Publications by authors named "Tianyi Ma"

90 Publications

Colorectal cancer cell intrinsic fibroblast activation protein alpha binds to Enolase1 and activates NF-κB pathway to promote metastasis.

Cell Death Dis 2021 May 25;12(6):543. Epub 2021 May 25.

Colorectal Cancer Surgery Department, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.

Fibroblast activation protein alpha (FAP) is a marker of cancer-associated fibroblast, which is also expressed in cancer epithelial cells. However, the role of FAP in colorectal cancer (CRC) cells remains to be elucidated. Here we investigate the expression pattern of FAP in CRC tissues and cells to prove that FAP is upregulated in CRC cells. Loss- of and gain-of-function assays identified FAP promotes migration and invasion instead of an effect on cell proliferation. Microarray assays are adopted to identify the different expressed genes after FAP knockdown and gene set enrichment analysis (GSEA) is used to exploit the involved signaling pathway. Our works reveal FAP exerts a function dependent on NF-κB signaling pathway and FAP expression is associated with NF-κB signaling pathway in clinical samples. Our work shows FAP is secreted by CRC cells and soluble FAP could promote metastasis. To investigate the mechanism of FAP influencing the NF-κB signaling pathway, LC/MS is performed to identify the proteins interacting with FAP. We find that FAP binds to ENO1 and activates NF-κB signaling pathway dependent on ENO1. Blocking ENO1 could partially reverse the pro-metastatic effect mediated by FAP. We also provide evidences that both FAP and ENO1 are associated with CRC stages, and high levels of FAP and ENO1 predict a poor survival in CRC patients. In summary, our work could provide a novel mechanism of FAP in CRC cells and a potential strategy for treatment of metastatic CRC.
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http://dx.doi.org/10.1038/s41419-021-03823-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8149633PMC
May 2021

Association Between Famotidine Use and Clinical Outcomes in Patients With COVID-19: Assessment of Available Evidence.

Authors:
Tianyi Ma Meng Wu

Am J Gastroenterol 2021 04;116(4):848-849

1Department of Hepatopancreatobiliary Medicine, The Second Hospital of Jilin University, Jilin, China.

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http://dx.doi.org/10.14309/ajg.0000000000001008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7553027PMC
April 2021

Exceptional Cocatalyst-Free Photo-Enhanced Piezocatalytic Hydrogen Evolution of Carbon Nitride Nanosheets from Strong In-Plane Polarization.

Adv Mater 2021 May 8:e2101751. Epub 2021 May 8.

Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes, National Laboratory of Mineral Materials, School of Materials Science and Technology, China University of Geosciences, Beijing, 100083, China.

Utilizing mechanical energy to produce hydrogen is emerging as a promising way to generate renewable energy, but is challenged by low efficiency and scanty cognition. In this work, graphitic carbon nitride (g-C N ) with an atomically thin sheet-like structure is applied for prominent piezocatalytic and photo-enhanced piezocatalytic H production. It is revealed that the anomalous piezoelectricity in g-C N originates from the strong in-plane polarization along the a-axis, contributed by the superimposed polar tri-s-triazine units and flexoelectric effect derived from the structured triangular cavities, which provides powerful electrochemical driving force for the water reduction reaction. Furthermore, the photo-enhanced charge transfer enables g-C N nanosheets to reserve more energized polarization charges to fully participate in the reaction at the surface reactive sites enriched by strain-induced carbon vacancies. Without any cocatalysts, an exceptional photo-piezocatalytic H evolution rate of 12.16 mmol g h is delivered by the g-C N nanosheets, far exceeding that of previously reported piezocatalysts and g-C N photocatalysts. Further, high pure-water-splitting performance with production of the value-added oxidation product H O via photo-piezocatalysis is also disclosed. This work not only exposes the potential of g-C N as a piezo-semiconductor for catalytic H evolution, but also breaks a new ground for the conversion of solar and mechanical energy by photomediated piezocatalytic reaction.
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http://dx.doi.org/10.1002/adma.202101751DOI Listing
May 2021

Modification of structure and functionalities of ginkgo seed proteins by pH-shifting treatment.

Food Chem 2021 Oct 20;358:129862. Epub 2021 Apr 20.

Department of Food Science and Engineering, College of Light Industry and Food Engineering, Nanjing Forestry University, Nanjing 210037, China. Electronic address:

Modification and improvement of protein functionalities are important for expanding the applications of proteins in food. The objective of this study was to investigate the effects of pH-shifting treatments on the structural and functional properties of ginkgo seed protein isolate (GSPI). GSPI was exposed to acidic (pH 2.0-4.0) and basic (pH 10.0-12.0) pHs for 0, 0.5, 1, 2, and 4 h and subsequently neutralized for refolding. The pH-shifting treatments significantly increased GSPI solubility by 43-141% except for the treatment at pH 2.0, which decreased protein solubility by 16-39%. All pH-shifting treatments more than doubled the surface hydrophobicity of GSPI and significantly improved the emulsifying activity. The highest emulsifying activity was observed in the pH 2.0-treated GSPI, which was 4.9-fold higher than the control. Acid-induced GSPI degradation likely promoted protein adsorption to the oil-water interface. In summary, the pH-shifting-modified GSPI may serve as a promising emulsifier in various food systems.
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http://dx.doi.org/10.1016/j.foodchem.2021.129862DOI Listing
October 2021

Comparison of natural orifice specimen extraction surgery and conventional laparoscopic-assisted resection in the treatment effects of low rectal cancer.

Sci Rep 2021 Apr 29;11(1):9338. Epub 2021 Apr 29.

Department of Colorectal Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150081, China.

