Clinical Neurosciences, University of Oxford.

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http://dx.doi.org/10.3238/arztebl.2017.0831DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5754573PMC
December 2017

The German ROP Registry: data from 90 infants treated for retinopathy of prematurity.

Acta Ophthalmol 2016 Dec 20;94(8):e744-e752. Epub 2016 May 20.

Eye Center, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1111/aos.13069DOI Listing
December 2016

Inflammasome priming increases retinal pigment epithelial cell susceptibility to lipofuscin phototoxicity by changing the cell death mechanism from apoptosis to pyroptosis.

J Photochem Photobiol B 2016 Aug 21;161:177-83. Epub 2016 May 21.

Department of Ophthalmology, University of Bonn, Bonn, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jphotobiol.2016.05.018DOI Listing
August 2016

Complement Component C5a Primes Retinal Pigment Epithelial Cells for Inflammasome Activation by Lipofuscin-mediated Photooxidative Damage.

J Biol Chem 2015 Dec 12;290(52):31189-98. Epub 2015 Nov 12.

From the Department of Ophthalmology, University of Bonn, 53127 Bonn, Germany

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http://dx.doi.org/10.1074/jbc.M115.671180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4692241PMC
December 2015

Light induces NLRP3 inflammasome activation in retinal pigment epithelial cells via lipofuscin-mediated photooxidative damage.

J Mol Med (Berl) 2015 Aug 18;93(8):905-16. Epub 2015 Mar 18.

Department of Ophthalmology, University of Bonn, Ernst-Abbe-Str. 2, 53127, Bonn, Germany.

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http://dx.doi.org/10.1007/s00109-015-1275-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510924PMC
August 2015

Influence of ocular volume and lens status on pharmacokinetics and duration of action of intravitreal vascular endothelial growth factor inhibitors.

Retina 2015 Jan;35(1):69-74

*Department of Ophthalmology, University of Bonn, Bonn, Germany; †Department of Ophthalmology, University of Cologne, Cologne, Germany; and ‡Department of Ophthalmology, Pallas Clinics, Aarau, Switzerland.

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http://pdfs.journals.lww.com/retinajournal/2015/01000/INFLUE
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/IAE.0000000000000265DOI Listing
January 2015

In-depth mass spectrometric mapping of the human vitreous proteome.

Proteome Sci 2013 May 20;11(1):22. Epub 2013 May 20.

Institute of Pathology, University of Heidelberg, Im Neuenheimer Feld 220, Heidelberg, D-69120, Germany.

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http://dx.doi.org/10.1186/1477-5956-11-22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689628PMC
May 2013

Intraocular pharmacokinetics of ranibizumab following a single intravitreal injection in humans.

Am J Ophthalmol 2012 Oct 19;154(4):682-686.e2. Epub 2012 Jul 19.

University of Bonn, Department of Ophthalmology, Germany.

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http://dx.doi.org/10.1016/j.ajo.2012.03.047DOI Listing
October 2012

Using flow cytometry to compare the dynamics of photoreceptor outer segment phagocytosis in iPS-derived RPE cells.

Invest Ophthalmol Vis Sci 2012 Sep 14;53(10):6282-90. Epub 2012 Sep 14.

Department of Cell Biology, The Scripps Research Institute, La Jolla, California, USA.

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http://dx.doi.org/10.1167/iovs.12-9721DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3444211PMC
September 2012

Concentrations of unbound bevacizumab in the aqueous of untreated fellow eyes after a single intravitreal injection in humans.

Acta Ophthalmol 2012 Feb 16;90(1):68-70. Epub 2010 Feb 16.

Department of Ophthalmology, University of Bonn, Bonn, Germany.

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http://dx.doi.org/10.1111/j.1755-3768.2009.01842.xDOI Listing
February 2012

Lipid metabolites in the pathogenesis and treatment of neovascular eye disease.

Br J Ophthalmol 2011 Nov 18;95(11):1496-501. Epub 2011 Mar 18.

Department of Ophthalmology, Harvard Medical School, Children's Hospital, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1136/bjo.2010.194241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3711020PMC
November 2011

Intraocular pharmacokinetics after a single intravitreal injection of 1.5 mg versus 3.0 mg of bevacizumab in humans.

Retina 2011 Oct;31(9):1877-84

Department of Ophthalmology, University of Bonn, Germany.

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http://dx.doi.org/10.1097/IAE.0b013e318217373cDOI Listing
October 2011

No evidence to support the use of plasmapheresis for age-related macular degeneration.

Ther Apher Dial 2010 Dec 29;14(6):607-8; author reply 608-9. Epub 2010 Oct 29.

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http://dx.doi.org/10.1111/j.1744-9987.2010.00879.xDOI Listing
December 2010

Stemming vision loss with stem cells.

J Clin Invest 2010 Sep 1;120(9):3012-21. Epub 2010 Sep 1.

