Tilman Brummer

Tilman Brummer

UNVERIFIED PROFILE

Are you Tilman Brummer?   Register this Author

Register author
Tilman Brummer

Tilman Brummer

Publications by authors named "Tilman Brummer"

Are you Tilman Brummer?   Register this Author

71Publications

1851Reads

44Profile Views

Design and Synthesis of Type-IV Inhibitors of BRAF Kinase That Block Dimerization and Overcome Paradoxical MEK/ERK Activation.

J Med Chem 2019 Apr 12;62(8):3886-3897. Epub 2019 Apr 12.

Drug Discovery and Biomedical Sciences , College of Pharmacy , Columbia , South Carolina 29208 , United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jmedchem.8b01288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750704PMC
April 2019

Erratum: Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells.

Authors:
Nimitha R Mathew Francis Baumgartner Lukas Braun David O'Sullivan Simone Thomas Miguel Waterhouse Tony A Müller Kathrin Hanke Sanaz Taromi Petya Apostolova Anna L Illert Wolfgang Melchinger Sandra Duquesne Annette Schmitt-Graeff Lena Osswald Kai-Li Yan Arnim Weber Sonia Tugues Sabine Spath Dietmar Pfeifer Marie Follo Rainer Claus Michael Lübbert Christoph Rummelt Hartmut Bertz Ralph Wäsch Johanna Haag Andrea Schmidts Michael Schultheiss Dominik Bettinger Robert Thimme Evelyn Ullrich Yakup Tanriver Giang Lam Vuong Renate Arnold Philipp Hemmati Dominik Wolf Markus Ditschkowski Cordula Jilg Konrad Wilhelm Christian Leiber Sabine Gerull Jörg Halter Claudia Lengerke Thomas Pabst Thomas Schroeder Guido Kobbe Wolf Rösler Soroush Doostkam Stephan Meckel Kathleen Stabla Stephan K Metzelder Sebastian Halbach Tilman Brummer Zehan Hu Joern Dengjel Björn Hackanson Christoph Schmid Udo Holtick Christof Scheid Alexandros Spyridonidis Friedrich Stölzel Rainer Ordemann Lutz P Müller Flore Sicre-de-Fontbrune Gabriele Ihorst Jürgen Kuball Jan E Ehlert Daniel Feger Eva-Maria Wagner Jean-Yves Cahn Jacqueline Schnell Florian Kuchenbauer Donald Bunjes Ronjon Chakraverty Simon Richardson Saar Gill Nicolaus Kröger Francis Ayuk Luca Vago Fabio Ciceri Antonia M Müller Takeshi Kondo Takanori Teshima Susan Klaeger Bernhard Kuster Dennis Dong Hwan Kim Daniel Weisdorf Walter van der Velden Daniela Dörfel Wolfgang Bethge Inken Hilgendorf Andreas Hochhaus Geoffroy Andrieux Melanie Börries Hauke Busch John Magenau Pavan Reddy Myriam Labopin Joseph H Antin Andrea S Henden Geoffrey R Hill Glen A Kennedy Merav Bar Anita Sarma Donal McLornan Ghulam Mufti Betul Oran Katayoun Rezvani Omid Shah Robert S Negrin Arnon Nagler Marco Prinz Andreas Burchert Andreas Neubauer Dietrich Beelen Andreas Mackensen Nikolas von Bubnoff Wolfgang Herr Burkhard Becher Gerard Socié Michael A Caligiuri Eliana Ruggiero Chiara Bonini Georg Häcker Justus Duyster Jürgen Finke Erika Pearce Bruce R Blazar Robert Zeiser

Nat Med 2018 Apr;24(4):526

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nm0418-526cDOI Listing
April 2018

BRAF inhibition upregulates a variety of receptor tyrosine kinases and their downstream effector Gab2 in colorectal cancer cell lines.

Oncogene 2018 03 12;37(12):1576-1593. Epub 2018 Jan 12.

Signal Transduction in Tumour Development and Drug Resistance Group, Institute of Molecular Medicine and Cell Research (IMMZ), Faculty of Medicine, University of Freiburg, Freiburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41388-017-0063-5DOI Listing
March 2018

Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells.

