Tim Becker

Tim Becker

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Tim Becker

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Evaluation of Deep Learning Strategies for Nucleus Segmentation in Fluorescence Images.

Cytometry A 2019 Jul 16. Epub 2019 Jul 16.

Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, Massachusetts.

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http://dx.doi.org/10.1002/cyto.a.23863DOI Listing
July 2019

OCTP: A Tool for On-the-Fly Calculation of Transport Properties of Fluids with the Order- n Algorithm in LAMMPS.

J Chem Inf Model 2019 Apr 21;59(4):1290-1294. Epub 2019 Feb 21.

Engineering Thermodynamics, Process & Energy Department, Faculty of Mechanical, Maritime and Materials Engineering , Delft University of Technology , Leeghwaterstraat 39 , 2628CB Delft , The Netherlands.

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http://dx.doi.org/10.1021/acs.jcim.8b00939DOI Listing
April 2019

Tumstatin fragment selectively inhibits neutrophil infiltration in experimental asthma exacerbation.

Clin Exp Allergy 2018 Nov 28;48(11):1483-1493. Epub 2018 Aug 28.

Division of Pediatric Pneumology and Allergology, University of Lübeck, Lübeck, Germany.

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http://dx.doi.org/10.1111/cea.13236DOI Listing
November 2018

Potential of polarizable force fields for predicting the separation performance of small hydrocarbons in M-MOF-74.

Phys Chem Chem Phys 2018 Nov;20(45):28848-28859

Engineering Thermodynamics, Process & Energy Department, Faculty of Mechanical, Maritime and Materials Engineering, Delft University of Technology, Leeghwaterstraat 39, 2628CB Delft, The Netherlands.

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http://xlink.rsc.org/?DOI=C8CP05750H
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http://dx.doi.org/10.1039/c8cp05750hDOI Listing
November 2018

Polarizable Force Field for CO in M-MOF-74 Derived from Quantum Mechanics.

J Phys Chem C Nanomater Interfaces 2018 Oct 9;122(42):24488-24498. Epub 2018 Oct 9.

Engineering Thermodynamics, Process & Energy Department, Faculty of Mechanical, Maritime and Materials Engineering, Delft University of Technology, Leeghwaterstraat 39, 2628CB Delft, The Netherlands.

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http://dx.doi.org/10.1021/acs.jpcc.8b08639DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369669PMC
October 2018

Finite-Size Effects of Binary Mutual Diffusion Coefficients from Molecular Dynamics.

J Chem Theory Comput 2018 May 30;14(5):2667-2677. Epub 2018 Apr 30.

Engineering Thermodynamics, Process & Energy Department, Faculty of Mechanical, Maritime and Materials Engineering , Delft University of Technology , Leeghwaterstraat 39 , 2628CB Delft , The Netherlands.

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http://dx.doi.org/10.1021/acs.jctc.8b00170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943679PMC
May 2018

Absorption Refrigeration Cycles with Ammonia-Ionic Liquid Working Pairs Studied by Molecular Simulation.

Ind Eng Chem Res 2018 Apr 29;57(15):5442-5452. Epub 2018 Mar 29.

Engineering Thermodynamics, Process & Energy Department, Faculty of Mechanical, Maritime and Materials Engineering, Delft University of Technology, Leeghwaterstraat 39, 2628CB Delft, The Netherlands.

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http://dx.doi.org/10.1021/acs.iecr.8b00442DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937689PMC
April 2018

Tumstatin regulates the angiogenic and inflammatory potential of airway smooth muscle extracellular matrix.

J Cell Mol Med 2017 Dec 13;21(12):3288-3297. Epub 2017 Jun 13.

Respiratory Cell and Molecular Biology, Woolcock Institute of Medical Research, Sydney, NSW, Australia.

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http://dx.doi.org/10.1111/jcmm.13232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706579PMC
December 2017

Thermodynamic and Transport Properties of Crown-Ethers: Force Field Development and Molecular Simulations.

J Phys Chem B 2017 09 25;121(35):8367-8376. Epub 2017 Aug 25.

Engineering Thermodynamics, Process & Energy Department, Faculty of Mechanical, Maritime and Materials Engineering, Delft University of Technology , Leeghwaterstraat 39, 2628CB Delft, The Netherlands.

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http://dx.doi.org/10.1021/acs.jpcb.7b06547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5592649PMC
September 2017

Identification of shared risk loci and pathways for bipolar disorder and schizophrenia.

