Tilat Rizvi

Tilat Rizvi

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Tilat Rizvi

Tilat Rizvi

Publications by authors named "Tilat Rizvi"

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34Publications

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STAT3 inhibition reduces macrophage number and tumor growth in neurofibroma.

Oncogene 2019 04 12;38(15):2876-2884. Epub 2018 Dec 12.

Department of Pediatrics, University of Cincinnati College of Medicine, Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital, 3333 Burnet Ave., Cincinnati, OH, 45229-0713, USA.

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http://dx.doi.org/10.1038/s41388-018-0600-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461477PMC
April 2019

Cxcr3-expressing leukocytes are necessary for neurofibroma formation in mice.

JCI Insight 2019 Feb 7;4(3). Epub 2019 Feb 7.

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

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http://dx.doi.org/10.1172/jci.insight.98601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413799PMC
February 2019

Angiotensin receptor signaling in sickle cell anemia has a reno-protective effect on urine concentrating ability but results in sickle glomerulopathy.

Am J Hematol 2018 07 15;93(7):E177-E181. Epub 2018 May 15.

Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, Cincinnati Children's Research Foundation, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 45229.

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http://dx.doi.org/10.1002/ajh.25118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037553PMC
July 2018

Programming of Schwann Cells by Lats1/2-TAZ/YAP Signaling Drives Malignant Peripheral Nerve Sheath Tumorigenesis.

Cancer Cell 2018 02;33(2):292-308.e7

Division of Experimental Hematology and Cancer Biology, Brain Tumor Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Key Laboratory of Birth Defects, Children's Hospital of Fudan University, Shanghai, China. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813693PMC
February 2018

Oligodendrocyte Nf1 Controls Aberrant Notch Activation and Regulates Myelin Structure and Behavior.

Cell Rep 2017 04;19(3):545-557

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247173045
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http://dx.doi.org/10.1016/j.celrep.2017.03.073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828008PMC
April 2017

Activity of Selumetinib in Neurofibromatosis Type 1-Related Plexiform Neurofibromas.

N Engl J Med 2016 12;375(26):2550-2560

From the Center for Cancer Research, Pediatric Oncology Branch, Bethesda (E.D., A. Baldwin, L.J.M., P. Whitcomb, S.M., R.E., P. Wolters, J.T., J.G., A.J.S., A.G., B.C.W.) and the Cancer Therapy Evaluation Program, Shady Grove (A.L.D.), National Cancer Institute, and the National Heart, Lung, and Blood Institute (A. Brofferio), Bethesda, National Institutes of Health, and the Food and Drug Administration, Silver Spring (L.J.M., R.E.) - all in Maryland; the Division of Oncology, Children's Hospital of Philadelphia, and the Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia (M.J.F., J.B.B.); Children's National Health System, Washington, DC (A.K.); and Cincinnati Children's Hospital, Cincinnati (B.W., L.E.A.-S., T.A.R., J.W., E.S., N.R.).

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http://dx.doi.org/10.1056/NEJMoa1605943DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508592PMC
December 2016

CK2 blockade causes MPNST cell apoptosis and promotes degradation of β-catenin.

Oncotarget 2016 Aug;7(33):53191-53203

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital, Department of Pediatrics, University of Cincinnati, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.18632/oncotarget.10668DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288178PMC
August 2016

Preclinical assessments of the MEK inhibitor PD-0325901 in a mouse model of Neurofibromatosis type 1.

Pediatr Blood Cancer 2015 Oct 22;62(10):1709-16. Epub 2015 Apr 22.

Division of Experimental Hematology and Cancer Biology, Children's Hospital Medical Center, Cincinnati, Ohio.

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http://dx.doi.org/10.1002/pbc.25546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546559PMC
October 2015

Genetic diminution of circulating prothrombin ameliorates multiorgan pathologies in sickle cell disease mice.

Blood 2015 Oct 18;126(15):1844-55. Epub 2015 Aug 18.

Division of Experimental Hematology and Cancer Biology, Division of Hematology, Cancer and Blood Diseases Institute, and.

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http://dx.doi.org/10.1182/blood-2015-01-625707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600020PMC
October 2015

The protein tyrosine phosphatase Shp2 is required for the generation of oligodendrocyte progenitor cells and myelination in the mouse telencephalon.

J Neurosci 2014 Mar;34(10):3767-78

Divisions of Experimental Hematology and Cancer Biology, Molecular Cardiovascular Biology, Oncology, and Developmental Biology and Neurosurgery, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, and Department of Medical Pharmacology and Physiology, Dalton Cardiovascular Research Center, University of Missouri Columbia, Columbia, Missouri 65211.

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http://dx.doi.org/10.1523/JNEUROSCI.3515-13.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942589PMC
March 2014

The protein kinase A regulatory subunit R1A (Prkar1a) plays critical roles in peripheral nerve development.

J Neurosci 2013 Nov;33(46):17967-75

Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, Department of Molecular, Virology, Immunology, and Medical Genetics, and Division of Endocrinology, Diabetes, and Metabolism, Department of Internal Medicine The Ohio State University, Columbus, Ohio 43210.

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http://dx.doi.org/10.1523/JNEUROSCI.0766-13.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828453PMC
November 2013

Nf1 loss and Ras hyperactivation in oligodendrocytes induce NOS-driven defects in myelin and vasculature.

