Publications by authors named "Tianyi Wang"

322 Publications

Mifepristone Increases Life Span in Female Without Detectable Antibacterial Activity.

Front Aging 2022 22;3:924957. Epub 2022 Jul 22.

Molecular and Computational Biology Section, Department of Biological Sciences, University of Southern California, Los Angeles, CA, United States.

Mifepristone dramatically increases the life span of mated female while reducing the expression of innate immune response genes. Previous results indicated that mifepristone also reduced the load of aero-tolerant bacteria in mated females. Experiments were conducted to further investigate the possible role of bacteria in mifepristone life span effects. Life span was assayed in flies grown from sterilized eggs on autoclaved media and in normally cultured controls in two independent assays. Sterilization increased mated female life span (+8.3% and +57%, respectively), and the effect of mifepristone was additive (+53% and +93%, respectively). High-throughput sequencing of 16S sequences revealed that sterilization reduced the abundance of multiple species and the classes , , , and By contrast, mifepristone caused no decreases and instead increased the abundance of three species Five aero-tolerant bacterial species were cultured from extracts of mated female flies, including both Gram-positive and Gram-negative species ( and ). There was no detectable effect of mifepristone on the growth of these bacteria , indicating that mifepristone does not have a direct antibiotic effect. To test if antibiotics could mimic the effects of mifepristone , mated female flies were treated throughout adult life span with high concentrations of the individual antibiotics doxycycline, ampicillin, kanamycin, and streptomycin, in replicate experiments. No significant effect on life span was observed for ampicillin, kanamycin, or streptomycin, and an inconsistent benefit was observed for doxycycline. Finally, supplementation of media with did not alter adult female life span in the presence or absence of mifepristone. Taken together, the results indicate the life span benefits of mifepristone are not due to an antibiotic effect.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3389/fragi.2022.924957DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9354577PMC
July 2022

Double-Layered Conductive Network Design of Flexible Strain Sensors for High Sensitivity and Wide Working Range.

ACS Appl Mater Interfaces 2022 Aug 4. Epub 2022 Aug 4.

Tianjin Key Laboratory of Pulp and Paper, Tianjin University of Science & Technology, Tianjin 300457, China.

For flexible strain sensors, the optimization between sensitivity and working range is a significant challenge due to the fact that high sensitivity and high working range are usually difficult to obtain at the same time. Herein, a breathable flexible strain sensor with a double-layered conductive network structure was designed and developed, which consists of a thermoplastic polyurethane (TPU)/carbon nanotube (CNT) layer (as a substrate layer) and a Ag nanowire (AgNW) layer. The TPU/CNT layer is made of electrospinning TPU with CNTs deposited onto the surface of TPU fibers, and the flexible TPU/CNT mat guarantees the integrity of the conductive path under a large strain. The AgNW layer was prepared by depositing different amounts of AgNWs on the surface of the TPU/CNT layer, and the high-conductivity AgNWs offer a low initial resistance. Benefitting from the synergistic two-layer structure, the as-obtained flexible strain sensor exhibits a very high sensitivity (up to 1477.7) and a very wide working range (up to 150%). Besides, the fabricated sensor exhibits fast response (88 ms), excellent dynamical stability (7000 cycles), and excellent breathability. The working mechanism of the strain sensor was further investigated using various techniques (microscopy, equivalent circuit, and thermal effects of current). Furthermore, the as-fabricated flexible strain sensors accurately detect the omnidirectional human motions, including subtle and large human motions. This work provides an efficient approach to achieve the optimization between high sensitivity and large working range of strain sensors, which may have great potential applications in health monitoring, body motion detection, and human-machine interactions.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsami.2c08285DOI Listing
August 2022

Design of ROS-Responsive Hyaluronic Acid-Methotrexate Conjugates for Synergistic Chemo-Photothermal Therapy for Cancer.

Mol Pharm 2022 Jul 28. Epub 2022 Jul 28.

Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China.

Combining chemotherapy with photothermal therapy (PTT) for cancer treatment could overcome the inherent limitations of both single-modality chemotherapy and PTT. However, the obstacle of accurate drug delivery to tumor sites based on chemo-photothermal remains challenging. This article describes development of a reactive oxygen species (ROS)-responsive hyaluronic acid-based nanoparticle to overcome these drawbacks. Herein, HA-TK-MTX (HTM) was synthesized by a ROS-responsive cleaved thioketal moiety linker (TK) of methotrexate (MTX) and hyaluronic acid (HA). Through hydrophobic interaction and π-π stacking interaction, a photothermal agent IR780 was integrated into the HTM, and the IR780/HTM nanoparticles (IHTM NPs) were obtained. The IHTM NPs show high photostability, excellent photothermal performance, remarkable tumor-targeting ability, and ROS sensibility. Due to the accurate drug delivery ability and superior chemo-photothermal treatment effect of IHTM NPs, the tumor inhibition rate reached 70.95% for 4T1 tumor-bearing mice. This work serves as a precedent for the chemo-photothermal therapy of cancer by rationally designing ROS-responsive nanoparticles.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.molpharmaceut.2c00472DOI Listing
July 2022

Deep Learning-Based Football Player Detection in Videos.

Comput Intell Neurosci 2022 12;2022:3540642. Epub 2022 Jul 12.

College of Physical Education, Qiqihar University, Qiqihar 161000, China.

The main task of football video analysis is to detect and track players. In this work, we propose a deep convolutional neural network-based football video analysis algorithm. This algorithm aims to detect the football player in real time. First, five convolution blocks were used to extract a feature map of football players with different spatial resolution. Then, features from different levels are combined together with weighted parameters to improve detection accuracy and adapt the model to input images with various resolutions and qualities. Moreover, this algorithm can be extended to a framework for detecting players in any other sports. The experimental results assure the effectiveness of our algorithm.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1155/2022/3540642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9296282PMC
July 2022

Radiographic adjacent segment degeneration and risk factors for osteoporotic vertebral compression fractures treated with percutaneous kyphoplasty.

