Tianxiao Huan

Tianxiao Huan

UNVERIFIED PROFILE

Are you Tianxiao Huan?   Register this Author

Register author
Tianxiao Huan

Tianxiao Huan

Publications by authors named "Tianxiao Huan"

Are you Tianxiao Huan?   Register this Author

53Publications

2111Reads

8Profile Views

Integrative Genomics Analysis Unravels Tissue-Specific Pathways, Networks, and Key Regulators of Blood Pressure Regulation.

Front Cardiovasc Med 2019 12;6:21. Epub 2019 Mar 12.

Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fcvm.2019.00021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423920PMC
March 2019

Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function.

Authors:
Annah B Wyss Tamar Sofer Mi Kyeong Lee Natalie Terzikhan Jennifer N Nguyen Lies Lahousse Jeanne C Latourelle Albert Vernon Smith Traci M Bartz Mary F Feitosa Wei Gao Tarunveer S Ahluwalia Wenbo Tang Christopher Oldmeadow Qing Duan Kim de Jong Mary K Wojczynski Xin-Qun Wang Raymond Noordam Fernando Pires Hartwig Victoria E Jackson Tianyuan Wang Ma'en Obeidat Brian D Hobbs Tianxiao Huan Hongsheng Gui Margaret M Parker Donglei Hu Lauren S Mogil Gleb Kichaev Jianping Jin Mariaelisa Graff Tamara B Harris Ravi Kalhan Susan R Heckbert Lavinia Paternoster Kristin M Burkart Yongmei Liu Elizabeth G Holliday James G Wilson Judith M Vonk Jason L Sanders R Graham Barr Renée de Mutsert Ana Maria Baptista Menezes Hieab H H Adams Maarten van den Berge Roby Joehanes Albert M Levin Jennifer Liberto Lenore J Launer Alanna C Morrison Colleen M Sitlani Juan C Celedón Stephen B Kritchevsky Rodney J Scott Kaare Christensen Jerome I Rotter Tobias N Bonten Fernando César Wehrmeister Yohan Bossé Shujie Xiao Sam Oh Nora Franceschini Jennifer A Brody Robert C Kaplan Kurt Lohman Mark McEvoy Michael A Province Frits R Rosendaal Kent D Taylor David C Nickle L Keoki Williams Esteban G Burchard Heather E Wheeler Don D Sin Vilmundur Gudnason Kari E North Myriam Fornage Bruce M Psaty Richard H Myers George O'Connor Torben Hansen Cathy C Laurie Patricia A Cassano Joohon Sung Woo Jin Kim John R Attia Leslie Lange H Marike Boezen Bharat Thyagarajan Stephen S Rich Dennis O Mook-Kanamori Bernardo Lessa Horta André G Uitterlinden Hae Kyung Im Michael H Cho Guy G Brusselle Sina A Gharib Josée Dupuis Ani Manichaikul Stephanie J London

Nat Commun 2018 07 30;9(1):2976. Epub 2018 Jul 30.

Epidemiology Branch National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, Research Triangle Park, NC, 27709, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-018-05369-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065313PMC
July 2018

Micro RNAs from DNA Viruses are Found Widely in Plasma in a Large Observational Human Population.

Sci Rep 2018 Apr 23;8(1):6397. Epub 2018 Apr 23.

University of Massachusetts Medical School, Department of Medicine, Division of Cardiovascular Medicine, Worcester, MA, 01605, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-018-24765-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913337PMC
April 2018

Epigenome-Wide Association Study of Soluble Tumor Necrosis Factor Receptor 2 Levels in the Framingham Heart Study.

Front Pharmacol 2018 24;9:207. Epub 2018 Apr 24.

National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fphar.2018.00207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928448PMC
April 2018

Genetic and Environmental Effects on Gene Expression Signatures of Blood Pressure: A Transcriptome-Wide Twin Study.

Hypertension 2018 03 8;71(3):457-464. Epub 2018 Jan 8.

From the Georgia Prevention Institution, Department of Population Health Sciences, Augusta University (Y.H., X.W., S.S., X.W.); Institute for Molecular Medicine Finland (M.O., J.K.) and Department of Public Health (P.S., L.M., J.K.), University of Helsinki; The National Heart, Lung, and Blood Institute's Framingham Heart Study, MA (T.H., D.L.); The Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, MD (T.H., D.L.); The Mississippi Center for Clinical and Translational Research (CCTR), The University of Mississippi Medical Center (J.W.); and Department of Epidemiology, University Medical Center Groningen, University of Groningen, the Netherlands (H.S.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/HYPERTENSIONAHA.117.10527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877117PMC
March 2018

DNA Methylation Analysis Identifies Loci for Blood Pressure Regulation.

