Tim Holland-Letz

Tim Holland-Letz

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Tim Holland-Letz

Tim Holland-Letz

Publications by authors named "Tim Holland-Letz"

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Ga-PSMA-11 PET/CT in patients with recurrent prostate cancer-a modified protocol compared with the common protocol.

Eur J Nucl Med Mol Imaging 2019 Nov 1. Epub 2019 Nov 1.

Department of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

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http://dx.doi.org/10.1007/s00259-019-04548-5DOI Listing
November 2019

Author Correction: The challenge of mapping the human connectome based on diffusion tractography.

Nat Commun 2019 Nov 4;10(1):5059. Epub 2019 Nov 4.

Sherbrooke Connectivity Imaging Lab (SCIL), Université de Sherbrooke, Sherbrooke, QC, J1K 0A5 QC, Canada.

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http://dx.doi.org/10.1038/s41467-019-12867-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6828749PMC
November 2019

Modeling dose-response functions for combination treatments with log-logistic or Weibull functions.

Arch Toxicol 2019 Nov 30. Epub 2019 Nov 30.

German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00204-019-02631-2DOI Listing
November 2019

Parametric modeling and optimal experimental designs for estimating isobolograms for drug interactions in toxicology.

J Biopharm Stat 2018 27;28(4):763-777. Epub 2017 Nov 27.

a Division of Biostatistics , German Cancer Research Center , Heidelberg , Germany.

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http://dx.doi.org/10.1080/10543406.2017.1397005DOI Listing
October 2019

Superior skin cancer classification by the combination of human and artificial intelligence.

Eur J Cancer 2019 Oct 10;120:114-121. Epub 2019 Sep 10.

National Center for Tumor Diseases, German Cancer Research Center, Heidelberg, Germany; Department of Dermatology, University Hospital Heidelberg, Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2019.07.019DOI Listing
October 2019

Deep neural networks are superior to dermatologists in melanoma image classification.

Eur J Cancer 2019 Sep 8;119:11-17. Epub 2019 Aug 8.

Department of Dermatology, Heidelberg University, Mannheim, Germany; Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.ejca.2019.05.023DOI Listing
September 2019

Pathologist-level classification of histopathological melanoma images with deep neural networks.

Eur J Cancer 2019 Jul 23;115:79-83. Epub 2019 May 23.

National Center for Tumor Diseases, German Cancer Research Center, Heidelberg, Germany; Department of Dermatology, University Hospital Heidelberg, Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2019.04.021DOI Listing
July 2019

Deep learning outperformed 136 of 157 dermatologists in a head-to-head dermoscopic melanoma image classification task.

Eur J Cancer 2019 May 10;113:47-54. Epub 2019 Apr 10.

National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 460, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.ejca.2019.04.001DOI Listing
May 2019

Role of CT Density in PET/CT-Based Assessment of Lymphoma.

Mol Imaging Biol 2018 08;20(4):641-649

Department of Nuclear Medicine, University Hospital Heidelberg, INF 400, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s11307-017-1155-xDOI Listing
August 2018

Tracer uptake in mediastinal and paraaortal thoracic lymph nodes as a potential pitfall in image interpretation of PSMA ligand PET/CT.

Eur J Nucl Med Mol Imaging 2018 07 1;45(7):1179-1187. Epub 2018 Mar 1.

Department of Nuclear Medicine, Heidelberg University Hospital, INF 400, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00259-018-3965-8DOI Listing
July 2018

Mapping Active Gene-Regulatory Regions in Human Repopulating Long-Term HSCs.

Cell Stem Cell 2018 Jul;23(1):132-146.e9

Department of Translational and Functional Cancer Genomics, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Translational Medical Oncology, NCT-Dresden, University Hospital, Carl Gustav Carus, Technische Universität Dresden, Dresden and DKFZ, Heidelberg, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2018.06.003DOI Listing
July 2018

Circulating free DNA integrity and concentration as independent prognostic markers in metastatic breast cancer.

Breast Cancer Res Treat 2018 May 16;169(1):69-82. Epub 2018 Jan 16.

Division of Molecular Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1007/s10549-018-4666-5DOI Listing
May 2018

Liquid Profiling of Circulating Tumor DNA in Plasma of Melanoma Patients for Companion Diagnostics and Monitoring of BRAF Inhibitor Therapy.

