Tim Beck

Tim Beck

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Tim Beck

Tim Beck

Publications by authors named "Tim Beck"

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GWAS Central: a comprehensive resource for the discovery and comparison of genotype and phenotype data from genome-wide association studies.

Nucleic Acids Res 2020 Jan;48(D1):D933-D940

Department of Genetics and Genome Biology, University of Leicester, Leicester LE1 7RH, UK.

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http://dx.doi.org/10.1093/nar/gkz895DOI Listing
January 2020

Tumor-Targeted Drug Conjugates as an Emerging Novel Therapeutic Approach in Small Cell Lung Cancer (SCLC).

Cancers (Basel) 2019 Sep 3;11(9). Epub 2019 Sep 3.

Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.

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http://dx.doi.org/10.3390/cancers11091297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769513PMC
September 2019

An improved method of delivering a sclerosing agent for the treatment of malignant pleural effusion.

BMC Cancer 2019 Jun 24;19(1):614. Epub 2019 Jun 24.

Department of Cardiothoracic Surgery, Drexel University College of Medicine, Hahnemann University Hospital, 230 North Broad Street, Philadelphia, PA, 19102, USA.

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http://dx.doi.org/10.1186/s12885-019-5777-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589887PMC
June 2019

Case report: reinitiating pembrolizumab treatment after small bowel perforation.

BMC Cancer 2019 Apr 24;19(1):379. Epub 2019 Apr 24.

Program in Molecular Therapeutics, Fox Chase Cancer Center, Philadelphia, PA, 19111, USA.

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http://dx.doi.org/10.1186/s12885-019-5577-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6482547PMC
April 2019

Molecular mechanisms of the preventable causes of cancer in the United States.

Genes Dev 2018 07 26;32(13-14):868-902. Epub 2018 Jun 26.

Koch Institute for Integrative Cancer Research, Biology Department, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1101/gad.314849.118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075032PMC
July 2018

Miliary Adenocarcinoma of the Lung Responds to Gefitinib and Afatinib.

J Thorac Oncol 2018 06;13(6):e95-e97

Program in Molecular Therapeutics, Fox Chase Cancer Center, Philadelphia, Pennsylvania; Department of Hematology/Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1016/j.jtho.2018.01.018DOI Listing
June 2018

Rare antibody-associated hemolytic transfusion reaction and transfusion-related acute lung injury: a case report.

BMC Surg 2017 Apr 26;17(1):48. Epub 2017 Apr 26.

Department of Surgery, WellSpan York Hospital, York, PA, 17403, USA.

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http://dx.doi.org/10.1186/s12893-017-0241-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405478PMC
April 2017

Head and neck squamous cell carcinoma: Ambiguous human papillomavirus status, elevated p16, and deleted retinoblastoma 1.

Head Neck 2017 03 8;39(3):E34-E39. Epub 2016 Nov 8.

Program in Molecular Therapeutics, Fox Chase Cancer Center, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1002/hed.24604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439525PMC
March 2017

EGFR and RB1 as Dual Biomarkers in HPV-Negative Head and Neck Cancer.

Mol Cancer Ther 2016 10 9;15(10):2486-2497. Epub 2016 Aug 9.

Molecular Therapeutics, Fox Chase Cancer Center, Philadelphia, Pennsylvania. Molecular and Cell Biology & Genetics Program, Drexel University College of Medicine, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/1535-7163.MCT-16-0243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522587PMC
October 2016

Anti-Müllerian Hormone Signaling Regulates Epithelial Plasticity and Chemoresistance in Lung Cancer.

Cell Rep 2016 07 7;16(3):657-71. Epub 2016 Jul 7.

Program in Molecular Therapeutics, Fox Chase Cancer Center, Philadelphia, PA 19111, USA; Program in Molecular and Cell Biology and Genetics, Drexel University College of Medicine, Philadelphia, PA 19129, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.06.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956518PMC
July 2016

Genomic insights into head and neck cancer.

Cancers Head Neck 2016 3;1. Epub 2016 Jun 3.

Program in Molecular Therapeutics, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA 19111, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638139PMC
http://dx.doi.org/10.1186/s41199-016-0003-zDOI Listing
June 2016

Musashi-2 (MSI2) supports TGF-β signaling and inhibits claudins to promote non-small cell lung cancer (NSCLC) metastasis.