Natural orifice specimen extraction surgery (NOSES) is an intra-abdominal procedure that does not require an auxiliary incision to take a surgical sample from the abdominal wall through the natural orifice, but there are few systematic clinical studies on it. The aim of this study was to demonstrate the safety and feasibility of NOSES. We retrospectively analyzed the clinical data and follow-up of 165 patients with low rectal cancer who underwent NOSES or conventional laparoscopic surgery at our center from January 2013 to June 2015. From the perioperative data and postoperative follow-up results of both groups, patients in the NOSES group had less intraoperative bleeding (49.3 ± 55.8 ml vs. 75.1 ± 57.3 ml, p = 0.02), shorter postoperative gastrointestinal recovery (42.3 ± 15.5 h vs. 50.1 ± 17.0 h, p = 0.01), less postoperative analgesic use (35.6% vs. 57.6%, p = 0.02), lower postoperative pain scores, lower rate of postoperative complications (6.8% vs. 25.4%, p = 0.01), better satisfaction of the image and cosmesis of the abdominal wall postoperatively, and higher quality of life. Moreover, there was no significant difference in overall survival (OS) and disease-free survival (DFS) between two groups. Overall, NOSES is a safe and reliable minimally invasive surgical technique for patients with low rectal cancer.
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http://dx.doi.org/10.1038/s41598-021-88790-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8085046PMC
April 2021

The Number of Patients with Acute Myocardial Infarction Decreased and Door-to-Balloon Time Delayed in COVID-19.

Cardiol Res Pract 2021 25;2021:6673313. Epub 2021 Mar 25.

Department of Cardiology, Shunde Hospital, Southern Medical University, Foshan, China.

Background: At present, COVID-19 is sweeping the world, and all countries are actively responding. During the COVID-19 epidemic, the treatment of patients with acute myocardial infarction (AMI) may be affected.

Methods: We reviewed data of patients with AMI from January 23 to April 23, 2020 (2020), and January 23 to April 23, 2019 (2019), who were admitted to two hospitals from Southern China. We collected clinical characteristics, comorbidities, treatment, prognosis, and key time segments to analyze.

Results: The total number of patients that had been diagnosed with AMI in the two hospitals was 218 in 2020 and 260 in 2019. The number of AMI patients that were admitted to hospitals per day decreased in 2020. The percentage of patients with AMI who refused hospitalization in 2020 was significantly higher than that in 2019 (5.0% vs 1.5%, =0.028). There is no statistical difference in symptoms of the first medical contact (S2FMC) time between 2020 and 2019 (=0.552). Door-to-balloon (D2B) time of ST-elevation myocardial infarction (STEMI) patients who were treated with a primary percutaneous coronary intervention (pPCI) in 2020 was 79 (63.75-105.25) mins, while D2B time in 2019 was 57.5 (41.5-76.5) mins, which was statistically different from the two groups.

Conclusions: COVID-19 had an impact on the number of AMI patients who were admitted to hospitals and the time of treatment. During the COVID-19 epidemic, the number of AMI patients that were admitted to hospitals per day was decreased, while the percentage of AMI patients that refused therapy in these two hospitals increased, and the D2B time of STEMI patients was also delayed.
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http://dx.doi.org/10.1155/2021/6673313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996045PMC
March 2021

Long-Term Outcome Comparison Between Two Specimen Extraction Approaches for Middle Rectum Cancer: A Retrospective Study.

Surg Innov 2021 Mar 31:15533506211006970. Epub 2021 Mar 31.

Department of Colorectal Surgery, 105821The Second Affiliated Hospital of Harbin Medical University, Harbin, China.

. There are few studies comparing the long-term results of natural orifice specimen extraction surgery (NOSES) and conventional laparoscopic-assisted resection (LA) in the treatment of middle rectal cancer. This retrospective analysis aimed to evaluate the reliability of NOSES. . From January 2013 to December 2017, all patients diagnosed with median rectal cancer in our hospital who underwent NOSES and LA were enrolled. We used propensity-score matching (PSM) to balance baseline data between the NOSES group and the laparoscopic group. The primary endpoint was overall survival (OS) and disease-free survival (DFS). We used the Kaplan-Meier method to estimate OS and DFS. Student's t-test was used to analyze the difference of continuous data. Categorical data were compared using the Kruskal-Wallis test or Fisher's exact test. . After PSM, 38 patients were included in each group. We found that surgical bleeding volume in the NOSES group was considerably lower than that in the LA group (49.5 ± 47.5 mL vs. 86.3 ± 83.5 mL, = .01). From the short-term results, the first flatus and regular diet time in the NOSES group were shorter than those in the LA group (41.3 ± 25.2 vs. 54.0 ± 19.2 hours, < .01 and 63.9 ± 42.6 hours vs. 105.1 ± 66.8 hours, < .01, respectively). Long-term OS and DFS were not different between the groups. . Therefore, NOSES is a reliable technique for middle rectal cancer treatment. Short-term outcomes are pointedly better than LA, while the two surgical approaches did not differ in the long-term outcomes or complication rate.
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http://dx.doi.org/10.1177/15533506211006970DOI Listing
March 2021

Engineering Bismuth-Tin Interface in Bimetallic Aerogel with a 3D Porous Structure for Highly Selective Electrocatalytic CO Reduction to HCOOH.

Angew Chem Int Ed Engl 2021 May 26;60(22):12554-12559. Epub 2021 Apr 26.

Centre for Translational Atomaterials, Faculty of Science, Engineering and Technology, Swinburne University of Technology, John Street, Hawthorn, VIC, 3122, Australia.

Electrochemical reduction of CO (CO RR) into valuable hydrocarbons is appealing in alleviating the excessive CO level. We present the very first utilization of metallic bismuth-tin (Bi-Sn) aerogel for CO RR with selective HCOOH production. A non-precious bimetallic aerogel of Bi-Sn is readily prepared at ambient temperature, which exhibits 3D morphology with interconnected channels, abundant interfaces and a hydrophilic surface. Superior to Bi and Sn, the Bi-Sn aerogel exposes more active sites and it has favorable mass transfer properties, which endow it with a high FE of 93.9 %. Moreover, the Bi-Sn aerogel achieves a FE of ca. 90 % that was maintained for 10 h in a flow battery. In situ ATR-FTIR measurements confirmed that the formation of *HCOO is the rate-determining step toward formic acid generation. DFT demonstrated the coexistence of Bi and Sn optimized the energy barrier for the production of HCOOH, thereby improving the catalytic activity.
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http://dx.doi.org/10.1002/anie.202102832DOI Listing
May 2021

Hybridized Graphene for Supercapacitors: Beyond the Limitation of Pure Graphene.

