Tim Hucho

Tim Hucho

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Tim Hucho

Tim Hucho

Publications by authors named "Tim Hucho"

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35Publications

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Dual Inhibition of GLUT1 and the ATR/CHK1 Kinase Axis Displays Synergistic Cytotoxicity in -Mutant Cancer Cells.

Cancer Res 2019 Oct 12;79(19):4855-4868. Epub 2019 Aug 12.

Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Dusseldorf, Center for Molecular Medicine Cologne, CECAD, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1158/0008-5472.CAN-18-3959DOI Listing
October 2019

High-Content Imaging of Immunofluorescently Labeled TRPV1-Positive Sensory Neurons.

Methods Mol Biol 2019 ;1987:111-124

Experimental Anesthesiology and Pain Research, Department of Anesthesiology and Intensive Care Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1007/978-1-4939-9446-5_8DOI Listing
January 2019

The Cdkn1a Mouse as a Tool to Study p53-Mediated Tumor Suppression.

Cell Rep 2018 10;25(4):1027-1039.e6

Department I of Internal Medicine, University Hospital Cologne, Weyertal 115b, 50931 Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Joseph Stelzmann Straße 26, 50931 Cologne, Germany; Center for Molecular Medicine, University Hospital Cologne, Robert Koch Straße 21, 50931 Cologne. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247183153
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http://dx.doi.org/10.1016/j.celrep.2018.09.079DOI Listing
October 2018

PKA-RII subunit phosphorylation precedes activation by cAMP and regulates activity termination.

J Cell Biol 2018 06 3;217(6):2167-2184. Epub 2018 Apr 3.

Department of Anesthesiology and Intensive Care Medicine, Experimental Anesthesiology and Pain Research, University Hospital of Cologne, Cologne, Germany

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http://dx.doi.org/10.1083/jcb.201708053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987717PMC
June 2018

A Hierarchical, Data-Driven Approach to Modeling Single-Cell Populations Predicts Latent Causes of Cell-To-Cell Variability.

Cell Syst 2018 05 2;6(5):593-603.e13. Epub 2018 May 2.

Helmholtz Zentrum München-German Research Center for Environmental Health, Institute of Computational Biology, 85764 Neuherberg, Germany; Technische Universität München, Center for Mathematics, Chair of Mathematical Modeling of Biological Systems, 85748 Garching, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cels.2018.04.008DOI Listing
May 2018

Crosstalk from cAMP to ERK1/2 emerges during postnatal maturation of nociceptive neurons and is maintained during aging.

J Cell Sci 2017 Jul 17;130(13):2134-2146. Epub 2017 May 17.

Department of Anesthesiology and Intensive Care Medicine, Experimental Anesthesiology and Pain Research, University Hospital of Cologne, Robert Koch Str. 10, Cologne D-50931, Germany

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http://dx.doi.org/10.1242/jcs.197327DOI Listing
July 2017

The bromodomain protein BRD4 regulates splicing during heat shock.

Nucleic Acids Res 2017 Jan 17;45(1):382-394. Epub 2016 Aug 17.

Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Ihnestr.63-73, 14195 Berlin, Germany

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http://dx.doi.org/10.1093/nar/gkw729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224492PMC
January 2017

Synergistic regulation of serotonin and opioid signaling contributes to pain insensitivity in Nav1.7 knockout mice.

Sci Signal 2017 01 10;10(461). Epub 2017 Jan 10.

Department of Anesthesiology and Intensive Care Medicine, Experimental Anesthesiology and Pain Research, University Hospital of Cologne, Robert Koch Str. 10, 50931 Cologne, Germany.

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http://stke.sciencemag.org/lookup/doi/10.1126/scisignal.aah4
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http://dx.doi.org/10.1126/scisignal.aah4874DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6711404PMC
January 2017

Subgroup-elimination transcriptomics identifies signaling proteins that define subclasses of TRPV1-positive neurons and a novel paracrine circuit.

