Publications by authors named "Tianming Zhao"

57 Publications

Association of child maltreatment and bullying victimization among chinese adolescents: The mediating role of family function, resilience, and anxiety.

J Affect Disord 2021 Nov 22;299:12-21. Epub 2021 Nov 22.

Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, No. 81 Meishan Road, Hefei 230032, Anhui, China; Center for Evidence-Based Practice, Anhui Medical University, No. 81 Meishan Road, Hefei 230032, Anhui, China. Electronic address:

Background: Among adolescents, child maltreatment is linked to being bullied at school. Nevertheless, little is known about the mediating mechanisms underlying this association. Therefore, our research aimed to explore and evaluate the potential mediators of the relationship between child maltreatment and bullying victimization among Chinese adolescents.

Methods: From October to December 2020, a population-based cross-sectional survey was conducted among 6247 adolescents (3401 males, 2846 females) in Anhui Province, China. The subjects of the survey were elementary and middle school students from grades 4 to 9. The data were collected through self-report questionnaires. Pearson correlation and linear regression were used to examine the relationships among child maltreatment, bullying victimization, family function, resilience, and anxiety. Structural equation modeling (SEM) was employed to conduct mediation analyses.

Results: The results indicated that child maltreatment positively predicted the later bullying victimization of adolescents. Resilience and anxiety were each shown to separately mediate this relationship. Moreover, the sequential mediating effects of family function, resilience, and anxiety also mediated the predictive effect of child maltreatment on bullying victimization.

Conclusions: Resilience and anxiety were both shown to be important independent mediators for the relationship between child maltreatment and bullying victimization. Furthermore, the combined mediating effects of family function, resilience, and anxiety were also of great significance. These findings provide additional evidence that family and individual factors are critical to understanding bullying victimization. Effective prevention and intervention strategies for school bullying should target family and individual vulnerabilities in adolescents.
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http://dx.doi.org/10.1016/j.jad.2021.11.053DOI Listing
November 2021

Chemical Composition and Biological Activities of Essential Oils from the Leaves, Stems, and Roots of .

Molecules 2021 Oct 16;26(20). Epub 2021 Oct 16.

College of Food and Pharmaceutical Engineering, Guizhou Institute of Technology, Guiyang 550003, China.

The chemical composition and biological activities of the essential oils from the leaves, stems, and roots of () were investigated. The essential oils were extracted by hydro distillation and analyzed by gas chromatography mass spectrometry (GC-MS) and gas chromatography with flame ionization detector (GC-FID). Antioxidant activities of the essential oils were examined with DPPH radical scavenging assay, ABTS cation radical scavenging assay, and ferric reducing antioxidant power assay. Antimicrobial activities were evaluated by determining minimum inhibitory concentrations (MIC) and minimum microbiocidal concentrations (MMC). Acetylcholinesterase and butyrylcholinesterase inhibitory activity of the essential oils were also tested. A total of 46, 44, and 47 components were identified in the leaf, stem, and root oils, representing 95.66%, 97.35%, and 92.72% of total composition, respectively. The major compounds of three essential oils were α-pinene (16.60-42.02%), β-pinene (10.03-18.82%), camphene (1.56-10.95%), borneol (0.50-7.71%), δ-cadinene (1.52-7.06%), and β-elemene (1.86-4.45%). The essential oils were found to have weak antioxidant activities and cholinesterase inhibition activities. The essential oils showed more inhibitory effects against () than those of other strains. The highest antimicrobial activity was observed in the root oil against , with MIC of 0.78 mg/mL. Therefore, essential oils might be considered as a natural antibacterial agent against with potential application in food and pharmaceutical industries.
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http://dx.doi.org/10.3390/molecules26206259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537082PMC
October 2021

Erratum to: How does China keep COVID-19 outside its border? First-hand experience of medical staff at an international airport in China.

J Travel Med 2021 Oct 6. Epub 2021 Oct 6.

AMITA Health Saint Joseph Hospital Chicago, 2900 N. Lake Shore Drive, Chicago 60657, IL, USA.

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http://dx.doi.org/10.1093/jtm/taab162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8500153PMC
October 2021

Self-Powered Biosensor for Specifically Detecting Creatinine in Real Time Based on the Piezo-Enzymatic-Reaction Effect of Enzyme-Modified ZnO Nanowires.