Clin Chem 2018 05 26;64(5):830-842. Epub 2018 Feb 26.

Department of Clinical Chemistry, University Medical Centre, Ruprecht-Karls University of Heidelberg, Mannheim, Germany;

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http://dx.doi.org/10.1373/clinchem.2017.281543DOI Listing
May 2018

Evaluation of Promoter Methylation of RASSF1A and ATM in Peripheral Blood of Breast Cancer Patients and Healthy Control Individuals.

Int J Mol Sci 2018 Mar 19;19(3). Epub 2018 Mar 19.

Molecular Biology of Breast Cancer, Department of Gynecology and Obstetrics, University of Heidelberg, Heidelberg 69120, Germany.

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http://dx.doi.org/10.3390/ijms19030900DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877761PMC
March 2018

The challenge of mapping the human connectome based on diffusion tractography.

Nat Commun 2017 11 7;8(1):1349. Epub 2017 Nov 7.

Sherbrooke Connectivity Imaging Lab (SCIL), Université de Sherbrooke, Sherbrooke, QC J1K 0A5, QC, Canada.

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http://dx.doi.org/10.1038/s41467-017-01285-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5677006PMC
November 2017

Highly efficient destruction of squamous carcinoma cells of the head and neck by photochemical internalization of Ranpirnase.

J Exp Ther Oncol 2017 Nov;12(2):113-120

Department of Medical Oncology, National Center for Tumor Diseases, Heidelberg University Hospital, Im Neuenheimer Feld 460, 69120 Heidelberg, Germany.

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November 2017

Combining standard clinical blood values for improving survival prediction in patients with newly diagnosed brain metastases-development and validation of the LabBM score.

Neuro Oncol 2017 Sep;19(9):1255-1262

Department of Medicine I, Medical University of Vienna, Vienna, Austria; Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria; Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland; Biostatistics Division, German Cancer Research Center, Heidelberg, Germany; Department of Neurosurgery, Medical University of Vienna, Vienna, Austria; Department of Radiotherapy, Medical University of Vienna, Vienna, Austria; Department of Pathology, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1093/neuonc/now290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570252PMC
September 2017

Asymmetric Centriole Numbers at Spindle Poles Cause Chromosome Missegregation in Cancer.

Cell Rep 2017 Aug;20(8):1906-1920

Clinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center (DKFZ) and Department of Internal Medicine V, University of Heidelberg, 69120 Heidelberg, Germany; Department of Internal Medicine V, University of Heidelberg, 69120 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.08.005DOI Listing
August 2017

Dissecting and modeling the emergent murine TEC compartment during ontogeny.

Eur J Immunol 2017 07 22;47(7):1153-1159. Epub 2017 May 22.

Division of Developmental Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://doi.wiley.com/10.1002/eji.201747006
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http://dx.doi.org/10.1002/eji.201747006DOI Listing
July 2017

Repeated PSMA-targeting radioligand therapy of metastatic prostate cancer with I-MIP-1095.

Eur J Nucl Med Mol Imaging 2017 Jun 9;44(6):950-959. Epub 2017 Mar 9.

Department of Nuclear Medicine, Heidelberg University Hospital, INF 400, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00259-017-3665-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397661PMC
June 2017

The Clinical Impact of Additional Late PET/CT Imaging with Ga-PSMA-11 (HBED-CC) in the Diagnosis of Prostate Cancer.

J Nucl Med 2017 May 6;58(5):750-755. Epub 2017 Jan 6.

Department of Nuclear Medicine, Heidelberg University Hospital, Heidelberg, Germany.

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http://dx.doi.org/10.2967/jnumed.116.183483DOI Listing
May 2017

On the combination of c- and D-optimal designs: General approaches and applications in dose-response studies.

Authors:
Tim Holland-Letz

Biometrics 2017 03 24;73(1):206-213. Epub 2016 May 24.

German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1111/biom.12545DOI Listing
March 2017

Correlation Between SUVmax and CT Radiomic Analysis Using Lymph Node Density in PET/CT-Based Lymph Node Staging.