PLoS One 2014 31;9(12):e115731. Epub 2014 Dec 31.

Department of Anesthesiology and Intensive Care Medicine, Experimental Anesthesiology and Pain Research, University Hospital of Cologne, Cologne, Germany; Department for Human Molecular Genetics, Max Planck Institute for Molecular Genetics, Berlin, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0115731PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281118PMC
October 2015

ODE constrained mixture modelling: a method for unraveling subpopulation structures and dynamics.

PLoS Comput Biol 2014 Jul 3;10(7):e1003686. Epub 2014 Jul 3.

Institute of Computational Biology, Helmholtz Center Munich, Munich, Germany; Division of Mathematical Modeling of Biological Systems, Department of Mathematics, University of Technology Munich, Munich, Germany.

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http://dx.doi.org/10.1371/journal.pcbi.1003686DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081021PMC
July 2014

5-Fluorouracil affects assembly of stress granules based on RNA incorporation.

Nucleic Acids Res 2014 Jun 11;42(10):6436-47. Epub 2014 Apr 11.

Otto Warburg Laboratory, Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany

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http://dx.doi.org/10.1093/nar/gku264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041438PMC
June 2014

Pain modulators regulate the dynamics of PKA-RII phosphorylation in subgroups of sensory neurons.

J Cell Sci 2014 Jan 4;127(Pt 1):216-29. Epub 2013 Nov 4.

University Hospital Cologne, Department of Anesthesiology and Intensive Care Medicine, Experimental Anesthesiology and Pain Research, Robert Koch Str. 10, 50931 Cologne, Germany.

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http://dx.doi.org/10.1242/jcs.136580DOI Listing
January 2014

Wound-healing growth factor, basic FGF, induces Erk1/2-dependent mechanical hyperalgesia.

Pain 2013 Oct 16;154(10):2216-26. Epub 2013 Jul 16.

Max Planck Institute for Molecular Genetics, Berlin, Germany; Institute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany.

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http://dx.doi.org/10.1016/j.pain.2013.07.005DOI Listing
October 2013

Ataxin-2-like is a regulator of stress granules and processing bodies.

PLoS One 2012 27;7(11):e50134. Epub 2012 Nov 27.

Otto Warburg Laboratory, Max Planck Institute for Molecular Genetics, Berlin, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0050134PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507954PMC
June 2013

Impaired left-ventricular cardiac function in male GPR30-deficient mice.

Mol Med Rep 2011 Jan-Feb;4(1):37-40. Epub 2010 Nov 30.

Cardiology Research, Bayer Schering Pharma AG, 42096 Wuppertal, Germany.

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http://dx.doi.org/10.3892/mmr.2010.402DOI Listing
August 2011

Estrogen destabilizes microtubules through an ion-conductivity-independent TRPV1 pathway.

J Neurochem 2011 Jun 13;117(6):995-1008. Epub 2011 May 13.

Department for Molecular Human Genetics, Max Planck Institute for Molecular Genetics, Berlin, Germany.

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http://dx.doi.org/10.1111/j.1471-4159.2011.07270.xDOI Listing
June 2011

Quantitative automated microscopy (QuAM) elucidates growth factor specific signalling in pain sensitization.

Mol Pain 2010 Dec 27;6:98. Epub 2010 Dec 27.

Department for Molecular Human Genetics, Max Planck Institute for Molecular Genetics, Ihnestrasse 73, Berlin, Germany.

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http://dx.doi.org/10.1186/1744-8069-6-98DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023724PMC
December 2010

Importance of non-selective cation channel TRPV4 interaction with cytoskeleton and their reciprocal regulations in cultured cells.

PLoS One 2010 Jul 19;5(7):e11654. Epub 2010 Jul 19.

Signal Transduction in Pain and Mental Retardation, Department for Molecular Human Genetics Max Planck Institute for Molecular Genetics, Berlin, Germany.