Small 2021 Mar 26;17(12):e2007311. Epub 2021 Feb 26.

Centre for Translational Atomaterials, Faculty of Science, Engineering and Technology, Swinburne University of Technology, P. O. Box 218, Hawthorn, VIC, 3122, Australia.

Graphene-based supercapacitors have been attracting growing attention due to the predicted intrinsic high surface area, high electron mobility, and many other excellent properties of pristine graphene. However, experimentally, the state-of-the-art graphene electrodes face limitations such as low surface area, low electrical conductivity, and low capacitance, which greatly limit their electrochemical performances for supercapacitor applications. To tackle these issues, hybridizing graphene with other species (e.g., atom, cluster, nanostructure, etc.) to enlarge the surface area, enhance the electrical conductivity, and improve capacitance behaviors are strongly desired. In this review, different hybridization principles (spacers hybridization, conductors hybridization, heteroatoms doping, and pseudocapacitance hybridization) are discussed to provide fundamental guidance for hybridization approaches to solve these challenges. Recent progress in hybridized graphene for supercapacitors guided by the above principles are thereafter summarized, pushing the performance of hybridized graphene electrodes beyond the limitation of pure graphene materials. In addition, the current challenges of energy storage using hybridized graphene and their future directions are discussed.
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http://dx.doi.org/10.1002/smll.202007311DOI Listing
March 2021

How Long is It Safe to Wait for Breast Surgery After Completion of Neoadjuvant Chemotherapy?

Cancer Manag Res 2021 3;13:989-998. Epub 2021 Feb 3.

Department of Breast Center of the Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, 266000, People's Republic of China.

Purpose: This study aimed to evaluate the impact of surgical time on postoperative complications and survival outcomes in breast cancer patients after neoadjuvant chemotherapy (NAC).

Patients And Methods: We retrospectively reviewed breast cancer patients treated at Breast Disease Center of the Affiliated Hospital of Qingdao University, from January 2013 to December 2018. The eligibility criteria were female patients with histologically confirmed primary stage II-III breast cancer and initially treated with NAC, who were <75 years old, and patients for whom medical records were available. The patients with severe comorbidities of other organs, with previous histories of other malignancies or breast cancer, and with distant metastasis or contralateral breast cancer, were excluded. Eligible patients were divided into three groups based on time to surgery (TTS): (A) ≤21 days; (B) between 21 and 28 days; and (C) >28 days. We collected medical records and followed up patients.

Results: Totally 422 patients were enrolled. The median TTS was 26 days. Among these patients, 119 (28.2%) were in Group A, 152 (36.0%) were in Group B, and 151 (35.8%) were in Group C. Eighty-two (19.4%) patients achieved pathologic complete response (pCR). Survival analysis showed that DFS (P=0.012) and OS (P=0.015) were significantly different among three groups. In multivariate analysis, DFS (HR=2.333, P=0.001) and OS (HR=2.783, P=0.030) were significantly worse when TTS >28 days. Postoperative complications occurred in 96 (22.7%) patients. The incidence of total postoperative complications in the three groups was statistically different (P=0.001) and Group A had worse performance. Multivariate analysis showed that age >50 years old (P=0.004) and TTS ≤21 days (P<0.001) were independent parameters for total postoperative complications.

Conclusion: Postoperative complications and survival outcomes in breast cancer patients seemed to be influenced by TTS after the NAC. The benefits were remarkable in patients undergoing surgery between 21 and 28 days.
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http://dx.doi.org/10.2147/CMAR.S287089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7868277PMC
February 2021

Long Noncoding RNA JAKMIP2-AS1 Promotes the Growth of Colorectal Cancer and Indicates Poor Prognosis.

Onco Targets Ther 2021 3;14:763-772. Epub 2021 Feb 3.

Department of Colorectal Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150001, People's Republic of China.

Background: The identification of cancer-associated long noncoding RNAs and the investigation of their molecular and biological functions are important for understanding the molecular biology and progression of cancer. JAKMIP2-AS1 has not been reported in the literature, especially in the context of colorectal cancer. The aim of the present study was to examine the expression pattern of JAKMIP2-AS1 in colorectal cancer (CRC) and evaluate its biological role and clinical significance in tumor progression.

Methods: JAKMIP2-AS1 expression was analyzed in 56 CRC tissues and nine CRC cell lines by quantitative reverse-transcription polymerase chain reaction (qRT-PCR). Overexpression and RNA interference (RNAi) approaches were used to investigate the biological functions of JAKMIP2-AS1. The effect of JAKMIP2-AS1 on proliferation was evaluated by CCK-8, colony formation, and EdU assays. Subcutaneous injection of cells was used to study proliferation in BALB/c nude male mice. Proliferation-related protein levels were examined by immunohistochemical analysis. Differences between groups were tested for significance using Student's -test (two-tailed).

Results: JAKMIP2-AS1 was highly expressed in both CRC samples and cell lines compared with the corresponding normal counterparts. The upregulation of JAKMIP2-AS1 expression promoted the proliferation of colorectal cancer cells. Moreover, patients with high levels of JAKMIP2-AS1 expression had a relatively poor prognosis. Inhibition of JAKMIP2-AS1 by RNAi decreased the proliferation of CRC cells in vitro and impeded cell growth in vivo. Ki-67 and PCNA levels were affected by JAKMIP2-AS1 knockdown or overexpression in vivo.

