Publications by authors named "Till Acker"

68Publications

Deep Learning Reveals Cancer Metastasis and Therapeutic Antibody Targeting in the Entire Body.

Cell 2019 Dec;179(7):1661-1676.e19

Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Zentrum München, 85764 Neuherberg, Germany; Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig Maximilian University of Munich (LMU), 81377 Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.11.013DOI Listing
December 2019

Diverse phenotype in patients with complex I deficiency due to mutations in NDUFB11.

Eur J Med Genet 2019 Nov 10;62(11):103572. Epub 2018 Nov 10.

Department of Clinical Genetics, United Laboratories, Tartu University Hospital, Tartu, Estonia; Department of Clinical Genetics, Institute of Clinical Medicine, University of Tartu, Tartu, Estonia. Electronic address:

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http://dx.doi.org/10.1016/j.ejmg.2018.11.006DOI Listing
November 2019

Endothelial Dab1 signaling orchestrates neuro-glia-vessel communication in the central nervous system.

Science 2018 08;361(6404)

Institute of Cell Biology and Neuroscience and Buchmann Institute for Molecular Life Sciences, University of Frankfurt, D-60438 Frankfurt am Main, Germany.

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http://dx.doi.org/10.1126/science.aao2861DOI Listing
August 2018

Implementing Pharmacogenomic Clinical Decision Support into German Hospitals.

Stud Health Technol Inform 2018 ;247:870-874

Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany.

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June 2018

DNA methylation-based classification of central nervous system tumours.

Authors:
David Capper David T W Jones Martin Sill Volker Hovestadt Daniel Schrimpf Dominik Sturm Christian Koelsche Felix Sahm Lukas Chavez David E Reuss Annekathrin Kratz Annika K Wefers Kristin Huang Kristian W Pajtler Leonille Schweizer Damian Stichel Adriana Olar Nils W Engel Kerstin Lindenberg Patrick N Harter Anne K Braczynski Karl H Plate Hildegard Dohmen Boyan K Garvalov Roland Coras Annett Hölsken Ekkehard Hewer Melanie Bewerunge-Hudler Matthias Schick Roger Fischer Rudi Beschorner Jens Schittenhelm Ori Staszewski Khalida Wani Pascale Varlet Melanie Pages Petra Temming Dietmar Lohmann Florian Selt Hendrik Witt Till Milde Olaf Witt Eleonora Aronica Felice Giangaspero Elisabeth Rushing Wolfram Scheurlen Christoph Geisenberger Fausto J Rodriguez Albert Becker Matthias Preusser Christine Haberler Rolf Bjerkvig Jane Cryan Michael Farrell Martina Deckert Jürgen Hench Stephan Frank Jonathan Serrano Kasthuri Kannan Aristotelis Tsirigos Wolfgang Brück Silvia Hofer Stefanie Brehmer Marcel Seiz-Rosenhagen Daniel Hänggi Volkmar Hans Stephanie Rozsnoki Jordan R Hansford Patricia Kohlhof Bjarne W Kristensen Matt Lechner Beatriz Lopes Christian Mawrin Ralf Ketter Andreas Kulozik Ziad Khatib Frank Heppner Arend Koch Anne Jouvet Catherine Keohane Helmut Mühleisen Wolf Mueller Ute Pohl Marco Prinz Axel Benner Marc Zapatka Nicholas G Gottardo Pablo Hernáiz Driever Christof M Kramm Hermann L Müller Stefan Rutkowski Katja von Hoff Michael C Frühwald Astrid Gnekow Gudrun Fleischhack Stephan Tippelt Gabriele Calaminus Camelia-Maria Monoranu Arie Perry Chris Jones Thomas S Jacques Bernhard Radlwimmer Marco Gessi Torsten Pietsch Johannes Schramm Gabriele Schackert Manfred Westphal Guido Reifenberger Pieter Wesseling Michael Weller Vincent Peter Collins Ingmar Blümcke Martin Bendszus Jürgen Debus Annie Huang Nada Jabado Paul A Northcott Werner Paulus Amar Gajjar Giles W Robinson Michael D Taylor Zane Jaunmuktane Marina Ryzhova Michael Platten Andreas Unterberg Wolfgang Wick Matthias A Karajannis Michel Mittelbronn Till Acker Christian Hartmann Kenneth Aldape Ulrich Schüller Rolf Buslei Peter Lichter Marcel Kool Christel Herold-Mende David W Ellison Martin Hasselblatt Matija Snuderl Sebastian Brandner Andrey Korshunov Andreas von Deimling Stefan M Pfister

