Tiffany N Seagroves

Tiffany N Seagroves

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Tiffany N Seagroves

Tiffany N Seagroves

Publications by authors named "Tiffany N Seagroves"

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An Orally Available Tubulin Inhibitor, VERU-111, Suppresses Triple-Negative Breast Cancer Tumor Growth and Metastasis and Bypasses Taxane Resistance.

Mol Cancer Ther 2020 02 23;19(2):348-363. Epub 2019 Oct 23.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee.

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http://dx.doi.org/10.1158/1535-7163.MCT-19-0536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007836PMC
February 2020

Colchicine Binding Site Agent DJ95 Overcomes Drug Resistance and Exhibits Antitumor Efficacy.

Mol Pharmacol 2019 07 1;96(1):73-89. Epub 2019 May 1.

Department of Pharmaceutical Sciences, College of Pharmacy (K.E.A., D.-J.H., D.M., D.D.M., W.L.), and Department of Pathology (D.N.P., T.N.S.), the University of Tennessee Health Science Center, Memphis, Tennessee; State Key Laboratory of Biotherapy and Cancer Center, Collaborative Innovation Center of Biotherapy (Y.W., Q.C., J.Y.), and Department of Respiratory Medicine (Y.W.), West China Hospital, Sichuan University, Chengdu, China; Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, Queens, New York (Z.-N.L., Z.-S.C.); and Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee (G.K., S.W.W.)

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http://dx.doi.org/10.1124/mol.118.114801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6553560PMC
July 2019

Chromatin Immunoprecipitation of HIF-α in Breast Tumor Cells Using Wild Type and Loss of Function Models.

Methods Mol Biol 2018 ;1742:67-79

Department of Pathology and Laboratory Medicine, Center for Cancer Research, University of Tennessee Health Science Center, Memphis, TN, USA.

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http://dx.doi.org/10.1007/978-1-4939-7665-2_7DOI Listing
January 2019

Fluorescence-Activated Cell Sorting of Murine Mammary Cancer Stem-Like Cell Subpopulations with HIF Activity.

Methods Mol Biol 2018 ;1742:247-263

Department of Pathology and Laboratory Medicine, Center for Cancer Research, University of Tennessee Health Science Center, Memphis, TN, USA.

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http://dx.doi.org/10.1007/978-1-4939-7665-2_22DOI Listing
January 2019

Taxol Induces Brk-dependent Prosurvival Phenotypes in TNBC Cells through an AhR/GR/HIF-driven Signaling Axis.

Mol Cancer Res 2018 11 10;16(11):1761-1772. Epub 2018 Jul 10.

Division of Hematology, Oncology, and Transplantation, Departments of Medicine and Pharmacology and The Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.

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http://mcr.aacrjournals.org/lookup/doi/10.1158/1541-7786.MCR
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http://dx.doi.org/10.1158/1541-7786.MCR-18-0410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214723PMC
November 2018

BHLHE40 confers a pro-survival and pro-metastatic phenotype to breast cancer cells by modulating HBEGF secretion.

Breast Cancer Res 2018 10 1;20(1):117. Epub 2018 Oct 1.

Department of Pathology and Laboratory Medicine, and the Center for Cancer Research, University of Tennessee Health Science Center, 19 South Manassas Street, Memphis, TN, 38163, USA.

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http://dx.doi.org/10.1186/s13058-018-1046-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167787PMC
October 2018

Methylparaben stimulates tumor initiating cells in ER+ breast cancer models.

J Appl Toxicol 2017 04 1;37(4):417-425. Epub 2016 Sep 1.

Department of Orthopedic Surgery and Biomedical Engineering, University of Tennessee Health Science Center, Memphis, TN, USA.

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http://dx.doi.org/10.1002/jat.3374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338571PMC
April 2017

Bisphenol A Induces Sox2 in ER Breast Cancer Stem-Like Cells.

Horm Cancer 2017 04 27;8(2):90-99. Epub 2017 Feb 27.

Department of Orthopaedic Surgery and Biomedical Engineering, University of Tennessee Health Science Center, Memphis, TN, USA.

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http://link.springer.com/10.1007/s12672-017-0286-5
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http://dx.doi.org/10.1007/s12672-017-0286-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458606PMC
April 2017

SMARCE1 regulates metastatic potential of breast cancer cells through the HIF1A/PTK2 pathway.

Breast Cancer Res 2016 08 5;18(1):81. Epub 2016 Aug 5.

Department of Pathology and Laboratory Medicine and Center for Cancer Research, University of Tennessee Health Science Center, Memphis, TN, 38163, USA.

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http://dx.doi.org/10.1186/s13058-016-0738-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974701PMC
August 2016

Breast Tumor Kinase (Brk/PTK6) Is Induced by HIF, Glucocorticoid Receptor, and PELP1-Mediated Stress Signaling in Triple-Negative Breast Cancer.

Cancer Res 2016 Mar 29;76(6):1653-63. Epub 2016 Jan 29.

Division of Hematology, Oncology, and Transplantation, Departments of Medicine and Pharmacology and The Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-2510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794366PMC
March 2016

Assessment of the Tumorigenic Potential of Spontaneously Immortalized and hTERT-Immortalized Cultured Dental Pulp Stem Cells.

Stem Cells Transl Med 2015 Aug 1;4(8):905-12. Epub 2015 Jun 1.

Department of Pediatric Dentistry, Department of Neurology, Center for Cancer Research, Department of Pathology, IPBS Program, and Department of Pediatrics, The University of Tennessee Health Science Center, Memphis, Tennessee, USA; Genetics Associates Inc., Nashville, Tennessee, USA

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http://dx.doi.org/10.5966/sctm.2014-0196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511141PMC
August 2015

mTOR/MYC Axis Regulates O-GlcNAc Transferase Expression and O-GlcNAcylation in Breast Cancer.

