Publications by authors named "Tim Hucho"

41Publications

Prostate-Specific Membrane Antigen Uptake in a Peripheral Nerve and Respective Ganglia on 68Ga-Prostate-Specific Membrane Antigen-HBED-CC PET/CT.

Clin Nucl Med 2021 Jan;46(1):69-70

From the Department for Nuclear Medicine, Faculty of Medicine and University Hospital of Cologne, Center for Integrated, Oncology Aachen Bonn Cologne Duesseldorf.

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January 2021

Oncostatin M induces hyperalgesic priming and amplifies signaling of cAMP to ERK by RapGEF2 and PKA.

J Neurochem 2020 Sep 3. Epub 2020 Sep 3.

Department of Anaesthesiology and Intensive Care Medicine, Translational Pain Research, University Hospital Cologne, University Cologne, Cologne, Germany.

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September 2020

Hirudotherapy attenuates arthritic pain in patients with various chronic pain syndromes: A retrospective analysis.

J Integr Med 2020 Sep 18;18(5):425-433. Epub 2020 Jul 18.

Department of Anaesthesiology and Intensive Care Medicine, University Clinic of Cologne, Koeln 50937, Germany. Electronic address:

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September 2020

Direct, gabapentin-insensitive interaction of a soluble form of the calcium channel subunit αδ-1 with thrombospondin-4.

Sci Rep 2019 11 7;9(1):16272. Epub 2019 Nov 7.

Institute II for Pharmacology, Centre of Pharmacology, Medical Faculty, University of Cologne, Gleueler Str. 24, D-50931, Cologne, Germany.

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November 2019

Dual Inhibition of GLUT1 and the ATR/CHK1 Kinase Axis Displays Synergistic Cytotoxicity in -Mutant Cancer Cells.

Cancer Res 2019 Oct 12;79(19):4855-4868. Epub 2019 Aug 12.

Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Dusseldorf, Center for Molecular Medicine Cologne, CECAD, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.

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October 2019

High-Content Imaging of Immunofluorescently Labeled TRPV1-Positive Sensory Neurons.

Methods Mol Biol 2019 ;1987:111-124

Experimental Anesthesiology and Pain Research, Department of Anesthesiology and Intensive Care Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.

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January 2020

The Cdkn1a Mouse as a Tool to Study p53-Mediated Tumor Suppression.

Cell Rep 2018 10;25(4):1027-1039.e6

Department I of Internal Medicine, University Hospital Cologne, Weyertal 115b, 50931 Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Joseph Stelzmann Straße 26, 50931 Cologne, Germany; Center for Molecular Medicine, University Hospital Cologne, Robert Koch Straße 21, 50931 Cologne. Electronic address:

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October 2018

A Hierarchical, Data-Driven Approach to Modeling Single-Cell Populations Predicts Latent Causes of Cell-To-Cell Variability.

Cell Syst 2018 05 2;6(5):593-603.e13. Epub 2018 May 2.

Helmholtz Zentrum München-German Research Center for Environmental Health, Institute of Computational Biology, 85764 Neuherberg, Germany; Technische Universität München, Center for Mathematics, Chair of Mathematical Modeling of Biological Systems, 85748 Garching, Germany. Electronic address:

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May 2018

PKA-RII subunit phosphorylation precedes activation by cAMP and regulates activity termination.

J Cell Biol 2018 06 3;217(6):2167-2184. Epub 2018 Apr 3.

Department of Anesthesiology and Intensive Care Medicine, Experimental Anesthesiology and Pain Research, University Hospital of Cologne, Cologne, Germany

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June 2018

Crosstalk from cAMP to ERK1/2 emerges during postnatal maturation of nociceptive neurons and is maintained during aging.

J Cell Sci 2017 Jul 17;130(13):2134-2146. Epub 2017 May 17.

