Tim Stearns

Tim Stearns

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Tim Stearns

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Primary cilium loss in mammalian cells occurs predominantly by whole-cilium shedding.

PLoS Biol 2019 Jul 17;17(7):e3000381. Epub 2019 Jul 17.

Department of Biology, Stanford University, Stanford, California, United States of America.

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http://dx.doi.org/10.1371/journal.pbio.3000381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699714PMC
July 2019

Regulation of cilia abundance in multiciliated cells.

Elife 2019 Apr 26;8. Epub 2019 Apr 26.

Nephrology Division, Department of Medicine, Washington University, St Louis, United States.

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http://dx.doi.org/10.7554/eLife.44039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504233PMC
April 2019

Motional dynamics of single Patched1 molecules in cilia are controlled by Hedgehog and cholesterol.

Proc Natl Acad Sci U S A 2019 03 28;116(12):5550-5557. Epub 2019 Feb 28.

Department of Chemistry, Stanford University, Stanford, CA 94305;

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http://dx.doi.org/10.1073/pnas.1816747116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431229PMC
March 2019

Revealing Nanoscale Morphology of the Primary Cilium Using Super-Resolution Fluorescence Microscopy.

Biophys J 2019 01 7;116(2):319-329. Epub 2018 Dec 7.

Department of Applied Physics, Stanford University, Stanford, California; Department of Chemistry, Stanford University, Stanford, California. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00063495183445
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http://dx.doi.org/10.1016/j.bpj.2018.11.3136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349968PMC
January 2019

Cyclin-dependent kinase control of motile ciliogenesis.

Elife 2018 08 28;7. Epub 2018 Aug 28.

Department of Pathology, Stanford University School of Medicine, Stanford, United States.

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https://elifesciences.org/articles/36375
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http://dx.doi.org/10.7554/eLife.36375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145839PMC
August 2018

Cilium structure, assembly, and disassembly regulated by the cytoskeleton.

Biochem J 2018 07 31;475(14):2329-2353. Epub 2018 Jul 31.

Department of Molecular and Cellular Physiology, Stanford University, Stanford, CA 94305, U.S.A.

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http://dx.doi.org/10.1042/BCJ20170453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068341PMC
July 2018

The ABCs of Centriole Architecture: The Form and Function of Triplet Microtubules.

Cold Spring Harb Symp Quant Biol 2017 14;82:145-155. Epub 2018 Mar 14.

Department of Biology, Stanford University, Stanford, California 94305-5020.

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http://dx.doi.org/10.1101/sqb.2017.82.034496DOI Listing
March 2018

Mitosis sans Mitosis: The Mitotic Oscillator in Differentiation.

Dev Cell 2017 11;43(4):385-386

Department of Biology, Stanford University, Stanford, CA 94305, USA; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2017.11.001DOI Listing
November 2017

Probing mammalian centrosome structure using BioID proximity-dependent biotinylation.

Methods Cell Biol 2015 27;129:153-170. Epub 2015 May 27.

Department of Biology and Department of Genetics, Stanford University, Stanford, CA, USA.

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http://dx.doi.org/10.1016/bs.mcb.2015.03.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720124PMC
April 2016

Observing planar cell polarity in multiciliated mouse airway epithelial cells.

Methods Cell Biol 2015 7;127:37-54. Epub 2015 Mar 7.

Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.

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http://dx.doi.org/10.1016/bs.mcb.2015.01.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423753PMC
January 2016

Sperm Centrosomes: Kiss Your Asterless Goodbye, for Fertility's Sake.

Curr Biol 2015 Dec;25(24):R1178-81

Departments of Biology & Genetics, Stanford University, Stanford, CA 94305, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2015.11.015DOI Listing
December 2015

MDM1 is a microtubule-binding protein that negatively regulates centriole duplication.

Mol Biol Cell 2015 Nov 2;26(21):3788-802. Epub 2015 Sep 2.