Authors:
Nimitha R Mathew Francis Baumgartner Lukas Braun David O'Sullivan Simone Thomas Miguel Waterhouse Tony A Müller Kathrin Hanke Sanaz Taromi Petya Apostolova Anna L Illert Wolfgang Melchinger Sandra Duquesne Annette Schmitt-Graeff Lena Osswald Kai-Li Yan Arnim Weber Sonia Tugues Sabine Spath Dietmar Pfeifer Marie Follo Rainer Claus Michael Lübbert Christoph Rummelt Hartmut Bertz Ralph Wäsch Johanna Haag Andrea Schmidts Michael Schultheiss Dominik Bettinger Robert Thimme Evelyn Ullrich Yakup Tanriver Giang Lam Vuong Renate Arnold Philipp Hemmati Dominik Wolf Markus Ditschkowski Cordula Jilg Konrad Wilhelm Christian Leiber Sabine Gerull Jörg Halter Claudia Lengerke Thomas Pabst Thomas Schroeder Guido Kobbe Wolf Rösler Soroush Doostkam Stephan Meckel Kathleen Stabla Stephan K Metzelder Sebastian Halbach Tilman Brummer Zehan Hu Joern Dengjel Björn Hackanson Christoph Schmid Udo Holtick Christof Scheid Alexandros Spyridonidis Friedrich Stölzel Rainer Ordemann Lutz P Müller Flore Sicre-de-Fontbrune Gabriele Ihorst Jürgen Kuball Jan E Ehlert Daniel Feger Eva-Maria Wagner Jean-Yves Cahn Jacqueline Schnell Florian Kuchenbauer Donald Bunjes Ronjon Chakraverty Simon Richardson Saar Gill Nicolaus Kröger Francis Ayuk Luca Vago Fabio Ciceri Antonia M Müller Takeshi Kondo Takanori Teshima Susan Klaeger Bernhard Kuster Dennis Dong Hwan Kim Daniel Weisdorf Walter van der Velden Daniela Dörfel Wolfgang Bethge Inken Hilgendorf Andreas Hochhaus Geoffroy Andrieux Melanie Börries Hauke Busch John Magenau Pavan Reddy Myriam Labopin Joseph H Antin Andrea S Henden Geoffrey R Hill Glen A Kennedy Merav Bar Anita Sarma Donal McLornan Ghulam Mufti Betul Oran Katayoun Rezvani Omid Shah Robert S Negrin Arnon Nagler Marco Prinz Andreas Burchert Andreas Neubauer Dietrich Beelen Andreas Mackensen Nikolas von Bubnoff Wolfgang Herr Burkhard Becher Gerard Socié Michael A Caligiuri Eliana Ruggiero Chiara Bonini Georg Häcker Justus Duyster Jürgen Finke Erika Pearce Bruce R Blazar Robert Zeiser

Nat Med 2018 03 12;24(3):282-291. Epub 2018 Feb 12.

Department of Hematology, Oncology and Stem Cell Transplantation, Faculty of Medicine, University Medical Center Freiburg, University of Freiburg, Freiburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nm.4484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029618PMC
March 2018

Targeting oncogenic Ras by the toxin TpeL.

Oncotarget 2018 Mar 27;9(23):16489-16500. Epub 2018 Mar 27.

Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Medizinische Fakultät, Albert-Ludwigs-Universität Freiburg, Freiburg, Germany.

View Article

Download full-text PDF

Source
http://www.oncotarget.com/fulltext/24740
Publisher Site
http://dx.doi.org/10.18632/oncotarget.24740DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893256PMC
March 2018

Quantitative Proteomics Analysis of Leukemia Cells.

Methods Mol Biol 2016 ;1465:139-48

Institute of Molecular Medicine and Cell Research (IMMZ), Faculty of Medicine, University of Freiburg, Stefan Meier Strasse 17, 79104, Freiburg im Breisgau, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-4011-0_12DOI Listing
January 2018

Specific role of RhoC in tumor invasion and metastasis.

Oncotarget 2017 Oct 16;8(50):87364-87378. Epub 2017 Sep 16.

