Tim Schedl

Tim Schedl

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Tim Schedl

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GLP-1 Notch-LAG-1 CSL control of the germline stem cell fate is mediated by transcriptional targets lst-1 and sygl-1.

PLoS Genet 2020 Mar 20;16(3):e1008650. Epub 2020 Mar 20.

Department of Genetics, Washington University School of Medicine, Saint Louis, Missouri, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1008650DOI Listing
March 2020

Biology of the Germline Stem Cell System.

Genetics 2019 12;213(4):1145-1188

and Department of Genetics, Washington University School of Medicine, St. Louis, Missouri 63110

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http://dx.doi.org/10.1534/genetics.119.300238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893382PMC
December 2019

Rapid population-wide declines in stem cell number and activity during reproductive aging in .

Development 2019 04 23;146(8). Epub 2019 Apr 23.

Department of Genetics, Washington University School of Medicine, St Louis, MO 63110, USA

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http://dx.doi.org/10.1242/dev.173195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503983PMC
April 2019

Cell Cycle Analysis in the C. elegans Germline with the Thymidine Analog EdU.

J Vis Exp 2018 10 22(140). Epub 2018 Oct 22.

Department of Genetics, Washington University School of Medicine, St. Louis, Missouri;

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http://dx.doi.org/10.3791/58339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235580PMC
October 2018

Caenorhabditis nomenclature.

WormBook 2018 08 8;2018:1-14. Epub 2018 Aug 8.

Department of Genetics, Washington University School of Medicine, St. Louis MO 63110, USA.

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http://dx.doi.org/10.1895/wormbook.1.183.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369580PMC
August 2018

Initiation of Meiotic Development Is Controlled by Three Post-transcriptional Pathways in .

Genetics 2018 08 25;209(4):1197-1224. Epub 2018 Jun 25.

Department of Genetics, School of Medicine, Washington University in St. Louis, Missouri 63110

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http://dx.doi.org/10.1534/genetics.118.300985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063227PMC
August 2018

Cell cycle accumulation of the proliferating cell nuclear antigen PCN-1 transitions from continuous in the adult germline to intermittent in the early embryo of C. elegans.

BMC Dev Biol 2018 05 30;18(1):12. Epub 2018 May 30.

Department of Genetics, Washington University in St. Louis, 660 S. Euclid Ave, St. Louis, MO, 63108, USA.

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http://dx.doi.org/10.1186/s12861-018-0171-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977546PMC
May 2018

Indirect Immunofluorescence of Proteins in Oogenic Germ Cells of Caenorhabditis elegans.

Methods Mol Biol 2016 ;1457:9-17

Department of Genetics, Washington University School of Medicine, 4515 McKinley, St. Louis, MO, 63110, USA.

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http://dx.doi.org/10.1007/978-1-4939-3795-0_2DOI Listing
January 2018

Micropublication: incentivizing community curation and placing unpublished data into the public domain.

Database (Oxford) 2018 01;2018

Division of Biology and Biological Engineering 156-29, California Institute of Technology, Pasadena, CA 91125, USA.

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http://dx.doi.org/10.1093/database/bay013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836261PMC
January 2018

Sirt3 prevents maternal obesity-associated oxidative stress and meiotic defects in mouse oocytes.

Cell Cycle 2015 19;14(18):2959-68. Epub 2015 Mar 19.

b State Key Laboratory of Reproductive Medicine; Nanjing Medical University ; Nanjing , China.

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http://dx.doi.org/10.1080/15384101.2015.1026517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825572PMC
August 2016

Germline Stem Cell Differentiation Entails Regional Control of Cell Fate Regulator GLD-1 in Caenorhabditis elegans.

Genetics 2016 Mar 12;202(3):1085-103. Epub 2016 Jan 12.

Department of Genetics, Washington University School of Medicine, St. Louis, Missouri 63110

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http://dx.doi.org/10.1534/genetics.115.185678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788111PMC
March 2016

Caenorhabditis elegans glp-4 Encodes a Valyl Aminoacyl tRNA Synthetase.

G3 (Bethesda) 2015 Oct 13;5(12):2719-28. Epub 2015 Oct 13.

Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110

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http://dx.doi.org/10.1534/g3.115.021899DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683644PMC
October 2015

Analysis of Germline Stem Cell Differentiation Following Loss of GLP-1 Notch Activity in Caenorhabditis elegans.

Genetics 2015 Sep 8;201(1):167-84. Epub 2015 Jul 8.

Department of Genetics, Washington University School of Medicine, St. Louis, Missouri 63110

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http://www.genetics.org/content/genetics/201/1/167.full.pdf
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http://www.genetics.org/cgi/doi/10.1534/genetics.115.178061
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http://dx.doi.org/10.1534/genetics.115.178061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566261PMC
September 2015

Differing roles of pyruvate dehydrogenase kinases during mouse oocyte maturation.

J Cell Sci 2015 Jul 19;128(13):2319-29. Epub 2015 May 19.

State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 210029, China

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http://dx.doi.org/10.1242/jcs.167049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510846PMC
July 2015

Rab5a is required for spindle length control and kinetochore-microtubule attachment during meiosis in oocytes.

FASEB J 2014 Sep 29;28(9):4026-35. Epub 2014 May 29.

State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China; and

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http://www.fasebj.org/doi/10.1096/fj.14-250886
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http://dx.doi.org/10.1096/fj.14-250886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5395731PMC
September 2014

Discovery of anthelmintic drug targets and drugs using chokepoints in nematode metabolic pathways.

PLoS Pathog 2013 1;9(8):e1003505. Epub 2013 Aug 1.

The Genome Institute, Washington University School of Medicine, St. Louis, Missouri, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1003505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731235PMC
March 2014

Sirt2 functions in spindle organization and chromosome alignment in mouse oocyte meiosis.

FASEB J 2014 Mar 12;28(3):1435-45. Epub 2013 Dec 12.

2State Key Laboratory of Reproductive Medicine, Nanjing Medical University, 140 Hanzhong Rd, Nanjing, Jiangsu, 210029 China,

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http://dx.doi.org/10.1096/fj.13-244111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929683PMC
March 2014

Generation and purification of highly specific antibodies for detecting post-translationally modified proteins in vivo.

Nat Protoc 2014 Feb 23;9(2):375-95. Epub 2014 Jan 23.

Department of Genetics, Washington University in St. Louis, St. Louis, Missouri, USA.

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http://dx.doi.org/10.1038/nprot.2014.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124490PMC
February 2014

WormBase 2014: new views of curated biology.

Nucleic Acids Res 2014 Jan 4;42(Database issue):D789-93. Epub 2013 Nov 4.

Informatics and Bio-computing Platform, Ontario Institute for Cancer Research, Toronto, ON M5G0A3, Canada, Genome Sequencing Center, Washington University, School of Medicine, St Louis, MO 63108, USA, Division of Biology and Biological Engineering 156-29, California Institute of Technology, Pasadena, CA 91125, USA, European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK, Department of Genetics Campus, Washington University School of Medicine, St. Louis, MO 63110, USA, Genetics Unit, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK and Howard Hughes Medical Institute, California Institute of Technology, Pasadena, CA 91125, USA.

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http://dx.doi.org/10.1093/nar/gkt1063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965043PMC
January 2014

Introduction to germ cell development in Caenorhabditis elegans.

Adv Exp Med Biol 2013 ;757:1-16

Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.

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http://dx.doi.org/10.1007/978-1-4614-4015-4_1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781019PMC
November 2012

Stem cell proliferation versus meiotic fate decision in Caenorhabditis elegans.

Adv Exp Med Biol 2013 ;757:71-99

Department of Biological Sciences, University of Calgary, Calgary, AB, Canada.

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http://dx.doi.org/10.1007/978-1-4614-4015-4_4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3786863PMC
November 2012

An intercellular pathway for glucose transport into mouse oocytes.

Am J Physiol Endocrinol Metab 2012 Jun 3;302(12):E1511-8. Epub 2012 Apr 3.

State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China.

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http://dx.doi.org/10.1152/ajpendo.00016.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378161PMC
June 2012

G3, GENETICS, and the GSA: Two Journals, One Mission.

G3 (Bethesda) 2011 Sep 1;1(4):245-6. Epub 2011 Sep 1.