Int Orthop 2022 Jul 22. Epub 2022 Jul 22.

Department of Orthopedics, Beijing Chaoyang Hospital, Capital Medical University, 5 JingYuan Road, Shijingshan District, Beijing, 100043, China.

Purpose: In this study, we aimed to clarify whether osteoporotic vertebral compression fracture (OVCF) following percutaneous kyphoplasty (PKP) was associated with a high risk for radiographic adjacent segment degeneration (ASD) and to identify the risk factors for radiographic ASD in these individuals.

Methods: We retrospectively reviewed consecutive patients with OVCFs who underwent PKP at our institution between November 2015 and January 2021. The incidence of radiographic ASD was calculated and specific subgroups of ASD were identified. Univariate and multivariate analyses of demographic, clinical baseline, and radiologic data were performed to identify risk factors associated with radiographic ASD.

Results: With a mean follow-up time of 27.3 months, a total of 95 eligible patients were enrolled. The incidence of radiographic ASD distinguished from natural degeneration was 52.6%. Patients with OVCFs who underwent PKP had a high risk of developing radiographic ASD, particularly disc degeneration. Intradiscal cement leakage (odds ratio [OR], 5.706; 95% confidence interval [CI], 2.039-15.970; P = 0.001) and preoperative disc height (OR, 0.681; 95% CI, 0.518-0.895; P = 0.006) were identified as independent risk factors.

Conclusion: Patients with OVCFs who underwent PKP were more likely to develop radiographic ASD, and their progression was distinguished from natural degeneration. Disc degeneration was the most common type of degeneration. Intradiscal cement leakage and preoperative disc height were identified as independent risk factors for developing radiographic ASD in these patients. Further validation through prospective multicenter studies is required.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00264-022-05510-1DOI Listing
July 2022

Construction of Protective Films on Zn Metal Anodes Natural Protein Additives Enabling High-Performance Zinc Ion Batteries.

ACS Nano 2022 Jul 18. Epub 2022 Jul 18.

Centre for Clean Energy Technology, School of Mathematical and Physical Sciences, Faculty of Science, University of Technology Sydney, Ultimo New South Wales 2007, Australia.

The strong activity of water molecules causes a series of parasitic side reactions on Zn anodes in the aqueous electrolytes. Herein, we introduce silk fibroin (SF) as a multifunctional electrolyte additive for aqueous zinc-ion (Zn-ion) batteries. The secondary structure transformation of SF molecules from α-helices to random coils in the aqueous electrolytes allows them to break the hydrogen bond network among free water molecules and participate in Zn ion solvation structure. The SF molecules released from the [Zn(HO)(SF)] solvation sheath appear to be gradually adsorbed on the surface of Zn anodes and form a hydrostable and self-healable protective film. This SF-based protective film not only shows strong Zn ion affinity to promote homogeneous Zn deposition but also has good insulating behavior to suppress parasitic reactions. Benefiting from these multifunctional advantages, the cycle life of the Zn||Zn symmetric cells reaches over 1600 h in SF-containing ZnSO electrolytes. In addition, by adopting a potassium vanadate cathode, the full cell shows excellent cycling stability for 1000 cycles at 3 A g. The construction of a protective film on the Zn anode from natural protein molecules provides an effective strategy to achieve high-performance Zn metal anodes for Zn-ion batteries.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsnano.2c05285DOI Listing
July 2022

Factors predicting improvement of differential renal function after pyeloplasty in children of ureteropelvic junction obstruction.

J Pediatr Urol 2022 Jun 20. Epub 2022 Jun 20.

Department of Urology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.

Introduction: To evaluate differential renal function (DRF) in unilateral ureteropelvic junction obstruction (UPJO) patients under 18 years old after pyeloplasty and to identify factors predicting postoperative improvement.

Material And Methods: A total of 95 patients with unilateral UPJO treated by pyeloplasty between March 2019 to March 2020 were prospective enrolled. All patients had preoperative dynamic renal scintigraphy and were required to review after surgery 6 months. We defined DRF improvement as postoperative DRF increased ≥5% (If preoperative DRF less than 55%) or postoperative DRF reduced ≥5% and reached a normal range (45-55%) (preoperative DRF more than 55%) with drainage improvement. Drainage improvement indications were defined as a resolution of symptoms; decrease in hydronephrosis without requiring additional procedures and T<20min in dynamic renal scintigraphy. All parameters were statistically compared.

Results: In the study, 28 (29.5%) patients showed improvement in postoperative DRF, and 67 (70.5%) patients maintained stable postoperative DRF. Gender, age, baseline DRF, anteroposterior pelvic diameters (APD), minimum and maximum renal parenchymal thickness (PT), and anterior-posterior diameter/maximum renal parenchymal thickness (APD/PT) were correlated with postoperative DRF improvement in univariable analysis. In the multivariable analyses, maximum PT and APD/PT were predictors of improvement in postoperative DRF.

Discussion: In our study, the maximum PT was associated with the improvement of renal function in patients with UPJO, and when the thickest part of the renal parenchyma was measured, APD/PT can predict the improvement of renal function. We infer that the compression of the thickest part of the renal parenchyma may be the reason for the impaired renal function in some patients, and when the obstruction was relieved, the compressed parenchyma function can be significantly improved.

Conclusions: Postoperative DRF of UPJO patients can be effectively improved and preserved through pyeloplasty. Maximum PT and APD/PT can predict improvement of renal function in patients with UPJO after pyeloplasty.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpurol.2022.06.017DOI Listing
June 2022

mA-modified circRNAs: detections, mechanisms, and prospects in cancers.