Department of Biology, Stanford University, Stanford, CA 94305 Department of Genetics, Stanford University School of Medicine, Stanford University, Stanford, CA 94305

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http://www.molbiolcell.org/content/early/2015/08/30/mbc.E15-
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http://www.molbiolcell.org/content/26/21/3788.full.pdf
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http://www.molbiolcell.org/cgi/doi/10.1091/mbc.E15-04-0235
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http://dx.doi.org/10.1091/mbc.E15-04-0235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626064PMC
November 2015

Zeta-Tubulin Is a Member of a Conserved Tubulin Module and Is a Component of the Centriolar Basal Foot in Multiciliated Cells.

Curr Biol 2015 Aug 30;25(16):2177-83. Epub 2015 Jul 30.

Department of Biology, Stanford University, Stanford, CA 94305, USA; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address:

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http://www.cell.com/current-biology/pdf/S0960-9822(15)00790-
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http://web.stanford.edu/group/stearnslab/papers/Turk_CB_supp
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http://linkinghub.elsevier.com/retrieve/pii/S096098221500790
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http://dx.doi.org/10.1016/j.cub.2015.06.063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546511PMC
August 2015

Cell biology. Centrioles, in absentia.

Authors:
Tim Stearns

Science 2015 Jun;348(6239):1091-2

Department of Biology, Stanford University, Stanford, CA, USA.

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http://www.sciencemag.org/cgi/doi/10.1126/science.aac4860
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http://dx.doi.org/10.1126/science.aac4860DOI Listing
June 2015

Centrosome-kinase fusions promote oncogenic signaling and disrupt centrosome function in myeloproliferative neoplasms.

PLoS One 2014 21;9(3):e92641. Epub 2014 Mar 21.

Department of Biology, Stanford University, Stanford, California, United States of America; Department of Genetics, Stanford School of Medicine, Stanford, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0092641PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962438PMC
November 2014

Proteomic analysis of mammalian sperm cells identifies new components of the centrosome.

J Cell Sci 2014 Oct 29;127(Pt 19):4128-33. Epub 2014 Jul 29.

Department of Biology, Stanford University, Stanford, CA 94305-5020, USA Department of Genetics, Stanford School of Medicine, Stanford, CA 94305-5120, USA

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http://dx.doi.org/10.1242/jcs.157008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4179487PMC
October 2014

Cby1 promotes Ahi1 recruitment to a ring-shaped domain at the centriole-cilium interface and facilitates proper cilium formation and function.

Mol Biol Cell 2014 Oct 7;25(19):2919-33. Epub 2014 Aug 7.

Department of Biology, Stanford School of Medicine, Stanford University, Stanford, CA 94305 Department of Genetics, Stanford School of Medicine, Stanford University, Stanford, CA 94305

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http://dx.doi.org/10.1091/mbc.E14-02-0735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230582PMC
October 2014

The centriole duplication cycle.

Philos Trans R Soc Lond B Biol Sci 2014 Sep;369(1650)

Department of Biology, Stanford University, Stanford, CA 94305-5020, USA Department of Genetics, Stanford University Medical School, Stanford, CA 94305-5120, USA

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http://dx.doi.org/10.1098/rstb.2013.0460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113104PMC
September 2014

Proximity interactions among centrosome components identify regulators of centriole duplication.

Curr Biol 2014 Mar 6;24(6):664-70. Epub 2014 Mar 6.

Department of Biology, Stanford University, Stanford, CA 94305-5020, USA; Department of Genetics, Stanford School of Medicine, Stanford, CA 94305-5120, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2014.01.067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004176PMC
March 2014

Journey to the center of the centrosome.

Authors:
Tim Stearns

Dev Cell 2014 Mar;28(6):603-4

Department of Biology, Stanford University, Stanford, CA 94305, USA; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2014.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038696PMC
March 2014

Myb promotes centriole amplification and later steps of the multiciliogenesis program.

Development 2013 Oct 18;140(20):4277-86. Epub 2013 Sep 18.

Department of Biochemistry and Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1242/dev.094102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787764PMC
October 2013

Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites.

Nature 2013 Oct 2;502(7470):254-7. Epub 2013 Oct 2.

Center for Autophagy Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

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http://www.nature.com/articles/nature12606
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http://dx.doi.org/10.1038/nature12606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4075283PMC
October 2013

Remembrance of cilia past.