Conclusion: Our findings indicate that JAKMIP2-AS1 is significantly upregulated in CRC tissues and regulates CRC cell proliferation. Thus, JAKMIP2-AS1 may represent a new marker of poor prognosis and is a potential therapeutic target for CRC intervention.
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http://dx.doi.org/10.2147/OTT.S289617DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7868292PMC
February 2021

Pickering emulsion-embedded hierarchical solid-liquid hydrogel spheres for static and flow photocatalysis.

J Colloid Interface Sci 2021 May 14;589:587-596. Epub 2021 Jan 14.

Liaoning Key Laboratory for Green Synthesis and Preparative Chemistry of Advanced Materials, College of Chemistry, Liaoning University, Shenyang 110036, China. Electronic address:

Pickering emulsion-based photocatalysis is considered to be a promising system due to its large active surface area and water/oil spatial separation capability for enrichment of substrates and products. In this work, a novel hierarchical structure composed of calcium alginate gel sphere wrapped ionic liquid-in-water Pickering emulsion with TiO in the water phase, which are stabilized by graphene oxide, is prepared via a facile one-step emulsion gelation method. Such subtle combination of Pickering emulsion, hydrogel and TiO with a multi-stage solid-liquid assemblage structure shows enhanced degradation activity of 2-naphthol into small molecular alkanes under simulated solar irradiation. The photodegradation activity is attributed to the ionic liquid as adsorption medium for 2-naphthol, and the high-efficient charge separation at graphene oxide/TiO interface superior to that of pure TiO. More importantly, the as-prepared millimeter-sized assembled gel spheres can be directly used as the column filler to construct continuous flow photocatalytic system, maintaining the promising performance in removing pollutants from water with ~100% remove ability of 2-naphthol on stream. A charge transfer mechanism of the photocatalyst is proposed, i.e. photogenerated charges are separated in TiO/graphene oxide p-n heterostructure at the interface of Pickering emulsion droplets.
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http://dx.doi.org/10.1016/j.jcis.2021.01.020DOI Listing
May 2021

Atomic-Level Charge Separation Strategies in Semiconductor-Based Photocatalysts.

Adv Mater 2021 Mar 27;33(10):e2005256. Epub 2021 Jan 27.

Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes, National Laboratory of Mineral Materials, School of Materials Science and Technology, China University of Geosciences, Beijing, 100083, China.

Semiconductor-based photocatalysis as a productive technology furnishes a prospective solution to environmental and renewable energy issues, but its efficiency greatly relies on the effective bulk and surface separation of photoexcited charge carriers. Exploitation of atomic-level strategies allows in-depth understanding on the related mechanisms and enables bottom-up precise design of photocatalysts, significantly enhancing photocatalytic activity. Herein, the advances on atomic-level charge separation strategies toward developing robust photocatalysts are highlighted, elucidating the fundamentals of charge separation and transfer processes and advanced probing techniques. The atomic-level bulk charge separation strategies, embodied by regulation of charge movement pathway and migration dynamic, boil down to shortening the charge diffusion distance to the atomic-scale, establishing atomic-level charge transfer channels, and enhancing the charge separation driving force. Meanwhile, regulating the in-plane surface structure and spatial surface structure are summarized as atomic-level surface charge separation strategies. Moreover, collaborative strategies for simultaneous manipulation of bulk and surface photocharges are also introduced. Finally, the existing challenges and future prospects for fabrication of state-of-the-art photocatalysts are discussed on the basis of a thorough comprehension of atomic-level charge separation strategies.
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http://dx.doi.org/10.1002/adma.202005256DOI Listing
March 2021

Photocatalytic Oxygen Evolution from Water Splitting.

Adv Sci (Weinh) 2020 Jan 18;8(1):2002458. Epub 2020 Nov 18.

Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes National Laboratory of Mineral Materials School of Materials Science and Technology China University of Geosciences Beijing 100083 China.

Photocatalytic water splitting has attracted a lot of attention in recent years, and O evolution is the decisive step owing to the complex four-electrons reaction process. Though many studies have been conducted, it is necessary to systematically summarize and introduce the research on photocatalytic O evolution, and thus a systematic review is needed. First, the corresponding principles about O evolution and some urgently encountered issues based on the fundamentals of photocatalytic water splitting are introduced. Then, several types of classical water oxidation photocatalysts, including TiO, BiVO, WO, -FeO, and some newly developed ones, such as Sillén-Aurivillius perovskites, porphyrins, metal-organic frameworks, etc., are highlighted in detail, in terms of their crystal structures, synthetic approaches, and morphologies. Third, diverse strategies for O evolution activity improvement via enhancing photoabsorption and charge separation are presented, including the cocatalysts loading, heterojunction construction, doping and vacancy formation, and other strategies. Finally, the key challenges and future prospects with regard to photocatalytic O evolution are proposed. The purpose of this review is to provide a timely summary and guideline for the future research works for O evolution.
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http://dx.doi.org/10.1002/advs.202002458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7788637PMC
January 2020

Performance of UV/acetylacetone process for saline dye wastewater treatment: Kinetics and mechanism.

J Hazard Mater 2021 03 5;406:124774. Epub 2020 Dec 5.

Shanghai Engineering Research Center of Biotransformation of Organic Solid Waste, Shanghai 200241, China; State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical Process, East China University of Science and Technology, Shanghai 200237, China.