Department of Anesthesiology and Intensive Care Medicine, Experimental Anesthesiology and Pain Research, University Hospital of Cologne, Robert Koch Str. 10, Cologne D-50931, Germany

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July 2017

Synergistic regulation of serotonin and opioid signaling contributes to pain insensitivity in Nav1.7 knockout mice.

Sci Signal 2017 01 10;10(461). Epub 2017 Jan 10.

Department of Anesthesiology and Intensive Care Medicine, Experimental Anesthesiology and Pain Research, University Hospital of Cologne, Robert Koch Str. 10, 50931 Cologne, Germany.

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January 2017

The bromodomain protein BRD4 regulates splicing during heat shock.

Nucleic Acids Res 2017 Jan 17;45(1):382-394. Epub 2016 Aug 17.

Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Ihnestr.63-73, 14195 Berlin, Germany

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January 2017

Subgroup-elimination transcriptomics identifies signaling proteins that define subclasses of TRPV1-positive neurons and a novel paracrine circuit.

PLoS One 2014 31;9(12):e115731. Epub 2014 Dec 31.

Department of Anesthesiology and Intensive Care Medicine, Experimental Anesthesiology and Pain Research, University Hospital of Cologne, Cologne, Germany; Department for Human Molecular Genetics, Max Planck Institute for Molecular Genetics, Berlin, Germany.

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October 2015

ODE constrained mixture modelling: a method for unraveling subpopulation structures and dynamics.

PLoS Comput Biol 2014 Jul 3;10(7):e1003686. Epub 2014 Jul 3.

Institute of Computational Biology, Helmholtz Center Munich, Munich, Germany; Division of Mathematical Modeling of Biological Systems, Department of Mathematics, University of Technology Munich, Munich, Germany.

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July 2014

5-Fluorouracil affects assembly of stress granules based on RNA incorporation.

Nucleic Acids Res 2014 Jun 11;42(10):6436-47. Epub 2014 Apr 11.

Otto Warburg Laboratory, Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany

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June 2014

Pain modulators regulate the dynamics of PKA-RII phosphorylation in subgroups of sensory neurons.

J Cell Sci 2014 Jan 4;127(Pt 1):216-29. Epub 2013 Nov 4.

University Hospital Cologne, Department of Anesthesiology and Intensive Care Medicine, Experimental Anesthesiology and Pain Research, Robert Koch Str. 10, 50931 Cologne, Germany.

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January 2014

Wound-healing growth factor, basic FGF, induces Erk1/2-dependent mechanical hyperalgesia.

Pain 2013 Oct 16;154(10):2216-2226. Epub 2013 Jul 16.

Max Planck Institute for Molecular Genetics, Berlin, Germany Institute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany Institute for Systems Theory and Automatic Control, University of Stuttgart, Stuttgart, Germany Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München, Germany Department of Neurology, Yale University School of Medicine, New Haven, CT, USA Center for Neuroscience and Regeneration Research, New Haven, CT, USA Division of Neuroscience, Departments of Medicine and Oral & Maxillofacial Surgery, University of California, San Francisco, CA, USA Klinik für Anästhesiologie und Operative Intensivmedizin, Experimentelle Anästhesiologie und Schmerzforschung, Uniklinik Köln, Köln, Germany.

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October 2013

Ataxin-2-like is a regulator of stress granules and processing bodies.

PLoS One 2012 27;7(11):e50134. Epub 2012 Nov 27.

Otto Warburg Laboratory, Max Planck Institute for Molecular Genetics, Berlin, Germany.

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June 2013

Threshold-free population analysis identifies larger DRG neurons to respond stronger to NGF stimulation.

PLoS One 2012 27;7(3):e34257. Epub 2012 Mar 27.

Max Planck Institute for Molecular Genetics, Berlin, Germany.

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November 2012

Estrogen destabilizes microtubules through an ion-conductivity-independent TRPV1 pathway.

J Neurochem 2011 Jun 13;117(6):995-1008. Epub 2011 May 13.

