Publications by authors named "Tibor Harkany"

100Publications

The p(l)ot thickens: cannabinoid receptors on astroglial mitochondria coordinate animal behaviors by regulating lactate availability for neurons.

Signal Transduct Target Ther 2020 Sep 3;5(1):189. Epub 2020 Sep 3.

SE NAP Research Group of Experimental Neuroanatomy and Developmental Biology, Semmelweis University, Budapest, Hungary.

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September 2020

A Neuro-hormonal Circuit for Paternal Behavior Controlled by a Hypothalamic Network Oscillation.

Cell 2020 Aug 6;182(4):960-975.e15. Epub 2020 Aug 6.

Department of Neuroscience, Biomedicum B4, Karolinska Institutet, Solnavägen 9, 171 65 Stockholm, Sweden; Department of Biochemistry and Biophysics, Stockholm University, Svante Arrhenius väg 16C, 106 91 Stockholm, Sweden. Electronic address:

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August 2020

Unified Classification of Molecular, Network, and Endocrine Features of Hypothalamic Neurons.

Annu Rev Neurosci 2019 07 8;42:1-26. Epub 2019 Feb 8.

Department of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, 1090 Vienna, Austria; email:

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July 2019

Hypothalamic cell diversity: non-neuronal codes for long-distance volume transmission by neuropeptides.

Curr Opin Neurobiol 2019 06 22;56:16-23. Epub 2018 Nov 22.

Department of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, A-1090 Vienna, Austria; Department of Neuroscience, Karolinska Institutet, SE-17165 Solna, Sweden. Electronic address:

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June 2019

Diversity matters: combinatorial information coding by GABA receptor subunits during spatial learning and its allosteric modulation.

Cell Signal 2018 Oct 11;50:142-159. Epub 2018 Jul 11.

Department of Molecular Neurosciences, Medical University of Vienna, Spitalgasse 4, A-1090 Vienna, Austria; Department of Neuroscience, Karolinska Institutet, Retzius väg 8, SE-17177 Stockholm, Sweden. Electronic address:

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October 2018

Secretagogin protects Pdx1 from proteasomal degradation to control a transcriptional program required for β cell specification.

Mol Metab 2018 08 5;14:108-120. Epub 2018 Jun 5.

Department of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, A-1090, Vienna, Austria; Department of Neuroscience, Karolinska Institutet, Retzius väg 8, SE-17177, Stockholm, Sweden. Electronic address:

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August 2018

GABA receptor subunit deregulation in the hippocampus of human foetuses with Down syndrome.

Brain Struct Funct 2018 Apr 22;223(3):1501-1518. Epub 2017 Nov 22.

Center for Brain Research, Department of Molecular Neurosciences, Medical University of Vienna, Spitalgasse 4, 1090, Vienna, Austria.

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April 2018

Secretagogin-dependent matrix metalloprotease-2 release from neurons regulates neuroblast migration.

Proc Natl Acad Sci U S A 2017 03 21;114(10):E2006-E2015. Epub 2017 Feb 21.

MTA-SE NAP B Research Group of Experimental Neuroanatomy and Developmental Biology, Hungarian Academy of Sciences, H-1051 Budapest, Hungary;

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March 2017

(S)Pot on Mitochondria: Cannabinoids Disrupt Cellular Respiration to Limit Neuronal Activity.

Cell Metab 2017 01;25(1):8-10

Program in Integrative Cell Signaling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06510, USA.

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January 2017

Molecular diversity of corticotropin-releasing hormone mRNA-containing neurons in the hypothalamus.

J Endocrinol 2017 03 5;232(3):R161-R172. Epub 2017 Jan 5.

Department of Molecular NeurosciencesCenter for Brain Research, Medical University of Vienna, Vienna, Austria

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March 2017

Orthopedic surgery modulates neuropeptides and BDNF expression at the spinal and hippocampal levels.

Proc Natl Acad Sci U S A 2016 10 10;113(43):E6686-E6695. Epub 2016 Oct 10.