Biosensors (Basel) 2021 Sep 16;11(9). Epub 2021 Sep 16.

College of Sciences, Northeastern University, Shenyang 110819, China.

Creatinine has become an important indicator for the early detection of uremia. However, due to the disadvantages of external power supply and large volume, some commercial devices for detecting creatinine concentration have lost a lot of popularity in everyday life. This paper describes the development of a self-powered biosensor for detecting creatinine in sweat. The biosensor can detect human creatinine levels in real time without the need for an external power source, providing information about the body's overall health. The piezoelectric output voltage of creatininase/creatinase/sarcosine oxidase-modified ZnO nanowires (NWs) is significantly dependent on the creatinine concentration due to the coupling effect of the piezoelectric effect and enzymatic reaction (piezo-enzymatic-reaction effect), which can be regarded as both electrical energy and biosensing signal. Our results can be used for the detection of creatinine levels in the human body and have great potential in the prediction of related diseases.
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http://dx.doi.org/10.3390/bios11090342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468492PMC
September 2021

Harmine-inspired design and synthesis of benzo[d]imidazo[2,1-b]thiazole derivatives bearing 1,3,4-oxadiazole moiety as potential tumor suppressors.

Bioorg Med Chem 2021 09 13;46:116367. Epub 2021 Aug 13.

Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address:

Standard chemotherapy and personalized target therapies are commonly used in patients with advanced non-small cell lung cancer (NSCLC). However, multidrug resistance (MDR) and tumor metastasis lead to the decline of therapeutic efficacy, which are closely related to epithelial-mesenchymal transition (EMT). Twist1, an EMT transcription factor, plays an essential role in promoting EMT, MDR and tumor metastasis. In view of the essential role of Twist1 in the tumorigenesis of NSCLC, developing antitumor small molecules that can suppress the expression of Twist1 is of far-reaching significance for the treatment of NSCLC. A series of novel benzo[d]imidazo[2,1-b]thiazole derivatives possessing 1,3,4-oxadiazole moiety were designed based on the structure of the first-in-class Twist1 inhibitor harmine. Among the synthetic twenty-two compounds, the compound containing 2-(piperidine-1-yl) ethyl exhibited remarkable anti-proliferative activity with IC value of 2.03 μM and 9.80 μM against A549 and H2228 cell lines superior to harmine (IC = 17.12 μM against A549, IC = 31.06 μM against H2228). Meanwhile, western blot assay showed that the optimal compound significantly down-regulated Twist1 protein expression in a dose-dependent manner and reduced Twist1 level better than harmine. Collectively, the promising compound was identified a potential antineoplastic lead with the ability of down-regulating Twist1 level.
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http://dx.doi.org/10.1016/j.bmc.2021.116367DOI Listing
September 2021

An Effective Self-Powered Piezoelectric Sensor for Monitoring Basketball Skills.

Sensors (Basel) 2021 Jul 29;21(15). Epub 2021 Jul 29.

College of Sciences, Northeastern University, Shenyang 110819, China.

Self-powered piezoelectric sensor can achieve real-time and harmless monitoring of motion processes without external power supply, which can be attached on body skin or joints to detect human motion and powered by mechanical energy. Here, a sensor for monitoring emergent motion is developed using the PVDF as active material and piezoelectric output as sensing signal. The multi-point control function enables the sensor to monitor the sequence of force order, angle change, and motion frequency of the "elbow lift, arm extension, and wrist compression" during shooting basketball. In addition, the sensor shows can simultaneously charge the capacitor to provide more power for intelligence, typically Bluetooth transmission. The sensor shows good performance in other field, such as rehabilitation monitoring and speech input systems. Therefore, the emerging application of flexible sensors have huge long-term prospects in sport big data collection and Internet of Things (IoT).
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http://dx.doi.org/10.3390/s21155144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8347581PMC
July 2021

Wearable Battery-Free Perspiration Analyzing Sites Based on Sweat Flowing on ZnO Nanoarrays.

Nanomicro Lett 2020 May 2;12(1):105. Epub 2020 May 2.

School of Physics, University of Electronic Science and Technology of China, Chengdu, 610054, People's Republic of China.

