Tim J Schulz

Tim J Schulz

UNVERIFIED PROFILE

Are you Tim J Schulz?   Register this Author

Register author
Tim J Schulz

Tim J Schulz

Publications by authors named "Tim J Schulz"

Are you Tim J Schulz?   Register this Author

53Publications

1349Reads

18Profile Views

Pancreatic adipocytes mediate hypersecretion of insulin in diabetes-susceptible mice.

Metabolism 2019 08 18;97:9-17. Epub 2019 May 18.

Department of Experimental Diabetology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), 14558 Nuthetal, Germany; German Center for Diabetes Research (DZD), München-Neuherberg 85764, Germany; Institute of Nutritional Science, University of Potsdam, 14558 Nuthetal, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.metabol.2019.05.005DOI Listing
August 2019

Aging of Brown and Beige/Brite Adipose Tissue.

Handb Exp Pharmacol 2019 ;251:55-72

Department of Adipocyte Development and Nutrition, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/164_2018_151
Publisher Site
http://dx.doi.org/10.1007/164_2018_151DOI Listing
July 2019

Identification of functional lipid metabolism biomarkers of brown adipose tissue aging.

Mol Metab 2019 06 4;24:1-17. Epub 2019 Apr 4.

Department of Adipocyte Development and Nutrition, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany; German Center for Diabetes Research (DZD), München, Neuherberg, Germany; Institute of Nutritional Science, University of Potsdam, Potsdam-Rehbrücke, Nuthetal, Germany. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S22128778183119
Publisher Site
http://dx.doi.org/10.1016/j.molmet.2019.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6531832PMC
June 2019

p53 Functions in Adipose Tissue Metabolism and Homeostasis.

Int J Mol Sci 2018 Sep 4;19(9). Epub 2018 Sep 4.

Gottfried Schatz Research Center for Cell Signaling, Metabolism & Aging, Department of Cell Biology, Histology and Embryology, Medical University Graz, 8010 Graz, Austria.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms19092622DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165290PMC
September 2018

Cold-Activated Lipid Dynamics in Adipose Tissue Highlights a Role for Cardiolipin in Thermogenic Metabolism.

Cell Rep 2018 07;24(3):781-790

Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2018.06.073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117118PMC
July 2018

Author Correction: Partial involvement of Nrf2 in skeletal muscle mitohormesis as an adaptive response to mitochondrial uncoupling.

Sci Rep 2018 Jul 24;8(1):11382. Epub 2018 Jul 24.

Department of Physiology of Energy Metabolism, German Institute of Human Nutrition Potsdam-Rehbrücke, 14558, Nuthetal, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-018-29610-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056490PMC
July 2018

p53 as a Dichotomous Regulator of Liver Disease: The Dose Makes the Medicine.

Int J Mol Sci 2018 Mar 20;19(3). Epub 2018 Mar 20.

Gottfried Schatz Research Center for Cell Signaling, Metabolism & Aging, Medical University of Graz, 8010 Graz, Austria.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms19030921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877782PMC
March 2018

Flow Cytometric Isolation and Differentiation of Adipogenic Progenitor Cells into Brown and Brite/Beige Adipocytes.

Methods Mol Biol 2017 ;1566:25-36

Research Group Adipocyte Development, German Institute of Human Nutrition (DlfE), Potsdam-Rehbrucke 114-116, Arthur-Scheunert-Allee, D-14558, Nuthetal, Germany.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/978-1-4939-6820-6_4
Publisher Site
http://dx.doi.org/10.1007/978-1-4939-6820-6_4DOI Listing
February 2018

Partial involvement of Nrf2 in skeletal muscle mitohormesis as an adaptive response to mitochondrial uncoupling.

Sci Rep 2018 02 5;8(1):2446. Epub 2018 Feb 5.

Department of Physiology of Energy Metabolism, German Institute of Human Nutrition Potsdam-Rehbrücke, 14558, Nuthetal, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-018-20901-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5799251PMC
February 2018

The emerging role of bone marrow adipose tissue in bone health and dysfunction.

J Mol Med (Berl) 2017 Dec 3;95(12):1291-1301. Epub 2017 Nov 3.

Department of Adipocyte Development and Nutrition, German Institute of Human Nutrition Potsdam-Rehbrücke, Arthur-Scheunert-Allee 114-116, 14558, Nuthetal, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00109-017-1604-7DOI Listing
December 2017

Sex matters: The effects of biological sex on adipose tissue biology and energy metabolism.

Redox Biol 2017 08 13;12:806-813. Epub 2017 Apr 13.

Department of Adipocyte Development and Nutrition, German Institute of Human Nutrition Potsdam-Rehbrücke, 114-116, Arthur-Scheunert-Allee, 14558 Nuthetal, Germany; German Center for Diabetes Research (DZD), 85764 München-Neuherberg, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.redox.2017.04.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406544PMC
August 2017

Short-chain fatty acids and inulin, but not guar gum, prevent diet-induced obesity and insulin resistance through differential mechanisms in mice.

