Tim Sparwasser

Tim Sparwasser

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Tim Sparwasser

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Epithelium-specific MyD88 signaling, but not DCs or macrophages, control acute intestinal infection with Clostridium difficile.

Eur J Immunol 2019 May 10;49(5):747-757. Epub 2019 Mar 10.

Institute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Germany.

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http://dx.doi.org/10.1002/eji.201848022DOI Listing
May 2019

A Weaning Reaction to Microbiota Is Required for Resistance to Immunopathologies in the Adult.

Immunity 2019 05 19;50(5):1276-1288.e5. Epub 2019 Mar 19.

Microenvironment & Immunity Unit, Institut Pasteur, 75724 Paris, France; INSERM U1224, 75724 Paris, France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10747613193008
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http://dx.doi.org/10.1016/j.immuni.2019.02.014DOI Listing
May 2019

Enzymatic Activity of HPGD in Treg Cells Suppresses Tconv Cells to Maintain Adipose Tissue Homeostasis and Prevent Metabolic Dysfunction.

Immunity 2019 05 23;50(5):1232-1248.e14. Epub 2019 Apr 23.

Molecular Immunology in Neurodegeneration, German Center for Neurodegenerative Diseases (DZNE), Sigmund-Freud-Str. 27, 53127 Bonn, Germany; LIMES-Institute, Laboratory for Genomics and Immunoregulation, University of Bonn, Carl-Troll-Str. 31, 53115 Bonn, Germany; PRECISE, Platform for Single Cell Genomics and Epigenomics at the German Center for Neurodegenerative Diseases and the University of Bonn, Sigmund-Freud-Str. 27, 53127 Bonn, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10747613193013
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http://dx.doi.org/10.1016/j.immuni.2019.03.014DOI Listing
May 2019

Targeting Antigens to Dendritic Cells the DC-Specific-ICAM3-Grabbing-Nonintegrin Receptor Induces Strong T-Helper 1 Immune Responses.

Front Immunol 2018 9;9:471. Epub 2018 Mar 9.

Institute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research, A Joint Venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Germany.

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http://dx.doi.org/10.3389/fimmu.2018.00471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890140PMC
April 2019

Fatty Acid Synthesis During Mycobacterial Infection Is a Prerequisite for the Function of Highly Proliferative T Cells, But Not for Dendritic Cells or Macrophages.

Front Immunol 2018 5;9:495. Epub 2018 Apr 5.

Institute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research, A Joint Venture Between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Germany.

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http://dx.doi.org/10.3389/fimmu.2018.00495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895737PMC
April 2019

Regulatory T Cells in an Endogenous Mouse Lymphoma Recognize Specific Antigen Peptides and Contribute to Immune Escape.

Cancer Immunol Res 2019 Apr 20;7(4):600-608. Epub 2019 Mar 20.

Helmholtz-Zentrum München, Eigenständige Forschungseinheit Translationale Molekulare Immunologie, München, Germany.

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http://dx.doi.org/10.1158/2326-6066.CIR-18-0419DOI Listing
April 2019

TLR7 Controls VSV Replication in CD169 SCS Macrophages and Associated Viral Neuroinvasion.

Front Immunol 2019 15;10:466. Epub 2019 Mar 15.

Institute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research, A Joint Venture Between the Medical School Hannover and the Helmholtz Centre for Infection Research (HZI), Hannover, Germany.

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http://dx.doi.org/10.3389/fimmu.2019.00466DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428728PMC
March 2019

Efficient oral vaccination by bioengineering virus-like particles with protozoan surface proteins.

Nat Commun 2019 01 21;10(1):361. Epub 2019 Jan 21.

Centro de Investigación y Desarrollo en Inmunología y Enfermedades Infecciosas (CIDIE), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)/Universidad Católica de Córdoba (UCC), Córdoba, X5016DHK, Argentina.