PLoS One 2017 6;12(2):e0171595. Epub 2017 Feb 6.

Institute of Human Genetics, University of Bonn, Bonn, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0171595PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5293228PMC
August 2017

Intersession Reliability of Isokinetic Strength Testing in Knee and Elbow Extension and Flexion Using the BTE PrimusRS.

J Sport Rehabil 2017 07 24;26(4). Epub 2017 Mar 24.

1 Otto von Guericke University Magdeburg, Institute III: Sport Science, Germany, Magdeburg, Germany.

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http://dx.doi.org/10.1123/jsr.2016-0209DOI Listing
July 2017

Parent-of-origin Effect in Alopecia Areata: A Large-scale Pedigree Study.

Acta Derm Venereol 2017 Jul;97(7):862-863

Heinrich-Heine-University, Medical Faculty, , Institute of Human Genetics, , 40225 Düsseldorf, Germany.

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http://dx.doi.org/10.2340/00015555-2658DOI Listing
July 2017

Indium-Free Perovskite Solar Cells Enabled by Impermeable Tin-Oxide Electron Extraction Layers.

Adv Mater 2017 Jul 8;29(27). Epub 2017 May 8.

Institute of Electronic Devices, University of Wuppertal, Rainer-Gruenter-Str. 21, 42119, Wuppertal, Germany.

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http://dx.doi.org/10.1002/adma.201606656DOI Listing
July 2017

SiMA: A simplified migration assay for analyzing neutrophil migration.

Cytometry A 2017 07 19;91(7):675-685. Epub 2017 May 19.

Department of Pediatric Allergy and Pulmonology, Children's Hospital at the University of Lübeck, Lübeck, Germany.

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http://dx.doi.org/10.1002/cyto.a.23114DOI Listing
July 2017

Polarizable Force Fields for CO and CH Adsorption in M-MOF-74.

J Phys Chem C Nanomater Interfaces 2017 Mar 31;121(8):4659-4673. Epub 2017 Jan 31.

Engineering Thermodynamics, Process & Energy Department, Faculty of Mechanical, Maritime and Materials Engineering, Delft University of Technology , Leeghwaterstraat 39, 2628CB Delft, The Netherlands.

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http://dx.doi.org/10.1021/acs.jpcc.6b12052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338003PMC
March 2017

Haplotype synthesis analysis reveals functional variants underlying known genome-wide associated susceptibility loci.

Bioinformatics 2016 07 21;32(14):2136-42. Epub 2016 Mar 21.

Institute for Community Medicine, Ernst Moritz Arndt University Greifswald, Greifswald 17475, Germany.

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http://dx.doi.org/10.1093/bioinformatics/btw125DOI Listing
July 2016

TREM2 rare variant p.R47H is not associated with Parkinson's disease.

Parkinsonism Relat Disord 2016 Feb 25;23:109-11. Epub 2015 Nov 25.

Department of Psychiatry and Psychotherapy, University of Bonn, 53127 Bonn, Germany; Institute of Human Genetics, University of Bonn, 53127 Bonn, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.parkreldis.2015.11.026DOI Listing
February 2016

Association of age-of-onset groups with GWAS significant schizophrenia and bipolar disorder loci in Romanian bipolar I patients.

Psychiatry Res 2015 Dec 10;230(3):964-7. Epub 2015 Nov 10.

Institute for Community Medicine, Ernst Moritz Arndt University Greifswald, D-17475 Greifswald, Germany.

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http://dx.doi.org/10.1016/j.psychres.2015.11.008DOI Listing
December 2015

Evaluation of a supervised multi-modal physical exercise program for prostate cancer survivors in the rehabilitation phase: Rationale and study protocol of the ProCaLife study.

Contemp Clin Trials 2015 Nov 30;45(Pt B):311-319. Epub 2015 Sep 30.

Department of Training and Health, Institute of Sport Science, Otto von Guericke University Magdeburg, Zschokkestraße 32, 39104 Magdeburg, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15517144153009
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http://dx.doi.org/10.1016/j.cct.2015.09.020DOI Listing
November 2015

Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease.