Cell 2013 Oct;155(2):271-3

Department of Biology, Stanford University, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1016/j.cell.2013.09.027DOI Listing
October 2013

FOP is a centriolar satellite protein involved in ciliogenesis.

PLoS One 2013 12;8(3):e58589. Epub 2013 Mar 12.

Department of Biology, Stanford University, Stanford, California, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0058589PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3595297PMC
September 2013

The Rilp-like proteins Rilpl1 and Rilpl2 regulate ciliary membrane content.

Mol Biol Cell 2013 Feb 21;24(4):453-64. Epub 2012 Dec 21.

Department of Biology, Stanford University, Department of Genetics, Stanford School of Medicine, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1091/mbc.E12-08-0598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3571868PMC
February 2013

Cell architecture: putting the building blocks together.

Curr Opin Cell Biol 2013 Feb 30;25(1):3-5. Epub 2012 Dec 30.

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http://dx.doi.org/10.1016/j.ceb.2012.12.003DOI Listing
February 2013

The centriolar satellite proteins Cep72 and Cep290 interact and are required for recruitment of BBS proteins to the cilium.

Mol Biol Cell 2012 Sep 5;23(17):3322-35. Epub 2012 Jul 5.

Department of Biology, Stanford School of Medicine, Stanford, CA 94305-5020, USA.

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http://dx.doi.org/10.1091/mbc.E12-02-0134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431927PMC
September 2012

Supernumerary centrosomes nucleate extra cilia and compromise primary cilium signaling.

Curr Biol 2012 Sep 26;22(17):1628-34. Epub 2012 Jul 26.

Department of Biology, Stanford University, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1016/j.cub.2012.06.057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094149PMC
September 2012

STED microscopy with optimized labeling density reveals 9-fold arrangement of a centriole protein.

Biophys J 2012 Jun 19;102(12):2926-35. Epub 2012 Jun 19.

Department of Chemistry, Stanford University, Stanford, California, USA.

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http://dx.doi.org/10.1016/j.bpj.2012.05.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3379620PMC
June 2012

Curcumin inhibits growth of Saccharomyces cerevisiae through iron chelation.

Eukaryot Cell 2011 Nov 9;10(11):1574-81. Epub 2011 Sep 9.

Department of Biology, Stanford University, Stanford, CA 94305-5020, USA.

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http://dx.doi.org/10.1128/EC.05163-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3209049PMC
November 2011

The centrosome cycle: Centriole biogenesis, duplication and inherent asymmetries.

Nat Cell Biol 2011 Oct 3;13(10):1154-60. Epub 2011 Oct 3.

Biozentrum, University of Basel, Klingelbergstrasse 50/70, CH-4056 Basel, Switzerland.

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http://dx.doi.org/10.1038/ncb2345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947860PMC
October 2011

Cep152 interacts with Plk4 and is required for centriole duplication.

J Cell Biol 2010 Nov 8;191(4):721-9. Epub 2010 Nov 8.

Department of Biology, Stanford University, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1083/jcb.201006049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2983069PMC
November 2010

Cep120 is asymmetrically localized to the daughter centriole and is essential for centriole assembly.

J Cell Biol 2010 Oct;191(2):331-46

Department of Biology, Stanford University, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1083/jcb.201003009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958470PMC
October 2010

Centriole age underlies asynchronous primary cilium growth in mammalian cells.

Curr Biol 2009 Sep 13;19(17):1498-502. Epub 2009 Aug 13.

Department of Biology, Stanford University, Stanford, CA 94305-5020, USA.

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http://dx.doi.org/10.1016/j.cub.2009.07.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312602PMC
September 2009

Plk1-dependent recruitment of gamma-tubulin complexes to mitotic centrosomes involves multiple PCM components.

PLoS One 2009 Jun 19;4(6):e5976. Epub 2009 Jun 19.

Institut de Sciences et Technologies du Médicament de Toulouse, Centre National de la Recherche Scientifique/Pierre Fabre, Toulouse, France.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0005976PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695007PMC
June 2009

Exploring the pole: an EMBO conference on centrosomes and spindle pole bodies.

Nat Cell Biol 2008 Dec;10(12):1375-8

Stowers Institute for Medical Research, Kansas City, MO 64110, USA.

