Publications by authors named "Tianshuang Wang"

14 Publications

  • Page 1 of 1

MOF-Derived Mesoporous and Hierarchical Hollow-Structured InO-NiO Composites for Enhanced Triethylamine Sensing.

ACS Sens 2021 Sep 2;6(9):3451-3461. Epub 2021 Sep 2.

State Key Laboratory of Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, 2699 Qianjin Street, Changchun 130012, China.

It remains a challenge to design and fabricate high-performance gas sensors using metal-organic framework (MOF)-derived metal oxide semiconductors (MOS) as sensing materials due to the structural damage during the annealing process. In this study, the mesoporous InO-NiO hollow spheres consisting of nanosheets were prepared via a solvothermal reaction and subsequent cation exchange. More importantly, the transformation of Ni-MOF into In/Ni-MOF through exchanging the Ni ion with In ion can prevent the destruction of the porous reticular skeleton and hierarchical structure of Ni-MOF during calcination. Thus, the mesoporous InO-NiO hollow composites possess high porosity and large specific surface area (55.5 m g), which can produce sufficient permeability pathways for volatile organic compound (VOCs) molecules, maximize the active sites, and enhance the capacity of VOC capture. The mesoporous InO-NiO-based sensors exhibit enhanced triethylamine (TEA) sensing performance ( = 33.9-100 ppm) with distinct selectivity, good long-term stability, and lower detection limit (500 ppb) at 200 °C. These results can be attributed to the mesoporous hollow hierarchical structure and p-n junction of InO-NiO. The preparation concept mentioned in this work may provide a versatile platform applicable to various mesoporous composite sensing material-based hollow structures.
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http://dx.doi.org/10.1021/acssensors.1c01374DOI Listing
September 2021

Water-soluble brown carbon in atmospheric aerosols along the transport pathway of Asian dust: Optical properties, chemical compositions, and potential sources.

Sci Total Environ 2021 Oct 24;789:147971. Epub 2021 May 24.

Key Laboratory for Semi-Arid Climate Change of the Ministry of Education, College of Atmospheric Sciences, Lanzhou University, Lanzhou 730000, China; Institute of Surface-Earth System Science, School of Earth System Science, Tianjin University, Tianjin 300072, China. Electronic address:

As an important type of light-absorbing aerosol, brown carbon (BrC) has the potential to affect the atmospheric photochemistry and Earth's energy budget. A comprehensive field campaign was carried out along the transport pathway of Asian dust during the spring of 2016, including a desert site (Erenhot), a rural site (Zhangbei), and an urban site (Jinan), in northern China. Optical properties, bulk chemical compositions, and potential sources of water-soluble brown carbon (WS-BrC) were investigated in atmospheric total suspended particulate (TSP) samples. Samples from Zhangbei had higher mass absorption efficiency at 365 nm (MAE, 1.32 ± 0.34 m g) than those from Jinan (1.00 ± 0.23 m g) and Erenhot (0.84 ± 0.30 m g). Compere to the non-dust samples, elevated water-soluble organic carbon (WSOC) concentrations and MAE values of dust samples from Erenhot are related to the input of high molecular weight organic compounds and biogenic matter from the Gobi Desert, while lower values from Zhangbei and Jinan are attributed to the dilution effect caused by strong northwesterly winds. Based on fluorescence excitation-emission matrix spectra and parallel factor analysis, two humic-like (C1 and C2) and two protein-like (C3 and C4) substances were identified. Together, C1 and C2 accounted for ~64% of total fluorescence intensity at the highly polluted urban Jinan site; C3 represented ~45% at the rural Zhangbei site where local biomass burning affects; and C4 contributed ~24% in the desert region (Erenhot) due to dust-sourced biogenic substances. The relative absorptive forcing of WS-BrC compared to black carbon at 300-400 nm was about 31.3%, 13.9%, and 9.2% during non-dust periods at Erenhot, Zhangbei, and Jinan, respectively, highlighting that WS-BrC may significantly affect the radiative balance of Earth's climate system and should be included in radiative forcing models.
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http://dx.doi.org/10.1016/j.scitotenv.2021.147971DOI Listing
October 2021

Interannual variability of dust height and the dynamics of its formation over East Asia.