Sci Rep 2017 07 21;7(1):6109. Epub 2017 Jul 21.

Department Physiology of Energy Metabolism, German Institute of Human Nutrition in Potsdam Rehbruecke, Arthur-Scheunert-Allee 114-116, 14558, Nuthetal, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-017-06447-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522422PMC
July 2017

Adipocyte Accumulation in the Bone Marrow during Obesity and Aging Impairs Stem Cell-Based Hematopoietic and Bone Regeneration.

Cell Stem Cell 2017 06 16;20(6):771-784.e6. Epub 2017 Mar 16.

German Institute of Human Nutrition Potsdam-Rehbrücke, 14558 Nuthetal, Germany; German Center for Diabetes Research (DZD), 85764 München-Neuherberg, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.stem.2017.02.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5459794PMC
June 2017

Pharmacological and Genetic Manipulation of p53 in Brown Fat at Adult But Not Embryonic Stages Regulates Thermogenesis and Body Weight in Male Mice.

Endocrinology 2016 07 16;157(7):2735-49. Epub 2016 May 16.

Department of Physiology (O.A.-M., B.P., M.J.G.-R., M.G.-L., E.D.R., M.Q., A.S., C.V.A., M.L., C.D., R.N.), Center for Research in Molecular Medicine and Chronic Diseases, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela 15782, Spain; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (O.A.-M., B.P., M.J.G.-R., M.Q., M.L., C.D., R.N.), Santiago de Compostela 15706, Spain; Department of Adipocyte Development and Nutrition (D.K., M.K., T.J.S.), German Institute of Human Nutrition Potsdam-Rehbrücke, 14558 Nuthetal, Germany; and German Center for Diabetes Research (T.J.S.), München-Neuherberg 85764, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/en.2016-1209DOI Listing
July 2016

Mechanisms of aging-related impairment of brown adipocyte development and function.

Gerontology 2015 20;61(3):211-7. Epub 2014 Dec 20.

Junior Research Group Adipocyte Development, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000366557DOI Listing
April 2016

Bone morphogenetic proteins in inflammation, glucose homeostasis and adipose tissue energy metabolism.

Cytokine Growth Factor Rev 2016 Feb 29;27:105-18. Epub 2015 Dec 29.

University of Zagreb School of Medicine, Center for Translational and Clinical Research, Laboratory for Mineralized Tissues, Zagreb, Croatia. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cytogfr.2015.12.009DOI Listing
February 2016

MicroRNA-455 regulates brown adipogenesis via a novel HIF1an-AMPK-PGC1α signaling network.

EMBO Rep 2015 Oct 24;16(10):1378-93. Epub 2015 Aug 24.

Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15252/embr.201540837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766451PMC
October 2015

Clonal analyses and gene profiling identify genetic biomarkers of the thermogenic potential of human brown and white preadipocytes.

Nat Med 2015 Jul 15;21(7):760-8. Epub 2015 Jun 15.

1] Section on Integrative Physiology and Metabolism, Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA. [2] Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nm.3881DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496292PMC
July 2015

Adipogenic fate commitment of muscle-derived progenitor cells: isolation, culture, and differentiation.

Methods Mol Biol 2014 ;1213:229-43

Research Group Adipocyte Development, German Institute of Human Nutrition, Arthur-Scheunert-Allee 114-116, Nuthetal, 14558, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-1453-1_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511918PMC
May 2015

Disruption of insulin signaling in Myf5-expressing progenitors leads to marked paucity of brown fat but normal muscle development.

Endocrinology 2015 May 27;156(5):1637-47. Epub 2015 Jan 27.

Section on Integrative Physiology and Metabolism (M.D.L., Y.-H.T.), Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215; Department of Adipocyte Development (T.J.S.), German Institute of Human Nutrition, Potsdam-Rehbrücke, Germany 14558; Stem Cell and Regenerative Biology Department (A.J.P.), Harvard University, Cambridge, Massachusetts; and Harvard Stem Cell Institute (Y.-H.T.), Harvard University, Cambridge, Massachusetts 02138.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/en.2014-1773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4398768PMC
May 2015

Intramuscular adipogenesis is inhibited by myo-endothelial progenitors with functioning Bmpr1a signalling.

Nat Commun 2014 Jun 5;5:4063. Epub 2014 Jun 5.

Division of Genetics, Boston Children's Hospital, Boston, Massachusetts 02115, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms5063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4084855PMC
June 2014

D-Glucosamine supplementation extends life span of nematodes and of ageing mice.

Nat Commun 2014 Apr 8;5:3563. Epub 2014 Apr 8.

1] Energy Metabolism Laboratory, ETH Zürich (Swiss Federal Institute of Technology Zurich), Zürich CH-8603, Switzerland [2] German Institute of Human Nutrition Potsdam-Rehbrücke, D-14558 Nuthetal, Germany [3] Department of Human Nutrition, Institute of Nutrition, University of Jena, D-07743 Jena, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms4563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988823PMC
April 2014

Systemic control of brown fat thermogenesis: integration of peripheral and central signals.