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http://dx.doi.org/10.1038/s41467-018-08265-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341118PMC
January 2019

Etomoxir Actions on Regulatory and Memory T Cells Are Independent of Cpt1a-Mediated Fatty Acid Oxidation.

Cell Metab 2018 09 28;28(3):504-515.e7. Epub 2018 Jun 28.

Institute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research, A Joint Venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Niedersachsen 30625, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2018.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747686PMC
September 2018

Regulatory T cells control endothelial chemokine production and migration of T cells into intestinal tumors of APC mice.

Cancer Immunol Immunother 2018 07 18;67(7):1067-1077. Epub 2018 Apr 18.

Department of Microbiology and Immunology, Institute of Biomedicine, The Sahlgrenska Academy, University of Gothenburg, Box 435, 405 30, Gothenburg, Sweden.

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http://link.springer.com/10.1007/s00262-018-2161-9
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http://dx.doi.org/10.1007/s00262-018-2161-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006230PMC
July 2018

A new RelB-dependent CD117 CD172a murine DC subset preferentially induces Th2 differentiation and supports airway hyperresponses in vivo.

Eur J Immunol 2018 06 6;48(6):923-936. Epub 2018 Apr 6.

Research Group Immunology, Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), Jena, Germany.

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http://dx.doi.org/10.1002/eji.201747332DOI Listing
June 2018

Cytokines, Antibodies, and Histopathological Profiles during Giardia Infection and Variant-Specific Surface Protein-Based Vaccination.

Infect Immun 2018 06 22;86(6). Epub 2018 May 22.

Centro de Investigación y Desarrollo en Inmunología y Enfermedades Infecciosas, Consejo Nacional de Investigaciones Científicas y Técnicas, Cordoba, Argentina

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http://dx.doi.org/10.1128/IAI.00773-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964528PMC
June 2018

Fatty acid metabolism in CD8 T cell memory: Challenging current concepts.

Immunol Rev 2018 05;283(1):213-231

Institute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Germany.

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http://dx.doi.org/10.1111/imr.12655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691976PMC
May 2018

Adenoviral vector-mediated GM-CSF gene transfer improves anti-mycobacterial immunity in mice - role of regulatory T cells.

Immunobiology 2018 03 26;223(3):331-341. Epub 2017 Oct 26.

Department of Experimental Pneumology, Germany; German Center for Infection Research, Hannover, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.imbio.2017.10.042DOI Listing
March 2018

Dendritic cells conditioned by activin A-induced regulatory T cells exhibit enhanced tolerogenic properties and protect against experimental asthma.

J Allergy Clin Immunol 2018 02 1;141(2):671-684.e7. Epub 2017 Jun 1.

Cellular Immunology Laboratory, Center for Basic Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2017.03.047DOI Listing
February 2018

Osteopontin Promotes Protective Antigenic Tolerance against Experimental Allergic Airway Disease.

J Immunol 2018 02 12;200(4):1270-1282. Epub 2018 Jan 12.

Cellular Immunology Laboratory, Center for Basic Research, Biomedical Research Foundation of the Academy of Athens, 11527 Athens, Greece;

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http://dx.doi.org/10.4049/jimmunol.1701345DOI Listing
February 2018

MyD88 signaling in dendritic cells and the intestinal epithelium controls immunity against intestinal infection with C. rodentium.

PLoS Pathog 2017 May 16;13(5):e1006357. Epub 2017 May 16.

Institute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research; a joint venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Germany.

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http://dx.doi.org/10.1371/journal.ppat.1006357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433783PMC
May 2017

Metabolites: deciphering the molecular language between DCs and their environment.

Semin Immunopathol 2017 02 5;39(2):177-198. Epub 2016 Dec 5.

Institute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Feodor-Lynen Straße 7, 30625, Hannover, Germany.

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http://dx.doi.org/10.1007/s00281-016-0609-6DOI Listing
February 2017

The Special Relationship in the Development and Function of T Helper 17 and Regulatory T Cells.