Sci Total Environ 2021 Jan 11;751:142288. Epub 2020 Sep 11.

Key Laboratory for Semi-Arid Climate Change of the Ministry of Education, College of Atmospheric Sciences, Lanzhou University, Lanzhou 730000, China; Institute of Surface-Earth System Science, Tianjin University, Tianjin 300072, China. Electronic address:

The vertical structure of dust layers is rarely investigated, despite its critical role in exploring the radiative and microphysical effects of dust aerosols. In this study, we primarily investigate the temporal variability of most probable dust height (MPDH) over dust source regions in East Asia and its interactions with climate parameters using CALIPSO lidar measurements under cloud-free conditions in spring from 2007 to 2018. The vertical profile of dust aerosols exhibits significant interannual variability over this time; dust is mainly concentrated below 7 km and associated with a dust occurrence frequency (DOF) of 0.6, and the DOF is much higher than that over the Sahara and West Asia. We also found that high Indian Ocean sea surface temperature (SST) significantly contributes to the transport of dust aerosols to downstream areas by changing the circulation field near the equator and in the mid-low latitudes of the Northern Hemisphere, which results in low MPDH over northern China. MPDH is significantly negatively correlated with 500-hPa westerly wind and precipitation, and is positively correlated with surface air temperature (SAT) and normalized difference vegetation index (NDVI). Furthermore, MPDH is positively correlated with the Arctic Oscillation (AO) and the Atlantic Multidecadal Oscillation (AMO), but negatively correlated with the El Niño-Southern Oscillation (ENSO). The correlation coefficient between AMO and MPDH is 0.71 after detrending, which indicates that the AMO also plays an important role in the interannual variability of MPDH over East Asia. Furthermore, the Indian Ocean SST is the main influencing factor of the interannual variability of MPDH over northern China, but zonal wind is probably only the intermediate mechanism.
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http://dx.doi.org/10.1016/j.scitotenv.2020.142288DOI Listing
January 2021

Somatic variants in new candidate genes identified in focal cortical dysplasia type II.

Epilepsia 2020 04 26;61(4):667-678. Epub 2020 Mar 26.

Department of Pediatrics, Peking University First Hospital, Beijing, China.

Objective: Focal cortical dysplasia type II (FCDII) is a malformation of cortex development commonly found in children with drug-resistant epilepsy. FCDII has been associated with somatic mutations in mammalian target of rapamycin (mTOR)-related pathway genes and an upregulation of mTOR. Somatic mutations were found in 10%-63% of FCDII samples; the frequency of the mutant allele was 0.93%-33.5%. This study aimed to find new candidate genes involved in FCDII.

Methods: We collected resected FCD lesions, perilesional brain tissues, and peripheral blood from 17 children with pathologically confirmed FCDII. We performed whole exome sequencing and followed a set of screening and analysis strategies to identify potentially deleterious somatic variants (PDSVs) in brain-expressed genes. We performed site-specific amplicon sequencing to validate the results. We also performed an in vitro functional study on an IRS1 variant.

Results: In six of 17 samples, we identified seven PDSVs in seven genes, including two frameshift variants and five missense variants. The frequencies of the variant allele were 1.29%-5.50%. The genes were MTOR, TSC2, IRS1, RAB6B, RALA, HTR6, and ZNF337. PDSVs in IRS1, RAB6B, ZNF337, RALA, and HTR6 had not been previously associated with FCD. In one lesion, two PDSVs were found in two genes. In a transfected cell line, we demonstrated that the c.1791dupG (identified in FCDII from Patient 1) led to a truncated IRS1 and significant mTOR hyperactivation compared to cells that carried wild-type IRS1. mTOR was also activated in FCDII tissue from Patient 1.