Department of Physiology and Pharmacology, Section for Anesthesiology and Intensive Care Medicine, Karolinska Institutet, Stockholm 171 77, Sweden; Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710;

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October 2016

Nonsulfated cholecystokinins in cerebral neurons.

Neuropeptides 2016 Dec 10;60:37-44. Epub 2016 Aug 10.

Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. Electronic address:

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December 2016

Integration of electrophysiological recordings with single-cell RNA-seq data identifies neuronal subtypes.

Nat Biotechnol 2016 Feb 21;34(2):175-183. Epub 2015 Dec 21.

Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.

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February 2016

At the Tip of an Iceberg: Prenatal Marijuana and Its Possible Relation to Neuropsychiatric Outcome in the Offspring.

Biol Psychiatry 2016 Apr 25;79(7):e33-45. Epub 2015 Sep 25.

Division of Molecular Neurosciences, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden; Department of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Vienna, Austria. Electronic address:

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April 2016

Fetal endocannabinoids orchestrate the organization of pancreatic islet microarchitecture.

Proc Natl Acad Sci U S A 2015 Nov 22;112(45):E6185-94. Epub 2015 Oct 22.

Division of Molecular Neurobiology, Department of Medical Biochemistry & Biophysics, Karolinska Institutet, SE-17177 Stockholm, Sweden; Department of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, A-1090 Vienna, Austria;

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November 2015

Lack of presynaptic interaction between glucocorticoid and CB1 cannabinoid receptors in GABA- and glutamatergic terminals in the frontal cortex of laboratory rodents.

Neurochem Int 2015 Nov 18;90:72-84. Epub 2015 Jul 18.

CNC, Center for Neuroscience and Cell Biology of Coimbra, University of Coimbra, 3004-504 Coimbra, Portugal; Institute for Interdisciplinary Research, University of Coimbra, 3030-789 Coimbra, Portugal. Electronic address:

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November 2015

Replacing SNAP-25b with SNAP-25a expression results in metabolic disease.

Proc Natl Acad Sci U S A 2015 Aug 20;112(31):E4326-35. Epub 2015 Jul 20.

Department of Molecular Medicine and Surgery, Karolinska Institutet, 171 76 Stockholm, Sweden;

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August 2015

Protracted brain development in a rodent model of extreme longevity.

Sci Rep 2015 Jun 29;5:11592. Epub 2015 Jun 29.

1] Division of Molecular Neurobiology, Department of Medical Biochemistry &Biophysics, Scheeles väg 1:A1, Karolinska Institutet, SE-17177 Stockholm, Sweden [2] Department of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, A-1090 Vienna, Austria.

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June 2015

A secretagogin locus of the mammalian hypothalamus controls stress hormone release.

EMBO J 2015 Jan 27;34(1):36-54. Epub 2014 Nov 27.

Department of Medical Biochemistry & Biophysics, Karolinska Institutet, Stockholm, Sweden Department of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Vienna, Austria

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January 2015

Programming of neural cells by (endo)cannabinoids: from physiological rules to emerging therapies.

Nat Rev Neurosci 2014 Dec;15(12):786-801

1] Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Scheeles väg 1:A1, Karolinska Institutet, SE-17177 Stockholm, Sweden. [2] Department of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, A-1090 Vienna, Austria.

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December 2014

Endocannabinoids modulate cortical development by configuring Slit2/Robo1 signalling.

Nat Commun 2014 Jul 17;5:4421. Epub 2014 Jul 17.

1] Division of Molecular Neurobiology, Department of Medical Biochemistry & Biophysics, Karolinska Institutet, Scheeles väg 1:A1, SE-17177 Stockholm, Sweden [2] Department of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, A-1090 Vienna, Austria [3].

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July 2014

The endocannabinoid 2-AG controls skeletal muscle cell differentiation via CB1 receptor-dependent inhibition of Kv7 channels.

Proc Natl Acad Sci U S A 2014 Jun 3;111(24):E2472-81. Epub 2014 Jun 3.