Ann N Y Acad Sci 2013 Oct 23;1302:35-41. Epub 2013 Sep 23.

Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/nyas.12277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3805713PMC
October 2013

Brown adipose tissue: development, metabolism and beyond.

Biochem J 2013 Jul;453(2):167-78

Research Group Adipocyte Development, German Institute of Human Nutrition, Nuthetal 14558, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1042/BJ20130457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887508PMC
July 2013

Brown-fat paucity due to impaired BMP signalling induces compensatory browning of white fat.

Nature 2013 Mar 13;495(7441):379-83. Epub 2013 Mar 13.

Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature11943DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3623555PMC
March 2013

Intrinsic differences in adipocyte precursor cells from different white fat depots.

Diabetes 2012 Jul 17;61(7):1691-9. Epub 2012 May 17.

Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts,USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/db11-1753DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3379665PMC
July 2012

Insulin/IGF-I regulation of necdin and brown adipocyte differentiation via CREB- and FoxO1-associated pathways.

Endocrinology 2011 Oct 23;152(10):3680-9. Epub 2011 Aug 23.

Research Division, Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA.

View Article

Download full-text PDF

Source
https://academic.oup.com/endo/article-lookup/doi/10.1210/en.
Publisher Site
http://dx.doi.org/10.1210/en.2011-1229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176640PMC
October 2011

The Friedreich's ataxia protein frataxin modulates DNA base excision repair in prokaryotes and mammals.

Biochem J 2010 Nov;432(1):165-72

Department of Food Toxicology and Replacement/Complementary Methods to Animal Testing, University of Veterinary Medicine Hannover, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1042/BJ20101116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2976068PMC
November 2010

Opposing effects of dietary sugar and saturated fat on cardiovascular risk factors and glucose metabolism in mitochondrially impaired mice.

Eur J Nutr 2010 Oct 10;49(7):417-27. Epub 2010 Mar 10.

Department of Human Nutrition, Institute of Nutrition, University of Jena, 07743 Jena, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00394-010-0100-4DOI Listing
October 2010

Cross talk between insulin and bone morphogenetic protein signaling systems in brown adipogenesis.

Mol Cell Biol 2010 Sep 28;30(17):4224-33. Epub 2010 Jun 28.

Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/MCB.00363-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2937545PMC
September 2010

Emerging role of bone morphogenetic proteins in adipogenesis and energy metabolism.

Cytokine Growth Factor Rev 2009 Oct-Dec;20(5-6):523-31. Epub 2009 Nov 6.

Joslin Diabetes Center, One Joslin Place, and Harvard Medical School, Boston, MA 02215, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cytogfr.2009.10.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2799934PMC
March 2010

Improved glucose metabolism in mice lacking alpha-tocopherol transfer protein.

Eur J Nutr 2007 Oct 19;46(7):397-405. Epub 2007 Sep 19.

Dept. of Human Nutrition, Inst. of Nutrition, University of Jena, Dornburger Strasse 29, 07743, Jena, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00394-007-0679-2DOI Listing
October 2007

Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress.

Cell Metab 2007 Oct;6(4):280-93

Department of Human Nutrition, Institute of Nutrition, University of Jena, D-07743 Jena, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cmet.2007.08.011DOI Listing
October 2007

Impaired respiration is positively correlated with decreased life span in Caenorhabditis elegans models of Friedreich Ataxia.

FASEB J 2007 Apr 10;21(4):1271-5. Epub 2007 Jan 10.

Department of Human Nutrition, Inst. of Nutrition, University of Jena, 29 Dornburger St., Jena D-07743, Germany.

View Article

Download full-text PDF

Source
http://www.fasebj.org/doi/10.1096/fj.06-6994com
Publisher Site
http://dx.doi.org/10.1096/fj.06-6994comDOI Listing
April 2007

Reduced expression of mitochondrial frataxin in mice exacerbates diet-induced obesity.

Proc Natl Acad Sci U S A 2007 Apr 2;104(15):6377-81. Epub 2007 Apr 2.

Department of Clinical Nutrition, German Institute of Human Nutrition, D-14558 Potsdam-Rehbrücke, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0611631104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1847459PMC
April 2007

Induction of oxidative metabolism by mitochondrial frataxin inhibits cancer growth: Otto Warburg revisited.

J Biol Chem 2006 Jan 1;281(2):977-81. Epub 2005 Nov 1.

German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M511064200DOI Listing
January 2006

Targeted disruption of hepatic frataxin expression causes impaired mitochondrial function, decreased life span and tumor growth in mice.

Hum Mol Genet 2005 Dec 8;14(24):3857-64. Epub 2005 Nov 8.

German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal-Berlin, and Charité University Medicine, Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/hmg/ddi410DOI Listing
December 2005