Significance: Seven PDSVs were identified in FCDII lesions in six of 17 children. Five variant genes had not been previously associated with cortical malformations. We demonstrated that the IRS1 variant led to mTOR hyperactivation in vitro. Although functional experiments are needed, the results provide evidence for novel candidate genes in the pathogenesis of FCDII.
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http://dx.doi.org/10.1111/epi.16481DOI Listing
April 2020

A Patient With CAD Deficiency Responsive to Uridine and Literature Review.

Front Neurol 2020 5;11:64. Epub 2020 Feb 5.

Department of Pediatrics, Peking University First Hospital, Beijing, China.

CAD encodes a multifunctional enzyme involved in pyrimidine biosynthesis, and pyrimidine can be alternatively recycled from uridine. Trio whole-exome sequencing identified CAD compound heterozygous mutations in a new male patient with global developmental delay (DD), refractory epilepsy, and anemia with anisopoikilocytosis. We further reviewed all published cases with CAD deficiency. Five patients were collected from two publications, including three males and two females, and all presented with DD, drug-resistant epilepsy, and anemia with anisopoikilocytosis. Four out of six patients (including the present case) were supplemented with uridine, which led to immediate cessation of seizures, resolved anemia with anisopoikilocytosis, and progress in global development. The other two patients, who were not treated with uridine, died at the ages of 4 and 5 years. In summary, CAD deficiency is probably a treatable neurometabolic disorder.
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http://dx.doi.org/10.3389/fneur.2020.00064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012989PMC
February 2020

Fluorescent hydrogel test kit coordination with smartphone: Robust performance for on-site dimethoate analysis.

Biosens Bioelectron 2019 Dec 18;145:111706. Epub 2019 Sep 18.

State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, Changchun, 130012, China.

Precise monitoring of pesticide with portable device was challenging because it required high sensitivity, short response time, strong stability and excellent selectivity. Herein, we newly constructed a stimuli-responsive hydrogel (SRHg)-based portable kit by embedding copper nanoparticles (CuNPs) in agarose hydrogel. In this work, dimethoate as inhibitor of urease restrained the generation of ammonia, which reduced in-situ etching of CuNPs, resulting in the fluorescence color response of test kit under ultraviolet illumination. Interestingly, by means of smartphone-based nanocolorimetry, the photo image of portable kit could be translated into digital information using ImageJ software, achieving a direct quantitative tool for dimethoate identification. The simplicity of SRHg-based portable kit combined with smartphone-based color recognition not only improved the analysis sensitivity (detection limit of 1.0 μg L), accuracy and stability, but also simplified operation process and shortened sample-to-answer analysis time (55 min), demonstrating that the methodology met the needs of daily testing and provided a new sight for on-site monitoring of food safety and human health.
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http://dx.doi.org/10.1016/j.bios.2019.111706DOI Listing
December 2019

Reanalysis of whole exome sequencing data in patients with epilepsy and intellectual disability/mental retardation.

Gene 2019 Jun 21;700:168-175. Epub 2019 Mar 21.

Department of Pediatrics, Peking University First Hospital, Beijing, China. Electronic address:

To evaluate the additional diagnostic yield of whole exome sequencing (WES) reanalysis in patients with epilepsy and intellectual disability/mental retardation, we reanalyzed raw WES data and clinical information for 76 patient trios whose initial reports returned negative results. Eight patients (10.5%, 8/76) had positive genetic diagnoses finally, including six novel mutations in five genes. The reasons for the previous false-negative reports were divided into four categories: specific gene-disease associations had not been established at the time of the initial report; the disease database of the genetic test center had not been updated in a timely manner; the patient's clinical phenotype had not been carefully or correctly collected, submitted and reviewed when applicating genetic test and analyzing the variants; and the first round of data analysis missed a synonymous variant that affected splicing. Therefore, physicians should not give up the discovery of disease-causing mutations before re-examining the WES data and clinical phenotype by themselves or by collaborating with bioinformatic experts in the genetic test centers, especially for patients with strongly suspected genetic disease whose initial WES result was "negative". The suitable time points for reanalysis might be the 6-12 months after initial report.
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http://dx.doi.org/10.1016/j.gene.2019.03.037DOI Listing
June 2019

