Till Milde

Till Milde

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Till Milde

Till Milde

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Retinoblastoma with late metastatic spread-a case report.

Pediatr Blood Cancer 2019 06 5;66(6):e27656. Epub 2019 Feb 5.

Hopp Children's Cancer Center (KiTZ), Heidelberg University Hospital, Heidelberg, Germany.

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https://onlinelibrary.wiley.com/doi/abs/10.1002/pbc.27656
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http://dx.doi.org/10.1002/pbc.27656DOI Listing
June 2019

Brainstem biopsy in pediatric diffuse intrinsic pontine glioma in the era of precision medicine: the INFORM study experience.

Eur J Cancer 2019 Jun 22;114:27-35. Epub 2019 Apr 22.

Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Heidelberg, Germany; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09598049193022
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http://dx.doi.org/10.1016/j.ejca.2019.03.019DOI Listing
June 2019

Klinischer Nutzen der molekularen Diagnostik pädiatrischer Hirntumore.

Klin Padiatr 2018 10 6;230(6):289-290. Epub 2018 Nov 6.

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http://dx.doi.org/10.1055/a-0750-8353DOI Listing
October 2018

Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort.

Lancet Oncol 2018 06 9;19(6):785-798. Epub 2018 May 9.

Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Heidelberg, Germany; Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany; Hopp Children's Cancer Center at the NCT Heidelberg, Heidelberg, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S14702045183024
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http://dx.doi.org/10.1016/S1470-2045(18)30242-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984248PMC
June 2018

Response in a child with a BRAF V600E mutated desmoplastic infantile astrocytoma upon retreatment with vemurafenib.

Pediatr Blood Cancer 2018 03 12;65(3). Epub 2017 Dec 12.

Department of Pediatric Hematology and Oncology, Hopp Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1002/pbc.26893DOI Listing
March 2018

DNA methylation-based classification of central nervous system tumours.

Authors:
David Capper David T W Jones Martin Sill Volker Hovestadt Daniel Schrimpf Dominik Sturm Christian Koelsche Felix Sahm Lukas Chavez David E Reuss Annekathrin Kratz Annika K Wefers Kristin Huang Kristian W Pajtler Leonille Schweizer Damian Stichel Adriana Olar Nils W Engel Kerstin Lindenberg Patrick N Harter Anne K Braczynski Karl H Plate Hildegard Dohmen Boyan K Garvalov Roland Coras Annett Hölsken Ekkehard Hewer Melanie Bewerunge-Hudler Matthias Schick Roger Fischer Rudi Beschorner Jens Schittenhelm Ori Staszewski Khalida Wani Pascale Varlet Melanie Pages Petra Temming Dietmar Lohmann Florian Selt Hendrik Witt Till Milde Olaf Witt Eleonora Aronica Felice Giangaspero Elisabeth Rushing Wolfram Scheurlen Christoph Geisenberger Fausto J Rodriguez Albert Becker Matthias Preusser Christine Haberler Rolf Bjerkvig Jane Cryan Michael Farrell Martina Deckert Jürgen Hench Stephan Frank Jonathan Serrano Kasthuri Kannan Aristotelis Tsirigos Wolfgang Brück Silvia Hofer Stefanie Brehmer Marcel Seiz-Rosenhagen Daniel Hänggi Volkmar Hans Stephanie Rozsnoki Jordan R Hansford Patricia Kohlhof Bjarne W Kristensen Matt Lechner Beatriz Lopes Christian Mawrin Ralf Ketter Andreas Kulozik Ziad Khatib Frank Heppner Arend Koch Anne Jouvet Catherine Keohane Helmut Mühleisen Wolf Mueller Ute Pohl Marco Prinz Axel Benner Marc Zapatka Nicholas G Gottardo Pablo Hernáiz Driever Christof M Kramm Hermann L Müller Stefan Rutkowski Katja von Hoff Michael C Frühwald Astrid Gnekow Gudrun Fleischhack Stephan Tippelt Gabriele Calaminus Camelia-Maria Monoranu Arie Perry Chris Jones Thomas S Jacques Bernhard Radlwimmer Marco Gessi Torsten Pietsch Johannes Schramm Gabriele Schackert Manfred Westphal Guido Reifenberger Pieter Wesseling Michael Weller Vincent Peter Collins Ingmar Blümcke Martin Bendszus Jürgen Debus Annie Huang Nada Jabado Paul A Northcott Werner Paulus Amar Gajjar Giles W Robinson Michael D Taylor Zane Jaunmuktane Marina Ryzhova Michael Platten Andreas Unterberg Wolfgang Wick Matthias A Karajannis Michel Mittelbronn Till Acker Christian Hartmann Kenneth Aldape Ulrich Schüller Rolf Buslei Peter Lichter Marcel Kool Christel Herold-Mende David W Ellison Martin Hasselblatt Matija Snuderl Sebastian Brandner Andrey Korshunov Andreas von Deimling Stefan M Pfister