Nature 2018 03 14;555(7697):469-474. Epub 2018 Mar 14.

Hopp Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/nature26000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093218PMC
March 2018

Analysis of Hypoxia and the Hypoxic Response in Tumor Xenografts.

Methods Mol Biol 2018 ;1742:283-300

Institute of Neuropathology, University of Giessen, Giessen, Germany.

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http://dx.doi.org/10.1007/978-1-4939-7665-2_25DOI Listing
January 2019

Hypoxia-inducible factor-1α activation in HPV-positive head and neck squamous cell carcinoma cell lines.

Oncotarget 2017 Oct 11;8(52):89681-89691. Epub 2017 Sep 11.

Department of Otorhinolaryngology, Head and Neck Surgery, University of Giessen, Giessen, Germany.

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http://dx.doi.org/10.18632/oncotarget.20813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685701PMC
October 2017

The experience of physicians in pharmacogenomic clinical decision support within eight German university hospitals.

Pharmacogenomics 2017 Jun 8;18(8):773-785. Epub 2017 Jun 8.

Chair of Medical Informatics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.

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http://dx.doi.org/10.2217/pgs-2017-0027DOI Listing
June 2017

Quantification of muscle pathology in infantile Pompe disease.

Neuromuscul Disord 2017 Feb 3;27(2):141-152. Epub 2016 Nov 3.

Department of Child Neurology, Justus Liebig University, Gießen, Germany.

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http://dx.doi.org/10.1016/j.nmd.2016.10.010DOI Listing
February 2017

Acidosis Acts through HSP90 in a PHD/VHL-Independent Manner to Promote HIF Function and Stem Cell Maintenance in Glioma.

Cancer Res 2016 10 3;76(19):5845-5856. Epub 2016 Aug 3.

Institute of Neuropathology, University of Giessen, Giessen, Germany.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-2630DOI Listing
October 2016

Implications of Oxygen Homeostasis for Tumor Biology and Treatment.

Adv Exp Med Biol 2016 ;903:169-85

Institute of Neuropathology, Justus Liebig University, Giessen, 35392, Germany.

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http://dx.doi.org/10.1007/978-1-4899-7678-9_12DOI Listing
June 2017

An improved anatomical MRI technique with suppression of fixative fluid artifacts for the investigation of human postmortem brain phantoms.

Magn Reson Med 2017 03 7;77(3):1115-1123. Epub 2016 Mar 7.

Brain Imaging Center (BIC), Goethe University, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1002/mrm.26196DOI Listing
March 2017

Acupuncture-brain interactions as hypothesized by mood scale recordings.

Med Hypotheses 2015 Sep 22;85(3):371-9. Epub 2015 May 22.

Forschungsinstitut für Notfallmedizin und Gesundheit, Dortmund, Germany.

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http://dx.doi.org/10.1016/j.mehy.2015.05.013DOI Listing
September 2015

PHD3 regulates EGFR internalization and signalling in tumours.

Nat Commun 2014 Nov 25;5:5577. Epub 2014 Nov 25.

1] Institute of Neuropathology, University of Giessen, 35392 Giessen, Germany [2].

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http://dx.doi.org/10.1038/ncomms6577DOI Listing
November 2014

Isolation and culture of primary glioblastoma cells from human tumor specimens.

