Publications by authors named "Tim Clausen"

64Publications

Native Mass Spectrometry Can Effectively Predict PROTAC Efficacy.

ACS Cent Sci 2020 Jul 6;6(7):1223-1230. Epub 2020 Jul 6.

Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Campus-Vienna-Biocenter 1, 1030 Vienna, Austria.

View Article and Find Full Text PDF
July 2020

Activation by substoichiometric inhibition.

Proc Natl Acad Sci U S A 2020 01 6;117(3):1414-1418. Epub 2020 Jan 6.

Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, 45117 Essen, Germany;

View Article and Find Full Text PDF
January 2020

Shaping Striated Muscles with Ubiquitin Proteasome System in Health and Disease.

Trends Mol Med 2019 09 21;25(9):760-774. Epub 2019 Jun 21.

Institut de Pharmacologie et de Biologie Structurale, IPBS, Université de Toulouse, CNRS, UPS, Toulouse, France. Electronic address:

View Article and Find Full Text PDF
September 2019

UFD-2 is an adaptor-assisted E3 ligase targeting unfolded proteins.

Nat Commun 2018 02 2;9(1):484. Epub 2018 Feb 2.

Research Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), Campus-Vienna-Biocenter 1, 1030, Vienna, Austria.

View Article and Find Full Text PDF
February 2018

The crystal structure of Deg9 reveals a novel octameric-type HtrA protease.

Nat Plants 2017 Dec 27;3(12):973-982. Epub 2017 Nov 27.

Photosynthesis Research Center, Key Laboratory of Photobiology, Institute of Botany, Chinese Academy of Sciences, Beijing, China.

View Article and Find Full Text PDF
December 2017

Arginine phosphorylation marks proteins for degradation by a Clp protease.

Nature 2016 11 6;539(7627):48-53. Epub 2016 Oct 6.

Research Institute of Molecular Pathology (IMP), Dr-Bohr-Gasse 7, 1030 Vienna, Austria.

View Article and Find Full Text PDF
November 2016

Structural mechanism for the recognition and ubiquitination of a single nucleosome residue by Rad6-Bre1.

Proc Natl Acad Sci U S A 2016 09 6;113(38):10553-8. Epub 2016 Sep 6.

Max F. Perutz Laboratories, Medical University of Vienna, Vienna Biocenter Campus, 1030 Vienna, Austria;

View Article and Find Full Text PDF
September 2016

Chemical Biology Interrogates Protein Arginine Phosphorylation.

Cell Chem Biol 2016 08;23(8):888-90

Research Institute of Molecular Pathology (IMP), Vienna Biocenter VBC, Dr Bohr-Gasse 7, 1030 Vienna, Austria. Electronic address:

View Article and Find Full Text PDF
August 2016

Determinants of amyloid fibril degradation by the PDZ protease HTRA1.

Nat Chem Biol 2015 Nov 5;11(11):862-9. Epub 2015 Oct 5.

Centre of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany.

View Article and Find Full Text PDF
November 2015

The Nuclear Pore-Associated TREX-2 Complex Employs Mediator to Regulate Gene Expression.

Cell 2015 Aug;162(5):1016-28

Max F. Perutz Laboratories, Medical University of Vienna, Vienna Biocenter Campus (VBC), Dr. Bohr-Gasse 9/3, 1030 Vienna, Austria. Electronic address:

View Article and Find Full Text PDF
August 2015

Versatile in vitro system to study translocation and functional integration of bacterial outer membrane proteins.

Nat Commun 2014 Nov 5;5:5396. Epub 2014 Nov 5.

Institute of Biochemistry and Molecular Biology, Zentrum für Biochemie und Molekulare Zellforschung, University of Freiburg, Freiburg D-79104, Germany.

View Article and Find Full Text PDF
November 2014

Chasing Phosphoarginine Proteins: Development of a Selective Enrichment Method Using a Phosphatase Trap.

Mol Cell Proteomics 2014 08 13;13(8):1953-64. Epub 2014 May 13.

From the ‡Research Institute of Molecular Pathology - IMP, Dr. Bohr-Gasse 7, A-1030 Vienna, Austria;

View Article and Find Full Text PDF
August 2014

RNA specificity and regulation of catalysis in the eukaryotic polynucleotide kinase Clp1.

Mol Cell 2014 Jun 8;54(6):975-86. Epub 2014 May 8.

Department of Biomolecular Mechanisms, Max Planck Institute for Medical Research, Heidelberg 69120, Germany. Electronic address:

View Article and Find Full Text PDF
June 2014

Myosin chaperones.

Curr Opin Struct Biol 2014 Apr 3;25:9-15. Epub 2013 Dec 3.

Research Institute of Molecular Pathology, Dr. Bohrgasse 7, A-1030 Vienna, Austria. Electronic address:

View Article and Find Full Text PDF
April 2014