Institute for Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, Albert-Ludwigs-University, Freiburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/oncotarget.20957DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675639PMC
October 2017

The Atypical Kinase RIOK1 Promotes Tumor Growth and Invasive Behavior.

EBioMedicine 2017 Jun 12;20:79-97. Epub 2017 Apr 12.

Institute of Molecular Medicine and Cell Research (IMMZ), Faculty of Medicine, Albert-Ludwigs-University (ALU), Freiburg, Germany; Faculty of Biology, ALU, Freiburg, Germany; BIOSS Centre for Biological Signalling Studies, BIOSS, ALU, Germany; German Cancer Consortium (DKTK, Freiburg) and German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ebiom.2017.04.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478185PMC
June 2017

UV-B-induced cutaneous inflammation and prospects for antioxidant treatment in Kindler syndrome.

Hum Mol Genet 2016 12;25(24):5339-5352

Department of Dermatology, Medical Center - University of Freiburg, Freiburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/hmg/ddw350DOI Listing
December 2016

BRAF inhibitors in colorectal cancer: Toward a differentiation therapy?

Mol Cell Oncol 2015 Oct-Dec;2(4):e1002709. Epub 2015 Jan 23.

Institute of Molecular Medicine and Cell Research (IMMZ); Albert-Ludwigs-University (ALU); Freiburg, Germany; University Medical Center, ALU; Freiburg, Germany; Centre for Biological Signaling Studies BIOSS, ALU; Freiburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/23723556.2014.1002709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905336PMC
June 2016

B-Raf activation loop phosphorylation revisited.

Cell Cycle 2016 05 21;15(9):1171-3. Epub 2016 Apr 21.

a Institute of Molecular Medicine and Cell Research, Faculty of Medicine, Albert-Ludwigs-University , Freiburg , Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/15384101.2016.1159111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889292PMC
May 2016

Small-Molecule Stabilization of the 14-3-3/Gab2 Protein-Protein Interaction (PPI) Interface.

ChemMedChem 2016 Apr 8;11(8):911-8. Epub 2015 Dec 8.

Department of Chemistry, University of Duisburg-Essen, Universitätstr. 7, 45141, Essen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cmdc.201500484DOI Listing
April 2016

ZEB1 turns into a transcriptional activator by interacting with YAP1 in aggressive cancer types.

Nat Commun 2016 Feb 15;7:10498. Epub 2016 Feb 15.

Department of Experimental Medicine 1, Nikolaus-Fiebiger-Center for Molecular Medicine, FAU University Erlangen-Nürnberg, Glückstrasse 6, 91054 Erlangen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms10498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756710PMC
February 2016

Axitinib and sorafenib are potent in tyrosine kinase inhibitor resistant chronic myeloid leukemia cells.

Cell Commun Signal 2016 Feb 24;14. Epub 2016 Feb 24.

Institute of Molecular Medicine and Cell Research (IMMZ), Faculty of Medicine, University of Freiburg, Freiburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-016-0129-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765141PMC
February 2016

Activation loop phosphorylation regulates B-Raf in vivo and transformation by B-Raf mutants.

EMBO J 2016 Jan 10;35(2):143-61. Epub 2015 Dec 10.

Faculty of Medicine, Institute of Molecular Medicine and Cell Research, Albert-Ludwigs-University (ALU), Freiburg, Germany Centre for Biological Systems Analysis ZBSA, ALU, Freiburg, Germany Faculty of Biology, ALU, Freiburg, Germany Centre for Biological Signalling Studies BIOSS, ALU, Freiburg, Germany Comprehensive Cancer Centre, Freiburg, Germany German Consortium for Translational Cancer Research DKTK, Standort Freiburg, Germany

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15252/embj.201592097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718462PMC
January 2016

A self-enforcing CD44s/ZEB1 feedback loop maintains EMT and stemness properties in cancer cells.

Int J Cancer 2015 Dec 30;137(11):2566-77. Epub 2015 Jun 30.

Department of Visceral Surgery, University Medical Center Freiburg, D-79106, Freiburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ijc.29642DOI Listing
December 2015

Differential tyrosine phosphorylation controls the function of CNK1 as a molecular switch in signal transduction.