Methods Mol Biol 2015 ;1235:263-75

Institute of Neuropathology, University of Giessen, Arndtstrasse 16, 35392, Giessen, Germany.

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http://dx.doi.org/10.1007/978-1-4939-1785-3_19DOI Listing
July 2015

Stress-induced upregulation of SLC19A3 is impaired in biotin-thiamine-responsive basal ganglia disease.

Brain Pathol 2014 Apr 29;24(3):270-9. Epub 2014 Jan 29.

Institute of Neuropathology, Justus-Liebig-University, Giessen, Germany.

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http://dx.doi.org/10.1111/bpa.12117DOI Listing
April 2014

Increased mitotic and proliferative activity are associated with worse prognosis in papillary tumors of the pineal region.

Am J Surg Pathol 2014 Jan;38(1):106-10

*Institute of Neuropathology, University Hospital Münster, Münster †Department of Neuropathology, Institute for Pathology and Neuropathology, University of Tübingen, Tübingen ‡Institute of Neurology (Edinger Institute), Goethe University, Frankfurt §Institute of Pathology and Neuropathology, University Hospital Essen, Essen ∥Department of Neuropathology, Regensburg University Hospital, Regensburg #Department of Neuropathology, Institute of Pathology, Hannover Medical School, Hannover **Institute of Neuropathology, Justus Liebig University, Giessen ††Department of Neuropathology, University Hospital Erlangen, Erlangen, Germany ¶Department of Clinical Pathology, Section of Neuropathology, Institute of Pathology, University of Bern, Bern, Switzerland.

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http://dx.doi.org/10.1097/PAS.0b013e31829e492dDOI Listing
January 2014

Extracellular RNA liberates tumor necrosis factor-α to promote tumor cell trafficking and progression.

Cancer Res 2013 Aug 17;73(16):5080-9. Epub 2013 Jun 17.

Department of Biochemistry, Medical School, Justus-Liebig-University, Giessen, Germany.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-4657DOI Listing
August 2013

The cancer stem cell niche(s): the crosstalk between glioma stem cells and their microenvironment.

Biochim Biophys Acta 2013 Feb 16;1830(2):2496-508. Epub 2012 Oct 16.

Institute of Neuropathology, University of Giessen, Germany.

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http://dx.doi.org/10.1016/j.bbagen.2012.10.008DOI Listing
February 2013

Cancer stem cells: a new framework for the design of tumor therapies.

J Mol Med (Berl) 2011 Feb 2;89(2):95-107. Epub 2010 Oct 2.

Institute of Neuropathology, Justus Liebig University, Giessen, Germany.

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http://www.springerlink.com/index/P524743141442118.pdf
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http://dx.doi.org/10.1007/s00109-010-0685-3DOI Listing
February 2011

Feedback regulators of hypoxia-inducible factors and their role in cancer biology.

Cell Cycle 2010 Jul 30;9(14):2749-63. Epub 2010 Jul 30.

Institute of Neuropathology, Giessen, Germany.

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http://dx.doi.org/10.4161/cc.9.14.12591DOI Listing
July 2010

Ephrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesis.

Nature 2010 May 5;465(7297):487-91. Epub 2010 May 5.

Frankfurt Institute for Molecular Life Sciences and Institute of Cell Biology and Neuroscience, Goethe University Frankfurt, Max-von-Laue-Strasse 9, D-60438 Frankfurt am Main, Germany.

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http://dx.doi.org/10.1038/nature08995DOI Listing
May 2010

Brain tumor stem cells.

Recent Results Cancer Res 2009 ;171:241-59

Neurological Institute (Edinger-Institute), Neuroscience Center, Heinrich-Hoffmann-Str. 7, Frankfurt am Main 60528, Germany.

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http://dx.doi.org/10.1007/978-3-540-31206-2_14DOI Listing
June 2009

Angiopoietin 1 and 2 gene and protein expression is differentially regulated in acute anti-Thy1.1 glomerulonephritis.