Futility of traditional advanced oxidation processes (AOPs) in saline wastewater treatment has stimulated the quest for novel "halotolerant" chemical oxidation technology. Acetylacetone (AA) has proven to be a potent photo-activator in the degradation of dyes, but the applicability of UV/AA for saline wastewater treatment needs to be verified. In this study, degradation of crystal violet (CV) was investigated in the UV/AA system in the presence of various concentrations of exogenic Cl or Br. The results reveal that degradation, mineralization and even accumulation of adsorbable organic halides (AOX) were not significantly affected by the addition of Cl or Br. Rates of CV degradation were enhanced by elevating either AA dosage or solution acidity. An apparent kinetic rate equation was developed as r = -d[CV]/dt = k[CV][AA] = (7.34 × 10 mM min) × [CV] [AA]. In terms of results of radical quenching experiments, direct electron/energy transfer is considered as the major reaction mechanism, while either singlet oxygen or triplet state ((AA)*) might be involved. Based on identification of degradation byproducts, a possible degradation pathway of CV in the UV/AA system is proposed.
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http://dx.doi.org/10.1016/j.jhazmat.2020.124774DOI Listing
March 2021

Electrical and Structural Dual Function of Oxygen Vacancies for Promoting Electrochemical Capacitance in Tungsten Oxide.

Small 2020 Dec 2:e2004709. Epub 2020 Dec 2.

Centre for Translational Atomaterials, Faculty of Science Engineering and Technology, Swinburne University of Technology, Hawthorn, VIC, 3122, Australia.

Intrinsic defects, including oxygen vacancies, can efficiently modify the electrochemical performance of metal oxides. There is, however, a limited understanding of how vacancies influence charge storage properties. Here, using tungsten oxide as a model system, an extensive study of the effects of structure, electrical properties, and charge storage properties of oxygen vacancies is carried out using both experimental and computational techniques. The results provide direct evidence that oxygen vacancies increase the interlayer spacing in the oxide, which suppress the structural pulverization of the material during electrolyte ion insertion and removal in prolonged stability tests. Specifically, no capacitive decay is detected after 30 000 cycles. The medium states and charge storage mechanism of oxygen-deficient tungsten oxide throughout electrochemical charging/discharging processes is studied. The enhanced rate capability of the oxygen-deficient WO is attributed to improved charge storage kinetics in the bulk material. The WO electrode exhibits the highest capacitance in reported tungsten-oxide based electrodes with comparable mass loadings. The capability to improve electrochemical capacitance performance of redox-active materials is expected to open up new opportunities for ultrafast supercapacitive electrodes.
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http://dx.doi.org/10.1002/smll.202004709DOI Listing
December 2020

Overexpressed miR-335-5p reduces atherosclerotic vulnerable plaque formation in acute coronary syndrome.

J Clin Lab Anal 2021 Feb 5;35(2):e23608. Epub 2020 Dec 5.

Cardiology Department, The First Affiliated Hospital of Hunan Normal University, Hunan Provincial People's Hospital, Changsha, P.R. China.

Background: Acute coronary syndrome (ACS) may induce cardiovascular death. The correlation of mast cells related microRNAs (miRs) with risk of ACS has been investigated. We explored regulatory mechanism of miR-335-5p on macrophage innate immune response, atherosclerotic vulnerable plaque formation, and revascularization in ACS in relation to Notch signaling.

Methods: ACS-related gene microarray was collected from Gene Expression Omnibus database. After different agomir or antagomir, or inhibitor of Notch signaling treatment, IL-6, IL-1β, TNF-α, MCP-1, ICAM-1, and VCAM-1 levels were tested in ACS mice. Additionally, Notch signaling-related genes and matrix metalloproteinases (MMPs) were measured after miR-335-5p interference. Finally, mouse atherosclerosis, lipid accumulation, and the collagen/vessel area ratio of plaque were determined.

Results: miR-335-5p targeted JAG1 and mediated Notch signaling in ACS. miR-335-5p up-regulation and Notch signaling inhibition reduced expression of JAG1, Notch pathway-related genes, IL-6, IL-1β, TNF-α, MCP-1, ICAM-1, VCAM-1, and MMPs, but promote TIMP1 and TIMP2 expression. Additionally, vulnerable plaques were decreased and collagen fiber contents were observed to increase after miR-335-5p overexpression and Notch signaling inhibition.

Conclusions: Overexpression of miR-335-5p inhibited innate immune response of macrophage, reduced atherosclerotic vulnerable plaque formation, and promoted revascularization in ACS mice targeting JAG1 through Notch signaling.
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http://dx.doi.org/10.1002/jcla.23608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7891542PMC
February 2021

Degradation Mechanism Study and Safety Hazard Analysis of Overdischarge on Commercialized Lithium-ion Batteries.

ACS Appl Mater Interfaces 2020 Dec 1;12(50):56086-56094. Epub 2020 Dec 1.

Department of Mechanical and Aeronautical Engineering, University of California, Davis, California 95616, United States.

With the continuous improvement of the energy density of traction batteries for electric vehicles, the safety of batteries over their entire lifecycle has become the most critical issue in the development of electric vehicles. Abuse of electricity encountered in the application of batteries has a great impact on the safety of traction batteries. In this study, focused on the overdischarge phenomenon that is most likely to be encountered in the practical use of electric vehicles and grid storage, the impact of overdischarge on battery performance degradation is analyzed by neutron imaging technology and its safety hazards is systematically explored, combined with multimethods including electrochemical analysis and structural characterization. Results reveal the deterioration of the internal structure of traction batteries due to the overdischarge behavior and play a guiding role in the testing and evaluation of the safety of traction batteries.
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http://dx.doi.org/10.1021/acsami.0c18185DOI Listing
December 2020

Breaking Platinum Nanoparticles to Single-Atomic Pt-C Co-catalysts for Enhanced Solar-to-Hydrogen Conversion.

Angew Chem Int Ed Engl 2021 Feb 26;60(5):2541-2547. Epub 2020 Nov 26.

Centre for Translational Atomaterials, Faculty of Science, Engineering & Technology, Swinburne University of Technology, Hawthorn, Victoria, 3122, Australia.