We fabricated wearable perspiration analyzing sites for actively monitoring physiological status during exercises without any batteries or other power supply. The device mainly consists of ZnO nanowire (NW) arrays and flexible polydimethylsiloxane substrate. Sweat on the skin can flow into the flow channels of the device through capillary action and flow along the channels to ZnO NWs. The sweat flowing on the NWs (with lactate oxidase modification) can output a DC electrical signal, and the outputting voltage is dependent on the lactate concentration in the sweat as the biosensing signal. ZnO NWs generate electric double layer (EDL) in sweat, which causes a potential difference between the upper and lower ends (hydrovoltaic effect). The product of the enzymatic reaction can adjust the EDL and influence the output. This device can be integrated with wireless transmitter and may have potential application in constructing sports big data. This work promotes the development of next generation of biosensors and expands the scope of self-powered physiological monitoring system.
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http://dx.doi.org/10.1007/s40820-020-00441-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7770781PMC
May 2020

The importance of social distancing policy.

J Public Health (Oxf) 2021 06;43(2):e269

Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, No. 81 Meishan Road, Hefei 230032, Anhui, China.

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http://dx.doi.org/10.1093/pubmed/fdaa219DOI Listing
June 2021

A Portable and Flexible Self-Powered Multifunctional Sensor for Real-Time Monitoring in Swimming.

Biosensors (Basel) 2021 May 8;11(5). Epub 2021 May 8.

Physical Education Department, Northeastern University, Shenyang 110819, China.

A portable and flexible self-powered biosensor based on ZnO nanowire arrays (ZnO NWs) and flexible PET substrate has been designed and fabricated for real-time monitoring in swimming. Based on the piezoelectric effect of polar ZnO NWs, the fabricated biosensor can work in both air and water without any external power supply. In addition, the biosensor can be easily attached to the surface of the skin to precisely monitor the motion state such as joint moving angle and frequency during swimming. The constant output piezoelectric signal in different relative humidity levels enables actual application in different sports, including swimming. Therefore, the biosensor can be utilized to monitor swimming strokes by attaching it on the surface of the skin. Finally, a wireless transmitting application is demonstrated by implanting the biosensor in vivo to detect angiogenesis. This portable and flexible self-powered biosensor system exhibits broad application prospects in sport monitoring, human-computer interaction and wireless sport big data.
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http://dx.doi.org/10.3390/bios11050147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151083PMC
May 2021

A predictive nomogram incorporating gait speed for all-cause mortality in hospitalized cirrhotics.

Postgrad Med 2021 Aug 15;133(6):680-687. Epub 2021 Jun 15.

Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Tianjin, China.

Objectives: No tailored model incorporating physical frailty for 2-year mortality in cirrhosis is available for practitioners in general practice. Thus we aimed to develop a model based on laboratory results and physical frailty allowing clinicians for stratifying cirrhotics by using individual estimate.

Methods: One hundred and thirteen cases were assigned to the primary cohort, and all other 76 patients were regarded as the validation cohort. Multivariate Cox regression was performed, and a nomogram including five-meter gait speed (5MGS) were generated. The performance of the proposed model was assessed by C-index, calibration curve, and decision curve analysis (DCA).

Results: On multivariate analysis, the Model for End-Stage Liver Disease-Sodium, albumin and 5MGS were independent predictors for 2-year mortality in cirrhosis. A nomogram incorporating all these parameters achieved a C-index of 0.804 (95%CI, 0.731-0.877). The calibration curve implied optimal correspondence between the predicted survival and actual outcomes. Our model is useful in the clinical settings based on DCA. Similar results were observed in the validation cohort with a C-index of 0.796 (95%CI, 0.689-0.899). Moreover, 5MGS, as a surrogate of physical performance, significantly correlated with multiple domains of general frailty according to Frailty Index (our published data), including instrumental activities of daily living, self-reported health, social activity and falls.

Conclusion: In conclusion, the nomogram incorporating 5MGS may represent an individualized tool for predicting mortality in cirrhosis for primary care physicians.
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http://dx.doi.org/10.1080/00325481.2021.1934494DOI Listing
August 2021

A Self-Powered Portable Flexible Sensor of Monitoring Speed Skating Techniques.

Biosensors (Basel) 2021 Apr 7;11(4). Epub 2021 Apr 7.

School of Physical Education, Northeast Normal University, Changchun 130024, China.