Prog Mol Biol Transl Sci 2015 18;136:99-129. Epub 2015 Aug 18.

Institute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research: A Joint Venture Between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Germany. Electronic address:

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http://dx.doi.org/10.1016/bs.pmbts.2015.07.013DOI Listing
November 2016

Immunometabolism and autoimmunity.

Immunol Cell Biol 2016 11 26;94(10):925-934. Epub 2016 Aug 26.

Institute of Infection Immunology, Twincore, Centre for Experimental and Clinical Infection Research GmbH, Hannover, Germany.

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http://dx.doi.org/10.1038/icb.2016.77DOI Listing
November 2016

Conventional Dendritic Cells Confer Protection against Mouse Cytomegalovirus Infection via TLR9 and MyD88 Signaling.

Cell Rep 2016 10;17(4):1113-1127

Institute of Infection Immunology, Centre for Experimental and Clinical Infection Research (Twincore), Hannover Medical School (MHH) and Helmholtz Centre for Infection Research (HZI), 30625 Hannover, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247163129
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http://dx.doi.org/10.1016/j.celrep.2016.09.055DOI Listing
October 2016

Hookworm recombinant protein promotes regulatory T cell responses that suppress experimental asthma.

Sci Transl Med 2016 10;8(362):362ra143

Centre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Queensland, Australia.

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http://dx.doi.org/10.1126/scitranslmed.aaf8807DOI Listing
October 2016

Metabolic pathways in T cell activation and lineage differentiation.

Semin Immunol 2016 10 4;28(5):514-524. Epub 2016 Nov 4.

Institute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research, A Joint Venture Between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.smim.2016.10.009DOI Listing
October 2016

pDCs Take a Deep Breath to Fight Viruses.

Immunity 2016 06;44(6):1246-8

Institute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research; a joint venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Feodor-Lynen-Strasse 7, 30625 Hannover, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2016.06.005DOI Listing
June 2016

In vivo activation of Treg cells with a CD28 superagonist prevents and ameliorates chronic destructive arthritis in mice.

Eur J Immunol 2016 05 20;46(5):1193-202. Epub 2016 Jan 20.

Institute of Immunology, Universitätsklinikum Jena, Jena, Germany.

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http://dx.doi.org/10.1002/eji.201546104DOI Listing
May 2016

Rapid rebound of the Treg compartment in DEREG mice limits the impact of Treg depletion on mycobacterial burden, but prevents autoimmunity.

PLoS One 2014 22;9(7):e102804. Epub 2014 Jul 22.

Institute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research, a Joint Venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0102804PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106855PMC
December 2015

CD4+ T Cell Tolerance to Tissue-Restricted Self Antigens Is Mediated by Antigen-Specific Regulatory T Cells Rather Than Deletion.

Immunity 2015 Nov 10;43(5):896-908. Epub 2015 Nov 10.

Center for Immunology and Inflammatory Diseases, and Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital; and Harvard Medical School, Charlestown, MA 02129, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2015.10.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654997PMC
November 2015

Superior Suppressive Capacity of Skin Tregs Compared with Lung Tregs in a Model of Epicutaneous Priming.

J Invest Dermatol 2015 Oct 22;135(10):2418-26. Epub 2015 May 22.

Department for Pediatric Pulmonology, Allergology and Neonatology, Medical School Hannover, Hannover, Germany.

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http://dx.doi.org/10.1038/jid.2015.191DOI Listing
October 2015

Selective Expression of the MAPK Phosphatase Dusp9/MKP-4 in Mouse Plasmacytoid Dendritic Cells and Regulation of IFN-β Production.

J Immunol 2015 Aug 13;195(4):1753-62. Epub 2015 Jul 13.

Institute of Clinical Microbiology, Immunology and Hygiene, University Hospital Erlangen, 91054 Erlangen, Germany; Institute of Medical Microbiology, Immunology and Hygiene, Technical University Munich, 81675 Munich, Germany;

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http://dx.doi.org/10.4049/jimmunol.1400658DOI Listing
August 2015

Active suppression of intestinal CD4(+)TCRαβ(+) T-lymphocyte maturation during the postnatal period.