Authors:
Valentina Escott-Price Céline Bellenguez Li-San Wang Seung-Hoan Choi Denise Harold Lesley Jones Peter Holmans Amy Gerrish Alexey Vedernikov Alexander Richards Anita L DeStefano Jean-Charles Lambert Carla A Ibrahim-Verbaas Adam C Naj Rebecca Sims Gyungah Jun Joshua C Bis Gary W Beecham Benjamin Grenier-Boley Giancarlo Russo Tricia A Thornton-Wells Nicola Denning Albert V Smith Vincent Chouraki Charlene Thomas M Arfan Ikram Diana Zelenika Badri N Vardarajan Yoichiro Kamatani Chiao-Feng Lin Helena Schmidt Brian Kunkle Melanie L Dunstan Maria Vronskaya Andrew D Johnson Agustin Ruiz Marie-Thérèse Bihoreau Christiane Reitz Florence Pasquier Paul Hollingworth Olivier Hanon Annette L Fitzpatrick Joseph D Buxbaum Dominique Campion Paul K Crane Clinton Baldwin Tim Becker Vilmundur Gudnason Carlos Cruchaga David Craig Najaf Amin Claudine Berr Oscar L Lopez Philip L De Jager Vincent Deramecourt Janet A Johnston Denis Evans Simon Lovestone Luc Letenneur Isabel Hernández David C Rubinsztein Gudny Eiriksdottir Kristel Sleegers Alison M Goate Nathalie Fiévet Matthew J Huentelman Michael Gill Kristelle Brown M Ilyas Kamboh Lina Keller Pascale Barberger-Gateau Bernadette McGuinness Eric B Larson Amanda J Myers Carole Dufouil Stephen Todd David Wallon Seth Love Ekaterina Rogaeva John Gallacher Peter St George-Hyslop Jordi Clarimon Alberto Lleo Anthony Bayer Debby W Tsuang Lei Yu Magda Tsolaki Paola Bossù Gianfranco Spalletta Petra Proitsi John Collinge Sandro Sorbi Florentino Sanchez Garcia Nick C Fox John Hardy Maria Candida Deniz Naranjo Paolo Bosco Robert Clarke Carol Brayne Daniela Galimberti Elio Scarpini Ubaldo Bonuccelli Michelangelo Mancuso Gabriele Siciliano Susanne Moebus Patrizia Mecocci Maria Del Zompo Wolfgang Maier Harald Hampel Alberto Pilotto Ana Frank-García Francesco Panza Vincenzo Solfrizzi Paolo Caffarra Benedetta Nacmias William Perry Manuel Mayhaus Lars Lannfelt Hakon Hakonarson Sabrina Pichler Minerva M Carrasquillo Martin Ingelsson Duane Beekly Victoria Alvarez Fanggeng Zou Otto Valladares Steven G Younkin Eliecer Coto Kara L Hamilton-Nelson Wei Gu Cristina Razquin Pau Pastor Ignacio Mateo Michael J Owen Kelley M Faber Palmi V Jonsson Onofre Combarros Michael C O'Donovan Laura B Cantwell Hilkka Soininen Deborah Blacker Simon Mead Thomas H Mosley David A Bennett Tamara B Harris Laura Fratiglioni Clive Holmes Renee F A G de Bruijn Peter Passmore Thomas J Montine Karolien Bettens Jerome I Rotter Alexis Brice Kevin Morgan Tatiana M Foroud Walter A Kukull Didier Hannequin John F Powell Michael A Nalls Karen Ritchie Kathryn L Lunetta John S K Kauwe Eric Boerwinkle Matthias Riemenschneider Mercè Boada Mikko Hiltunen Eden R Martin Reinhold Schmidt Dan Rujescu Jean-François Dartigues Richard Mayeux Christophe Tzourio Albert Hofman Markus M Nöthen Caroline Graff Bruce M Psaty Jonathan L Haines Mark Lathrop Margaret A Pericak-Vance Lenore J Launer Christine Van Broeckhoven Lindsay A Farrer Cornelia M van Duijn Alfredo Ramirez Sudha Seshadri Gerard D Schellenberg Philippe Amouyel Julie Williams

PLoS One 2014 12;9(6):e94661. Epub 2014 Jun 12.

Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0094661PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055488PMC
October 2015

Highly robust transparent and conductive gas diffusion barriers based on tin oxide.

Adv Mater 2015 Oct 27;27(39):5961-7. Epub 2015 Aug 27.

Institute of Electronic Devices, University of Wuppertal, Rainer-Gruenter-Str. 21, 42119, Wuppertal, Germany.

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http://dx.doi.org/10.1002/adma.201502973DOI Listing
October 2015

Rare variant testing of imputed data: an analysis pipeline typified.

Hum Hered 2014 10;78(3-4):164-78. Epub 2014 Dec 10.