Nature 2018 03 14;555(7697):469-474. Epub 2018 Mar 14.

Hopp Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/nature26000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093218PMC
March 2018

Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling.

Nature 2018 01 20;553(7686):101-105. Epub 2017 Dec 20.

Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.

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http://dx.doi.org/10.1038/nature25169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993422PMC
January 2018

Preclinical drug screen reveals topotecan, actinomycin D, and volasertib as potential new therapeutic candidates for ETMR brain tumor patients.

Neuro Oncol 2017 Nov;19(12):1607-1617

Division of Pediatric Neurooncology, German Cancer Research Center, Heidelberg, Germany; Cancer Consortium, Core Center Heidelberg, Heidelberg, Germany; Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, Alberta, Canada; Alberta Children's Hospital Research Institute and Charbonneau Cancer Institute, University of Calgary, Calgary, Alberta, Canada; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center, Heidelberg, Germany; Department of Pediatric Oncology, Hematology and Immunology, Section of Pediatric Brain Tumors, University Hospital Heidelberg, Heidelberg, Germany; National Center for Tumor Diseases, Clinical Trial Center, Heidelberg, Germany; Division of Neurosurgical Research, Department of Neurosurgery, University Hospital Heidelberg, Heidelberg, Germany; Clinical Cooperation Unit Neuropathology, German Cancer Research Center, Heidelberg, Germany; Department of Neuropathology, Heidelberg University Hospital, Heidelberg, Germany.

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http://dx.doi.org/10.1093/neuonc/nox093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716199PMC
November 2017

Three-dimensional tumor cell growth stimulates autophagic flux and recapitulates chemotherapy resistance.

Cell Death Dis 2017 08 24;8(8):e3013. Epub 2017 Aug 24.

Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), INF 280, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1038/cddis.2017.398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596581PMC
August 2017

The whole-genome landscape of medulloblastoma subtypes.

Nature 2017 07;547(7663):311-317

Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/nature22973DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905700PMC
July 2017

Next-generation personalised medicine for high-risk paediatric cancer patients - The INFORM pilot study.

Eur J Cancer 2016 09 29;65:91-101. Epub 2016 Jul 29.

Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Im Neuenheimer Feld 430, Heidelberg, 69120, Germany; German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, Heidelberg, 69120, Germany; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, 69120, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2016.06.009DOI Listing
September 2016

New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs.