Nat Commun 2015 Jul 21;6:7725. Epub 2015 Jul 21.

1] Institute of Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany [2] Institute of Medical Microbiology, RWTH University Hospital, Pauwelsstraße 30, 52074 Aachen, Germany.

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http://dx.doi.org/10.1038/ncomms8725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518322PMC
July 2015

Treg-cell depletion promotes chemokine production and accumulation of CXCR3(+) conventional T cells in intestinal tumors.

Eur J Immunol 2015 Jun 14;45(6):1654-66. Epub 2015 Apr 14.

Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.

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http://dx.doi.org/10.1002/eji.201445058DOI Listing
June 2015

Ligation of TLR7 on CD19(+) CD1d(hi) B cells suppresses allergic lung inflammation via regulatory T cells.

Eur J Immunol 2015 Jun 14;45(6):1842-54. Epub 2015 Apr 14.

Trinity Biomedical Sciences Institute, School of Medicine, Trinity College Dublin, Dublin, Ireland.

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http://dx.doi.org/10.1002/eji.201445211DOI Listing
June 2015

De novo-induced self-antigen-specific Foxp3+ regulatory T cells impair the accumulation of inflammatory dendritic cells in draining lymph nodes.

J Immunol 2015 Jun 6;194(12):5812-24. Epub 2015 May 6.

Division of Clinical, Experimental Surgery, & Translational Research, Biomedical Research Foundation of the Academy of Athens, 11527 Athens, Greece;

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http://dx.doi.org/10.4049/jimmunol.1500111DOI Listing
June 2015

Assessing the suppressive activity of Foxp3⁺ regulatory T cells.

Methods Mol Biol 2014 ;1193:85-96

Institute of Infection Immunology, TWINCORE/Centre for Experimental and Clinical Infection Research; a joint venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), GmbH Feodor-Lynen-Str. 7, 30625, Hannover, Germany.

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http://dx.doi.org/10.1007/978-1-4939-1212-4_9DOI Listing
April 2015

Foxp3+ regulatory T cells play a protective role in angiotensin II-induced aortic aneurysm formation in mice.

Hypertension 2015 Apr 19;65(4):889-95. Epub 2015 Jan 19.

From the Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan (K.Y., T.Y., N.S., K.K., T.E., T.M., T.K., Y.S., T.M., K.-i.H.); and Institute of Infection Immunology, TWINCORE, Center for Experimental and Clinical Infection Research; a joint venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Germany (T.S.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.114.04934DOI Listing
April 2015

A major role for myeloid-derived suppressor cells and a minor role for regulatory T cells in immunosuppression during Staphylococcus aureus infection.

J Immunol 2015 Feb 29;194(3):1100-11. Epub 2014 Dec 29.

Infection Immunology Research Group, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany;

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http://dx.doi.org/10.4049/jimmunol.1400196DOI Listing
February 2015

Fatty acid metabolism in the regulation of T cell function.

Trends Immunol 2015 Feb 12;36(2):81-91. Epub 2015 Jan 12.

Institute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research, a Joint Venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.it.2014.12.005DOI Listing
February 2015

Development of a unique epigenetic signature during in vivo Th17 differentiation.

Nucleic Acids Res 2015 Feb 15;43(3):1537-48. Epub 2015 Jan 15.

Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany

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http://dx.doi.org/10.1093/nar/gkv014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330377PMC
February 2015

Dendritic cell specific targeting of MyD88 signalling pathways in vivo.

Eur J Immunol 2015 Jan 16;45(1):32-9. Epub 2014 Dec 16.

Institute for Infection Immunology, TWINCORE, Center for Experimental and Clinical Infection Research, a Joint Venture between the Medical School Hannover (MHH) and the Helmholtz Center for Infection Research (HZI), Hannover, Germany.