Proc Natl Acad Sci U S A 2016 06 6;113(25):6955-60. Epub 2016 Jun 6.

Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PA, 19111; Department of Medical Oncology, University of New Mexico Cancer Center, Albuquerque, NM 87131; Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111

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http://dx.doi.org/10.1073/pnas.1513616113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4922167PMC
June 2016

Anti-necrotic and cardioprotective effects of a cytosolic renin isoform under ischemia-related conditions.

J Mol Med (Berl) 2016 Jan 11;94(1):61-9. Epub 2015 Aug 11.

Department of Physiology, University Medicine of Greifswald, Greifswalder Str. 11C, D-17495, Karlsburg, Germany.

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http://dx.doi.org/10.1007/s00109-015-1321-zDOI Listing
January 2016

Cafe Variome: general-purpose software for making genotype-phenotype data discoverable in restricted or open access contexts.

Hum Mutat 2015 Oct 25;36(10):957-64. Epub 2015 Aug 25.

Department of Genetics, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1002/humu.22841DOI Listing
October 2015

The BioMart community portal: an innovative alternative to large, centralized data repositories.

Authors:
Damian Smedley Syed Haider Steffen Durinck Luca Pandini Paolo Provero James Allen Olivier Arnaiz Mohammad Hamza Awedh Richard Baldock Giulia Barbiera Philippe Bardou Tim Beck Andrew Blake Merideth Bonierbale Anthony J Brookes Gabriele Bucci Iwan Buetti Sarah Burge Cédric Cabau Joseph W Carlson Claude Chelala Charalambos Chrysostomou Davide Cittaro Olivier Collin Raul Cordova Rosalind J Cutts Erik Dassi Alex Di Genova Anis Djari Anthony Esposito Heather Estrella Eduardo Eyras Julio Fernandez-Banet Simon Forbes Robert C Free Takatomo Fujisawa Emanuela Gadaleta Jose M Garcia-Manteiga David Goodstein Kristian Gray José Afonso Guerra-Assunção Bernard Haggarty Dong-Jin Han Byung Woo Han Todd Harris Jayson Harshbarger Robert K Hastings Richard D Hayes Claire Hoede Shen Hu Zhi-Liang Hu Lucie Hutchins Zhengyan Kan Hideya Kawaji Aminah Keliet Arnaud Kerhornou Sunghoon Kim Rhoda Kinsella Christophe Klopp Lei Kong Daniel Lawson Dejan Lazarevic Ji-Hyun Lee Thomas Letellier Chuan-Yun Li Pietro Lio Chu-Jun Liu Jie Luo Alejandro Maass Jerome Mariette Thomas Maurel Stefania Merella Azza Mostafa Mohamed Francois Moreews Ibounyamine Nabihoudine Nelson Ndegwa Céline Noirot Cristian Perez-Llamas Michael Primig Alessandro Quattrone Hadi Quesneville Davide Rambaldi James Reecy Michela Riba Steven Rosanoff Amna Ali Saddiq Elisa Salas Olivier Sallou Rebecca Shepherd Reinhard Simon Linda Sperling William Spooner Daniel M Staines Delphine Steinbach Kevin Stone Elia Stupka Jon W Teague Abu Z Dayem Ullah Jun Wang Doreen Ware Marie Wong-Erasmus Ken Youens-Clark Amonida Zadissa Shi-Jian Zhang Arek Kasprzyk

Nucleic Acids Res 2015 Jul 20;43(W1):W589-98. Epub 2015 Apr 20.

Center for Translational Genomics and Bioinformatics San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia

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http://dx.doi.org/10.1093/nar/gkv350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489294PMC
July 2015

The Human Phenotype Ontology: Semantic Unification of Common and Rare Disease.

Am J Hum Genet 2015 Jul 25;97(1):111-24. Epub 2015 Jun 25.

Institute for Medical and Human Genetics, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany; Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, 14195 Berlin, Germany; Berlin Brandenburg Center for Regenerative Therapies, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany; Institute of Bioinformatics, Department of Mathematics and Computer Science, Freie Universität Berlin, Takustrasse 9, 14195 Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2015.05.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572507PMC
July 2015

Adaptors for disorders of the brain? The cancer signaling proteins NEDD9, CASS4, and PTK2B in Alzheimer's disease.