Cell Rep 2013 Sep 12;4(6):1197-212. Epub 2013 Sep 12.

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1016/j.celrep.2013.08.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982616PMC
September 2013

Neurofibroma-associated macrophages play roles in tumor growth and response to pharmacological inhibition.

Acta Neuropathol 2013 Jan 26;125(1):159-68. Epub 2012 Oct 26.

Division of Human Genetics, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1007/s00401-012-1056-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547628PMC
January 2013

MEK inhibition exhibits efficacy in human and mouse neurofibromatosis tumors.

J Clin Invest 2013 Jan 10;123(1):340-7. Epub 2012 Dec 10.

Children’s Hospital Medical Center, Division of Experimental Hematology and Cancer Biology, 3333 Burnet Ave., M.L.C. 7013, Cincinnati, Ohio 45229, USA.

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http://dx.doi.org/10.1172/JCI60578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533264PMC
January 2013

Conditional Inactivation of Pten with EGFR Overexpression in Schwann Cells Models Sporadic MPNST.

Sarcoma 2012 18;2012:620834. Epub 2012 Dec 18.

Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA ; Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA ; Center for Genome Engineering, University of Minnesota, Minneapolis, MN 55455, USA ; Brain Tumor Program, University of Minnesota, Minneapolis, MN 55455, USA ; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.

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http://www.hindawi.com/journals/sarcoma/2012/620834/
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http://dx.doi.org/10.1155/2012/620834DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539440PMC
January 2013

Ras-driven transcriptome analysis identifies aurora kinase A as a potential malignant peripheral nerve sheath tumor therapeutic target.

Clin Cancer Res 2012 Sep 18;18(18):5020-30. Epub 2012 Jul 18.

Divisions of Experimental Hematology and Cancer Biology, Oncology, and Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-12-1072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902639PMC
September 2012

Ectopic myelinating oligodendrocytes in the dorsal spinal cord as a consequence of altered semaphorin 6D signaling inhibit synapse formation.

Development 2011 Sep 10;138(18):4085-95. Epub 2011 Aug 10.

Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1242/dev.066076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160102PMC
September 2011

Perinatal or adult Nf1 inactivation using tamoxifen-inducible PlpCre each cause neurofibroma formation.

Cancer Res 2011 Jul 6;71(13):4675-85. Epub 2011 May 6.

Cincinnati Children's Hospital Medical Center; Hoxworth Blood Center, University of Cincinnati, Cincinnati, Ohio, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-4558DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3464476PMC
July 2011

Nf1 mutation expands an EGFR-dependent peripheral nerve progenitor that confers neurofibroma tumorigenic potential.

Cell Stem Cell 2008 Dec;3(6):658-69

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Research Foundation, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1016/j.stem.2008.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3487385PMC
December 2008

Plexiform and dermal neurofibromas and pigmentation are caused by Nf1 loss in desert hedgehog-expressing cells.

Cancer Cell 2008 Feb;13(2):105-16

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Research Foundation, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1016/j.ccr.2007.12.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846699PMC
February 2008

Overexpression of the epidermal growth factor receptor confers migratory properties to nonmigratory postnatal neural progenitors.

J Neurosci 2005 Nov;25(48):11092-106

Center for Neuroscience Research, Children's Research Institute, Children's National Medical Center, Washington, DC 20010, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.2981-05.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6725641PMC
November 2005

Role for the epidermal growth factor receptor in neurofibromatosis-related peripheral nerve tumorigenesis.

Cancer Cell 2005 Jan;7(1):65-75

Departments of Cell Biology, Neurobiology, and Anatomy, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA.

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http://dx.doi.org/10.1016/j.ccr.2004.10.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2854500PMC
January 2005

CD44 overexpression by oligodendrocytes: a novel mouse model of inflammation-independent demyelination and dysmyelination.

Glia 2004 Sep;47(4):335-45

Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton 97006, USA.

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http://dx.doi.org/10.1002/glia.20042DOI Listing
September 2004

Aberrant growth and differentiation of oligodendrocyte progenitors in neurofibromatosis type 1 mutants.

J Neurosci 2003 Aug;23(18):7207-17

Department of Cell Biology, Neurobiology, and Anatomy, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0521, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6740670PMC
August 2003

Brain lipid binding protein in axon-Schwann cell interactions and peripheral nerve tumorigenesis.

Mol Cell Biol 2003 Mar;23(6):2213-24

Department of Cell Biology, Neurobiology and Anatomy, University of Cincinnati College of Medicine, 231 Bethesda Avenue, Cincinnati, OH 45267-0521, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC149461PMC
http://dx.doi.org/10.1128/mcb.23.6.2213-2224.2003DOI Listing
March 2003

Hypothalamic administration of cAMP agonist/PKA activator inhibits both schedule feeding and NPY-induced feeding in rats.

Peptides 2003 Feb;24(2):245-54

Department of Surgery, College of Medicine, University of Cincinnati, 231 Albert Sabin Way, 45267, Cincinnati, OH, USA.

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http://dx.doi.org/10.1016/s0196-9781(03)00037-8DOI Listing
February 2003

A novel cytokine pathway suppresses glial cell melanogenesis after injury to adult nerve.

J Neurosci 2002 Nov;22(22):9831-40

Department of Cell Biology, Neurobiology, and Anatomy, University of Cincinnati, College of Medicine, Cincinnati, Ohio 45267-0521, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1747535PMC
November 2002