Effective transfer and utilization of the photogenerated electrons are a key factor for achieving highly efficient H generation by photocatalytic water splitting. Apart from the activity of the co-catalyst, the interface between the co-catalyst and semiconductor is of particular importance. Guided by DFT calculations, single-atom (SA) Pt doped carbon nitride (CN) is successfully synthesized for use as the co-catalyst to the semiconducting CuS. The catalyst system ([email protected]) exhibits an enhanced photocatalytic performance for water splitting with a H production rate of 25.4 μmol h and an apparent quantum yield (AQY) of 50.3 % under the illumination of LED-530. Solar-to-hydrogen (STH) conversion efficiency is calculated to be 0.5 % under AM 1.5 illumination. This is the very first investigation of SA as the co-catalyst, which decreases the overpotential of CN during the water splitting and lowers interfacial resistance of the catalyst/co-catalyst and co-catalyst/electrolyte.
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http://dx.doi.org/10.1002/anie.202013206DOI Listing
February 2021

Combined Therapy Can Improve the Outcomes of Breast Cancer with Isolated Supraclavicular Lymph Node Involvement.

Cancer Manag Res 2020 19;12:11857-11869. Epub 2020 Nov 19.

Department of Breast Disease Center, The Affiliated Hospital of Qingdao University, Qingdao, People's Republic of China.

Purpose: This study aimed to evaluate the efficacy of systemic combined with local therapies in isolated metachronous ipsilateral supraclavicular lymph node metastasis (mISLM) breast cancer patients.

Patients And Methods: We reviewed the data of mISLM patients admitted by Breast Disease Center of the Affiliated Hospital of Qingdao University, from January 2009 to July 2019. Ninety-nine patients were included and were divided into two groups: the systemic group, which referred to patients who received only systemic therapy, and the combined group, which referred to patients who received systemic therapy plus local therapy (including neck radiotherapy (RT) and/or supraclavicular lymph node dissection surgery). In the combined group, patients were further divided into systemic therapy plus: 1) neck RT, 2) supraclavicular lymph node dissection surgery, and 3) neck RT and supraclavicular lymph node dissection surgery.

Results: The median duration of follow-up was 36 months. The median PFS was 15 months, and the median OS was 35 months. Local control rates of 1 year, 2 years and 3 years were 92.9%, 86.9% and 84.8%, respectively. The combined group (n=56) had a significantly better PFS (P<0.001) and OS (P=0.001) than the systemic group (n=43). Compared with Group B (n=13) and Group C (n=14), Group A (n=29) had a significantly better PFS (P=0.007). Higher dose and conventional dose showed no significant differences regarding the local control rate (P=1.000), PFS (P=0.787) or OS (P=0.690) in the patients who received RT. In multivariate analysis, pN3 stage and combined therapy (systemic therapy plus local therapy) for mISLM affected PFS (P<0.001 and P=0.002, respectively). Neck RT was an independent parameter affecting OS (P=0.002).

Conclusion: In breast cancer patients with mISLM, systemic therapy combined with local therapy could improve PFS and OS. Based on systemic therapy, RT had a better effect on survival than surgery. However, more aggressive methods, such as systemic therapy combined with both RT and surgery or a higher dose of RT, may not be associated with improved PFS or OS in these patients.
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http://dx.doi.org/10.2147/CMAR.S276996DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7682445PMC
November 2020

Interface Chemistry Special Collection.

Chem Asian J 2020 Nov 29;15(22):3582-3583. Epub 2020 Oct 29.

School of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China.

Developing efficient electrochemical energy conversion and storage technologies plays a critical role in establishing a sustainable and clean energy system. Chemistry - An Asian Journal, together with Prof. Jianmin Ma (Hunan University, China), Prof. Wenping Sun (Zhejiang University, China), Dr. Tianyi Ma (The University of Newcastle, Australia), and Dr. Lei Wang (Hunan University, China) are greatly honored to assemble a compendium of the latest works on surface and interface chemistry towards electrochemical energy conversion and storage applications.
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http://dx.doi.org/10.1002/asia.202000719DOI Listing
November 2020

Unsaturated p-Metal-Based Metal-Organic Frameworks for Selective Nitrogen Reduction under Ambient Conditions.

ACS Appl Mater Interfaces 2020 Oct 23;12(40):44830-44839. Epub 2020 Sep 23.

Discipline of Chemistry, School of Environmental and Life Sciences, University of Newcastle, Callaghan, New South Wales 2308, Australia.

Electrochemical ammonia synthesis that utilizes renewable electricity in the nitrogen reduction reaction (NRR) has recently been remarkably considered. Of particular importance is to develop efficient electrocatalysts at low costs. Herein, highly selective nitrogen capture using porous aluminum-based metal-organic frameworks (MOFs) materials, MIL-100 (Al), is first designed for the electrochemical nitrogen fixation in alkaline media under ambient conditions. Owing to the unique structure, MIL-100 (Al) exhibits remarkable NRR properties (NH yield: 10.6 μg h cm mg and Faradaic efficiency: 22.6%) at a low overpotential (177 mV). Investigation indicates that the catalyst shows excellent N-selective captures due to the unsaturated metal sites binding with N. More specifically, as the Al 3p band can strongly interact with N 2p orbitals, Al as a main group metal presents a high and selective affinity to N. The utilization of multifunctional MOF catalysts delivers both high N selectivity and abundant catalytic sites, resulting in remarkable efficiency for NH production.
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http://dx.doi.org/10.1021/acsami.0c13902DOI Listing
October 2020

Surface engineered 2D materials for photocatalysis.

Chem Commun (Camb) 2020 Sep;56(75):11000-11013

Discipline of Chemistry, School of Environmental & Life Sciences, The University of Newcastle, Callaghan, NSW 2308, Australia.