Am J Hum Genet 2017 Dec 30;101(6):888-902. Epub 2017 Nov 30.

Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX 77030, USA; Human Genetics Center, School of Public Health, University of Texas Health Science Center, Houston, TX 77030, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajhg.2017.09.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5812919PMC
December 2017

Whole blood gene expression and white matter Hyperintensities.

Mol Neurodegener 2017 09 18;12(1):67. Epub 2017 Sep 18.

National Heart Lung and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13024-017-0209-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604498PMC
September 2017

Dynamic Role of trans Regulation of Gene Expression in Relation to Complex Traits.

Am J Hum Genet 2017 Apr 9;100(4):571-580. Epub 2017 Mar 9.

The Framingham Heart Study, 73 Mt. Wayte Avenue, Framingham, MA 01702, USA; The Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajhg.2017.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384035PMC
April 2017

Messenger RNA and MicroRNA transcriptomic signatures of cardiometabolic risk factors.

BMC Genomics 2017 02 8;18(1):139. Epub 2017 Feb 8.

National Heart Lung and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12864-017-3533-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5299677PMC
February 2017

Epigenetic Patterns in Blood Associated With Lipid Traits Predict Incident Coronary Heart Disease Events and Are Enriched for Results From Genome-Wide Association Studies.

Circ Cardiovasc Genet 2017 Jan;10(1)

From the Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory (Å.K.H., S.G., E.I.) and Department of Medical Sciences, Molecular Medicine and Science for Life Laboratory (J.K.S.), Uppsala University, Sweden; Cardiovascular Medicine unit, Department of Medicine Solna, Karolinska Institute, Stockholm, Sweden (Å.K.H.) Framingham Heart Study, MA (M.M.M., R.J., C.Y., C.L., T.H., S.D., L.A.C., D.L.); Department of Biostatistics (C.L., L.A.C., S.D.), Boston University, MA; Boston University, MA (M.M.M.); Department of Cardiology, Boston Children's Hospital, MA (M.M.M.); Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (M.M.M., R.J., C.Y., C.L., T.H., D.L.); Centre for Cognitive Ageing and Cognitive Epidemiology (R.E.M., J.M.S., I.J.D.), Medical Genetics Section, Centre for Genomics and Experimental Medicine, Institute of Genetics and Molecular Medicine (R.E.M.), Alzheimer Scotland Dementia Research Centre (J.M.S.), and Department of Psychology (I.J.D.), University of Edinburgh, United Kingdom; Queensland Brain Institute, The University of Queensland, Brisbane, Australia (R.E.M., A.F.M., S.S.); Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia (S.S., A.F.M.); Hebrew Senior Life, Harvard Medical School, Boston, MA (R.J.); Department of Epidemiology, School of Public Health (M.R.I.) and Department of Biostatistics, Section on Statistical Genetics (D.Z.), University of Alabama at Birmingham; Department of Biostatistics, Harvard School of Public Health, Boston, MA (L. Liang); William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom (P.D.); Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, Saudi Arabia (P.D.); Department of Twin Research and Genetic Epidemiology, King's College London, United Kingdom (T.D.S.); Deparment of Medical Sciences, Cardiovascular Epidemiology, Uppsala University Hospital, Sweden (J.S., L.L.); Children's Hospital Oakland Research Institute, CA (R.M.K.); College of Public Health, University of Kentucky, Lexington (D.K.A.); and Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, CA (E.I.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCGENETICS.116.001487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331877PMC
January 2017

DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases.

Genome Biol 2016 12 12;17(1):255. Epub 2016 Dec 12.

Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13059-016-1119-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5151130PMC
December 2016

Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci.

Nat Genet 2016 10 12;48(10):1162-70. Epub 2016 Sep 12.

Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng.3660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5320952PMC
October 2016

Epigenetic Signatures of Cigarette Smoking.

Circ Cardiovasc Genet 2016 Oct 20;9(5):436-447. Epub 2016 Sep 20.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCGENETICS.116.001506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5267325PMC
October 2016

The transcriptional landscape of age in human peripheral blood.