Department for Molecular Human Genetics, Max Planck Institute for Molecular Genetics, Berlin, Germany.

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June 2011

Impaired left-ventricular cardiac function in male GPR30-deficient mice.

Mol Med Rep 2011 Jan-Feb;4(1):37-40. Epub 2010 Nov 30.

Cardiology Research, Bayer Schering Pharma AG, 42096 Wuppertal, Germany.

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August 2011

Quantitative automated microscopy (QuAM) elucidates growth factor specific signalling in pain sensitization.

Mol Pain 2010 Dec 27;6:98. Epub 2010 Dec 27.

Department for Molecular Human Genetics, Max Planck Institute for Molecular Genetics, Ihnestrasse 73, Berlin, Germany.

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December 2010

Importance of non-selective cation channel TRPV4 interaction with cytoskeleton and their reciprocal regulations in cultured cells.

PLoS One 2010 Jul 19;5(7):e11654. Epub 2010 Jul 19.

Signal Transduction in Pain and Mental Retardation, Department for Molecular Human Genetics Max Planck Institute for Molecular Genetics, Berlin, Germany.

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July 2010

TRPV1 acts as a synaptic protein and regulates vesicle recycling.

J Cell Sci 2010 Jun 18;123(Pt 12):2045-57. Epub 2010 May 18.

Signal Transduction in Pain and Mental Retardation, Department for Molecular Human Genetics, Max-Planck Institute for Molecular Genetics, Berlin, Germany.

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June 2010

Novel aspects of the submembraneous microtubule cytoskeleton.

FEBS J 2008 Oct 27;275(19):4653. Epub 2008 Aug 27.

Max Planck Institute for Molecular Genetics, Berlin, Germany.

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October 2008

Submembraneous microtubule cytoskeleton: biochemical and functional interplay of TRP channels with the cytoskeleton.

FEBS J 2008 Oct 27;275(19):4684-99. Epub 2008 Aug 27.

Department for Molecular Human Genetics, Max Planck Institute for Molecular Genetics, Berlin, Germany.

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October 2008

GPR30 estrogen receptor agonists induce mechanical hyperalgesia in the rat.

Eur J Neurosci 2008 Apr 26;27(7):1700-9. Epub 2008 Mar 26.

Department for Molecular Human Genetics, Max Planck Institute for Molecular Genetics, Ihnestrasse 73, 14195 Berlin, Germany.

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April 2008

Signaling pathways in sensitization: toward a nociceptor cell biology.

Neuron 2007 Aug;55(3):365-76

Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany.

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August 2007

Identification and characterisation of novel tubulin-binding motifs located within the C-terminus of TRPV1.

J Neurochem 2007 Apr 9;101(1):250-62. Epub 2007 Feb 9.

Freie Universität Berlin, Institut für Chemie und Biochemie, Berlin, Germany.

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April 2007

Estrogen controls PKCepsilon-dependent mechanical hyperalgesia through direct action on nociceptive neurons.

Eur J Neurosci 2006 Jul 12;24(2):527-34. Epub 2006 Jul 12.

NIH Pain Center, UCSF, University of California, San Francisco, 521 Parnassus Avenue, PO-Box 0440, 94143, USA.

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July 2006

Epac mediates a cAMP-to-PKC signaling in inflammatory pain: an isolectin B4(+) neuron-specific mechanism.

J Neurosci 2005 Jun;25(26):6119-26

National Institutes of Health Pain Center, University of California, San Francisco, San Francisco, California 94143, USA.

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June 2005

Primary afferent second messenger cascades interact with specific integrin subunits in producing inflammatory hyperalgesia.

Pain 2005 May;115(1-2):191-203

Department of Medicine, Division of Neuroscience and Biomedical Sciences Program, NIH Pain Center (UCSF), University of California at San Francisco, Campus Box 0440, Room C-555 521, San Francisco, CA 94143-0440, USA.

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May 2005