Department of Cell Biology, The Scripps Research Institute, La Jolla, California, USA.

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http://dx.doi.org/10.1172/JCI42951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2929728PMC
September 2010

Effects of lipid peroxidation products on lipofuscinogenesis and autophagy in human retinal pigment epithelial cells.

Exp Eye Res 2010 Mar 6;90(3):465-71. Epub 2010 Jan 6.

Department of Ophthalmology, University of Bonn, Bonn, Germany.

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http://dx.doi.org/10.1016/j.exer.2009.12.011DOI Listing
March 2010

Lipid peroxidation products reduce lysosomal protease activities in human retinal pigment epithelial cells via two different mechanisms of action.

Exp Eye Res 2010 Feb 4;90(2):261-6. Epub 2009 Nov 4.

Department of Ophthalmology, University of Bonn, Bonn, Germany.

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http://dx.doi.org/10.1016/j.exer.2009.10.014DOI Listing
February 2010

Apical-to-basolateral transcytosis of photoreceptor outer segments induced by lipid peroxidation products in human retinal pigment epithelial cells.

Invest Ophthalmol Vis Sci 2010 Jan 20;51(1):553-60. Epub 2009 Aug 20.

Department of Ophthalmology, University of Bonn, Bonn, Germany.

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http://dx.doi.org/10.1167/iovs.09-3755DOI Listing
January 2010

ICAM-1 depletion does not alter retinal vascular development in a model of oxygen-mediated neovascularization.

Exp Eye Res 2009 Oct 29;89(4):503-10. Epub 2009 May 29.

Department of Ophthalmology, Heinrich-Heine University, Moorenstrasse 5, 40225 Duesseldorf, Germany.

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http://dx.doi.org/10.1016/j.exer.2009.05.005DOI Listing
October 2009

Intraocular pharmacokinetics of bevacizumab after a single intravitreal injection in humans.

Am J Ophthalmol 2008 Oct 17;146(4):508-12. Epub 2008 Jul 17.

Department of Ophthalmology, University of Bonn, Bonn, Germany.

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http://dx.doi.org/10.1016/j.ajo.2008.05.036DOI Listing
October 2008

Effects of lipid peroxidation-related protein modifications on RPE lysosomal functions and POS phagocytosis.

Invest Ophthalmol Vis Sci 2007 Mar;48(3):1342-7

Department of Pathology, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1167/iovs.06-0549DOI Listing
March 2007

Geldanamycin treatment reduces neovascularization in a mouse model of retinopathy of prematurity.

Graefes Arch Clin Exp Ophthalmol 2007 Feb;245(2):258-66

Department of Vitreoretinal Surgery, Center for Ophthalmology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany.

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http://link.springer.com/10.1007/s00417-006-0355-x
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http://dx.doi.org/10.1007/s00417-006-0355-xDOI Listing
February 2007

Pathological but not physiological retinal neovascularization is altered in TNF-Rp55-receptor-deficient mice.

Invest Ophthalmol Vis Sci 2006 Nov;47(11):5057-65

Department of Vitreoretinal Surgery, Center for Ophthalmology, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1167/iovs.06-0407DOI Listing
November 2006

New pharmacologic approaches to therapy for age-related macular degeneration.

BioDrugs 2006 ;20(3):167-79

Department of Ophthalmology, University of Bonn Medical Center, Bonn, Germany.

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http://dx.doi.org/10.2165/00063030-200620030-00004DOI Listing
October 2006

Pharmacokinetics and safety of intravitreally delivered etanercept.

Graefes Arch Clin Exp Ophthalmol 2004 Jul 17;242(7):582-6. Epub 2004 Mar 17.

Abteilung für Netzhaut- und Glaskörperchirurgie des Zentrums für Augenheilkunde und Zentrum für Molekulare Medizin (ZMMK), Universität zu Köln, Joseph-Stelzmann-Strasse 9, 50931 Cologne, Germany.

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http://dx.doi.org/10.1007/s00417-004-0895-xDOI Listing
July 2004

[Pathogenesis of diabetic macular oedema].

Klin Monbl Augenheilkd 2003 Aug;220(8):521-5

Abteilung für Netzhaut- und Glaskörperchirurgie des Zentrums für Augenheilkunde und Zentrum für Molekulare Medizin, Universität zu Köln, Germany.

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http://dx.doi.org/10.1055/s-2003-41872DOI Listing
August 2003

[Diabetic maculopathy - classification and therapy].

Klin Monbl Augenheilkd 2003 Aug;220(8):526-31

Abteilung für Netzhaut- und Glaskörperchirurgie des Zentrums für Augenheilkunde und Zentrum für Molekulare Medizin, Universität zu Köln.

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http://dx.doi.org/10.1055/s-2003-41871DOI Listing
August 2003