Endocannabinoid Research Group, Institute of Biomolecular Chemistry, National Council of Research (Consiglio Nazionale delle Ricerche), 80078 Pozzuoli, Italy;

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June 2014

Neuronal substrates and functional consequences of prenatal cannabis exposure.

Eur Child Adolesc Psychiatry 2014 Oct 3;23(10):931-41. Epub 2014 May 3.

Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 17177, Stockholm, Sweden.

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October 2014

Revival of calcium-binding proteins for neuromorphology: secretagogin typifies distinct cell populations in the avian brain.

Brain Behav Evol 2014 24;83(2):82-92. Epub 2014 Apr 24.

Department of Anatomy, Histology and Embryology, Semmelweis University, Budapest, Hungary.

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December 2014

Neuronal calcium-binding proteins 1/2 localize to dorsal root ganglia and excitatory spinal neurons and are regulated by nerve injury.

Proc Natl Acad Sci U S A 2014 Mar 10;111(12):E1149-58. Epub 2014 Mar 10.

Department of Neuroscience, Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, and Science for Life Laboratory, Department of Neuroscience, Karolinska Institutet, 17177 Stockholm, Sweden.

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March 2014

The molecular interplay between endocannabinoid and neurotrophin signals in the nervous system and beyond.

Eur J Neurosci 2014 Feb;39(3):334-43

Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Scheeles väg 1:A1, SE-17177, Stockholm, Sweden; Department of Molecular Neuroscience, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, A-1090, Vienna, Austria.

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February 2014

Neurotrophin and endocannabinoid interactions in the neurobiology of pain.

Eur J Neurosci 2014 Feb;39(3):331-3

Division of Molecular Neurobiology, Department of Medical Biochemistry & Biophysics, Karolinska Institutet, Stockholm, Sweden; Department of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Vienna, Austria.

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February 2014

Endocannabinoid signals in the developmental programming of delayed-onset neuropsychiatric and metabolic illnesses.

Biochem Soc Trans 2013 Dec;41(6):1569-76

*Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Scheeles väg 1:A1, Karolinska Institutet, SE-17177 Stockholm, Sweden.

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December 2013

GABAergic terminals are a source of galanin to modulate cholinergic neuron development in the neonatal forebrain.

Cereb Cortex 2014 Dec 29;24(12):3277-88. Epub 2013 Jul 29.

Department of Neuroscience, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm SE-17177, Sweden.

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December 2014

Targeted lipidomics in Drosophila melanogaster identifies novel 2-monoacylglycerols and N-acyl amides.

PLoS One 2013 11;8(7):e67865. Epub 2013 Jul 11.

Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.

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April 2014

Orexin neurons use endocannabinoids to break obesity-induced inhibition.

Proc Natl Acad Sci U S A 2013 Jun 29;110(24):9625-6. Epub 2013 May 29.

Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-17177 Stockholm, Sweden.

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June 2013

Clusters of secretagogin-expressing neurons in the aged human olfactory tract lack terminal differentiation.

Proc Natl Acad Sci U S A 2012 Apr 2;109(16):6259-64. Epub 2012 Apr 2.

Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne NE4 5PL, United Kingdom.

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April 2012

Sticking out of the crowd: the molecular identity and development of cholecystokinin-containing basket cells.

J Physiol 2012 Feb 4;590(4):703-14. Epub 2012 Jan 4.

Division of Molecular Neurobiology, Department of Medical Biochemistry & Biophysics, Scheeles väg 1:A1, Karolinska Institutet, S-17177 Stockholm, Sweden.

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February 2012

Molecular mechanisms of neuronal specification.

Authors:
Tibor Harkany

Eur J Neurosci 2011 Nov;34(10):1513-5

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November 2011

The renaissance of Ca2+-binding proteins in the nervous system: secretagogin takes center stage.

Cell Signal 2012 Feb 1;24(2):378-87. Epub 2011 Oct 1.

European Neuroscience Institute at Aberdeen, University of Aberdeen, Aberdeen, United Kingdom.

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February 2012

Molecular model of cannabis sensitivity in developing neuronal circuits.