Realizing the Control of Electronic Energy Level Structure and Gas-Sensing Selectivity over Heteroatom-Doped InO Spheres with an Inverse Opal Microstructure.

ACS Appl Mater Interfaces 2019 Mar 19;11(9):9600-9611. Epub 2019 Feb 19.

State Key Laboratory on Integrated Optoelectronics, Key Laboratory of Gas Sensors, Jilin Province, College of Electronic Science and Engineering , Jilin University , 2699 Qianjin Street , Changchun 130012 , People's Republic of China.

Understanding the effect of substitutional doping on gas-sensing performances is essential for designing high-activity sensing nanomaterials. Herein, formaldehyde sensors based on gallium-doped InO inverse opal (IO-(Ga In)O) microspheres were purposefully prepared by a simple ultrasonic spray pyrolysis method combined with self-assembled sulfonated polystyrene sphere templates. The well-aligned inverse opal structure, with three different-sized pores, plays the dual role of accelerating the diffusion of gas molecules and providing more active sites. The Ga substitutional doping can alter the electronic energy level structure of (Ga In)O, leading to the elevation of the Fermi level and the modulation of the band gap close to a suitable value (3.90 eV), hence, effectively optimizing the oxidative catalytic activity for preferential CHO oxidation and increasing the amount of adsorbed oxygen. More importantly, the gas selectivity could be controlled by varying the energy level of adsorbed oxygen. Accordingly, the IO-(GaIn)O microsphere sensor showed a high response toward formaldehyde with fast response and recovery speeds, and ultralow detection limit (50 ppb). Our findings finally offer implications for designing Fermi level-tailorable semiconductor nanomaterials for the control of selectivity and monitoring indoor air pollutants.
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http://dx.doi.org/10.1021/acsami.8b21543DOI Listing
March 2019

Novel Self-Assembly Route Assisted Ultra-Fast Trace Volatile Organic Compounds Gas Sensing Based on Three-Dimensional Opal Microspheres Composites for Diabetes Diagnosis.

ACS Appl Mater Interfaces 2018 Sep 13;10(38):32913-32921. Epub 2018 Sep 13.

State Key Laboratory on Integrated Optoelectronics, Key Laboratory of Gas Sensors, College of Electronic Science and Engineering , Jilin University , 2699 Qianjin Street , Changchun 130012 , Jilin Province , People's Republic of China.

The development of ultra-fast response semiconductor gas sensors for high-accuracy detection of trace volatile organic compounds in human exhaled breath still remains a challenge. Herein, we propose a novel self-assembly synthesis concept for preparing intricate three-dimensional (3D) opal porous (OP) SnO-ZnO hollow microspheres (HM), by employing sulfonated polystyrene (S-PS) spheres template-assisted ultrasonic spray pyrolysis. The high gas accessibility of the unique opal hollow structures resulted in the existence of 3D interconnection and bimodal (mesoscale and macroscale) pores, and the n-n heterojunction-induced change in oxygen adsorption. The 3D OP SnO-ZnO HM sensor exhibited high response and ultra-fast dynamic process (response time ∼4 s and recovery time ∼17 s) to 1.8 ppm acetone under highly humid ambient condition (98% relative humidity), and it could rapidly identify the states of the exhaled breath of healthy people and simulated diabetics. In addition, the rational structure design of the 3D OP SnO HM enables the ultra-fast detection (within 1 s) of ethanol in simulation drunk driving testing. Our results obtained in this work provided not only a facile self-assembly approach to fabricate metal oxides with 3D OP HM structures but also a new methodology for achieving noninvasive real-time exhaled breath detection.
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http://dx.doi.org/10.1021/acsami.8b13010DOI Listing
September 2018

[Focal zone integral and multiple axial scanning based acoustic resolution photoacoustic microscopy with high lateral resolution in-depth].