Mol Med 2022 07 14;28(1):79. Epub 2022 Jul 14.

Department of Laboratory Medicine, Affiliated Hospital of Nantong University, No. 20, Xisi Road, Nantong, 226001, Jiangsu, China.

Circular RNAs (circRNAs) have become a research hotspot in recent years with their universality, diversity, stability, conservativeness, and spatiotemporal specificity. N-methyladenosine (mA), the most abundant modification in the eukaryotic cells, is engaged in the pathophysiological processes of various diseases. An increasing amount of evidence has suggested that mA modification is common in circRNAs and is associated with their biological functions. This review summarizes the effects of mA modification on circRNAs and their regulation mechanisms in cancers, providing some suggestions of mA-modified circRNAs in cancer therapy.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1186/s10020-022-00505-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9284916PMC
July 2022

A super pan-genomic landscape of rice.

Cell Res 2022 Jul 12. Epub 2022 Jul 12.

State Key Laboratory of Rice Biology, China National Rice Research Institute, Hangzhou, Zhejiang, China.

Pan-genomes from large natural populations can capture genetic diversity and reveal genomic complexity. Using de novo long-read assembly, we generated a graph-based super pan-genome of rice consisting of a 251-accession panel comprising both cultivated and wild species of Asian and African rice. Our pan-genome reveals extensive structural variations (SVs) and gene presence/absence variations. Additionally, our pan-genome enables the accurate identification of nucleotide-binding leucine-rich repeat genes and characterization of their inter- and intraspecific diversity. Moreover, we uncovered grain weight-associated SVs which specify traits by affecting the expression of their nearby genes. We characterized genetic variants associated with submergence tolerance, seed shattering and plant architecture and found independent selection for a common set of genes that drove adaptation and domestication in Asian and African rice. This super pan-genome facilitates pinpointing of lineage-specific haplotypes for trait-associated genes and provides insights into the evolutionary events that have shaped the genomic architecture of various rice species.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41422-022-00685-zDOI Listing
July 2022

A Ce-UiO-66 Metal-Organic Framework-Based Graphene-Embedded Photocatalyst with Controllable Activation for Solar Ammonia Fertilizer Production.

Angew Chem Int Ed Engl 2022 Jul 5:e202207026. Epub 2022 Jul 5.

College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, 225002, P. R. China.

Currently, nitrogen fertilizers feed half of the global population, but their use is limited by energy consumption and transportation. Therefore, it is important to study photocatalysts for use in solar nitrogen fertilizers. Herein, a new type of graphene-embedded Ce-based UiO-66 (Ce-UiO-66) photocatalyst (GSCe) is investigated. Ce-UiO-66 is activated by the breakage of benzene-C bonds and the formation of active sites by ultraviolet light in water. Moreover, embedding graphene effectively controls activation and improves nitrogen fixation. GSCe exhibited a remarkable apparent quantum efficiency (AQE) of 9.25 % and stability under 365 nm light with solar-level intensity. GSCe also performed well as a solar ammonia fertilizer for crop cultivation. This investigation opens up opportunities for nitrogen fixation photocatalysts to be used as environmentally friendly solar nitrogen fertilizers.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1002/anie.202207026DOI Listing
July 2022

Focusing on Hippo Pathway in Stem Cells of Oral Origin, Enamel Formation and Periodontium Regeneration.

Organogenesis 2022 12;18(1):2082236

State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.

Hippo pathway is a cellular regulatory pathway composed of core molecules such as MST1/2, LATS1/2, SAV1, MOB1A/B and downstream YAP/TAZ. Fully involved in regulating cell proliferation, differentiation, migration and apoptosis, the Hippo pathway is critical in regulating stem cells of oral origin, for instance, DPSCs and PDLSCs, enamel formation and periodontium regeneration. Here, we summarized the Hippo pathway involved in these progresses and concluded crosstalks of the Hippo pathway with BCL-2, ERK1/2, ROCK, TGF-β/BMP and Wnt/β-catenin pathways, hoping to provide foundation for further clinical therapy.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1080/15476278.2022.2082236DOI Listing
December 2022

Tobacco Smoking and Survival Following a Diagnosis with Ovarian Cancer.

Cancer Epidemiol Biomarkers Prev 2022 Jul;31(7):1376-1382

Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.

Background: Little is known about the influence of smoking on ovarian cancer survival. We investigated this relationship in a hospital-based study.

Methods: Analyses included 519 women with ovarian cancer. We used multivariable adjusted Cox proportional hazards regression models to estimate HRs and 95% confidence intervals (CI).

Results: Risk of all-cause mortality was increased for current smokers (HR = 1.70; 95% CI: 1.09-2.63) versus never smokers, especially for those with ≥15 cigarettes per day (HR = 1.92; 95% CI: 1.15-3.20). Results were largely similar after additional adjustment for debulking status (current vs. never smokers, HR = 2.96; 95% CI: 1.07-8.21) or neoadjuvant chemotherapy (comparable HR = 2.87; 95% CI: 1.02-8.06). Compared with never smokers, smoking duration ≥20 years (HR = 1.38; 95% CI: 0.94-2.03) and ≥20 pack-years (HR = 1.35; 95% CI: 0.92-1.99) were suggestively associated with worse outcomes. Current smoking was also positively associated with the risk of mortality among patients with ovarian cancer recurrence (current vs. never/past smokers, HR = 2.79; 95% CI: 1.44-5.41), despite the null association between smoking and recurrence (HR = 1.46; 95% CI: 0.86-2.48). Furthermore, no association was observed for smoking initiation before age 18 (HR = 1.22; 95% CI: 0.80-1.85), or either environmental smoke exposure at home (HR = 1.16; 95% CI: 0.76-1.78) or at work (HR = 1.10; 95% CI: 0.75-1.60).

Conclusions: Our results suggest active tobacco smoking is associated with worse ovarian cancer outcomes, particularly after a recurrence.