Authors:
Marjolein J Peters Roby Joehanes Luke C Pilling Claudia Schurmann Karen N Conneely Joseph Powell Eva Reinmaa George L Sutphin Alexandra Zhernakova Katharina Schramm Yana A Wilson Sayuko Kobes Taru Tukiainen Yolande F Ramos Harald H H Göring Myriam Fornage Yongmei Liu Sina A Gharib Barbara E Stranger Philip L De Jager Abraham Aviv Daniel Levy Joanne M Murabito Peter J Munson Tianxiao Huan Albert Hofman André G Uitterlinden Fernando Rivadeneira Jeroen van Rooij Lisette Stolk Linda Broer Michael M P J Verbiest Mila Jhamai Pascal Arp Andres Metspalu Liina Tserel Lili Milani Nilesh J Samani Pärt Peterson Silva Kasela Veryan Codd Annette Peters Cavin K Ward-Caviness Christian Herder Melanie Waldenberger Michael Roden Paula Singmann Sonja Zeilinger Thomas Illig Georg Homuth Hans-Jörgen Grabe Henry Völzke Leif Steil Thomas Kocher Anna Murray David Melzer Hanieh Yaghootkar Stefania Bandinelli Eric K Moses Jack W Kent Joanne E Curran Matthew P Johnson Sarah Williams-Blangero Harm-Jan Westra Allan F McRae Jennifer A Smith Sharon L R Kardia Iiris Hovatta Markus Perola Samuli Ripatti Veikko Salomaa Anjali K Henders Nicholas G Martin Alicia K Smith Divya Mehta Elisabeth B Binder K Maria Nylocks Elizabeth M Kennedy Torsten Klengel Jingzhong Ding Astrid M Suchy-Dicey Daniel A Enquobahrie Jennifer Brody Jerome I Rotter Yii-Der I Chen Jeanine Houwing-Duistermaat Margreet Kloppenburg P Eline Slagboom Quinta Helmer Wouter den Hollander Shannon Bean Towfique Raj Noman Bakhshi Qiao Ping Wang Lisa J Oyston Bruce M Psaty Russell P Tracy Grant W Montgomery Stephen T Turner John Blangero Ingrid Meulenbelt Kerry J Ressler Jian Yang Lude Franke Johannes Kettunen Peter M Visscher G Gregory Neely Ron Korstanje Robert L Hanson Holger Prokisch Luigi Ferrucci Tonu Esko Alexander Teumer Joyce B J van Meurs Andrew D Johnson

Nat Commun 2015 Oct 22;6:8570. Epub 2015 Oct 22.

The National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, Massachusetts 01702, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms9570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4639797PMC
October 2015

Dissecting the roles of microRNAs in coronary heart disease via integrative genomic analyses.

Arterioscler Thromb Vasc Biol 2015 Apr 5;35(4):1011-21. Epub 2015 Feb 5.

From the National Heart, Lung, and Blood Institute's Framingham Heart Study, MA (T.H., R.J., P.C., A.D.J., C.J.O., D.L.); The Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, MD (T.H., R.J., P.C., D.L.); Cardiovascular Epidemiology and Human Genomics Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, MD (A.D.J., C.J.O.); Department of Mathematics and Statistics, Boston University, MA (J.R., M.G.L.); Department of Medicine, University of Massachusetts Medical School, Worcester (K.T., D.D.M., J.E.F.); Department of Integrative Biology and Physiology, University of California, Los Angeles (Q.M., A.B., X.Y.); Mathematical and Statistical Computing Laboratory, Center for Information Technology, National Institutes of Health, Bethesda, MD (R.J., P.J.M); Department of Medicine, Harvard Medical School, Harvard University, Boston, MA (R.J.); Department of Medicine, Stanford University School of Medicine, Palo Alto, CA (T.L.A.); Departments of Medicine and Biochemistry, University of Ottawa, Ottawa, Ontario, Canada (R.M.); Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, United Kingdom (N.J.S.); National Institute for Health Research (NIHR) Leicester Cardiovascular Biomedical Research Unit, Leicester, United Kingdom; Institut für Integrative und Experimentelle Genomik, Universität zu Lübeck, Lübeck, Germany (J.E.); DZHK (German Research Centre for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Germany (J.E.); Deutsches Herzzentrum München, Technische Universität München, München, Germany (H.S.); DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany (H.S.); and Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY (B.Z.).

View Article

Download full-text PDF

Source
http://escholarship.org/uc/item/18r5k54x.pdf
Web Search
http://atvb.ahajournals.org/lookup/doi/10.1161/ATVBAHA.114.3
Publisher Site
http://dx.doi.org/10.1161/ATVBAHA.114.305176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376567PMC
April 2015

Identification of common genetic variants controlling transcript isoform variation in human whole blood.

Nat Genet 2015 Apr 16;47(4):345-52. Epub 2015 Feb 16.

1] Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA. [2] National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, USA. [3] Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng.3220DOI Listing
April 2015

Integrative network analysis reveals molecular mechanisms of blood pressure regulation.

Mol Syst Biol 2015 Apr 16;11(1):799. Epub 2015 Apr 16.

The National Heart Lung and Blood Institute's Framingham Heart Study, Framingham, MA, USA The Population Sciences Branch and the Division of Intramural Research, National Heart, Lung and Blood Institute, Bethesda, MD, USA

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422556PMC
http://dx.doi.org/10.15252/msb.20145399DOI Listing
April 2015

A systematic heritability analysis of the human whole blood transcriptome.

Hum Genet 2015 Mar 14;134(3):343-58. Epub 2015 Jan 14.

Framingham Heart Study, Population Sciences Branch, National Heart, Lung and Blood Institute, 73 Mt. Wayte Avenue, Suite 2, Framingham, MA, 01702, USA,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00439-014-1524-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339826PMC
March 2015

Integromic analysis of genetic variation and gene expression identifies networks for cardiovascular disease phenotypes.

Circulation 2015 Feb 22;131(6):536-49. Epub 2014 Dec 22.

From the National Heart, Lung, and Blood Institute's Framingham Heart Study, National Institutes of Health, Bethesda, MD (C.Y., B.H.C., R.J., X.Z., C.L., T.H., L.A.C., C.S.F., P.C., C.J.O'D., D.L.); Population Sciences Branch, National Institutes of Health, National Heart, Lung, and Blood Institute, Bethesda, MD (C.Y., B.H.C., R.J., X.Z., C.L., T.H., P.C., D.L.); Mathematical and Statistical Computing Laboratory, Center for Information Technology, National Institutes of Health, Bethesda, MD (R.J., P.J.M.); Department of Computer Engineering, Middle East Technical University, Ankara, Turkey (B.O.); Department of Computer Engineering, Bilkent University, Ankara, Turkey (O.T.); Department of Biostatistics, Boston University School of Public Health, Boston, MA (L.A.C.); Harvard Medical School, Boston, MA (J.B.M.); Division of Endocrinology, Metabolism, and Diabetes, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (C.S.F.); Department of Medicine, University of Massachusetts Medical School, Worchester (J.E.F.); Division of Cardiology, Massachusetts General Hospital, Boston, MA (C.J.O'D.); and Departments of Statistics and of Biostatistics and Medical Informatics, University of Wisconsin-Madison (S.K.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCULATIONAHA.114.010696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369387PMC
February 2015

Domain combination of the vertebrate-like TLR gene family: implications for their origin and evolution.

J Genet 2011 Dec;90(3):401-8

Laboratory of Developmental Immunology, School of Life Science, Shandong University, Jinan 250100, People's Republic of China.

View Article

Download full-text PDF

Source
December 2011

Prolonged survival of human hepatocarcinoma cells in the liver of newborn C57BL/6 mice and resulting cellular xenorejection, especially the activation of hepatic natural killer T cells.

Pathobiology 2010 28;77(3):115-28. Epub 2010 May 28.

Laboratory for Developmental Immunology, School of Life Science, Shandong University, Shenyang, People's Republic of China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000292645DOI Listing
August 2010

Systems biology visualization tools for drug target discovery.

Expert Opin Drug Discov 2010 May 19;5(5):425-39. Epub 2010 Apr 19.

Shandong University, College of Life Sciences, Shandong, JN 250100, PR China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1517/17460441003725102DOI Listing
May 2010

Finding fractal patterns in molecular interaction networks: a case study in Alzheimer's disease.

Int J Comput Biol Drug Des 2009 4;2(4):340-52. Epub 2009 Jan 4.

School of Informatics, Indiana University, Indianapolis, IN 46202, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1504/IJCBDD.2009.030765DOI Listing
April 2010

HAPPI: an online database of comprehensive human annotated and predicted protein interactions.

BMC Genomics 2009 Jul 7;10 Suppl 1:S16. Epub 2009 Jul 7.

School of Informatics, Indiana University - Purdue University, Indianapolis, IN, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1471-2164-10-S1-S16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709259PMC
July 2009

ProteoLens: a visual analytic tool for multi-scale database-driven biological network data mining.

BMC Bioinformatics 2008 Aug 12;9 Suppl 9:S5. Epub 2008 Aug 12.

School of Informatics, Indiana University - Purdue University, Indianapolis, IN 46202, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1471-2105-9-S9-S5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2537576PMC
August 2008