Am J Physiol Renal Physiol 2008 May 13;294(5):F1174-84. Epub 2008 Feb 13.

Department of Pathology, University of Erlangen-Nürnberg, Krankenhausstr. 12, 91054 Erlangen, Germany.

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http://dx.doi.org/10.1152/ajprenal.00320.2007DOI Listing
May 2008

Analysis of glomerular VEGF mRNA and protein expression in murine mesangioproliferative glomerulonephritis.

Virchows Arch 2007 Jan 22;450(1):81-92. Epub 2006 Nov 22.

Department of Internal Medicine, University of Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.1007/s00428-006-0340-0DOI Listing
January 2007

The good, the bad and the ugly in oxygen-sensing: ROS, cytochromes and prolyl-hydroxylases.

Cardiovasc Res 2006 Jul 22;71(2):195-207. Epub 2006 Apr 22.

Neurologisches Institut, Edinger Institut, Klinikum der J.W. Goethe Universität Frankfurt am Main, Deutschordenstr. 46, D-60528 Frankfurt, Germany.

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http://dx.doi.org/10.1016/j.cardiores.2006.04.008DOI Listing
July 2006

Vascularization and expression of hypoxia-related tissue factors in intracranial ependymoma and their impact on patient survival.

Acta Neuropathol 2005 Feb 22;109(2):211-6. Epub 2004 Dec 22.

Institute of Neurology, Medical University Vienna, AKH 4J, Waehringer Guertel 18-20, PO Box 48, 1097, Vienna, Austria.

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http://dx.doi.org/10.1007/s00401-004-0938-8DOI Listing
February 2005

Cellular oxygen sensing need in CNS function: physiological and pathological implications.

J Exp Biol 2004 Aug;207(Pt 18):3171-88

Karolinska Institute, Cellular and Molecular Biology, Stockholm, Sweden.

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http://dx.doi.org/10.1242/jeb.01075DOI Listing
August 2004

Hypoxia and hypoxia inducible factors (HIF) as important regulators of tumor physiology.

Cancer Treat Res 2004 ;117:219-48

Edinger Institute, Neuropathology, Johann-Wolfgang Goethe University, Deutschordenstr. 46, 60528 Frankfurt, Germany.

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http://dx.doi.org/10.1007/978-1-4419-8871-3_14DOI Listing
April 2004

Role of hypoxia in tumor angiogenesis-molecular and cellular angiogenic crosstalk.

Cell Tissue Res 2003 Oct 29;314(1):145-55. Epub 2003 Jul 29.

Department of Cell and Molecular Biology, Karolinska Institute, Box 285, SE-17177, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00441-003-0763-8DOI Listing
October 2003

Participation of bone marrow-derived cells in long-term repair processes after experimental stroke.

J Cereb Blood Flow Metab 2003 Jun;23(6):709-17

GSF-Research Center for Environment & Health, Institute for Clinical Molecular Biology and Tumor Genetics, Munich, Germany.

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http://dx.doi.org/10.1097/01.WCB.0000065940.18332.8DDOI Listing
June 2003

A role for hypoxia and hypoxia-inducible transcription factors in tumor physiology.

J Mol Med (Berl) 2002 Sep 21;80(9):562-75. Epub 2002 Jun 21.

Edinger Institute, Johann Wolfgang Goethe University, Deutschordenstrasse 46, 60528 Frankfurt, Germany.

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http://link.springer.com/10.1007/s00109-002-0355-1
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http://dx.doi.org/10.1007/s00109-002-0355-1DOI Listing
September 2002

Cell type-specific expression of neuropilins in an MCA-occlusion model in mice suggests a potential role in post-ischemic brain remodeling.

J Neuropathol Exp Neurol 2002 Apr;61(4):339-50

Institute of Neurology (Edinger-institute), JWG University, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1093/jnen/61.4.339DOI Listing
April 2002