Oncoscience 2014 23;1(7):486-503. Epub 2014 Jul 23.

Developmental Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PA, USA ; Program in Molecular and Cell Biology and Genetics, Drexel University College of Medicine, Philadelphia, PA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278314PMC
http://dx.doi.org/10.18632/oncoscience.64DOI Listing
January 2015

Bioinformatic approaches to augment study of epithelial-to-mesenchymal transition in lung cancer.

Physiol Genomics 2014 Oct 5;46(19):699-724. Epub 2014 Aug 5.

Developmental Therapeutics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania; Temple University School of Medicine, Philadelphia, Pennsylvania; and Program in Molecular and Cell Biology and Genetics, Drexel University College of Medicine, Philadelphia, Pennsylvania; and

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http://www.physiology.org/doi/10.1152/physiolgenomics.00062.
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http://dx.doi.org/10.1152/physiolgenomics.00062.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187119PMC
October 2014

GWAS Central: a comprehensive resource for the comparison and interrogation of genome-wide association studies.

Eur J Hum Genet 2014 Jul 4;22(7):949-52. Epub 2013 Dec 4.

Department of Genetics, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1038/ejhg.2013.274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060122PMC
July 2014

Integrating in silico resources to map a signaling network.

Methods Mol Biol 2014 ;1101:197-245

Fox Chase Cancer Center, Philadelphia, PA, USA.

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http://dx.doi.org/10.1007/978-1-62703-721-1_11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3831179PMC
June 2014

WaveCNV: allele-specific copy number alterations in primary tumors and xenograft models from next-generation sequencing.

Bioinformatics 2014 Mar 4;30(6):768-74. Epub 2013 Nov 4.

Ontario Institute for Cancer Research, Toronto, ON, M5G 0A3, Canada and Department of Medical Biophysics, University of Toronto, Toronto, ON, M5G 2M9, Canada.

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http://dx.doi.org/10.1093/bioinformatics/btt611DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3957071PMC
March 2014

Semantically enabling a genome-wide association study database.

J Biomed Semantics 2012 Dec 17;3(1). Epub 2012 Dec 17.

Department of Genetics, University of Leicester, University Road, Leicester, UK.

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http://dx.doi.org/10.1186/2041-1480-3-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3579732PMC
December 2012

Knowledge engineering for health: a new discipline required to bridge the "ICT gap" between research and healthcare.

Hum Mutat 2012 May 4;33(5):797-802. Epub 2012 Apr 4.

Department of Genetics, University of Leicester, Leicester, United Kingdom.

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http://dx.doi.org/10.1002/humu.22066DOI Listing
May 2012

MouseBook: an integrated portal of mouse resources.

Nucleic Acids Res 2010 Jan 23;38(Database issue):D593-9. Epub 2009 Oct 23.

MRC Harwell, Mammalian Genetics Unit and the Mary Lyon Centre, Harwell Science and Innovation Campus, Oxfordshire OX11 0RD, UK.

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http://dx.doi.org/10.1093/nar/gkp867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808969PMC
January 2010

EuroPhenome: a repository for high-throughput mouse phenotyping data.

Nucleic Acids Res 2010 Jan 23;38(Database issue):D577-85. Epub 2009 Nov 23.

MRC Harwell, Mammalian Genetics Unit, MRC Harwell, Mary Lyon Centre, Harwell Science and Innovation Campus, Oxfordshire OX11 0RD, UK.

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http://dx.doi.org/10.1093/nar/gkp1007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808931PMC
January 2010

Mouse, man, and meaning: bridging the semantics of mouse phenotype and human disease.

Mamm Genome 2009 Aug 2;20(8):457-61. Epub 2009 Aug 2.

Bioinformatics Group, MRC Harwell, Harwell, Oxfordshire, OX11 0RD, UK.

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http://dx.doi.org/10.1007/s00335-009-9208-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2759022PMC
August 2009

Practical application of ontologies to annotate and analyse large scale raw mouse phenotype data.

BMC Bioinformatics 2009 May 6;10 Suppl 5:S2. Epub 2009 May 6.

MRC Harwell, Harwell Science and Innovation Campus, Oxfordshire, OX11 0RD, UK.

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http://dx.doi.org/10.1186/1471-2105-10-S5-S2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2679402PMC
May 2009