J Nucl Med 2017 Feb 22;58(2):282-287. Epub 2016 Sep 22.

Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany

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http://dx.doi.org/10.2967/jnumed.116.179648DOI Listing
February 2017

miR-339-3p Is a Tumor Suppressor in Melanoma.

Cancer Res 2016 06 15;76(12):3562-71. Epub 2016 Apr 15.

GMP and T-Cell Therapy Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-2932DOI Listing
June 2016

Myeloid Cells and Related Chronic Inflammatory Factors as Novel Predictive Markers in Melanoma Treatment with Ipilimumab.

Clin Cancer Res 2015 Dec 19;21(24):5453-9. Epub 2015 Aug 19.

Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg and Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-0676DOI Listing
December 2015

Optimal experimental designs for dose-response studies with continuous endpoints.

Arch Toxicol 2015 Nov 26;89(11):2059-68. Epub 2014 Aug 26.

Biostatistics Division, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00204-014-1335-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655015PMC
November 2015

Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells.

Nature 2015 Apr 18;520(7548):549-52. Epub 2015 Feb 18.

1] Heidelberg Institute for Stem Cell Technology and Experimental Medicine gGmbH (HI-STEM), 69120 Heidelberg, Germany [2] Deutsches Krebsforschungszentrum (DKFZ), Division of Stem Cells and Cancer, Experimental Hematology Group, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1038/nature14131DOI Listing
April 2015

Fundamental properties of unperturbed haematopoiesis from stem cells in vivo.

Nature 2015 Feb 11;518(7540):542-6. Epub 2015 Feb 11.

Division of Cellular Immunology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1038/nature14242DOI Listing
February 2015

Co-expression of MET and CD47 is a novel prognosticator for survival of luminal breast cancer patients.

Oncotarget 2014 Sep;5(18):8147-60

Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany. Divison of Stem Cells and Cancer, Deutsches Krebsforschungszentrum (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany. German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226673PMC
http://dx.doi.org/10.18632/oncotarget.2385DOI Listing
September 2014

True four-dimensional analysis of thoracic aortic displacement and distension using model-based segmentation of computed tomography angiography.

Int J Cardiovasc Imaging 2014 Jan 18;30(1):185-94. Epub 2013 Oct 18.

Diagnostic and Interventional Radiology, University Medical Center Heidelberg, INF 110, 69120, Heidelberg, Germany,

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http://dx.doi.org/10.1007/s10554-013-0307-6DOI Listing
January 2014

ATRX loss refines the classification of anaplastic gliomas and identifies a subgroup of IDH mutant astrocytic tumors with better prognosis.

Acta Neuropathol 2013 Sep 1;126(3):443-51. Epub 2013 Aug 1.

Department of Neurooncology, Neurology Clinic and National Center for Tumor Disease, University of Heidelberg and German Cancer Research Center, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00401-013-1156-zDOI Listing
September 2013

Efficient algorithms for optimal designs with correlated observations in pharmacokinetics and dose-finding studies.

Biometrics 2012 Mar 12;68(1):138-45. Epub 2011 Aug 12.

Ruhr-Universität Bochum, Medizinische Fakultät, Bochum, Germany.

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http://dx.doi.org/10.1111/j.1541-0420.2011.01657.xDOI Listing
March 2012

Multidetector-CT angiography in pulmonary embolism-can image parameters predict clinical outcome?

Eur Radiol 2011 Sep 11;21(9):1928-37. Epub 2011 Apr 11.

Institute of Diagnostic Radiology, Interventional Radiology and Nuclear Medicine, Berufsgenossenschaftliches Universitaetsklinikum Bergmannsheil GmbH, Ruhr-University of Bochum, Buerkle-de-la-Camp Platz 1, 44789 Bochum, Germany.

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http://dx.doi.org/10.1007/s00330-011-2125-3DOI Listing
September 2011

A geometric characterization of optimal designs for regression models with correlated observations.

J R Stat Soc Series B Stat Methodol 2011 Mar;73(2):239-252

Ruhr-Universität Bochum, Medizinische Fakultät, 44780 Bochum, Germany.

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http://dx.doi.org/10.1111/j.1467-9868.2010.00757.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3106301PMC
March 2011

Association of nucleated red blood cells in blood and arterial oxygen partial tension.