German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.

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http://dx.doi.org/10.1159/000368676DOI Listing
September 2015

Influence of genetic variants in SORL1 gene on the manifestation of Alzheimer's disease.

Neurobiol Aging 2015 Mar 11;36(3):1605.e13-20. Epub 2014 Dec 11.

Alzheimer Center and Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, the Netherlands; Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1016/j.neurobiolaging.2014.12.007DOI Listing
March 2015

METAINTER: meta-analysis of multiple regression models in genome-wide association studies.

Bioinformatics 2015 Jan 23;31(2):151-7. Epub 2014 Sep 23.

Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn and German Center for Neurodegenerative Diseases (DZNE), Sigmund-Freud-Str. 25, D-53105 Bonn, Germany Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn and German Center for Neurodegenerative Diseases (DZNE), Sigmund-Freud-Str. 25, D-53105 Bonn, Germany.

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http://dx.doi.org/10.1093/bioinformatics/btu629DOI Listing
January 2015

Analysis of the progression of systolic blood pressure using imputation of missing phenotype values.

BMC Proc 2014 17;8(Suppl 1):S83. Epub 2014 Jun 17.

German Center for Neurodegenerative Diseases (DZNE), Ludwig-Erhard-Allee 2, D-53175 Bonn, Germany.

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http://dx.doi.org/10.1186/1753-6561-8-S1-S83DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143701PMC
December 2014

The rare TREM2 R47H variant exerts only a modest effect on Alzheimer disease risk.

Neurology 2014 Oct 3;83(15):1353-8. Epub 2014 Sep 3.

From the MassGeneral Institute for Neurodegenerative Diseases (B.V.H., A.R.P., K.M., R.E.T.), Department of Neurology, Massachusetts General Hospital, Boston; Department of Biostatistics (W.-K.Y., D.Q., C.L.), Harvard School of Public Health, Boston, MA; Department of Vertebrate Genomics (T.L., J.T.R., L.B.), Max Planck Institute for Molecular Genetics, Berlin; Department of Psychiatry and Psychotherapy (F.J., A.R.), Institute for Medical Biometry, Informatics and Epidemiology (T.B.), and Institute of Human Genetics (A.R.), University of Bonn; German Center for Neurodegenerative Diseases (DZNE) (F.J., T.B.), Bonn; and Department of Psychiatry (O.P.), Charité University Medicine, Berlin, Germany.

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http://www.neurology.org/content/83/15/1353.full.pdf
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http://www.neurology.org/cgi/doi/10.1212/WNL.000000000000085
Publisher Site
http://dx.doi.org/10.1212/WNL.0000000000000855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189101PMC
October 2014

A one-degree-of-freedom test for supra-multiplicativity of SNP effects.

PLoS One 2013 30;8(10):e78038. Epub 2013 Oct 30.

German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany ; Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0078038PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813579PMC
September 2014

The CF-modifying gene EHF promotes p.Phe508del-CFTR residual function by altering protein glycosylation and trafficking in epithelial cells.

Eur J Hum Genet 2014 May 9;22(5):660-6. Epub 2013 Oct 9.

1] Department of Pediatrics, Hannover Medical School, Hannover, Germany [2] Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research, Hannover, Germany.

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http://dx.doi.org/10.1038/ejhg.2013.209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3992571PMC
May 2014

Genome-wide association study reveals two new risk loci for bipolar disorder.

Nat Commun 2014 Mar 11;5:3339. Epub 2014 Mar 11.

1] Institute of Human Genetics, University of Bonn, D-53127 Bonn, Germany [2] Department of Genomics, Life & Brain Center, University of Bonn, D-53127 Bonn, Germany [3] Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, D-52425 Jülich, Germany [4] Division of Medical Genetics, Department of Biomedicine, University of Basel, Basel CH-4012, Switzerland [5].

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http://www.nature.com/articles/ncomms4339
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http://dx.doi.org/10.1038/ncomms4339DOI Listing
March 2014

Genome-wide association analysis of genetic generalized epilepsies implicates susceptibility loci at 1q43, 2p16.1, 2q22.3 and 17q21.32.

Hum Mol Genet 2012 Dec 4;21(24):5359-72. Epub 2012 Sep 4.

Institute for Medical Biometry, Informatic and Epidemiology, University of Bonn, Bonn, Germany.