Impact: Our findings support structured smoking cessation programs for patients with ovarian cancer, especially in recurrent settings. Further research to confirm these findings and examine the interplay between smoking and the tumor immune microenvironment may help provide insight into ovarian cancer etiology.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-21-1327DOI Listing
July 2022

Pre-diagnosis and post-diagnosis dietary patterns and survival in women with ovarian cancer.

Br J Cancer 2022 Jun 27. Epub 2022 Jun 27.

Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Background: Evidence is limited on inflammation-related dietary patterns and mortality in ovarian cancer survivors.

Methods: We examined the associations between pre- and post-diagnosis dietary patterns, including change in diet from before to after diagnosis, and mortality among 1003 ovarian cancer survivors in two prospective cohort studies. Dietary pattern scores for empirical dietary inflammatory pattern (EDIP) and Alternative Healthy Eating Index (AHEI) were calculated based on food frequency questionnaires. We used Cox proportional hazard models to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for ovarian cancer-specific and all-cause mortality.

Results: Pre-diagnosis EDIP score and AHEI were not associated with mortality. Among non-high grade serous cases, a higher post-diagnosis EDIP score was associated with increased risk of all-cause mortality (HR = 1.95, 95% CI = 1.04-3.67, p-trend = 0.06). Compared to survivors consuming a low EDIP score diet before and after diagnosis, high post-diagnosis EDIP was associated with increased risk of ovarian cancer specific mortality (pre-to-post diagnosis low/high, HR = 1.38, 95% CI = 0.99-1.92; high/high HR = 1.58, 95% CI = 1.09-2.30) and all-cause mortality (low/high HR = 1.44, 95% CI = 1.06-1.95; high/high HR = 1.55, 95% CI = 1.10-2.19).

Conclusion: Consuming a more inflammatory dietary pattern post-diagnosis was associated with increased mortality in ovarian cancer survivors, suggesting limiting the inflammatory potential of diet post-diagnosis could lead to enhanced survivorship.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41416-022-01901-8DOI Listing
June 2022

Heat shock protein 101 contributes to the thermotolerance of male meiosis in maize.

Plant Cell 2022 Jun 27. Epub 2022 Jun 27.

State Key Laboratory of Plant Physiology and Biochemistry, National Maize Improvement Center of China, Beijing Key Laboratory of Crop Genetic Improvement, Key Laboratory of Crop Heterosis and Utilization, Ministry of Education, China Agricultural University, Beijing 100193, China.

High temperatures interfere with meiotic recombination and the subsequent progression of meiosis in plants, but few genes involved in meiotic thermotolerance have been characterized. Here we characterize a maize (Zea mays) classic dominant male sterile mutant Ms42, which has defects in pairing and synapsis of homologous chromosomes and DNA double-strand break repair. Ms42 encodes a member of the heat shock protein family, HSP101, which accumulates in pollen mother cells. Analysis of the dominant Ms42 mutant and hsp101 null mutants reveals that HSP101 functions in RAD51 loading, double-strand break repair, and subsequent meiosis. Consistent with these functions, overexpression of Hsp101 in anthers results in robust microspores with enhanced heat tolerance. These results demonstrate that HSP101 mediates thermotolerance during microsporogenesis, shedding light on the genetic basis underlying the adaptation of male meiocytes to high temperatures.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1093/plcell/koac184DOI Listing
June 2022

Platelet-Membrane-Encapsulated Carvedilol with Improved Targeting Ability for Relieving Myocardial Ischemia-Reperfusion Injury.

Membranes (Basel) 2022 Jun 10;12(6). Epub 2022 Jun 10.

Nantong Key Laboratory of Translational Medicine in Cardiothoracic Diseases, Research Institution of Translational Medicine in Cardiothoracic Diseases, Affiliated Hospital of Nantong University, Nantong 226001, China.

In recent years, cell membrane drug delivery systems have received increasing attention. However, drug-loaded membrane delivery systems targeting therapy in myocardial ischemia-reperfusion injury (MIRI) have been relatively rarely studied. The purpose of this study was to explore the protective effect of platelet-membrane-encapsulated Carvedilol on MIRI. We extracted platelets from the blood of adult SD rats and prepared platelet membrane vesicles (PMVs). Carvedilol, a nonselective β-blocker, was encapsulated into the PMVs. In order to determine the best encapsulation rate and drug-loading rate, three different concentrations of Carvedilol in low, medium, and high amounts were fused to the PMVs in different volume ratios (drugs/PMVs at 2:1, 1:1, 1:2, and 4:1) for determining the optimum concentration and volume ratio. By comparing other delivery methods, including abdominal injection and intravenous administration, the efficacy of PMVs-encapsulated drug-targeted delivery treatment was observed. The PMVs have the ability to target ischemic-damaged myocardial tissue, and the concentration and volume ratio at the optimum encapsulation rate and the drug-loading rate are 0.5 mg and 1:1. We verified that [email protected] had better therapeutic effects compared to other treatment groups, and immunofluorescence observation showed a significant improvement in the apoptosis indicators and infarction area of myocardial cells. Targeted administration of [email protected] may be a promising treatment for myocardial reperfusion injury, as it significantly improves postinjury cardiac function and increases drug utilization compared to other delivery methods.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3390/membranes12060605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9227294PMC
June 2022

Recent Advances in Application of Graphitic Carbon Nitride-Based Catalysts for Photocatalytic Nitrogen Fixation.

Small 2022 Jul 16;18(28):e2202252. Epub 2022 Jun 16.

Centre for Clean Energy Technology, Faculty of Science, University of Technology Sydney, Broadway, Sydney, NSW, 2007, Australia.