Authors:
Dominik Sturm Brent A Orr Umut H Toprak Volker Hovestadt David T W Jones David Capper Martin Sill Ivo Buchhalter Paul A Northcott Irina Leis Marina Ryzhova Christian Koelsche Elke Pfaff Sariah J Allen Gnanaprakash Balasubramanian Barbara C Worst Kristian W Pajtler Sebastian Brabetz Pascal D Johann Felix Sahm Jüri Reimand Alan Mackay Diana M Carvalho Marc Remke Joanna J Phillips Arie Perry Cynthia Cowdrey Rachid Drissi Maryam Fouladi Felice Giangaspero Maria Łastowska Wiesława Grajkowska Wolfram Scheurlen Torsten Pietsch Christian Hagel Johannes Gojo Daniela Lötsch Walter Berger Irene Slavc Christine Haberler Anne Jouvet Stefan Holm Silvia Hofer Marco Prinz Catherine Keohane Iris Fried Christian Mawrin David Scheie Bret C Mobley Matthew J Schniederjan Mariarita Santi Anna M Buccoliero Sonika Dahiya Christof M Kramm André O von Bueren Katja von Hoff Stefan Rutkowski Christel Herold-Mende Michael C Frühwald Till Milde Martin Hasselblatt Pieter Wesseling Jochen Rößler Ulrich Schüller Martin Ebinger Jens Schittenhelm Stephan Frank Rainer Grobholz Istvan Vajtai Volkmar Hans Reinhard Schneppenheim Karel Zitterbart V Peter Collins Eleonora Aronica Pascale Varlet Stephanie Puget Christelle Dufour Jacques Grill Dominique Figarella-Branger Marietta Wolter Martin U Schuhmann Tarek Shalaby Michael Grotzer Timothy van Meter Camelia-Maria Monoranu Jörg Felsberg Guido Reifenberger Matija Snuderl Lynn Ann Forrester Jan Koster Rogier Versteeg Richard Volckmann Peter van Sluis Stephan Wolf Tom Mikkelsen Amar Gajjar Kenneth Aldape Andrew S Moore Michael D Taylor Chris Jones Nada Jabado Matthias A Karajannis Roland Eils Matthias Schlesner Peter Lichter Andreas von Deimling Stefan M Pfister David W Ellison Andrey Korshunov Marcel Kool

Cell 2016 Feb;164(5):1060-1072

Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.

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http://www.cell.com/cell/pdf/S0092-8674(16)00055-6.pdf
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http://www.cell.com/cms/attachment/2048488015/2058390163/mmc
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http://linkinghub.elsevier.com/retrieve/pii/S009286741600055
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http://dx.doi.org/10.1016/j.cell.2016.01.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5139621PMC
February 2016

Quantification of vorinostat and its main metabolites in plasma and intracellular vorinostat in PBMCs by liquid chromatography coupled to tandem mass spectrometry and its relation to histone deacetylase activity in human blood.

J Chromatogr B Analyt Technol Biomed Life Sci 2014 Aug 18;964:212-21. Epub 2014 Feb 18.

Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Im Neuenheimer Feld 410, Heidelberg, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15700232140009
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http://dx.doi.org/10.1016/j.jchromb.2014.02.014DOI Listing
August 2014

GRHL1 acts as tumor suppressor in neuroblastoma and is negatively regulated by MYCN and HDAC3.

Cancer Res 2014 May 13;74(9):2604-16. Epub 2014 Jan 13.

Authors' Affiliations: Clinical Cooperation Unit Pediatric Oncology; Departments of Biostatistics and Tumor Genetics; Clinical Cooperation Unit Neuropathology; Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ); Departments of Neuropathology and Pediatric Hematology and Oncology, University of Heidelberg, Heidelberg; Transcriptome Analysis Laboratory, University of Goettingen, Goettingen; St. Lukas Klinik Solingen, Solingen; Department of Pediatric Hematology and Oncology; and Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-1904DOI Listing
May 2014

Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition.

Cancer Cell 2014 Mar;25(3):393-405

Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69121 Heidelberg, Germany; Department of Pediatric Oncology, Hematology and Immunology, University Hospital Heidelberg, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.ccr.2014.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493053PMC
March 2014

Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma.

Nat Genet 2013 Aug 30;45(8):927-32. Epub 2013 Jun 30.

Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://pubman.mpdl.mpg.de/pubman/item/escidoc:1982973/compon
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http://www.nature.com/doifinder/10.1038/ng.2682
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http://dx.doi.org/10.1038/ng.2682DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951336PMC
August 2013

Targeting of histone deacetylases in brain tumors.

CNS Oncol 2013 Jul;2(4):359-76

Clinical Cooperation Unit Pediatric Oncology (G340), German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.2217/cns.13.24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166540PMC
July 2013

Emerging insights into the ependymoma epigenome.