With the development of 5G technology, contemporary technologies such as Internet of Things (IoT) and Big Data analyses have been widely applied to the sport industry. This paper focuses on the design of a portable, self-powered, flexible sensor, which does not require an external power supply. The sensor is capable of monitoring speed skating techniques, thereby helping professional athletes to enhance their performance. This sensor mainly consists of Polyvinylidene Fluoride (PVDF) with polarization after a silvering electrode and a flexible polyester substrate. Flexible sensors are attached to the push-off joint part of speed skaters and the ice skate blade. During motion, it produces different piezoelectricity signals depending on the states of motion. The monitoring and analyzing of the real-time sensor signals will adjust the athlete's skating angle, frequency, and push-off techniques, thus improving user training and enhancing performance. Moreover, the production of piezoelectric signals can charge the capacitor, provide power for small electronic equipment (e.g., wireless device), and extend the applications of wearable flexible sensors to the Big Data and IoT technologies in the sport industry.
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http://dx.doi.org/10.3390/bios11040108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8067624PMC
April 2021

The impact of prenatal stressful life events on adverse birth outcomes: A systematic review and meta-analysis.

J Affect Disord 2021 05 31;287:406-416. Epub 2021 Mar 31.

Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, No. 81 Meishan Road, Hefei 230032, Anhui, China; Centre for Evidence-Based Practice, Anhui Medical University, No. 81 Meishan Road, Hefei 230032, Anhui, China. Electronic address:

Background: Stressful life events as important stressors have gradually been recognized as the potential etiology that may lead to adverse birth outcomes such as preterm birth (PTB), low birth weight (LBW), and small for gestational age (SGA). However, researches on this topic have shown relatively inconsistent results. This systematic review and meta-analysis was performed to synthesize available data on the association between prenatal stressful life events and increased risks of PTB, LBW, and SGA.

Methods: Electronic databases were searched from their inception until September 2020. Pooled relative risks (RRs) and 95% confidence intervals (CIs) were calculated to assess the association between prenatal stressful life events and PTB, LBW, and SGA using random effects models. In addition, subgroup analyses, cumulative meta-analyses, sensitivity analyses, and publication bias diagnosis were conducted. STATA 14.0 was applied for statistical analyses.

Results: Totally 31 cohort studies involving 5,665,998 pregnant women were included. Prenatal stressful life events were associated with a 20% higher risk of PTB (RR = 1.20, 95%CI = 1.10-1.32), a 23% increased risk for LBW (RR = 1.23, 95%CI = 1.10-1.39), and a 14% higher risk of SGA (RR = 1.14, 95%CI = 1.08-1.20). Sensitivity analysis indicated the results were stable.

Conclusions: Findings indicated that pregnant women experiencing prenatal stressful life events were at increased risk of PTB, LBW, and SGA. This information provided additional supports that pregnant women experiencing prenatal stressful life events would benefit from receiving assessment and management in prenatal care services.
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http://dx.doi.org/10.1016/j.jad.2021.03.083DOI Listing
May 2021

Discovery and antitumor activity of Benzo[d]imidazol-containing 2,4-diarylaminopyrimidine analogues as ALK inhibitors with mutation-combating effects.

Bioorg Med Chem 2021 05 14;37:116108. Epub 2021 Mar 14.

Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address:

To address drug resistance caused by ALK kinase mutations, a series of novel 2,4-diarylaminopyrimidine (DAAP) analogues were designed by incorporating 1H-benzo[d]imidazol motif onto the maternal framework. All compounds were efficiently synthesized and antiproliferative activities against Karpas299, H2228 and A549 cell lines were evaluated by MTT assay. Delightly, the most promising derivative H-11 was detected with IC values of 0.016 μM and 0.099 μM against ALK- positive Karpas299 and H2228 cells. Meanwhile, H-11 displayed encouraging enzymatic inhibitory potency with IC values of 2.7 nM, 3.8 nM and 5.7 nM toward ALK, ALK and ALK, respectively. Ultimately, the binding modes of optimal H-11 with ALK wild-type and mutants were ideally established which further confirmed the structural basis in accordance with the SARs analysis.
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http://dx.doi.org/10.1016/j.bmc.2021.116108DOI Listing
May 2021

Neutrophil-to-lymphocyte ratio is associated with malnutrition risk estimated by the Royal Free Hospital-Nutritional Prioritizing Tool in hospitalized cirrhosis.