Benefitting from their unique structure and physicochemical properties, two-dimensional (2D) materials have aroused tremendous interest from academia and industry, being regarded as an important class of photocatalysts. However, their photocatalytic activities still need further improvement to satisfy the requirement of scale-up production. In this regard, the surface engineering strategy is considered as one of the most effective methods for optimizing their photocatalytic performance. This feature article not only classifies the 2D photocatalysts into layered and non-layered 2D photocatalysts and presents their preferred synthesis methods, but also summarizes the advantages of the surface engineering strategy for boosting the photocatalytic performance of 2D materials from the aspects of light absorption, charge carrier separation and surface active sites. Various surface engineering strategies, such as surface decorating, vacancy engineering, element doping, surface heterojunction construction and regulation of facet-dependent sites, have also been presented as advantages of the surface engineering strategy. Eventually, the challenges and future outlook for optimizing the photocatalytic activities of 2D materials through surface engineering are addressed.
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http://dx.doi.org/10.1039/d0cc04790bDOI Listing
September 2020

Prognostic Value of Secreted Frizzled-Related Protein 5 in Heart Failure Patients With and Without Type 2 Diabetes Mellitus.

Circ Heart Fail 2020 09 26;13(9):e007054. Epub 2020 Aug 26.

Department of Cardiology, Shunde Hospital (H.Z., X.L., J. Luo, X.H., Y. Hu, Y. Huang), Southern Medical University, Foshan, China.

Background: Patients with heart failure (HF) with diabetes mellitus have distinct biomarker profiles compared with those without diabetes mellitus. SFRP5 (secreted frizzled-related protein 5) is an anti-inflammatory adipokine with an important suppressing role on the development of type 2 diabetes mellitus (T2DM). This study aimed to evaluate the prognostic value of SFRP5 in patients with HF with and without T2DM.

Methods: The study included 833 consecutive patients with HF, 312 (37.5%) of whom had T2DM. Blood samples were collected at presentation, and SFRP5 levels were measured. The primary outcome was the composite end points of first occurrence of HF rehospitalization or all-cause mortality during follow-up.

Results: During median follow-up of 2.1 years, 335 (40.2%) patients in the cohort experienced the composite primary outcome. After adjustment for multiple risk factors, each doubling of SFRP5 level was associated with a 21% decreased risk of primary outcomes in the overall study population (<0.001). Subgroup analyses showed that the association between level of SFPR5 and primary outcomes may be stronger in patients with T2DM (hazard ratio, 0.69 [95% CI, 0.61-0.79]) than in patients without T2DM (hazard ratio, 0.89 [95% CI, 0.79-1.01]; interaction =0.006). Similar associations were observed when taking SFRP5 as a categorical variable. Addition of SFRP5 significantly improved discrimination and reclassification of the incident primary outcomes beyond clinical risk factors and N-terminal pro-B-type natriuretic peptide in all patients with HF and those with T2DM (all <0.01).

Conclusions: SFRP5 is an independent novel biomarker for risk stratification in HF, especially in HF with T2DM.
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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.120.007054DOI Listing
September 2020

Proton pump inhibitors and the risk of colorectal cancer: a systematic review and meta-analysis of observational studies.

Int J Colorectal Dis 2020 Dec 18;35(12):2157-2169. Epub 2020 Aug 18.

Department of Hepatopancreatobiliary Medicine, The Second Hospital of Jilin University, No. 218 Ziqiang Road, Changchun, Jilin, 130000, China.

Purpose: The increased risk of colorectal cancer (CRC) associated with long-term use of proton pump inhibitors (PPIs) has attracted considerable attention; however, the conclusions of studies evaluating this correlation are inconsistent or even controversial. Therefore, we conducted a systematic review and meta-analysis to determine the association of PPI use with the risk of CRC.

Methods: A systematic literature search was conducted in PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials to identify relevant studies. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) for the associations between PPI use and the risk of CRC were estimated with a fixed-effects or random-effects model.

Results: We identified and included 9 observational studies (3 cohort studies and 6 case-control studies) comprising 1,036,438 participants. Overall, there was no statistically significant association between PPI use and the risk of CRC (pooled OR 1.26, 95% CI: 0.90-1.73; p = 0.166) when PPI exposure was assessed as a binary variable. However, a weak association between long-term use of PPIs and CRC was demonstrated (pooled OR 1.19, 95% CI: 1.09-1.31; p < 0.001) when the cumulative duration of PPI exposure was confined to > 5 years.

Conclusions: Although the present meta-analysis suggests a weak association between long-term use (> 5 years) of PPIs and CRC, there is not enough statistical power to refute or confirm an association between the use of PPIs and CRC. More high-quality prospective cohort studies are needed to assess this correlation.
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http://dx.doi.org/10.1007/s00384-020-03717-5DOI Listing
December 2020

Photocatalysis Enhanced by External Fields.

Angew Chem Int Ed Engl 2020 Aug 7. Epub 2020 Aug 7.

Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes, School of Materials Science and Technology, China University of Geosciences, Beijing, 100083, P. R. China.

The efficient conversion of solar energy by means of photocatalysis shows huge potential to relieve the ongoing energy crisis and increasing environmental pollution. However, unsatisfactory conversion efficiency still hinders its practical application. The introduction of external fields can remarkably enhance the photocatalytic performance of semiconductors from the inside out. This review focuses on recent advances in the application of diverse external fields, including microwaves, mechanical stress, temperature gradient, electric field, magnetic field, and coupled fields, to boost photocatalytic reactions, for applications in, for example, contaminant degradation, water splitting, CO reduction, and bacterial inactivation. The relevant reinforcement mechanisms of photoabsorption, the transport and separation of photoinduced charges, and adsorption of reagents by the external fields are highlighted. Finally, the challenges and outlook for the development of external-field-enhanced photocatalysis are presented.
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http://dx.doi.org/10.1002/anie.202009518DOI Listing
August 2020

MiR-30d inhibits cardiomyocytes autophagy promoting ferroptosis after myocardial infarction.

Panminerva Med 2020 Jul 27. Epub 2020 Jul 27.

Department of Cardiology, Affiliated Haikou Hospital of Xiangya Medical College, Central South University, Haikou, China -

Background: To investigate the effect of microRNA-30d (miR-30d) on autophagy and reveal the mechanism of autophagy promoting ferroptosis in H9C2 cells.