Ammonia, the second most-produced chemical, is widely used in agricultural and industrial applications. However, traditional industrial ammonia production dominated by the Haber-Bosch process presents huge resource and environment issues due to the massive energy consumption and CO emission. The newly emerged nitrogen fixation technology, photocatalytic N reduction reaction (p-NRR), uses clean solar energy with zero-emission, holding great prospect to achieve sustainable ammonia synthesis. Although great efforts are made, the p-NRR catalysts still suffer from poor N adsorption and activation, inferior light absorption, and fast recombination of photocarriers. Due to the tunable electronic structure of the metal-free polymeric graphitic carbon nitride (g-C N ), the above-mentioned issues can be significantly alleviated, making it the most promising p-NRR photocatalyst. This review summarizes the recent development of g-C N -based catalysts for p-NRR, including the working principle of p-NRR catalysts, the challenges of developing p-NRR catalysts, and corresponding solutions. Particularly, the roles of defect engineering and heterojunction construction on g-C N to the enhancement of photocatalytic performances are emphasized. In addition, computational studies are introduced to deepen the understanding of reaction pathways. At last, perspectives are provided on the development of p-NRR catalysts.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1002/smll.202202252DOI Listing
July 2022

Effect of local coordination on catalytic activities and selectivities of Fe-based catalysts for N reduction.

Phys Chem Chem Phys 2022 Jun 15;24(23):14517-14524. Epub 2022 Jun 15.

School of Environmental Science and Engineering, State Key Laboratory of Bio-fibers and Eco-textiles, Shandong Collaborative Innovation Center of Marine Biobased Fibers and Ecological Textiles, Qingdao University, Qingdao 266071, P. R. China.

Electrochemical reduction of nitrogen is considered a promising route for achieving green and sustainable ammonia synthesis under ambient conditions. A transition metal atom loaded on N-doped graphene is commonly used in the nitrogen reduction reaction (NRR), but the effect of the graphene's coordination environment on electron transfer has rarely been studied. Herein, the NRR performance of Fe clusters, anchored on single-vacancy and N-doped graphene, is investigated systematically density functional theory (DFT). The calculation results show that the Fe cluster supported by two N atom-modified single-vacancy graphene displays the highest catalytic performance of NRR with the lowest energy barrier of 0.62 eV among the 12 candidates, and exhibits efficient selectivity. It has superior performance because of the highly asymmetrical distribution of electrons on graphene, the large positive charge of the Fe, and the strong adsorption of *NNH. This study provides a new strategy to improve the NRR performance by regulating the Fe clusters coordination environment.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1039/d1cp05140gDOI Listing
June 2022

Tin nanoparticle in-situ decorated on nitrogen-deficient carbon nitride with excellent sodium storage performance.

J Colloid Interface Sci 2022 Oct 20;624:40-50. Epub 2022 May 20.

Institute for Innovative Materials and Energy, Faculty of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou City, Jiangsu Province, China. Electronic address:

Tin (Sn)-based electrodes, featuring high electrochemical activity and suitable voltage plateau, gain tremendous attention as promising anode materials for sodium-ion batteries. However, the application of Sn-based electrodes has been largely restricted by the serious pulverization upon repeated cycling due to their large volume expansion, especially at high current densities. Herein, a unique three-dimensional decorated structure was designed, containing ultrafine Sn nanoparticles and nitrogen-deficient carbon nitride (Sn/D-CN), to efficiently alleviate the expansion stress and prevent the aggregation of Sn nanoparticles. Furthermore, the density functional theory calculations have proved the high sodium adsorption ability and improved diffusion kinetics through the hybridization of D-CN with Sn nanoparticles. Further combining the high electronic/ionic conductivity provided by the porous CN matrix, high charge contribution from capacitive behavior, and high sodium storage activity of ultrafine Sn nanoparticles, the resultant Sn/D-CN can achieve an ultrahigh reversible capacity of 518.3 mA g after 300 cycles at 1.0 A g, and even maintaining a reversible capacity of 436.1 mAh g up to 500 cycles (5.0 A g). What's more, the optimized Sn/D-CN∥NaV(PO)/C full cell can keep a high capacity retention of 87.1% at 1.0 A g even after 5000 cycles, manifesting excellent sodium storage performance.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcis.2022.05.090DOI Listing
October 2022

Genetic support of a causal relationship between iron status and atrial fibrillation: a Mendelian randomization study.

Genes Nutr 2022 May 30;17(1). Epub 2022 May 30.

Department of Internal Medicine, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China.

Background: Atrial fibrillation is the most common arrhythmia disease. Animal and observational studies have found a link between iron status and atrial fibrillation. However, the causal relationship between iron status and AF remains unclear. The purpose of this investigation was to use Mendelian randomization (MR) analysis, which has been widely applied to estimate the causal effect, to reveal whether systemic iron status was causally related to atrial fibrillation.

Methods: Single nucleotide polymorphisms (SNPs) strongly associated (P < 5 × 10) with four biomarkers of systemic iron status were obtained from a genome-wide association study involving 48,972 subjects conducted by the Genetics of Iron Status consortium. Summary-level data for the genetic associations with atrial fibrillation were acquired from the AFGen (Atrial Fibrillation Genetics) consortium study (including 65,446 atrial fibrillation cases and 522,744 controls). We used a two-sample MR analysis to obtain a causal estimate and further verified credibility through sensitivity analysis.

Results: Genetically instrumented serum iron [OR 1.09; 95% confidence interval (CI) 1.02-1.16; p = 0.01], ferritin [OR 1.16; 95% CI 1.02-1.33; p = 0.02], and transferrin saturation [OR 1.05; 95% CI 1.01-1.11; p = 0.01] had positive effects on atrial fibrillation. Genetically instrumented transferrin levels [OR 0.90; 95% CI 0.86-0.97; p = 0.006] were inversely correlated with atrial fibrillation.