Editor-in-Chief, G3: Genes | Genomes | Genetics.

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http://dx.doi.org/10.1534/g3.111.000877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276146PMC
September 2011

Cyclin E and CDK-2 regulate proliferative cell fate and cell cycle progression in the C. elegans germline.

Development 2011 Jun;138(11):2223-34

Department of Genetics, Washington University School of Medicine, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1242/dev.059535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3091494PMC
June 2011

C. elegans star proteins, GLD-1 and ASD-2, regulate specific RNA targets to control development.

Adv Exp Med Biol 2010 ;693:106-22

Department of Biological Sciences, University at Albany, SUNY, Albany, New York 12222, USA.

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http://dx.doi.org/10.1007/978-1-4419-7005-3_8DOI Listing
February 2011

Cellular reprogramming: chromatin puts on the brake.

Curr Biol 2011 Feb;21(4):R157-9

Department of Biology and National Center for Behavioral Genomics, Brandeis University, Waltham, MA 02454, USA.

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http://dx.doi.org/10.1016/j.cub.2010.12.044DOI Listing
February 2011

Mitochondrial dysfunction and apoptosis in cumulus cells of type I diabetic mice.

PLoS One 2010 Dec 28;5(12):e15901. Epub 2010 Dec 28.

Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, Missouri, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0015901PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3011018PMC
December 2010

EOR-2 is an obligate binding partner of the BTB-zinc finger protein EOR-1 in Caenorhabditis elegans.

Genetics 2010 Apr 11;184(4):899-913. Epub 2010 Jan 11.

Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1534/genetics.109.111591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865926PMC
April 2010

A role for dynein in the inhibition of germ cell proliferative fate.

Mol Cell Biol 2009 Nov 14;29(22):6128-39. Epub 2009 Sep 14.

Department of Genetics, Washington University School of Medicine, Saint Louis, MO 63110, USA.

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http://mcb.asm.org/content/29/22/6128.full.pdf
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http://mcb.asm.org/content/early/2009/09/14/MCB.00815-09.ful
Web Search
http://mcb.asm.org/cgi/doi/10.1128/MCB.00815-09
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http://dx.doi.org/10.1128/MCB.00815-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2772574PMC
November 2009

Maternal diabetes causes mitochondrial dysfunction and meiotic defects in murine oocytes.

Mol Endocrinol 2009 Oct 2;23(10):1603-12. Epub 2009 Jul 2.

Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1210/me.2009-0033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2754898PMC
October 2009

METT-10, a putative methyltransferase, inhibits germ cell proliferative fate in Caenorhabditis elegans.

Genetics 2009 Sep 13;183(1):233-47. Epub 2009 Jul 13.

Department of Genetics, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1534/genetics.109.105270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746148PMC
September 2009

Multiple ERK substrates execute single biological processes in Caenorhabditis elegans germ-line development.

Proc Natl Acad Sci U S A 2009 Mar 5;106(12):4776-81. Epub 2009 Mar 5.

Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1073/pnas.0812285106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2660749PMC
March 2009

Whole-genome sequencing and variant discovery in C. elegans.

Nat Methods 2008 Feb 20;5(2):183-8. Epub 2008 Jan 20.

Washington University School of Medicine, Department of Genetics and Genome Sequencing Center, 4444 Forest Park Blvd., St. Louis, Missouri 63108, USA.

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http://dx.doi.org/10.1038/nmeth.1179DOI Listing
February 2008

Caenorhabditis elegans prom-1 is required for meiotic prophase progression and homologous chromosome pairing.

Mol Biol Cell 2007 Dec 3;18(12):4911-20. Epub 2007 Oct 3.

Department of Chromosome Biology and Max F. Perutz Laboratories, Faculty of Life Sciences, University of Vienna, A-1030 Vienna, Austria.

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http://www.molbiolcell.org/doi/10.1091/mbc.e07-03-0243
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http://dx.doi.org/10.1091/mbc.e07-03-0243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2096575PMC
December 2007

Sex determination in the germ line.

WormBook 2007 Mar 5:1-13. Epub 2007 Mar 5.

Department of Molecular Biology, University of Medicine and Dentistry of New Jersey, School of Osteopathic Medicine, Stratford, NJ 08084, USA.