Methods: First, we detected miR-30d expression of myocardial tissue in the sham and myocardial infarction (MI) group, and then analyzed by biochemical analysis and luciferase Genetic experiments to confirm its downstream target gene of. After using Lentivirus-ATG5 (LV-sh-ATG5) to effectively inhibit autophagy, in order to further clarify the possible mechanism of autophagy leading to ferroptosis in H9C2 cells, we have tested the relevant indicators ferroptosis.

Results: We first found that miR-30d expression was down-regulated in myocardial tissue after MI, while autophagy increased, and autophagy was reduced when miR-30d was overexpressed, and then analyzed by biochemical analysis and luciferase Genetic experiments confirmed that ATG5 was a downstream target gene of miR-30d. After using Lentivirus-ATG5 (LV-shATG5) to effectively inhibit autophagy and up-regulate the expression of FTH1 and GPX4 in H9C2 cells, reduce the content of MDA, increase the content of GSH, and increase the activity of GPX4, suggesting that autophagy after MI may promote ferroptosis in H9C2 cells.

Conclusions: The expression of miR-30d decreased in cardiomyocytes after MI and which can inhibit autophagy by binding to ATG5. Furthermore, autophagy after MI may promote ferroptosis.
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http://dx.doi.org/10.23736/S0031-0808.20.03979-8DOI Listing
July 2020

Proton Insertion Promoted a Polyfurfural/MnO Nanocomposite Cathode for a Rechargeable Aqueous Zn-MnO Battery.

ACS Appl Mater Interfaces 2020 Aug 2;12(32):36072-36081. Epub 2020 Aug 2.

Discipline of Chemistry, University of Newcastle, Callaghan, New South Wales 2308, Australia.

Rechargeable aqueous Zn-MnO batteries using a mild electrolyte have attracted considerable interest because of their high output voltage, high safety, low cost, and environmental friendliness. However, poor cycling stability remains a significant issue for their applications. Equally, the energy storage mechanism involved is still controversial thus far. Herein, porous polyfurfural/MnO (PFM) nanocomposites are prepared a facile one-step method. When tested in a rechargeable aqueous Zn-MnO cell, the PFM nanocomposites deliver high specific capacity, considerable rate performance, and excellent long-term cyclic stability. Based on the experimental results, the role of the hydrated basic zinc sulfate layer being linked to the cycling stability of the aqueous rechargeable zinc-ion batteries is revealed. The mechanistic details of the insertion reaction based on the H ion storage mechanism are proposed, which plays a crucial role in maintaining the cycling performance of the rechargeable aqueous Zn-MnO cell. We expect that this work will provide an insight into the energy storage mechanism of MnO in aqueous systems and pave the way for the design of long-term cycling stable electrode materials for rechargeable aqueous Zn-MnO batteries.
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http://dx.doi.org/10.1021/acsami.0c08579DOI Listing
August 2020

Coupling 0D and 1D Carbons for Electrochemical Hydrogen Production Promoted by a Percolation Mechanism.

ChemSusChem 2020 Aug 2;13(16):4094-4102. Epub 2020 Aug 2.

Discipline of Chemistry, University of Newcastle, Callaghan, NSW 2308, Australia.

Developing hydrogen evolution reaction (HER) electrocatalysts with high activity, durability and moderate price is essential for sustainable hydrogen energy utilization. Here, the facile coupling of carbon dots (CDs, 0D carbon materials) and carbon fibres (CFs, 1D carbon materials) for enhanced electrochemical hydrogen production was demonstrated. Electrochemical tests revealed that the CD/CF catalysts showed outstanding catalytic activity with a small overpotential of 280 mV at the current density of 10 mA cm , a small Tafel slope of 87 mV dec and prominent durability. Percolation theory was for the first time introduced to interpret the catalytic mechanism of the CD/CF catalysts. The special morphology assembled by the 0D carbons constituted the percolating clusters and promoted electron transport throughout the 1D carbons. The strategy and theory can be adapted to general electrocatalytic applications for achieving and interpreting precise tuning on highly efficient electron transfer in electrocatalysts.
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http://dx.doi.org/10.1002/cssc.202001227DOI Listing
August 2020

Dual Single-Atomic Ni-N and Fe-N Sites Constructing Janus Hollow Graphene for Selective Oxygen Electrocatalysis.

Adv Mater 2020 Jul 22;32(30):e2003134. Epub 2020 Jun 22.

Discipline of Chemistry, University of Newcastle, Callaghan, NSW, 2308, Australia.

Nitrogen-coordinated metal single atoms in carbon have aroused extensive interest recently and have been growing as an active research frontier in a wide range of key renewable energy reactions and devices. Herein, a step-by-step self-assembly strategy is developed to allocate nickel (Ni) and iron (Fe) single atoms respectively on the inner and outer walls of graphene hollow nanospheres (GHSs), realizing separate-sided different single-atom functionalization of hollow graphene. The Ni or Fe single atom is demonstrated to be coordinated with four N atoms via the formation of a Ni-N or Fe-N planar configuration. The developed Ni-N /GHSs/Fe-N Janus material exhibits excellent bifunctional electrocatalytic performance, in which the outer Fe-N clusters dominantly contribute to high activity toward the oxygen reduction reaction (ORR), while the inner Ni-N clusters are responsible for excellent activity toward the oxygen evolution reaction (OER). Density functional theory calculations demonstrate the structures and reactivities of Fe-N and Ni-N for the ORR and OER. The Ni-N /GHSs/Fe-N endows a rechargeable Zn-air battery with excellent energy efficiency and cycling stability as an air-cathode, outperforming that of the benchmark Pt/C+RuO air-cathode. The current work paves a new avenue for precise control of single-atom sites on carbon surface for the high-performance and selective electrocatalysts.
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http://dx.doi.org/10.1002/adma.202003134DOI Listing
July 2020