Tilo Kunath

Tilo Kunath

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Tilo Kunath

Tilo Kunath

Publications by authors named "Tilo Kunath"

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Multiomics Analyses of HNF4α Protein Domain Function during Human Pluripotent Stem Cell Differentiation.

iScience 2019 Jun 24;16:206-217. Epub 2019 May 24.

Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, 5 Little France Drive, Edinburgh, Scotland EH16 4UU, UK. Electronic address:

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http://dx.doi.org/10.1016/j.isci.2019.05.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556878PMC
June 2019

α-Synuclein-Confocal Nanoscanning (ASYN-CONA), a Bead-Based Assay for Detecting Early-Stage α-Synuclein Aggregation.

Anal Chem 2019 May 18;91(9):5582-5590. Epub 2019 Apr 18.

School of Biological Sciences and Edinburgh Medical School: Biomedical Sciences , University of Edinburgh , The King's Buildings, Edinburgh EH9 3BF , United Kingdom.

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http://pubs.acs.org/doi/10.1021/acs.analchem.8b03842
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http://dx.doi.org/10.1021/acs.analchem.8b03842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534341PMC
May 2019

Discovery of Volatile Biomarkers of Parkinson's Disease from Sebum.

ACS Cent Sci 2019 Apr 20;5(4):599-606. Epub 2019 Mar 20.

Manchester Institute of Biotechnology, School of Chemistry, The University of Manchester, Princess Street, Manchester, U.K., M1 7DN.

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http://dx.doi.org/10.1021/acscentsci.8b00879DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487537PMC
April 2019

Engineering synucleinopathy-resistant human dopaminergic neurons by CRISPR-mediated deletion of the SNCA gene.

Eur J Neurosci 2019 Feb 21;49(4):510-524. Epub 2018 Dec 21.

MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, The University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1111/ejn.14286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492083PMC
February 2019

Are PARKIN patients ideal candidates for dopaminergic cell replacement therapies?

Eur J Neurosci 2019 Feb 23;49(4):453-462. Epub 2019 Jan 23.

MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, DD1 5EH, Dundee, UK.

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http://dx.doi.org/10.1111/ejn.14314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492143PMC
February 2019

Preparation, characterization, and banking of clinical-grade cells for neural transplantation: Scale up, fingerprinting, and genomic stability of stem cell lines.

Prog Brain Res 2017 7;230:133-150. Epub 2017 Apr 7.

MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, The University of Edinburgh, Edinburgh, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/bs.pbr.2017.02.007DOI Listing
May 2018

Mono-Substituted Hydrocarbon Diastereomer Combinations Reveal Stapled Peptides with High Structural Fidelity.

Chemistry 2018 Feb 19;24(9):2094-2097. Epub 2018 Jan 19.

EaStChem School of Chemistry, University of Edinburgh, David Brewster Road, Edinburgh, EH9 3FJ, UK.

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http://dx.doi.org/10.1002/chem.201705983DOI Listing
February 2018

Producing Stem Cell-Based Transplants for Future Therapeutic Purposes.

Stem Cells Int 2017 11;2017:9592302. Epub 2017 Dec 11.

Departamento de Farmacología, Facultad de Medicina, Universidad Nacional Autónoma de México, 04510 Ciudad de México, Mexico.

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http://dx.doi.org/10.1155/2017/9592302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742504PMC
December 2017

maintains the balance of primitive endoderm versus epiblast specification during mouse embryonic development by suppression of .

Development 2017 10 4;144(20):3706-3718. Epub 2017 Sep 4.

Department of Stem Cells and Human Disease Models, Research Center for Animal Life Science, Shiga University of Medical Science, Seta, Tsukinowa-cho, Otsu, Shiga 520-2192, Japan

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http://dx.doi.org/10.1242/dev.150755DOI Listing
October 2017

A synthetic cell permeable antioxidant protects neurons against acute oxidative stress.

Sci Rep 2017 09 19;7(1):11857. Epub 2017 Sep 19.

MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, The University of Edinburgh, Edinburgh, EH16 4UU, UK.

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http://dx.doi.org/10.1038/s41598-017-12072-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605738PMC
September 2017

Modeling Parkinson's disease with induced pluripotent stem cells harboring α-synuclein mutations.

Brain Pathol 2017 07;27(4):545-551

MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, The University of Edinburgh, Edinburgh, EH16 4UU, UK.

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http://dx.doi.org/10.1111/bpa.12526DOI Listing
July 2017

The Molecular Karyotype of 25 Clinical-Grade Human Embryonic Stem Cell Lines.

Sci Rep 2015 Nov 26;5:17258. Epub 2015 Nov 26.

MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, The University of Edinburgh, UK.

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http://dx.doi.org/10.1038/srep17258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660465PMC
November 2015

Generation of human pluripotent stem cell reporter lines for the isolation of and reporting on astrocytes generated from ventral midbrain and ventral spinal cord neural progenitors.

Stem Cell Res 2015 Jul 6;15(1):203-20. Epub 2015 Jun 6.

Stem Cell Laboratory for CNS Disease Modeling, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, BMC A10, 22184, Lund, Sweden; Strategic Research Area MultiPark and Lund Stem Cell Center, Lund University, 22184, Lund, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2015.05.014DOI Listing
July 2015

A cell culture model for monitoring α-synuclein cell-to-cell transfer.

Neurobiol Dis 2015 May 16;77:266-75. Epub 2014 Jul 16.

Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Sweden; Laboratory for Translational Parkinson's Disease Research, Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, MI, USA. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2014.07.003DOI Listing
May 2015

Conformational dynamics of α-synuclein: insights from mass spectrometry.