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http://hmg.oxfordjournals.org/content/21/24/5359.full.pdf
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http://www.hmg.oxfordjournals.org/cgi/doi/10.1093/hmg/dds373
Publisher Site
http://dx.doi.org/10.1093/hmg/dds373DOI Listing
December 2012

Integrated genome-wide pathway association analysis with INTERSNP.

Hum Hered 2012 7;73(2):63-72. Epub 2012 Mar 7.

German Center for Neurodegenerative Diseases (DZNE), University of Bonn, Bonn, Germany.

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http://dx.doi.org/10.1159/000336196DOI Listing
September 2012

Quick, "imputation-free" meta-analysis with proxy-SNPs.

BMC Bioinformatics 2012 Sep 12;13:231. Epub 2012 Sep 12.

German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.

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http://dx.doi.org/10.1186/1471-2105-13-231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3472171PMC
September 2012

Photonic crystal slabs for surface contrast enhancement in microscopy of transparent objects.

Opt Express 2012 Jun;20(13):14451-9

Institute of Electrical and Information Engineering, Christian-Albrechts-Universität zu Kiel, D-24143 Kiel, Germany.

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http://dx.doi.org/10.1364/OE.20.014451DOI Listing
June 2012

The modulation of Amyotrophic Lateral Sclerosis risk by ataxin-2 intermediate polyglutamine expansions is a specific effect.

Neurobiol Dis 2012 Jan 25;45(1):356-61. Epub 2011 Aug 25.

Experimental Neurology, Goethe University Medical School, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany.

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http://dx.doi.org/10.1016/j.nbd.2011.08.021DOI Listing
January 2012

Significance levels in genome-wide interaction analysis (GWIA).

Ann Hum Genet 2011 Jan 18;75(1):29-35. Epub 2010 Oct 18.

Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Germany.

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http://dx.doi.org/10.1111/j.1469-1809.2010.00610.xDOI Listing
January 2011

INTERSNP: genome-wide interaction analysis guided by a priori information.

Bioinformatics 2009 Dec 16;25(24):3275-81. Epub 2009 Oct 16.

Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Sigmund-Freud-Str. 25, Germany.

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http://dx.doi.org/10.1093/bioinformatics/btp596DOI Listing
December 2009

Joint analysis of tightly linked SNPs in screening step of genome-wide association studies leads to increased power.

Eur J Hum Genet 2009 Aug 18;17(8):1043-9. Epub 2009 Feb 18.

Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Germany.

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http://www.nature.com/articles/ejhg20097
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http://dx.doi.org/10.1038/ejhg.2009.7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2986547PMC
August 2009

Evaluation of potential power gain with imputed genotypes in genome-wide association studies.

Hum Hered 2009 1;68(1):23-34. Epub 2009 Apr 1.

Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany.

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http://dx.doi.org/10.1159/000210446DOI Listing
May 2009

Genetic association analysis with FAMHAP: a major program update.

Bioinformatics 2009 Jan 9;25(1):134-6. Epub 2008 Nov 9.

Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Sigmund-Freud-Str. 25, D-53105 Bonn, Germany.

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http://dx.doi.org/10.1093/bioinformatics/btn581DOI Listing
January 2009

Testing association in the presence of linkage using the GRE and multiple markers.

Genet Epidemiol 2008 Jul;32(5):425-33

Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.1002/gepi.20315DOI Listing
July 2008

Gender specific differences in levels of DNA methylation at selected loci from human total blood: a tendency toward higher methylation levels in males.

Hum Genet 2007 Dec 13;122(5):505-14. Epub 2007 Sep 13.

Institute of Experimental Hematology and Transfusion Medicine, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany.

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http://dx.doi.org/10.1007/s00439-007-0430-3DOI Listing
December 2007

Transmission ratio distortion and maternal effects confound the analysis of modulators of cystic fibrosis disease severity on 19q13.

Eur J Hum Genet 2007 Jul 4;15(7):774-8. Epub 2007 Apr 4.

Institute of Medical Biometrics, Informatics and Genetics (IMBIE), University of Bonn, Bonn, Germany.

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http://dx.doi.org/10.1038/sj.ejhg.5201825DOI Listing
July 2007

Mitochondrial translation initiation factor 3 gene polymorphism associated with Parkinson's disease.

Neurosci Lett 2007 Mar 11;414(2):126-9. Epub 2007 Jan 11.

Institute for Experimental Neurobiology, University Hospital Frankfurt/Main, Germany.

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http://dx.doi.org/10.1016/j.neulet.2006.12.053DOI Listing
March 2007