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http://dx.doi.org/10.1895/wormbook.1.82.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4781493PMC
March 2007

The regulatory network controlling the proliferation-meiotic entry decision in the Caenorhabditis elegans germ line.

Curr Top Dev Biol 2006 ;76:185-215

Department of Biological Sciences, University of Calgary Calgary, Alberta, Canada T2N-1N4.

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http://linkinghub.elsevier.com/retrieve/pii/S007021530676006
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http://dx.doi.org/10.1016/S0070-2153(06)76006-9DOI Listing
January 2007

RNA in situ hybridization of dissected gonads.

WormBook 2006 Jun 14:1-7. Epub 2006 Jun 14.

Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1895/wormbook.1.107.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4781440PMC
June 2006

RNA-binding proteins.

WormBook 2006 Apr 18:1-13. Epub 2006 Apr 18.

Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1895/wormbook.1.79.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4781538PMC
April 2006

Translational repression of C. elegans p53 by GLD-1 regulates DNA damage-induced apoptosis.

Cell 2005 Feb;120(3):357-68

Department of Cell Biology, Max-Planck-Institute for Biochemistry, Am Klopferspitz 18a, D 82152 Martinsried, Germany.

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http://dx.doi.org/10.1016/j.cell.2004.12.009DOI Listing
February 2005

fog-2 and the evolution of self-fertile hermaphroditism in Caenorhabditis.

PLoS Biol 2005 Jan 28;3(1):e6. Epub 2004 Dec 28.

Department of Genetics, Washington University School of Medicine St. Louis, Missouri, USA.

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https://dx.plos.org/10.1371/journal.pbio.0030006
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http://dx.doi.org/10.1371/journal.pbio.0030006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC539060PMC
January 2005

Epsin potentiates Notch pathway activity in Drosophila and C. elegans.

Development 2004 Dec;131(23):5807-15

Department of Genetics, Washington University in St Louis, School of Medicine, 660 S. Euclid Avenue, St Louis, MO 63110, USA.

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http://dev.biologists.org/cgi/doi/10.1242/dev.01459
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http://dx.doi.org/10.1242/dev.01459DOI Listing
December 2004

Translation repression by GLD-1 protects its mRNA targets from nonsense-mediated mRNA decay in C. elegans.

Genes Dev 2004 May 22;18(9):1047-59. Epub 2004 Apr 22.

Department of Genetics, Washington University School of Medicine, Saint Louis, Missouri 63110, USA.

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http://www.genesdev.org/cgi/doi/10.1101/gad.1188404
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http://dx.doi.org/10.1101/gad.1188404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC406294PMC
May 2004

Multi-pathway control of the proliferation versus meiotic development decision in the Caenorhabditis elegans germline.

Dev Biol 2004 Apr;268(2):342-57

Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S001216060400020
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http://dx.doi.org/10.1016/j.ydbio.2003.12.023DOI Listing
April 2004

Control of the proliferation versus meiotic development decision in the C. elegans germline through regulation of GLD-1 protein accumulation.

Development 2004 Jan 3;131(1):93-104. Epub 2003 Dec 3.

Department of Genetics, Washington University School of Medicine, Saint Louis, MO 63110, USA.

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http://dev.biologists.org/cgi/doi/10.1242/dev.00916
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http://dx.doi.org/10.1242/dev.00916DOI Listing
January 2004

C. elegans ksr-1 and ksr-2 have both unique and redundant functions and are required for MPK-1 ERK phosphorylation.

Curr Biol 2002 Mar;12(5):427-33

Department of Genetics, Washington University School of Medicine, 63110, St. Louis, MO, USA

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http://dx.doi.org/10.1016/s0960-9822(02)00690-5DOI Listing
March 2002

Caenorhabditis elegans lin-45 raf is essential for larval viability, fertility and the induction of vulval cell fates.

Genetics 2002 Feb;160(2):481-92

Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1461998PMC
February 2002

The Caenorhabditis elegans Skp1-related gene family: diverse functions in cell proliferation, morphogenesis, and meiosis.

Curr Biol 2002 Feb;12(4):277-87

Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/s0960-9822(02)00682-6DOI Listing
February 2002