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 2018 02;35(1):115-122

Department of Biomedical Engineering, School of Basic Medical Science, Central South University, Changsha 410083,

Acoustic resolution photoacoustic microscopy (ARPAM) combines the advantages of high optical contrast, and high ultrasonic spatial resolution and penetration. However, in photoacoustic microscopy (PAM), the information from deep regions can be greatly affected by the shallow targets, and most importantly, the irreconcilable conflict between the lateral resolution and depth of fields has always be a major factor that limits the imaging quality. In this work, an ARPAM system was developed, in which a non-coaxial arrangement of light illumination and acoustic detection was adopted to alleviate the influence of the tissue surface on the deep targets, and a novel focal zone integral algorithm was applied with multiple axial scanning to improve the lateral resolution. Phantom experiment results show that, the build system can maintain a consistent high lateral resolution of 0.6 mm over a large range in axial direction, which is close to the theoretical calculations. The following tumor imaging results on nude mice indicate that, the proposed method can provide more in-depth information compared with the conventional back detection ARPAM method. With the development of fast repetition lasers and image scanning technologies, the proposed method may play an important role in cerebral vascular imaging, cervical cancer photoacoustic endoscopic detection, and superficial tumor imaging.
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http://dx.doi.org/10.7507/1001-5515.201609072DOI Listing
February 2018

Rational design of 3D inverse opal heterogeneous composite microspheres as excellent visible-light-induced NO sensors at room temperature.

Nanoscale 2018 Mar;10(10):4841-4851

State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, 2699 Qianjin Street, Changchun 130012, People's Republic of China.

The lower gas sensitivity, humidity dependence of the gas sensing properties, and long recovery times of room-temperature gas sensors severely limit their applications. Herein, to address these issues, a series of 3D inverse opal (IO) InO-ZnO heterogeneous composite microspheres (HCMs) are fabricated by ultrasonic spray pyrolysis (USP) employing self-assembled sulfonated polystyrene (S-PS) spheres as a sacrificial template. The 3D IO InO-ZnO HCMs possess highly ordered 3D inverse opal structures and bimodal (meso-scale and macro-scale) pores, which can provide large accessible surface areas and rapid mass transfer, resulting in enhanced gas sensing characteristics. Furthermore, the 3D IO architecture and n-n heterojunctions can extend the photoabsorption range to the visible light area, effectively prolonging the lifetimes of photo-generated charge carriers, and can increase separation of visible light-generated charges. As a result, the as-prepared 3D IO InO-ZnO HCMs deliver excellent NO sensing performance under visible light irradiation at room temperature, such as high sensitivity (R/R = 54.3 to 5 ppm NO), low detection limit (250 ppb), fast recovery time (188 s), excellent selectivity and humidity independence. These enhanced photo-electronic gas sensing properties are attributed to the combination of highly ordered 3D IO microspheres and InO-ZnO heterogeneous composites.
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http://dx.doi.org/10.1039/c7nr08366aDOI Listing
March 2018

Self-Assembly Template Driven 3D Inverse Opal Microspheres Functionalized with Catalyst Nanoparticles Enabling a Highly Efficient Chemical Sensing Platform.

ACS Appl Mater Interfaces 2018 Feb 2;10(6):5835-5844. Epub 2018 Feb 2.

State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University , 2699 Qianjin Street, Changchun 130012, People's Republic of China.