Trends Pharmacol Sci 2011 Sep 13;32(9):551-61. Epub 2011 Jul 13.

European Neuroscience Institute at Aberdeen, University of Aberdeen, Aberdeen AB25 2ZD, UK.

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September 2011

WNT signaling in activated microglia is proinflammatory.

Glia 2011 Jan 21;59(1):119-31. Epub 2010 Oct 21.

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

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January 2011

En masse in vitro functional profiling of the axonal mechanosensitivity of sensory neurons.

Proc Natl Acad Sci U S A 2010 Sep 24;107(37):16336-41. Epub 2010 Aug 24.

Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S-17177 Stockholm, Sweden.

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September 2010

Increased abundance of opioid receptor heteromers after chronic morphine administration.

Sci Signal 2010 Jul 20;3(131):ra54. Epub 2010 Jul 20.

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA.

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July 2010

SAT1, A Glutamine Transporter, is Preferentially Expressed in GABAergic Neurons.

Front Neuroanat 2010 8;4. Epub 2010 Feb 8.

The Biotechnology Centre of Oslo, University of Oslo Oslo, Norway.

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July 2011

Secretagogin is a Ca2+-binding protein specifying subpopulations of telencephalic neurons.

Proc Natl Acad Sci U S A 2009 Dec 16;106(52):22492-7. Epub 2009 Dec 16.

European Neuroscience Institute at Aberdeen, University of Aberdeen, Aberdeen AB25 2ZD, United Kingdom.

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December 2009

Neurobiological consequences of maternal cannabis on human fetal development and its neuropsychiatric outcome.

Eur Arch Psychiatry Clin Neurosci 2009 Oct 2;259(7):395-412. Epub 2009 Jul 2.

Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA.

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October 2009

GABA action in immature neocortical neurons directly depends on the availability of ketone bodies.

J Neurochem 2009 Aug 22;110(4):1330-8. Epub 2009 Jun 22.

INMED-INSERM U901, Université de la Méditerranée, Marseille, France.

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August 2009

Wiring and firing neuronal networks: endocannabinoids take center stage.

Curr Opin Neurobiol 2008 Jun;18(3):338-45

Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Scheeles väg 1 :A1, Karolinska Institute, SE-17177 Stockholm, Sweden.

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June 2008

Calpain activity contributes to the control of SNAP-25 levels in neurons.

Mol Cell Neurosci 2008 Nov 29;39(3):314-23. Epub 2008 Jul 29.

Dipartimento di Farmacologia Medica, Istituto CNR di Neuroscienze, Universita' di Milano, Italy.

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November 2008

Endocannabinoid signaling controls pyramidal cell specification and long-range axon patterning.

Proc Natl Acad Sci U S A 2008 Jun 18;105(25):8760-5. Epub 2008 Jun 18.

Department of Neuroscience, Retzius väg 8, and Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Scheeles väg 1, Karolinska Institutet, 17177 Stockholm, Sweden.

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June 2008

Endocannabinoid functions controlling neuronal specification during brain development.

Mol Cell Endocrinol 2008 Apr 4;286(1-2 Suppl 1):S84-90. Epub 2008 Mar 4.

Institute of Medical Sciences, School of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, Scotland, United Kingdom.

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April 2008

Cholesterol loss enhances TrkB signaling in hippocampal neurons aging in vitro.

Mol Biol Cell 2008 May 20;19(5):2101-12. Epub 2008 Feb 20.

VIB and Department of Human Genetics, Catholic University of Leuven, B-3000 Leuven, Belgium.

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May 2008

The emerging functions of endocannabinoid signaling during CNS development.

Trends Pharmacol Sci 2007 Feb 10;28(2):83-92. Epub 2007 Jan 10.

Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm SE-17177, Sweden.

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February 2007

Brain-derived neurotrophic factor selectively regulates dendritogenesis of parvalbumin-containing interneurons in the main olfactory bulb through the PLCgamma pathway.

J Neurobiol 2006 Nov;66(13):1437-51

Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S-171 77 Stockholm, Sweden.

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November 2006