Brain Pathol 2013 Mar;23(2):206-9

Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1111/bpa.12020DOI Listing
March 2013

Molecular approaches to ependymoma: the next step(s).

Curr Opin Neurol 2012 Dec;25(6):745-50

Division of Pediatric Neurooncology, German Cancer Research Center, Heidelberg, Germany.

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http://pdfs.journals.lww.com/co-neurology/2012/12000/Molecul
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/WCO.0b013e328359cdf5DOI Listing
December 2012

Nestin expression identifies ependymoma patients with poor outcome.

Brain Pathol 2012 Nov 30;22(6):848-60. Epub 2012 May 30.

Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center, Heidelberg, Germany.

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http://dx.doi.org/10.1111/j.1750-3639.2012.00600.xDOI Listing
November 2012

Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma.

Cancer Cell 2012 Oct;22(4):425-37

Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) Heidelberg, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.ccr.2012.08.024DOI Listing
October 2012

Dissecting the genomic complexity underlying medulloblastoma.

Nature 2012 Aug;488(7409):100-5

Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.

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http://dx.doi.org/10.1038/nature11284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3662966PMC
August 2012

HDAC5 and HDAC9 in medulloblastoma: novel markers for risk stratification and role in tumor cell growth.

Clin Cancer Res 2010 Jun 22;16(12):3240-52. Epub 2010 Apr 22.

Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center, Heidelberg, Germany.

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http://dx.doi.org/10.1158/1078-0432.CCR-10-0395DOI Listing
June 2010

Slitrk5 deficiency impairs corticostriatal circuitry and leads to obsessive-compulsive-like behaviors in mice.

Nat Med 2010 May 25;16(5):598-602, 1p following 602. Epub 2010 Apr 25.

[1] Howard Hughes Medical Institute, Ansary Stem Cell Institute and Department of Genetic Medicine, Weill Cornell Medical College, New York, New York, USA. [2] These authors contributed equally to this work.

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http://www.nature.com/articles/nm.2125
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http://dx.doi.org/10.1038/nm.2125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2907076PMC
May 2010

Targeting of HDAC8 and investigational inhibitors in neuroblastoma.

Expert Opin Investig Drugs 2009 Nov;18(11):1605-17

German Cancer Research Center, CCU Pediatric Oncology, INF 280, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1517/14728220903241658DOI Listing
November 2009

HDAC family: What are the cancer relevant targets?

Cancer Lett 2009 May 27;277(1):8-21. Epub 2008 Sep 27.

CCU Pediatric Oncology (G340), German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg, Germany.

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http://www.ibrarian.net/navon/paper/HDAC_family__What_are_th
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http://dx.doi.org/10.1016/j.canlet.2008.08.016DOI Listing
May 2009

Stepwise accumulation of distinct genomic aberrations in a patient with progressively metastasizing ependymoma.

Genes Chromosomes Cancer 2009 Mar;48(3):229-38

Clinical Cooperation Unit Pediatric Oncology (G340), German Cancer Research Center, Heidelberg, Germany.

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http://doi.wiley.com/10.1002/gcc.20635
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http://dx.doi.org/10.1002/gcc.20635DOI Listing
March 2009

Thrombospondins deployed by thrombopoietic cells determine angiogenic switch and extent of revascularization.

J Clin Invest 2006 Dec;116(12):3277-91

Howard Hughes Medical Institute, Department of Genetic Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA.

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http://dx.doi.org/10.1172/JCI29314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1679710PMC
December 2006

Multifocal osteochondroma after repeated irradiation in a boy with Hodgkin disease.

J Pediatr Hematol Oncol 2005 Jun;27(6):344-5

Abteilung Pädiatrie I, Zentrum für Kinderheilkunde und Jugendmedizin, Universitätsklinikum Göttingen, Göttingen, Germany.

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http://dx.doi.org/10.1097/01.mph.0000170886.20335.cbDOI Listing
June 2005