Biochim Biophys Acta 2015 Nov 28;1853(11 Pt A):2847-55. Epub 2015 Aug 28.

Faculty of Biology, Department of Biochemistry and Functional Proteomics, University of Freiburg, Schaenzlestr. 1, 79104 Freiburg, Germany; BIOSS Centre for Biological Signalling Studies, University of Freiburg, Schaenzlestr. 1, 79104 Freiburg, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbamcr.2015.08.014DOI Listing
November 2015

Kidins220/ARMS binds to the B cell antigen receptor and regulates B cell development and activation.

J Exp Med 2015 Sep 31;212(10):1693-708. Epub 2015 Aug 31.

Department of Molecular Immunology, BioIII, Faculty of Biology, University of Freiburg and Max Planck Institute of Immunobiology and Epigenetics, 79104 Freiburg, Germany Centre for Biological Signaling Studies (BIOSS), Spemann Graduate School of Biology and Medicine (SGBM), Centre of Chronic Immunodeficiency (CCI), Department of Dermatology, Center for Biological Systems Analysis (ZBSA), Institute of Molecular Medicine and Cell Research, Comprehensive Cancer Centre Freiburg, and Institute of Pathology, University Medical Center Freiburg, University of Freiburg, 79104 Freiburg, Germany Centre for Biological Signaling Studies (BIOSS), Spemann Graduate School of Biology and Medicine (SGBM), Centre of Chronic Immunodeficiency (CCI), Department of Dermatology, Center for Biological Systems Analysis (ZBSA), Institute of Molecular Medicine and Cell Research, Comprehensive Cancer Centre Freiburg, and Institute of Pathology, University Medical Center Freiburg, University of Freiburg, 79104 Freiburg, Germany

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1084/jem.20141271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577850PMC
September 2015

Exometabolom analysis of breast cancer cell lines: Metabolic signature.

Sci Rep 2015 Aug 21;5:13374. Epub 2015 Aug 21.

Center for Biological Systems Analysis ZBSA, Albert-Ludwigs-University Freiburg, 79104 Freiburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep13374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4544000PMC
August 2015

The EMT-activator ZEB1 induces bone metastasis associated genes including BMP-inhibitors.

Oncotarget 2015 Jun;6(16):14399-412

Department of Experimental Medicine I, Nikolaus-Fiebiger-Center for Molecular Medicine, University Erlangen-Nürnberg, Erlangen, Germany.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546475PMC
http://dx.doi.org/10.18632/oncotarget.3882DOI Listing
June 2015

Global gene expression profiling analysis reveals reduction of stemness after B-RAF inhibition in colorectal cancer cell lines.

Genom Data 2015 Jun 28;4:158-61. Epub 2015 Apr 28.

Systems Biology of the Cellular Microenvironment Group, Institute of Molecular Medicine and Cell Research (IMMZ), Albert-Ludwigs-University (ALU), Freiburg, Germany ; German Cancer Consortium (DKTK), Freiburg, Germany ; German Cancer Research Center (DKFZ), Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.gdata.2015.04.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535967PMC
June 2015

Metadherin exon 11 skipping variant enhances metastatic spread of ovarian cancer.

Int J Cancer 2015 May 8;136(10):2328-40. Epub 2014 Nov 8.

Department of Hematology and Oncology, Freiburg University Medical Center, University of Freiburg, Germany; Department of Psychiatry and Psychotherapy, Freiburg University Medical Center, University of Freiburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ijc.29289DOI Listing
May 2015

B-Raf inhibitors induce epithelial differentiation in BRAF-mutant colorectal cancer cells.

Cancer Res 2015 Jan 7;75(1):216-29. Epub 2014 Nov 7.

Signal Transduction in Tumour Development and Drug Resistance Group, Institute of Molecular Medicine and Cell Research (IMMZ), Albert-Ludwigs-University (ALU), Freiburg, Germany. Centre for Biological Signalling Studies BIOSS, ALU Freiburg.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-13-3686DOI Listing
January 2015

Expression pattern and first functional characterization of riok-1 in Caenorhabditis elegans.