The design of semiconductor metal oxides (SMOs) with well-ordered porous structure has attracted tremendous attention owing to their larger specific surface area. Herein, three-dimensional inverse opal InO microspheres (3D-IO InO MSs) were fabricated through one-step ultrasonic spray pyrolysis (USP) which employed self-assembly sulfonated polystyrene (S-PS) spheres as a sacrificial template. The spherical pores observed in the 3D-IO InO MSs had diameters of about 4 and 80 nm. Subsequently, the catalytic palladium oxide nanoparticles (PdO NPs) were loaded on 3D-IO InO MSs via a simple impregnation method, and their gas sensing properties were investigated. In a comparison with pristine 3D-IO InO MSs, the 3D-IO [email protected] MSs exhibited a 3.9 times higher response (R/R = 50.9) to 100 ppm acetone at 250 °C and a good acetone selectivity. The detection limit for acetone could extend down to ppb level. Furthermore, the 3D-IO [email protected] MSs-based sensor also possess good long-term stability. The extraordinary sensing performance can be attributed to the novel 3D periodic porous structure, highly three-dimensional interconnection, larger specific surface area, size-tunable (meso- and macroscale) bimodal pores, and PdO NP catalysts.
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http://dx.doi.org/10.1021/acsami.7b19641DOI Listing
February 2018

Design of α-Fe2O3 nanorods functionalized tubular NiO nanostructure for discriminating toluene molecules.

Sci Rep 2016 05 19;6:26432. Epub 2016 May 19.

State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, Changchun 130012, People's Republic of China.

A novel tubular NiO nanostructure was synthesized by a facile and low-cost hydrothermal strategy and then further functionalized by decorating α-Fe2O3 nanorods. The images of electron microscopy indicated that the α-Fe2O3 nanorods were assembled epitaxially on the surfaces of NiO nanotubes to form α-Fe2O3/NiO nanotubes. As a proof-of-concept demonstration of the function, gas sensing devices were fabricated from as-prepared α-Fe2O3/NiO nanotubes, and showed enhanced gas response and excellent selectivity toward toluene, giving a response of 8.8 to 5 ppm target gas, which was about 7.8 times higher than that of pure NiO nanotubes at 275 °C. The improved gas sensing performance of α-Fe2O3/NiO nanotubes could be attributed to the unique tubular morphology features, p-n heterojunctions and the synergetic behavior of α-Fe2O3 and NiO.
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http://dx.doi.org/10.1038/srep26432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872228PMC
May 2016

Enhanced Gas Sensing Properties of SnO2 Hollow Spheres Decorated with CeO2 Nanoparticles Heterostructure Composite Materials.

ACS Appl Mater Interfaces 2016 Mar 2;8(10):6669-77. Epub 2016 Mar 2.

Department of Energy and Material Sciences, Faculty of Engineering Sciences, Kyushu University , Kasuga-shi, Fukuoka 816-8580, Japan.

CeO2 decorated SnO2 hollow spheres were successfully synthesized via a two-step hydrothermal strategy. The morphology and structures of as-obtained CeO2/SnO2 composites were analyzed by various kinds of techniques. The SnO2 hollow spheres with uniform size around 300 nm were self-assembled with SnO2 nanoparticles and were hollow with a diameter of about 100 nm. The CeO2 nanoparticles on the surface of SnO2 hollow spheres could be clearly observed. X-ray photoelectron spectroscopy results confirmed the existence of Ce(3+) and the increased amount of both chemisorbed oxygen and oxygen vacancy after the CeO2 decorated. Compared with pure SnO2 hollow spheres, such composites revealed excellent enhanced sensing properties to ethanol. When the ethanol concentration was 100 ppm, the sensitivity of the CeO2/SnO2 composites was 37, which was 2.65-times higher than that of the primary SnO2 hollow spheres. The sensing mechanism of the enhanced gas sensing properties was also discussed.
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http://dx.doi.org/10.1021/acsami.6b00169DOI Listing
March 2016
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