Conclusion: In conclusion, our results strongly elucidated a causal link between genetically determined higher iron status and increased risk of atrial fibrillation. This provided new ideas for the clinical prevention and treatment of atrial fibrillation.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12263-022-00708-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9153204PMC
May 2022

[Research progress of targeting macrophage surface receptors in the treatment of inflammatory bowel disease].

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2022 May;38(5):460-465

Department of Gastroenterology, the Second Hospital of Lanzhou University, Lanzhou 730000, China. *Corresponding author, E-mail:

Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), is a chronic inflammatory disorder of the gastrointestinal tract with unknown etiology and pathogenesis. In the intestinal tissues of IBD patients, dysregulation of macrophages results in persistent intestinal inflammation. Macrophages are highly adaptable and their phenotypes and functions could be regulated by various factors in the microenvironment via ligand-receptor binding, thus affecting the progression of the disease.
View Article and Find Full Text PDF

Download full-text PDF

Source
May 2022

Silk Fibroin Coating Enables Dendrite-free Zinc Anode for Long-Life Aqueous Zinc-Ion Batteries.

ChemSusChem 2022 Aug 15;15(15):e202200656. Epub 2022 Jun 15.

College of Chemistry and Chemical Engineering, Yangzhou University, 225009, Yangzhou, Jiangsu, P. R. China.

Due to the advantages of the low cost of Zn and the safety of aqueous electrolytes, the aqueous Zn ion battery (AZIB) is expected to become the next-generation battery after lithium-ion batteries. However, the problems of Zn anode dendrite growth, self-corrosion, and passivation in AZIBs lead to short cycle life and short circuit of the battery. In this work, uniform and stable Silk II-silk fibroin (Silk II-SF) coating was prepared on the surface of Zn anode by a simple method. Experiments showed that the SF coating could prevent dendritic growth and hydrogen evolution corrosion. Therefore, symmetric cells using Silk [email protected] anode achieved a cycle life over 3300 and 1500 h at current densities of 10 and 20 mA cm , respectively. Using Silk II-SF coating to protect Zn anode is a simple and effective strategy to realize dendrite-free Zn anode and long-cycle-life AZIBs.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1002/cssc.202200656DOI Listing
August 2022

Youth Aware of Mental Health (YAM) Program With Texas Adolescents: Depression, Anxiety, and Substance Use Outcomes.

J Clin Psychiatry 2022 05 16;83(4). Epub 2022 May 16.

Peter O'Donnell Jr Brain Institute and the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas.

To determine the state of mental health problems among a general youth population and assess whether the Youth Aware of Mental Health (YAM) intervention can improve symptoms of depression and anxiety.

We implemented YAM with a cluster quasi-experimental study design from August 2017 through June 2019 in 29 middle schools and high schools in North Texas. Students completed the Quick Inventory of Depressive Symptomatology, Adolescent version; the Generalized Anxiety Disorder Screener; and additional substance use questionnaires before YAM delivery and 3-6 months after implementation. Multilevel models, with students nested within schools, were used to model difference scores of depression and anxiety, controlling for various student-level and school-level characteristics. Missing data were imputed during analysis. Sensitivity analyses were performed on non-imputed data.

Among 3,302 adolescents at pre-test, 27% had moderate-to-severe depression, 22% had moderate-to-severe anxiety, and 4% expressed suicidal ideation. We found that on average, compared to those who had no depression at pre-test, depression decreased at post-test by () 4.62 units ( < .05) for those who had severe to very severe depression at pre-test, () 2.92 units ( < .0001) for those who had moderate depression at pre-test, and () 1.5 units ( < .001) for those who had mild depression at pre-test, controlling for all other factors in the model. Similar significant decreases were observed in anxiety, controlling for student-level characteristics.

These findings demonstrate the effectiveness of YAM in reducing symptoms of depression and anxiety among adolescents in North Texas.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.4088/JCP.21m14221DOI Listing
May 2022

Lipid-Lowering Efficacy of Kuding Tea in Patients With Metabolic Disorders: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Front Nutr 2022 28;9:802687. Epub 2022 Apr 28.

Department of Cardiology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.

Background: Kuding tea (KT), traditional tea material and widely used in China, has been found to have lipid-lowering effect in clinical and experimental studies. However, there has been no systematic review of the evidence on this subject.

Methods: Eight electronic databases were searched from database inception until September 2021 for relevant randomized controlled trials (RCTs). We used the Cochrane Reviewer's Handbook to assess the quality of the included studies. Weighted mean difference (WMD) and 95% confidence interval (CI) were used to measure the pooled effect size by random-effects model. Funnel plot, Egger regression test, and the Begg's test was used to assess publication bias.

Results: Eight RCTs involving 716 patients were included in our meta-analysis. Comparing with the control group, KT group reduced serum total cholesterol (TC) levels (WMD: -0.56 mmol/L; 95% CI: -0.64, -0.47; = 56.56%; = 0.00), triglyceride (TG) levels (WMD: -0.30 mmol/L; 95% CI: -0.35, -0.24; = 88.60%; = 0.00), and low-density lipoprotein cholesterol (LDL-C) levels (WMD: -0.29 mmol/L; 95% CI: -0.37, -0.21; = 89.43%; = 0.00), but no significant effects on high-density lipoprotein cholesterol (HDL-C) (WMD: 0.07 mmol/L; 95% CI: -0.02, 0.16; = 93.92%; = 0.12). The results of sensitivity analysis were not altered after removing each study in turn. Subgroup analyses showed that KT intervention period was the source of heterogeneity. Following analysis, results revealed that long-term (>4 weeks and ≤8 weeks) use of KT increased HDL-C levels (WMD: 0.19; 95% CI: 0.13, 0.25). In addition, both the sensitivity analysis and subgroup analysis showed that our results were robust. No potentially significant publication bias was found from the funnel plot, Begg-Mazumdar correlation test and Egger regression test.

