Tim Demuth

Tim Demuth

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Tim Demuth

Tim Demuth

Publications by authors named "Tim Demuth"

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Phase I Study Evaluating WEE1 Inhibitor AZD1775 As Monotherapy and in Combination With Gemcitabine, Cisplatin, or Carboplatin in Patients With Advanced Solid Tumors.

J Clin Oncol 2016 12 31;34(36):4371-4380. Epub 2016 Oct 31.

Suzanne Leijen, Robin M.J.M. van Geel, and Jan H.M. Schellens, The Netherlands Cancer Institute, Amsterdam; Jan H.M. Schellens, Utrecht University, Utrecht, the Netherlands; Anna C. Pavlick, New York University Medical Center, New York, NY; Lee Rosen, University of California Los Angeles, Santa Monica, CA; Raymond Lam, Shelonitda Rose, Mark A. Lee, Tomoko Freshwater, and Stuart Shumway, Merck, Kenilworth, NJ; Geoffrey I. Shapiro, Dana-Farber Cancer Institute, Boston, MA; Albiruni R. Abdul Razak and Amit M. Oza, Princess Margaret Hospital, Toronto, Ontario, Canada; Raoul Tibes, University Hospital of Würzburg, Würzburg; Tim Demuth, Sandoz AG, Holzkirchen, Germany; and Li Wen Liang, Merck Sharp & Dohme R&D, Beijing, China.

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http://dx.doi.org/10.1200/JCO.2016.67.5991DOI Listing
December 2016

Combination therapy using Notch and Akt inhibitors is effective for suppressing invasion but not proliferation in glioma cells.

Neurosci Lett 2013 Feb 20;534:316-21. Epub 2012 Dec 20.

Department of Neurosurgery, The First Bethune Clinical Hospital of Jilin University, 71 Xinmin Avenue, Changchun 130021, People's Republic of China.

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http://dx.doi.org/10.1016/j.neulet.2012.12.008DOI Listing
February 2013

RNAi screening of the kinome with cytarabine in leukemias.

Blood 2012 Mar 20;119(12):2863-72. Epub 2012 Jan 20.

Division of Hematology and Oncology, Mayo Clinic, Scottsdale, AZ 85259, USA.

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http://dx.doi.org/10.1182/blood-2011-07-367557DOI Listing
March 2012

Targeting radiation-induced G(2) checkpoint activation with the Wee-1 inhibitor MK-1775 in glioblastoma cell lines.

Mol Cancer Ther 2011 Dec 12;10(12):2405-14. Epub 2011 Oct 12.

Department of Radiation Oncology and Experimental Therapeutics, H. Lee Moffitt Cancer Center and Research Institute, SRB3, 12902 Magnolia Drive, Tampa, FL 33612, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-11-0469DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753756PMC
December 2011

The phosphorylation of ephrin-B2 ligand promotes glioma cell migration and invasion.

Int J Cancer 2010 Mar;126(5):1155-65

Cancer and Cell Biology Division, The Translational Genomics Research Institute, Phoenix, AZ, USA.

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http://dx.doi.org/10.1002/ijc.24849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2801764PMC
March 2010

Autotaxin: a secreted autocrine/paracrine factor that promotes glioma invasion.

J Neurooncol 2008 Feb 11;86(3):297-309. Epub 2007 Oct 11.

Cancer and Cell Biology Division, Translational Genomics Research Institute, 445 North 5th Street, 5th floor, Phoenix, AZ 85004, USA.

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http://link.springer.com/10.1007/s11060-007-9480-6
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http://dx.doi.org/10.1007/s11060-007-9480-6DOI Listing
February 2008

Autocrine factors that sustain glioma invasion and paracrine biology in the brain microenvironment.

J Natl Cancer Inst 2007 Nov 30;99(21):1583-93. Epub 2007 Oct 30.

Cancer and Cell Biology Division, Translational Genomics Research Institute, 445 North Fifth Street, Phoenix, AZ 85004, USA.

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http://dx.doi.org/10.1093/jnci/djm187DOI Listing
November 2007

Estimating the cell density and invasive radius of three-dimensional glioblastoma tumor spheroids grown in vitro.

Appl Opt 2007 Aug;46(22):5110-8

Department of Mathematics, University of Michigan, 2074 East Hall, 525 Church Street Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1364/ao.46.005110DOI Listing
August 2007

A mathematical model of glioblastoma tumor spheroid invasion in a three-dimensional in vitro experiment.

Biophys J 2007 Jan 13;92(1):356-65. Epub 2006 Oct 13.

Department of Mathematics, University of Michigan, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1529/biophysj.106.093468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1697862PMC
January 2007

Correlating velocity patterns with spatial dynamics in glioma cell migration.

Acta Biotheor 2005 ;53(3):181-90

Complex Biosystems Modeling Laboratory, HST-Biomedical Engineering Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1007/s10441-005-2527-1DOI Listing
April 2006

Molecular mechanisms of glioma cell migration and invasion.

J Neurooncol 2004 Nov;70(2):217-28

TGen, The Translational Genomics Research Institute, Phoenix, Arizona 85004, USA.

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http://link.springer.com/content/pdf/10.1007/s11060-004-2751
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http://www.springerlink.com/index/p557286323526714.pdf
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http://link.springer.com/10.1007/s11060-004-2751-6
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http://dx.doi.org/10.1007/s11060-004-2751-6DOI Listing
November 2004

Migrating glioma cells activate the PI3-K pathway and display decreased susceptibility to apoptosis.

J Cell Sci 2003 Nov 16;116(Pt 21):4409-17. Epub 2003 Sep 16.

The Translational Genomics Research Institute, 400 North 5th Street, Suite 1600, Phoenix, AZ 85004, USA.

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http://jcs.biologists.org/cgi/doi/10.1242/jcs.00712
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http://dx.doi.org/10.1242/jcs.00712DOI Listing
November 2003