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http://dx.doi.org/10.1002/eji.201444747DOI Listing
January 2015

PD-L1hi B cells are critical regulators of humoral immunity.

Nat Commun 2015 Jan 22;6:5997. Epub 2015 Jan 22.

1] Translational Immunology Group, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland [2] National Children's Research Centre, Our Lady's Children's Hospital, Dublin 12, Ireland [3] Institute of Molecular Medicine, School of Medicine St James's Hospital, Trinity College Dublin, Dublin 2, Ireland.

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http://dx.doi.org/10.1038/ncomms6997DOI Listing
January 2015

Fluorochrome-based definition of naturally occurring Foxp3(+) regulatory T cells of intra- and extrathymic origin.

Eur J Immunol 2014 Dec 23;44(12):3632-45. Epub 2014 Sep 23.

Molecular and Cellular Immunology/Immune Regulation, DFG-Center for Regenerative Therapies Dresden (CRTD), Technische Universität Dresden, Dresden, Germany.

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http://dx.doi.org/10.1002/eji.201444750DOI Listing
December 2014

CD4(+) FoxP3(+) regulatory T cells suppress fatal T helper 2 cell immunity during pulmonary fungal infection.

Eur J Immunol 2014 Dec 29;44(12):3596-604. Epub 2014 Oct 29.

Institute of Immunology/Molecular Pathogenesis, Center for Biotechnology and Biomedicine, College of Veterinary Medicine, University of Leipzig, Leipzig, Germany.

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http://dx.doi.org/10.1002/eji.201444963DOI Listing
December 2014

Regulatory T cells and T-cell-derived IL-10 interfere with effective anti-cytomegalovirus immune response.

Immunol Cell Biol 2014 Nov 29;92(10):860-71. Epub 2014 Jul 29.

1] Institute of Medical Microbiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany [2] Institute for Virology, University Medical Center Freiburg, Albert-Ludwigs University, Freiburg, Germany.

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http://dx.doi.org/10.1038/icb.2014.62DOI Listing
November 2014

Selective and efficient generation of functional Batf3-dependent CD103+ dendritic cells from mouse bone marrow.

Blood 2014 Nov 6;124(20):3081-91. Epub 2014 Aug 6.

Institute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research, Medical School Hannover and the Helmholtz Centre for Infection Research, Hannover, Germany; and.

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http://dx.doi.org/10.1182/blood-2013-12-545772DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260363PMC
November 2014

De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells.

Nat Med 2014 Nov 5;20(11):1327-33. Epub 2014 Oct 5.

Institute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research; a joint venture between the Hannover Medical School and the Helmholtz Centre for Infection Research, Hannover, Germany.

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http://dx.doi.org/10.1038/nm.3704DOI Listing
November 2014

Advantages of Foxp3(+) regulatory T cell depletion using DEREG mice.

Immun Inflamm Dis 2014 Nov 26;2(3):162-5. Epub 2014 Oct 26.

Institute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research, A Joint Venture Between the Medical School Hannover and the Helmholtz Centre for Infection Research Feodor-Lynen-Str. 7, 30625, Hannover, Germany.

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http://dx.doi.org/10.1002/iid3.33DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4257761PMC
November 2014

Few Foxp3⁺ regulatory T cells are sufficient to protect adult mice from lethal autoimmunity.

Eur J Immunol 2014 Oct 11;44(10):2990-3002. Epub 2014 Aug 11.

Institute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research; a joint venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Germany.

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http://dx.doi.org/10.1002/eji.201344315DOI Listing
October 2014

Regulatory T cells suppress muscle inflammation and injury in muscular dystrophy.

Sci Transl Med 2014 Oct;6(258):258ra142

Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA. Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA. Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1126/scitranslmed.3009925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889432PMC
October 2014

The immunotherapeutic role of regulatory T cells in Leishmania (Viannia) panamensis infection.