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http://dx.doi.org/10.1038/ncb1208-1375DOI Listing
December 2008

Primary cilia mediate mechanosensing in bone cells by a calcium-independent mechanism.

Proc Natl Acad Sci U S A 2007 Aug 2;104(33):13325-30. Epub 2007 Aug 2.

Palo Alto Veterans Administration Medical Center, Palo Alto, CA 94304, USA.

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http://dx.doi.org/10.1073/pnas.0700636104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1939687PMC
August 2007

Molecular characterization of centriole assembly in ciliated epithelial cells.

J Cell Biol 2007 Jul;178(1):31-42

Department of Genetics, Stanford University School of Medicine, Stanford University, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1083/jcb.200703064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064416PMC
July 2007

Microtubule-organizing centres: a re-evaluation.

Nat Rev Mol Cell Biol 2007 Feb;8(2):161-7

Department of Biological Sciences, Stanford University, CA 94305, USA.

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http://www.nature.com/articles/nrm2100
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http://dx.doi.org/10.1038/nrm2100DOI Listing
February 2007

Mechanism limiting centrosome duplication to once per cell cycle.

Nature 2006 Aug 19;442(7105):947-51. Epub 2006 Jul 19.

Department of Biological Sciences, Stanford University, Stanford University Medical School, Stanford, California 94305-5020, USA.

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http://www.nature.com/articles/nature04985
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http://dx.doi.org/10.1038/nature04985DOI Listing
August 2006

Controlling centrosome number: licenses and blocks.

Curr Opin Cell Biol 2006 Feb 19;18(1):74-8. Epub 2005 Dec 19.

Department of Biological Sciences, Stanford University, Stanford, California 94305, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S095506740500189
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http://dx.doi.org/10.1016/j.ceb.2005.12.008DOI Listing
February 2006

GCP-WD is a gamma-tubulin targeting factor required for centrosomal and chromatin-mediated microtubule nucleation.

Nat Cell Biol 2006 Feb 25;8(2):137-47. Epub 2005 Dec 25.

Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1038/ncb1349DOI Listing
February 2006

Insights into microtubule nucleation from the crystal structure of human gamma-tubulin.

Nature 2005 May;435(7041):523-7

Howard Hughes Medical Institute and Department of Biochemistry and Biophysics, University of California, San Francisco, 600 16th Street, San Francisco, California 94143, USA.

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http://dx.doi.org/10.1038/nature03586DOI Listing
May 2005

Mammalian cells lack checkpoints for tetraploidy, aberrant centrosome number, and cytokinesis failure.

BMC Cell Biol 2005 Feb 15;6(1). Epub 2005 Feb 15.

Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1186/1471-2121-6-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC554097PMC
February 2005

Centrosome number is controlled by a centrosome-intrinsic block to reduplication.

Nat Cell Biol 2003 Jun;5(6):539-44

Department of Biological Sciences, Stanford University, Stanford, CA 94305-5020, USA.

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http://dx.doi.org/10.1038/ncb993DOI Listing
June 2003

Dispatch. Centrosome biology: a SAS-sy centriole in the cell cycle.

Curr Biol 2003 Apr;13(9):R351-2

Dept. of Biological Sciences, Stanford University, Stanford, CA 94305-5020, USA.

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http://dx.doi.org/10.1016/s0960-9822(03)00273-2DOI Listing
April 2003

Epsilon-tubulin is required for centriole duplication and microtubule organization.

Nat Cell Biol 2003 Jan;5(1):71-6

Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1038/ncb900DOI Listing
January 2003

gamma-Tubulin.

Curr Biol 2002 Jun;12(12):R408-9

Department of Biological Sciences, Stanford University, California 94305-5020, USA.

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http://dx.doi.org/10.1016/s0960-9822(02)00908-9DOI Listing
June 2002

Systematic structure-function analysis of the small GTPase Arf1 in yeast.

Mol Biol Cell 2002 May;13(5):1652-64

Department of Genetics, Stanford University, California 94305, USA.

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http://dx.doi.org/10.1091/mbc.02-01-0007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC111134PMC
May 2002