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http://home.niser.ac.in/~chandan/files/2010-1.pdf
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http://dx.plos.org/10.1371/journal.pone.0011654
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0011654PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2906515PMC
July 2010

TRPV1 acts as a synaptic protein and regulates vesicle recycling.

J Cell Sci 2010 Jun 18;123(Pt 12):2045-57. Epub 2010 May 18.

Signal Transduction in Pain and Mental Retardation, Department for Molecular Human Genetics, Max-Planck Institute for Molecular Genetics, Berlin, Germany.

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http://dx.doi.org/10.1242/jcs.065144DOI Listing
June 2010

Submembraneous microtubule cytoskeleton: biochemical and functional interplay of TRP channels with the cytoskeleton.

FEBS J 2008 Oct 27;275(19):4684-99. Epub 2008 Aug 27.

Department for Molecular Human Genetics, Max Planck Institute for Molecular Genetics, Berlin, Germany.

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http://dx.doi.org/10.1111/j.1742-4658.2008.06617.xDOI Listing
October 2008

Novel aspects of the submembraneous microtubule cytoskeleton.

FEBS J 2008 Oct 27;275(19):4653. Epub 2008 Aug 27.

Max Planck Institute for Molecular Genetics, Berlin, Germany.

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http://dx.doi.org/10.1111/j.1742-4658.2008.06613.xDOI Listing
October 2008

GPR30 estrogen receptor agonists induce mechanical hyperalgesia in the rat.

Eur J Neurosci 2008 Apr 26;27(7):1700-9. Epub 2008 Mar 26.

Department for Molecular Human Genetics, Max Planck Institute for Molecular Genetics, Ihnestrasse 73, 14195 Berlin, Germany.

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http://dx.doi.org/10.1111/j.1460-9568.2008.06131.xDOI Listing
April 2008

Signaling pathways in sensitization: toward a nociceptor cell biology.

Neuron 2007 Aug;55(3):365-76

Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany.

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http://dx.doi.org/10.1016/j.neuron.2007.07.008DOI Listing
August 2007

Identification and characterisation of novel tubulin-binding motifs located within the C-terminus of TRPV1.

J Neurochem 2007 Apr 9;101(1):250-62. Epub 2007 Feb 9.

Freie Universität Berlin, Institut für Chemie und Biochemie, Berlin, Germany.

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http://dx.doi.org/10.1111/j.1471-4159.2006.04338.xDOI Listing
April 2007

Estrogen controls PKCepsilon-dependent mechanical hyperalgesia through direct action on nociceptive neurons.

Eur J Neurosci 2006 Jul 12;24(2):527-34. Epub 2006 Jul 12.

NIH Pain Center, UCSF, University of California, San Francisco, 521 Parnassus Avenue, PO-Box 0440, 94143, USA.

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http://dx.doi.org/10.1111/j.1460-9568.2006.04913.xDOI Listing
July 2006

Epac mediates a cAMP-to-PKC signaling in inflammatory pain: an isolectin B4(+) neuron-specific mechanism.

J Neurosci 2005 Jun;25(26):6119-26

National Institutes of Health Pain Center, University of California, San Francisco, San Francisco, California 94143, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.0285-05.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6725047PMC
June 2005

Primary afferent second messenger cascades interact with specific integrin subunits in producing inflammatory hyperalgesia.

Pain 2005 May;115(1-2):191-203

Department of Medicine, Division of Neuroscience and Biomedical Sciences Program, NIH Pain Center (UCSF), University of California at San Francisco, Campus Box 0440, Room C-555 521, San Francisco, CA 94143-0440, USA.

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http://dx.doi.org/10.1016/j.pain.2005.02.028DOI Listing
May 2005

Regulation, cellular localization, and function of the p75 neurotrophin receptor (p75NTR) during the regeneration of facial motoneurons.

Mol Cell Neurosci 2003 Oct;24(2):307-22

Department of Neuromorphology, Max-Planck-Institute of Neurobiology, D-82152 Martinsried, Germany.

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October 2003