J Immunol 2014 Sep 6;193(6):2961-70. Epub 2014 Aug 6.

Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06520;

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http://dx.doi.org/10.4049/jimmunol.1400728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170189PMC
September 2014

Mouse cytomegalovirus infection overrules T regulatory cell suppression on natural killer cells.

Virol J 2014 Aug 9;11:145. Epub 2014 Aug 9.

Institute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research; a joint venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Feodor-Lynen-Strasse 7, 30625 Hannover, Germany.

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http://dx.doi.org/10.1186/1743-422X-11-145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4254395PMC
August 2014

Loss of the TGFβ-activating integrin αvβ8 on dendritic cells protects mice from chronic intestinal parasitic infection via control of type 2 immunity.

PLoS Pathog 2013 3;9(10):e1003675. Epub 2013 Oct 3.

Manchester Immunology Group, Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom ; Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom ; Manchester Collaborative Centre for Inflammation Research, University of Manchester, Manchester, United Kingdom.

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http://dx.doi.org/10.1371/journal.ppat.1003675DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789784PMC
May 2014

MyD88 signalling in myeloid cells is sufficient to prevent chronic mycobacterial infection.

Eur J Immunol 2014 May 13;44(5):1399-409. Epub 2014 Feb 13.

Institute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research, a Joint Venture between the Medical School Hanover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hanover, Germany.

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http://dx.doi.org/10.1002/eji.201344039DOI Listing
May 2014

Regulatory CD4+Foxp3+ T cells control the severity of anaphylaxis.

PLoS One 2013 26;8(7):e69183. Epub 2013 Jul 26.

CIRI, International Center for Infectiology Research, Mucosal immunity, Vaccination & Biotherapies Team, Université de Lyon, Lyon, France.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0069183PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724852PMC
April 2014

Absence of Siglec-H in MCMV infection elevates interferon alpha production but does not enhance viral clearance.

PLoS Pathog 2013 26;9(9):e1003648. Epub 2013 Sep 26.

Institute for Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research: A Joint Venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Germany.

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http://dx.doi.org/10.1371/journal.ppat.1003648DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784486PMC
April 2014

Foxp3+ T cells inhibit antitumor immune memory modulated by mTOR inhibition.

Cancer Res 2014 Apr 26;74(8):2217-28. Epub 2014 Feb 26.

Authors' Affiliations: Department of Surgery, Division of Urology; Department of Medicine, Division of Hematology and Oncology, Cedars-Sinai Medical Center, Los Angeles, California; and Institute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research, Hannover, Germany.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-2928DOI Listing
April 2014

Salmonella enterica serovar Typhimurium infection-induced CD11b+ Gr1+ cells ameliorate allergic airway inflammation.

Infect Immun 2014 Mar 16;82(3):1052-63. Epub 2013 Dec 16.

Institute of Infection Immunology, Twincore, Centre for Experimental and Clinical Infection Research, Hanover, Germany.

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http://dx.doi.org/10.1128/IAI.01378-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958017PMC
March 2014

Schistosoma mansoni-mediated suppression of allergic airway inflammation requires patency and Foxp3+ Treg cells.

PLoS Negl Trop Dis 2013 15;7(8):e2379. Epub 2013 Aug 15.

Institute of Medical Microbiology, Immunology and Hygiene, Technische Universität München, Munich, Germany.

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http://dx.doi.org/10.1371/journal.pntd.0002379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744427PMC
February 2014

HIV Nef expression favors the relative preservation of CD4+ T regulatory cells that retain some important suppressive functions.

J Immunol 2014 Feb 24;192(4):1681-92. Epub 2014 Jan 24.

Laboratory of Molecular Biology, Clinical Research Institute of Montreal, Montreal, Quebec H2W 1R7, Canada;

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http://dx.doi.org/10.4049/jimmunol.1203272DOI Listing
February 2014

Dendritic cells coordinate innate immunity via MyD88 signaling to control Listeria monocytogenes infection.