Clin Chem Lab Med 2011 Feb 1;49(2):257-63. Epub 2010 Dec 1.

Institute of Clinical Chemistry, Transfusion and Laboratory Medicine, BG-University Hospital Bergmannsheil, Ruhr-University Bochum, Bochum, Germany.

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http://dx.doi.org/10.1515/CCLM.2011.041DOI Listing
February 2011

Outcome of the Norwood operation in patients with hypoplastic left heart syndrome: a 12-year single-center survey.

J Thorac Cardiovasc Surg 2010 Feb 30;139(2):359-65. Epub 2009 Oct 30.

Department of Pediatric Cardiology, University Hospital of Schleswig-Holstein, Campus Kiel, Kiel, Germany.

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http://dx.doi.org/10.1016/j.jtcvs.2009.07.063DOI Listing
February 2010

Adenosine-induced maximal coronary hyperemia for myocardial fractional flow reserve measurements: comparison of administration by femoral venous versus antecubital venous access.

Clin Res Cardiol 2009 Nov 15;98(11):717-23. Epub 2009 Aug 15.

Medizinische Klinik II, Universitätsklinik Bergmannsheil, Ruhr-Universität Bochum, 44789 Bochum, Germany.

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http://dx.doi.org/10.1007/s00392-009-0056-7DOI Listing
November 2009

Diagnostic value of hyperbilirubinemia as a predictive factor for appendiceal perforation in acute appendicitis.

Am J Surg 2009 Aug 23;198(2):193-8. Epub 2009 Mar 23.

Department of General and Visceral Surgery, Augusta Krankenanstalt, Academic Teaching Hospital of the Ruhr University, Bochum, Bergstr. 26, 44791, Bochum, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S000296100900010
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http://dx.doi.org/10.1016/j.amjsurg.2008.08.026DOI Listing
August 2009

High-dose cholecalciferol to correct vitamin D deficiency in haemodialysis patients.

Nephrol Dial Transplant 2008 Dec 1;23(12):4016-20. Epub 2008 Jul 1.

Department of Nephrology, Marienhospital Herne, Ruhr University, Bochum, Germany.

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http://dx.doi.org/10.1093/ndt/gfn367DOI Listing
December 2008

The CYP2J2 G-50T polymorphism and myocardial infarction in patients with cardiovascular risk profile.

BMC Cardiovasc Disord 2008 Dec 23;8:41. Epub 2008 Dec 23.

Department of Cardiology, St, Josef Hospital/Bergmannsheil, Ruhr-University, Bochum, Germany.

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http://dx.doi.org/10.1186/1471-2261-8-41DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2626571PMC
December 2008

A laboratory-based risk score for medical intensive care patients.

Clin Chem Lab Med 2008 ;46(6):855-62

Institute of Clinical Chemistry, Transfusion and Laboratory Medicine, BG-University Hospital Bergmannsheil, Ruhr-University, Bochum, Germany.

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http://dx.doi.org/10.1515/CCLM.2008.136DOI Listing
September 2008

Re-evaluation of established risk scores by measurement of nucleated red blood cells in blood of surgical intensive care patients.

J Trauma 2008 Sep;65(3):666-73

Institute of Clinical Chemistry, Transfusion and Laboratory Medicine, BG-University Hospital Bergmannsheil, Ruhr-University Bochum, Germany.

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http://dx.doi.org/10.1097/TA.0b013e318181e524DOI Listing
September 2008

CT angiography in suspected pulmonary embolism: impact of patient characteristics and different venous lines on vessel enhancement and image quality.

AJR Am J Roentgenol 2008 Jun;190(6):W351-9

Department of Interventional Radiology, Institute of Diagnostic Radiology, BG Clinics Bergmannsheil, Ruhr-University of Bochum, Buerkle-de-la-Camp Platz 1, D-44789 Bochum, Germany.

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http://dx.doi.org/10.2214/AJR.07.3402DOI Listing
June 2008

Nucleated red blood cells in the blood of medical intensive care patients indicate increased mortality risk: a prospective cohort study.