Conclusion: KT supplementation can effectively improve lipid profile and KT is a promising approach to reduce blood lipid level in patients with metabolic disorders.

Systematic Review Registration: [www.crd.york.ac.uk/prospero], identifier [CRD42020221850].
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3389/fnut.2022.802687DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9096904PMC
April 2022

Lifetime ovulatory years and ovarian cancer gene expression profiles.

J Ovarian Res 2022 May 13;15(1):59. Epub 2022 May 13.

Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.

Background: Greater ovulatory years is associated with increased ovarian cancer risk. Although ovulation leads to an acute pro-inflammatory local environment, how long-term exposure to ovulation impacts ovarian carcinogenesis is not fully understood. Thus, we examined the association between gene expression profiles of ovarian tumors and lifetime ovulatory years to enhance understanding of associated biological pathways.

Methods: RNA sequencing data was generated on 234 invasive ovarian cancer tumors that were high-grade serous, poorly differentiated, or high-grade endometrioid from the Nurses' Health Study (NHS), NHSII, and the New England Case Control Study. We used linear regression to identify differentially expressed genes by estimated ovulatory years, adjusted for birth decade and cohort, overall and stratified by menopausal status at diagnosis. We used false discovery rates (FDR) to account for multiple testing. Gene set enrichment analysis (GSEA) with Cancer Hallmarks, KEGG, and Reactome databases was used to identify biological pathways associated with ovulatory years.

Results: No individual genes were significantly differentially expressed by ovulatory years (FDR > 0.19). However, GSEA identified several pathways that were significantly associated with ovulatory years, including downregulation of pathways related to inflammation and proliferation (FDR < 1.0 × 10). Greater ovulatory years were more strongly associated with downregulation of genes related to proliferation (e.g., E2F targets, FDR = 1.53 × 10; G2M checkpoints, FDR = 3.50 × 10) among premenopausal versus postmenopausal women at diagnosis. The association of greater ovulatory years with downregulation of genes involved in inflammatory response such as interferon gamma response pathways (FDR = 7.81 × 10) was stronger in postmenopausal women.

Conclusions: Our results provide novel insight into the biological pathways that link ovulatory years to ovarian carcinogenesis, which may lead to development of targeted prevention strategies for ovarian cancer.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13048-022-00995-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102743PMC
May 2022

The Impact of a Nurse-Led Service on Tobacco Treatment Provision Within a Psychiatric Hospital: A Time Series Study.

J Am Psychiatr Nurses Assoc 2022 May 12:10783903221093582. Epub 2022 May 12.

Chizimuzo T. C. Okoli, PhD, MPH, MSN, PMHNP-BC, APRN, FAAN, Professor, University of Kentucky College of Nursing, Lexington, KY, USA.

Introduction: Psychiatric hospitalization is an opportunity to provide evidence-based tobacco treatment to optimize cessation efforts among people living with mental illnesses (MI). The purpose of this study was to examine the effectiveness of nurse-driven initiatives to enhance tobacco treatment within an inpatient psychiatric setting.

Aims: We assessed the 4-year impact of implementing a nurse-led tobacco treatment service offered to 11,314 inpatients at admissions in a tobacco-free psychiatric facility in Kentucky.

Method: Through a time-series design, we compared the differences in rates of screening for tobacco use and providing treatment from September to December 2015 (prior to implementing the nurse-led tobacco treatment services) to each subsequent year in a 4-year period (2016-2019).

Results: Approximately 60.0% of inpatients were persons using tobacco during the assessment period. Although there were no changes in tobacco use prevalence over the 4-year evaluation duration, there were significant increases in the provision of practical counseling and Food and Drug Administration-approved nicotine replacement therapies for persons using tobacco.

Conclusions: Our findings support the effectiveness of implementing tobacco treatment programs at the organizational level. Psychiatric hospitalizations provide an opportunity to optimize nurse-driven efforts to deliver tobacco treatment to people with MI. Similar models of nurse-led tobacco treatment services can be adopted within inpatient and other mental and behavioral health settings.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1177/10783903221093582DOI Listing
May 2022

Postural sway reduction by weak electrical noise into the wrist median nerve using portable stimulator.

J Biomech 2022 05 14;137:111080. Epub 2022 Apr 14.

Faculty of Science and Engineering, Ritsumeikan University, 1-1-1 Noji-higashi, Kusatsu, Shiga, Japan.

Stochastic resonance (SR) is a weak noise stimulation that improves the function of standing balance by increasing sensitivity to somatosensory information. SR implemented in the lower limbs may increase the standing balance function, but the effect of noise stimulation on upper limbs has not been investigated to date. This study aims to investigate the effect of weak electrical noise stimulation of the median nerve at the wrist on the balance control system function using a portable stimulator. Ten healthy individuals participated in the study. Each subject maintained quiet standing with their eyes closed for 40 s while receiving white noise electrical stimulation to the median nerve at the wrist. Center of pressure (COP) displacement and change in the joint position (left and right waist) were measured and compared between a no-stimulus trial (control trial) and a stimulus intensity trial that maximized the effect of SR (optimal trial). Experimental results show that weak electrical noise stimulation of the median nerve at the wrist stabilized the COP and joint position. The anteroposterior (AP) standard deviation of the optimal trial were significantly reduced compared to the control trial in terms of COP and left and right waist, and AP low-frequency range power of the optimal trial were significantly reduced compared to the control trial in terms of COP and left waist. AP mean velocity and AP high-frequency range power at the left waist were significantly reduced in the optimal trial. It was concluded that weak electrical noise stimulation applied to the median nerve can reduce static postural sway.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jbiomech.2022.111080DOI Listing
May 2022

Emerging roles of lncRNAs in the pathogenesis, diagnosis, and treatment of trigeminal neuralgia.