Cell Rep 2014 Feb 13;6(4):698-708. Epub 2014 Feb 13.

Institute for Infection Immunology, TWINCORE, Center for Experimental and Clinical Infection Research, a Joint Venture between the Medical School Hannover (MHH) and the Helmholtz Center for Infection Research (HZI), 30625 Hannover, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.01.023DOI Listing
February 2014

Gene trap mice reveal an essential function of dual specificity phosphatase Dusp16/MKP-7 in perinatal survival and regulation of Toll-like receptor (TLR)-induced cytokine production.

J Biol Chem 2014 Jan 5;289(4):2112-26. Epub 2013 Dec 5.

From the Institute of Clinical Microbiology, Immunology and Hygiene, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany.

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http://dx.doi.org/10.1074/jbc.M113.535245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900958PMC
January 2014

Treg depletion attenuates the severity of skin disease from ganglionic spread after HSV-2 flank infection.

Virology 2013 Dec 13;447(1-2):9-20. Epub 2013 Sep 13.

Centres for Perinatal Infection Research and Kidney Research, The Children's Hospital at Westmead, Westmead, NSW, Australia; Discipline of Paediatrics and Child Health, Sydney Medical School, University of Sydney, Locked Bag 4001, Westmead, NSW 2145, Australia. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00426822130050
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http://dx.doi.org/10.1016/j.virol.2013.08.027DOI Listing
December 2013

In vivo targeting of human DC-SIGN drastically enhances CD8⁺ T-cell-mediated protective immunity.

Eur J Immunol 2013 Oct 22;43(10):2543-53. Epub 2013 Jul 22.

Institute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Germany.

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http://dx.doi.org/10.1002/eji.201343429DOI Listing
October 2013

Administration of anti-CD25 mAb leads to impaired α-galactosylceramide-mediated induction of IFN-γ production in a murine model.

Immunobiology 2013 Jun 26;218(6):851-9. Epub 2012 Oct 26.

Department of Tumour Immunology of the Institute of Molecular Genetics, v. v. i., Academy of Sciences of the Czech Republic, Prague 4, Czech Republic.

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http://dx.doi.org/10.1016/j.imbio.2012.10.012DOI Listing
June 2013

Long-term prevention of chronic allograft rejection by regulatory T-cell immunotherapy involves host Foxp3-expressing T cells.

Blood 2013 May 11;121(21):4303-10. Epub 2013 Apr 11.

Institut National de la Santé et de la Recherche Médicale, U1043, Toulouse, France.

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http://dx.doi.org/10.1182/blood-2012-08-452037DOI Listing
May 2013

Foxp3(+) regulatory T cells in mouse models of type 1 diabetes.

J Diabetes Res 2013 14;2013:940710. Epub 2013 Mar 14.

Center for Regenerative Therapies Dresden, 01307 Dresden, Germany.

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http://dx.doi.org/10.1155/2013/940710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3647588PMC
May 2013

On the role of regulatory T cells during viral-induced inflammatory lesions.

J Immunol 2012 Dec 5;189(12):5924-33. Epub 2012 Nov 5.

Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA.

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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.1202322
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http://dx.doi.org/10.4049/jimmunol.1202322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518750PMC
December 2012

IκB(NS) protein mediates regulatory T cell development via induction of the Foxp3 transcription factor.

Immunity 2012 Dec 29;37(6):998-1008. Epub 2012 Nov 29.

Systems-oriented Immunology and Inflammation Research, Helmholtz Center for Infection Research, Braunschweig, Germany.

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http://dx.doi.org/10.1016/j.immuni.2012.08.023DOI Listing
December 2012

Regulatory T cells increase the avidity of primary CD8+ T cell responses and promote memory.

Science 2012 Oct;338(6106):532-6

INSERM U932, Immunity and Cancer, Institut Curie, F-75248 Paris Cedex 05, France.

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http://dx.doi.org/10.1126/science.1227049DOI Listing
October 2012