Analyst 2015 May 10;140(9):3070-81. Epub 2015 Mar 10.

Manchester Institute of Biotechnology, University of Manchester, Manchester, M1 7DN, UK.

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http://dx.doi.org/10.1039/c4an02306dDOI Listing
May 2015

Isolation and manipulation of mouse trophoblast stem cells.

Curr Protoc Stem Cell Biol 2015 Feb 2;32:1E.4.1-32. Epub 2015 Feb 2.

Laboratory of Cellular Biochemistry, Animal Resource Sciences/Veterinary Medical Sciences, The University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1002/9780470151808.sc01e04s32DOI Listing
February 2015

ERK2 suppresses self-renewal capacity of embryonic stem cells, but is not required for multi-lineage commitment.

PLoS One 2013 16;8(4):e60907. Epub 2013 Apr 16.

MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0060907PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3628700PMC
November 2013

Stepwise, non-adherent differentiation of human pluripotent stem cells to generate basal forebrain cholinergic neurons via hedgehog signaling.

Stem Cell Res 2013 Nov 9;11(3):1206-21. Epub 2013 Aug 9.

Henry Wellcome Laboratory for Integrative Neuroscience and Endocrinology, School of Clinical Sciences, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK.

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http://dx.doi.org/10.1016/j.scr.2013.08.002DOI Listing
November 2013

Functional endothelial progenitor cells selectively recruit neurovascular protective monocyte-derived F4/80(+) /Ly6c(+) macrophages in a mouse model of retinal degeneration.

Stem Cells 2013 Oct;31(10):2149-61

Department of Regenerative Medicine and Stem Cell Biology, Graduate School of Comprehensive Human Science; Department of Ophthalmology, Graduate School of Comprehensive Human Science, University of Tsukuba, Tsukuba, Japan.

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http://dx.doi.org/10.1002/stem.1469DOI Listing
October 2013

Extraembryonic endoderm cells as a model of endoderm development.

Dev Growth Differ 2013 Apr 18;55(3):301-8. Epub 2013 Feb 18.

Department of Molecular and Cell Biology, Centre of Biomedical Genetics, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1111/dgd.12036DOI Listing
April 2013

BMP signaling induces visceral endoderm differentiation of XEN cells and parietal endoderm.

Dev Biol 2012 Jan 14;361(1):90-102. Epub 2011 Oct 14.

MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, University of Edinburgh, Edinburgh, EH9 3JQ, United Kingdom.

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http://dx.doi.org/10.1016/j.ydbio.2011.10.013DOI Listing
January 2012

Primed for pluripotency.

Authors:
Tilo Kunath

Cell Stem Cell 2011 Mar;8(3):241-2

MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, EH9 3JQ, UK.

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http://dx.doi.org/10.1016/j.stem.2011.02.009DOI Listing
March 2011

Induced pluripotent stem cell technology and stem cell therapy for diabetes.

Exp Ther Med 2011 Jan 2;2(1):3-7. Epub 2010 Dec 2.

Tissue Injury and Repair Group, MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, Scotland EH16 4SB;

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http://dx.doi.org/10.3892/etm.2010.173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3440679PMC
January 2011

Transgenic RNA interference to investigate gene function in the mouse.

Authors:
Tilo Kunath

Methods Mol Biol 2008 ;461:165-86

Institute for Stem Cell Research, University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1007/978-1-60327-483-8_11DOI Listing
January 2009

Isolation and manipulation of mouse trophoblast stem cells.

Curr Protoc Stem Cell Biol 2008 Oct;Chapter 1:Unit 1E.4

Laboratory of Cellular Biochemistry, Animal Resource Sciences/Veterinary Medical Sciences, The University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1002/9780470151808.sc01e04s7DOI Listing
October 2008

FGF stimulation of the Erk1/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment.

Development 2007 Aug;134(16):2895-902

Centre Development in Stem Cell Biology, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1242/dev.02880DOI Listing
August 2007

p53-Independent apoptosis disrupts early organogenesis in embryos lacking both ataxia-telangiectasia mutated and Prkdc.

Mol Cancer Res 2006 May;4(5):311-8

Program in Developmental Biology, Hospital for Sick Children Research Institute, Toronto Medical Discovery Tower Building (East Tower), Room 14-312, 101 College Street, Toronto, Ontario, Canada M5G 1L7.

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http://dx.doi.org/10.1158/1541-7786.MCR-05-0258DOI Listing
May 2006

Mouse trophoblast stem cells.

Methods Mol Med 2006 ;121:125-48

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Ontario, Canada.

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December 2005

Imprinted X-inactivation in extra-embryonic endoderm cell lines from mouse blastocysts.

Development 2005 Apr;132(7):1649-61

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto M5G 1X5, Canada.

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http://dx.doi.org/10.1242/dev.01715DOI Listing
April 2005

Phenotypic analyses of mouse embryos with ubiquitous expression of Oct4: effects on mid-hindbrain patterning and gene expression.

Dev Dyn 2005 Jan;232(1):180-90

Departamento de Fisiología Molecular y Genética del Desarrollo, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, México.

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http://dx.doi.org/10.1002/dvdy.20211DOI Listing
January 2005

Transgenic RNA interference in ES cell-derived embryos recapitulates a genetic null phenotype.

Nat Biotechnol 2003 May 7;21(5):559-61. Epub 2003 Apr 7.

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada M5G 1X5.

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http://dx.doi.org/10.1038/nbt813DOI Listing
May 2003