Gene Expr Patterns 2014 Jul 12;15(2):124-34. Epub 2014 Jun 12.

Institute of Biology III, Faculty of Biology, University of Freiburg, Germany; Centre for Biological Systems Analysis (ZBSA), Freiburg, Germany; IMMZ - Institute of Molecular Medicine and Cell Research, Faculty of Medicine, University of Freiburg, Germany; BIOSS - Centre for Biological Signalling Studies, University of Freiburg, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.gep.2014.05.005DOI Listing
July 2014

Insulin-like growth factor-1 receptor (IGF1R) as a novel target in chronic lymphocytic leukemia.

Blood 2013 Aug 17;122(9):1621-33. Epub 2013 Jul 17.

Department of Hematology/Oncology, University Medical Center Freiburg, Freiburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2013-02-484386DOI Listing
August 2013

A generic strategy for pharmacological caging of growth factors for tissue engineering.

Chem Commun (Camb) 2013 Jul;49(53):5927-9

Faculty of Biology, University of Freiburg, Schänzlestrasse 1, 79104 Freiburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c3cc41616jDOI Listing
July 2013

Alterations of Gab2 signalling complexes in imatinib and dasatinib treated chronic myeloid leukaemia cells.

Cell Commun Signal 2013 Apr 22;11(1):30. Epub 2013 Apr 22.

Institute of Molecular Medicine and Cell Research (IMMZ), Faculty of Medicine, Albert-Ludwigs-University Freiburg, Stefan-Meier-Str, 17, Freiburg 79104, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1478-811X-11-30DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640961PMC
April 2013

Kidins220/ARMS associates with B-Raf and the TCR, promoting sustained Erk signaling in T cells.

J Immunol 2013 Mar 28;190(5):1927-35. Epub 2013 Jan 28.

Department of Molecular Immunology, Institute of Biology III, Faculty of Biology, University of Freiburg and Max Planck-Institute of Immunobiology and Epigenetics, Freiburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1200653DOI Listing
March 2013

PKD controls mitotic Golgi complex fragmentation through a Raf-MEK1 pathway.

Mol Biol Cell 2013 Feb 14;24(3):222-33. Epub 2012 Dec 14.

Institute of Cell Biology and Immunology, University of Stuttgart, 70569 Stuttgart, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1091/mbc.E12-03-0198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564543PMC
February 2013

The versatile role of Gab1 in the circulatory system.

Circ J 2012 11;76(8):1838-9. Epub 2012 Jul 11.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1253/circj.cj-12-0770DOI Listing
December 2012

Aberrant B-Raf signaling in human cancer -- 10 years from bench to bedside.

Crit Rev Oncog 2012 ;17(1):97-121

Spemann Graduate School of Biology and Medicine, Centre for Biological Systems Analysis, Faculty for Biology, Albert-Ludwigs-University of Freiburg, Germany.

View Article

Download full-text PDF

Source
May 2012

Mutated in colorectal cancer protein modulates the NFκB pathway.

Anticancer Res 2012 Jan;32(1):73-9

Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria Street, Sydney NSW 2010, Australia.

View Article

Download full-text PDF

Source
January 2012

Functional characterization of a BRAF insertion mutant associated with pilocytic astrocytoma.

Int J Cancer 2011 Nov 25;129(9):2297-303. Epub 2011 Jul 25.

Centre for Biological Systems Analysis (ZBSA), Albert-Ludwigs-University, Freiburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ijc.25893DOI Listing
November 2011

A novel MCF-10A line allowing conditional oncogene expression in 3D culture.

Cell Commun Signal 2011 Jul 13;9:17. Epub 2011 Jul 13.

Centre for Biological Systems Analysis (ZBSA), Albert-Ludwigs-University Freiburg, Habsburgerstraße 49, 79104 Freiburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1478-811X-9-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3163222PMC
July 2011

Docking proteins.

FEBS J 2010 Nov 30;277(21):4356-69. Epub 2010 Sep 30.