Crit Care 2007 ;11(3):R62

Institute of Clinical Chemistry, Transfusion and Laboratory Medicine, BG-University Hospital Bergmannsheil, Buerkle de la Camp-Platz 1, Ruhr-University Bochum, 44789 Bochum, Germany.

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http://dx.doi.org/10.1186/cc5932DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2206423PMC
March 2008

Single-center experience with the On-X prosthetic heart valve between 1996 and 2005.

J Heart Valve Dis 2007 Sep;16(5):551-7

Department of Cardiothoracic Surgery, BG Universitätsklinikum Bergmannsheil, University of Bochum, Bochum, Germany.

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September 2007

Clinical index-score and the ALMA study.

Arb Paul Ehrlich Inst Bundesamt Sera Impfstoffe Frankf A M 2006 (95):159-65; discussion 165-6

Exp. Pneumologie, Universitätsklinik Bergmannsheil, BGFA, Bochum.

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April 2007

Electrical ear acupuncture reduces histamine-induced itch (alloknesis).

Acta Derm Venereol 2006 ;86(5):399-403

Department of Oral and Maxillofacial Plastic Surgery, Ruhr-University of Bochum, Knappschaftskramkenhaus Bochum-Langendreer, In der Schornau 23-25, D-44892 Bochum, Germany.

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http://dx.doi.org/10.2340/00015555-0115DOI Listing
November 2006

Poor prognosis indicated by nucleated red blood cells in peripheral blood is not associated with organ failure of the liver or kidney.

Clin Chem Lab Med 2006 ;44(8):955-61

Institute of Clinical Chemistry, Transfusion and Laboratory Medicine, BG-University Hospital Bergmannsheil, Bochum, Germany.

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http://dx.doi.org/10.1515/CCLM.2006.183DOI Listing
October 2006

A new efficient trial design for assessing reliability of ankle-brachial index measures by three different observer groups.

BMC Cardiovasc Disord 2006 Jul 27;6:33. Epub 2006 Jul 27.

Department of Medical Informatics, Biometry and Epidemiology, Ruhr-University, Bochum, D-44801 Bochum, Germany.

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http://dx.doi.org/10.1186/1471-2261-6-33DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1560394PMC
July 2006

Daily monitoring of nucleated red blood cells in the blood of surgical intensive care patients.

Clin Chim Acta 2006 Apr 4;366(1-2):329-35. Epub 2006 Jan 4.

Institute of Clinical Chemistry, Transfusion and Laboratory Medicine, BG-University Hospital Bergmannsheil, Ruhr-University, Buerkle-de-la-Camp-Platz 1, D-44789 Bochum, Germany.

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http://dx.doi.org/10.1016/j.cca.2005.11.022DOI Listing
April 2006

Association between nucleated red blood cells in blood and the levels of erythropoietin, interleukin 3, interleukin 6, and interleukin 12p70.

Shock 2005 Jul;24(1):34-9

Institute of Clinical Chemistry, Transfusion, and Laboratory Medicine, BG-University Hospital Bergmannsheil, Ruhr-University, D-44789 Bochum, Germany.

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http://dx.doi.org/10.1097/01.shk.0000164693.11649.91DOI Listing
July 2005

Comparison of subtraction arthrography, radionuclide arthrography and conventional plain radiography to assess loosening of total knee arthroplasty.

Biomed Tech (Berl) 2005 May;50(5):143-7

Department of Orthopaedic Surgery, University of Duisburg-Essen, 45122 Essen, Germany.

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http://dx.doi.org/10.1515/BMT.2005.021DOI Listing
May 2005

High in-hospital mortality of intensive care patients with nucleated red blood cells in blood.

Clin Chem Lab Med 2004 ;42(8):933-8

Institute of Clinical Chemistry, Transfusion and Laboratory Medicine, BG-University Hospital Bergmannsheil, Ruhr-University Bochum, Germany.

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http://dx.doi.org/10.1515/CCLM.2004.151DOI Listing
February 2005

Cytokines and erythropoietin in the blood of patients with erythroblastemia.

Acta Haematol 2003 ;110(4):204-6

Institute of Clinical Chemistry, Transfusion and Laboratory Medicine, Ruhr University, Bochum, Germany.

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http://dx.doi.org/10.1159/000074228DOI Listing
January 2004