Mol Cancer Res 2015 May 30;13(5):923-33. Epub 2015 Jan 30.

Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/1541-7786.MCR-14-0536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433402PMC
May 2015

Hypoxia-inducible factor-1α induces ErbB4 signaling in the differentiating mammary gland.

J Biol Chem 2014 Aug 25;289(32):22459-69. Epub 2014 Jun 25.

From the Department of Medical Biochemistry and Genetics, and MediCity Research Laboratory, University of Turku, 20520 Turku, Finland, the Department of Oncology, Turku University Hospital, 20520 Turku, Finland

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http://dx.doi.org/10.1074/jbc.M113.533497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139252PMC
August 2014

Benzimidazole analogs as potent hypoxia inducible factor inhibitors: synthesis, biological evaluation, and profiling drug-like properties.

Anticancer Res 2014 Aug;34(8):3891-904

Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN, U.S.A.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346463PMC
August 2014

MicroRNA-18a inhibits hypoxia-inducible factor 1α activity and lung metastasis in basal breast cancers.

Breast Cancer Res 2014 Jul 28;16(4):R78. Epub 2014 Jul 28.

Departments of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, 19 South Manassas Street, Memphis, TN, 38163, USA.

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http://dx.doi.org/10.1186/bcr3693DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405876PMC
July 2014

O-GlcNAcylation regulates cancer metabolism and survival stress signaling via regulation of the HIF-1 pathway.

Mol Cell 2014 Jun 22;54(5):820-31. Epub 2014 May 22.

Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, PA 19102, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2014.04.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104413PMC
June 2014

Breast tumor kinase (Brk/PTK6) is a mediator of hypoxia-associated breast cancer progression.

Cancer Res 2013 Sep 8;73(18):5810-20. Epub 2013 Aug 8.

Authors' Affiliations: Division of Hematology, Oncology, and Transplantation, Department of Medicine and Pharmacology, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota; Center for Cancer Research, Department of Pathology and Laboratory Medicine, The University of Tennessee Health Science Center, Memphis, Tennessee; and Institute of Physiology and Zürich Center for Integrative Human Physiology, University of Zürich, Zürich, Switzerland.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-0523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820501PMC
September 2013

Chemoprevention activity of dipyridamole in the MMTV-PyMT transgenic mouse model of breast cancer.

Cancer Prev Res (Phila) 2013 May 27;6(5):437-47. Epub 2013 Feb 27.

Department Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, 847 Monroe Avenue, Suite 327, Memphis, TN 38163, USA.

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http://dx.doi.org/10.1158/1940-6207.CAPR-12-0345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829204PMC
May 2013

The oncogene HER2/neu (ERBB2) requires the hypoxia-inducible factor HIF-1 for mammary tumor growth and anoikis resistance.

J Biol Chem 2013 May 12;288(22):15865-77. Epub 2013 Apr 12.

Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19102, USA.

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http://dx.doi.org/10.1074/jbc.M112.426999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668743PMC
May 2013

Putative role of HIF transcriptional activity in melanocytes and melanoma biology.

Dermatoendocrinol 2013 Apr;5(2):239-51

Department of Pathology and Laboratory Medicine; Center for Adult Cancer Research; University of Tennessee Health Science Center; Memphis, TN USA.

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http://dx.doi.org/10.4161/derm.22678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772912PMC
April 2013

Hypoxia-inducible factor 1α promotes primary tumor growth and tumor-initiating cell activity in breast cancer.

Breast Cancer Res 2012 Jan 7;14(1):R6. Epub 2012 Jan 7.

Center for Cancer Research and the Department of Pathology and Laboratory Medicine, The University of Tennessee Health Science Center, Cancer Research Building, 19 South Manassas Street, Memphis, TN 38163, USA.

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http://dx.doi.org/10.1186/bcr3087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496121PMC
January 2012

VHL deletion impairs mammary alveologenesis but is not sufficient for mammary tumorigenesis.

Am J Pathol 2010 May 9;176(5):2269-82. Epub 2010 Apr 9.

Department of Pathology and Laboratory Medicine, Center for Cancer Research, University of Tennessee Health Science Center, Memphis, TN 38163, USA.

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http://dx.doi.org/10.2353/ajpath.2010.090310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2861092PMC
May 2010

Hypoxia-inducible factor-1alpha is a key regulator of metastasis in a transgenic model of cancer initiation and progression.

Cancer Res 2007 Jan;67(2):563-72

Division of Biological Sciences, Molecular Biology Section, and Department of Molecular Pathology, School of Medicine, University of California, San Diego, La Jolla, California 92093-0377, USA.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-06-2701DOI Listing
January 2007

Expression of the Rho-GEF Pbl/ECT2 is regulated by the UBE3A E3 ubiquitin ligase.

Hum Mol Genet 2006 Sep 11;15(18):2825-35. Epub 2006 Aug 11.

Section of Cell and Developmental Biology, University of California, San Diego, La Jolla 92093, USA.

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http://academic.oup.com/hmg/article/15/18/2825/643998/Expres
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http://dx.doi.org/10.1093/hmg/ddl225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742451PMC
September 2006

HIF1alpha is a critical regulator of secretory differentiation and activation, but not vascular expansion, in the mouse mammary gland.

Development 2003 Apr;130(8):1713-24

Division of Biological Sciences, Molecular Biology Section, University of California San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1242/dev.00403DOI Listing
April 2003