Centre for Biological Systems Analysis (ZBSA), Albert-Ludwigs-University of Freiburg, Freiburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1742-4658.2010.07865.xDOI Listing
November 2010

DUSP26 negatively affects the proliferation of epithelial cells, an effect not mediated by dephosphorylation of MAPKs.

Biochim Biophys Acta 2010 Sep 27;1803(9):1003-12. Epub 2010 Mar 27.

Garvan Institute of Medical Research, Darlinghurst, NSW, 2010 Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbamcr.2010.03.014DOI Listing
September 2010

Function, regulation and pathological roles of the Gab/DOS docking proteins.

Cell Commun Signal 2009 Sep 8;7:22. Epub 2009 Sep 8.

Centre for Biological Systems Analysis (ZBSA), Albert-Ludwigs-University of Freiburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1478-811X-7-22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2747914PMC
September 2009

How to Grb2 a Gab.

Structure 2009 Jun;17(6):779-81

Spemann Graduate School of Biology and Medicine, Albert-Ludwigs-University, 79104 Freiburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.str.2009.05.003DOI Listing
June 2009

Dual-specificity phosphatases: critical regulators with diverse cellular targets.

Biochem J 2009 Mar;418(3):475-89

Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst 2010, Sydney, NSW, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1042/bj20082234DOI Listing
March 2009

Increased proliferation and altered growth factor dependence of human mammary epithelial cells overexpressing the Gab2 docking protein.

J Biol Chem 2006 Jan 27;281(1):626-37. Epub 2005 Oct 27.

Cancer Research Program, Garvan Institute of Medical Research, Sydney, New South Wales 2010, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M509567200DOI Listing
January 2006

Adenosine and cAMP are potent inhibitors of the NF-kappa B pathway downstream of immunoreceptors.

Eur J Immunol 2005 Jan;35(1):31-41

Department of Molecular Immunology, Institute for Biology III, Albert Ludwigs University of Freiburg and Max Planck Institute for Immunobiology, 79108 Freiburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/eji.200425524DOI Listing
January 2005

B-cell signal transduction: tyrosine phosphorylation, kinase activity, and calcium mobilization.

Methods Mol Biol 2004 ;271:189-212

Department of Molecular Immunology, Biology III, University of Freiburg and Max-Planck-Institute for Immunobiology, Freiburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1385/1-59259-796-3:189DOI Listing
July 2004

A revised and complete map of the chicken c-mil/raf-1 locus.

Oncogene 2004 Apr;23(17):3128-31

Department of Molecular Immunology, Institute for Biology III, Albert-Ludwigs-University of Freiburg and Max-Planck-Institut for Immunobiology, Freiburg 79108, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/sj.onc.1207434DOI Listing
April 2004

Feedback regulation of lymphocyte signalling.

Nat Rev Immunol 2004 Apr;4(4):269-77

Department of Molecular Immunology, Institute for Biology III, Albert-Ludwigs-University of Freiburg and Max-Planck-Institut for Immunobiology, 79108 Freiburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nri1335DOI Listing
April 2004

Identification of novel ERK-mediated feedback phosphorylation sites at the C-terminus of B-Raf.

Oncogene 2003 Dec;22(55):8823-34

Department of Molecular Immunology, Biology III, University of Freiburg and Max-Planck Institute for Immunobiology, Stuebeweg 51, Freiburg 79108, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/sj.onc.1207185DOI Listing
December 2003

The adaptor protein SLP-65 acts as a tumor suppressor that limits pre-B cell expansion.

Nat Immunol 2003 Jan 18;4(1):38-43. Epub 2002 Nov 18.

Institute for Biology III, Albert-Ludwigs University of Freiburg and Max Planck Institute for Immunobiology, Stuebeweg 51, 79108 Freiburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ni862DOI Listing
January 2003

Inducible gene deletion reveals different roles for B-Raf and Raf-1 in B-cell antigen receptor signalling.

EMBO J 2002 Nov;21(21):5611-22

Department of Molecular Immunology, Biology III, University of Freiburg and Max-Planck-Institute for Immunobiology, Stuebeweg 51, Germany.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC131085PMC
http://dx.doi.org/10.1093/emboj/cdf588DOI Listing
November 2002