Biochem Soc Trans 2022 04;50(2):1013-1023

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

Trigeminal neuralgia (TN) is one of the most common neuropathic pain disorders and is often combined with other comorbidities if managed inadequately. However, the present understanding of its pathogenesis at the molecular level remains lacking. Long noncoding RNAs (lncRNAs) play crucial roles in neuropathic pain, and many studies have reported that specific lncRNAs are related to TN. This review summarizes the current understanding of lncRNAs in the pathogenesis, diagnosis, and treatment of TN. Recent studies have shown that the lncRNAs uc.48+, Gm14461, MRAK009713 and NONRATT021972 are potential candidate loci for the diagnosis and treatment of TN. The current diagnostic system could be enhanced and improved by a workflow for selecting transcriptomic biomarkers and the development of lncRNA-based molecular diagnostic systems for TN. The discovery of lncRNAs potentially impacts drug selection for TN; however, the current supporting evidence is limited to preclinical studies. Additional studies are needed to further test the diagnostic and therapeutic value of lncRNAs in TN.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1042/BST20220070DOI Listing
April 2022

Recombinase Polymerase Amplification Combined with Real-Time Fluorescent Probe for Detection.

J Clin Med 2022 Mar 23;11(7). Epub 2022 Mar 23.

Baoding Key Laboratory for Precision Diagnosis and Treatment of Infectious Diseases in Children, Baoding Children's Hospital, Baoding 071051, China.

() is one of the major causes of community-acquired pneumonia, accounting for 20-40% of total cases. Rapid and accurate detection of is crucial for the diagnosis and rational selection of antibiotics. In this study, we set up a real-time recombinase polymerase amplification (RPA) assay to detect the conserved gene CARDS of . The amplification can be finished in 20 min at a wide temperature range from 37-41 °C. The limit of detection of RPA assay was 10 fg per microliter. Cross-reaction with commonly detected respiratory pathogens was not observed using RPA assay. Among clinical sputum samples, the detection rate of RPA assay and real-time PCR assay was 48.4% (92/190) and 46.3% (88/190), respectively ( = 0.68). Therefore, the RPA assay for detection is rapid and easy to use and may serve as a promising test for early diagnosis of infection.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3390/jcm11071780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9000086PMC
March 2022

Ischemia-induced cleavage of OPA1 at S1 site aggravates mitochondrial fragmentation and reperfusion injury in neurons.

Cell Death Dis 2022 Apr 8;13(4):321. Epub 2022 Apr 8.

Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, Jiangsu Province, 215006, China.

Neuronal mitochondrial dynamics are disturbed after ischemic stroke. Optic atrophy 1 (OPA1) and its GTPase activity are involved in maintaining mitochondrial cristae and inner membrane fusion. This study aimed to explore the role of OMA1-mediated OPA1 cleavage (S1-OPA1) in neurons exposed to cerebral ischemia and reperfusion. After oxygen-glucose deprivation (OGD) for 60 min, we found that mitochondrial fragmentation occurred successively in the axon and soma of neurons, accompanied by an increase in S1-OPA1. In addition, S1-OPA1 overexpression significantly aggravated mitochondrial damage in neurons exposed to OGD for 60 min and 24 h after OGD/R, characterized by mitochondrial fragmentation, decreased mitochondrial membrane potential, mitochondrial cristae ultrastructural damage, increased superoxide production, decreased ATP production and increased mitochondrial apoptosis, which was inhibited by the lysine 301 to alanine mutation (K301A). Furthermore, we performed neuron-specific overexpression of S1-OPA1 in the cerebral cortex around ischemia of middle cerebral artery occlusion/reperfusion (MCAO/R) mice. The results further demonstrated in vivo that S1-OPA1 exacerbated neuronal mitochondrial ultrastructural destruction and injury induced by cerebral ischemia-reperfusion, while S1-OPA1-K301 overexpression had no effect. In conclusion, ischemia induced neuronal OMA1-mediated cleavage of OPA1 at the S1 site. S1-OPA1 aggravated neuronal mitochondrial fragmentation and damage in a GTPase-dependent manner, and participated in neuronal ischemia-reperfusion injury.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41419-022-04782-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8993832PMC
April 2022

Convolutional neural network-based computer-aided diagnosis in Hiesho (cold sensation).

Comput Biol Med 2022 06 16;145:105411. Epub 2022 Mar 16.

College of Science and Engineering, Ritsumeikan University, 1-1-1 Noji-higashi, Shiga, 525-8577, Kusatsu, Japan. Electronic address:

Hiesho (cold sensation) is a worldwide health problem primarily occurring in women. Females who suffered from Hiesho reported cold feeling at the extremities, which was also related to other chronic diseases. However, the diagnosis of Hiesho is still controversial because it depends on subjective approaches such as questionnaires. Quantitative and automatic Hiesho diagnosis is expected to increase diagnostic accuracy and lower the burden on patients and doctors. Following our previous study, which found that the temperature difference between females' foreheads and plantar soles was significant in Hiesho patients, it was considered that training a convolutional neural network (CNN) with thermographic images can contribute to a computer-aided diagnosis (CAD) for Hiesho. Thus, this study proposes a CNN-based Hiesho CAD system. A total of 5612 thermographic images from 46 subjects (23 Hiesho patients and 23 healthy subjects) were used to train AlexNet, and the performance of the proposed CNN model was evaluated and compared with other machine learning-based models using accuracy, precision, sensitivity, specificity, and F1 score. The experimental results showed that the proposed CNN-based Hiesho CAD model had the highest performance (100%) for all evaluated items. In addition, it was concluded that thermographic images showed high feasibility for discriminating Hiesho, and CNN-based CAD showed high accuracy and reliability for automatic Hiesho diagnosis.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.compbiomed.2022.105411DOI Listing
June 2022
-->