JPEN J Parenter Enteral Nutr 2021 Mar 15. Epub 2021 Mar 15.

Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Tianjin, China.

Background: Liver cirrhosis is characterized by immune dysfunction, contributing to malnutrition. We previously revealed neutrophil-to-lymphocyte ratio (NLR) as an indicator of disordered immune system. Herein we aimed to (1) determine the optimal NLR cutoff that best predicts malnutrition risk and (2) clarify the association between NLR and nutrition status.

Methods: A total of 135 hospitalized patients with cirrhosis were included. Immune dysfunction was evaluated by levels of serum C-reactive protein (CRP), NLR, and other parameters. Malnutrition was screened by a risk score referring to the Royal Free Hospital-Nutritional Prioritizing Tool (RFH-NPT). Receiver operating characteristic (ROC) curve was implemented to determine the best NLR cutoff that predicts malnutrition risk. Correlation between NLR and indicators of hepatic and physical function (handgrip strength) were also examined. Multivariable logistic regression was used to assess the association between NLR and malnutrition risk.

Results: ROC curve revealed that the optimum cutoff to predict malnutrition risk was NLR > 4.2, with a sensitivity of 47.2%, specificity of 81.0%, negative predictive value of 58.0%, and positive predictive value of 74.5%, respectively. Patients with NLR > 4.2 exhibited a higher RFH-NPT score, serum platelet-to-lymphocyte ratio, and CRP. A positive correlation was found between NLR values and Child-Turcotte-Pugh (r = 0.22; P = .010), model for end-stage liver disease (r = 0.36; P < .001), and RFH-NPT scores (r = 0.31; P < .001). NLR was a risk factor for malnutrition independently of alcoholic liver disease and presence of ascites.

Conclusions: Immune dysfunction measured by NLR was associated with malnutrition risk estimated by RFH-NPT in cirrhosis.
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http://dx.doi.org/10.1002/jpen.2097DOI Listing
March 2021

GLI1 reduces drug sensitivity by regulating cell cycle through PI3K/AKT/GSK3/CDK pathway in acute myeloid leukemia.

Cell Death Dis 2021 03 3;12(3):231. Epub 2021 Mar 3.

Department of Hematology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, 510630, China.

Acute myeloid leukemia (AML) is a hematological malignancy with high incidence and recurrence rates. Gene expression profiling has revealed that transcriptional overexpression of glioma-associated oncogene 1 (GLI1), a vital gene in the Hedgehog (Hh) signaling pathway, occurs in poor-prognosis AML, and high levels of phosphoinositide-3-kinase, regulatory subunit 1 (PIK3R1) and AKT3 predict shorter overall survival in AML patients. In this study, we discovered that GLI1 overexpression promotes cell proliferation and reduces chemotherapy sensitivity in AML cells while knocking down GLI1 has the opposite effect. Moreover, GLI1 promoted cell cycle progression and led to elevated protein levels of cyclins and cyclin-dependent kinases (CDKs) in AML cells. By luciferase assays and co-immunoprecipitation, we demonstrated that the PI3K/AKT pathway is directly activated by GLI1. GLI1 overexpression significantly accelerates tumor growth and upregulated p-AKT, CDK4, and cyclinD3 in vivo. Notably, the GLI1 inhibitor GANT61 and the CDK4/6 inhibitor PD 0332991 had synergistic effects in promoting Ara-c sensitivity in AML cell lines and patient samples. Collectively, our data demonstrate that GLI1 reduces drug sensitivity by regulating cell cycle through the PI3K/AKT/GSK3/CDK pathway, providing a new perspective for involving GLI1 and CDK4/6 inhibitors in relapsed/refractory (RR) patient treatment.
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http://dx.doi.org/10.1038/s41419-021-03504-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7930050PMC
March 2021

Structure-based optimization identified novel furyl-containing 2,4-diarylaminopyrimidine analogues as ALK/ROS1 dual inhibitors with anti-mutation effects.

Eur J Med Chem 2021 Mar 3;214:113259. Epub 2021 Feb 3.

Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China. Electronic address:

Aiming to develop ALK/ROS1 dual inhibitors overcoming ceritinib-resistant G1202R mutant, a dedicated structure-guided modification campaign was conducted based on ALK co-crystal structures. Twenty eight diarylaminopyrimidine (DAAP) analogues possessing furan or tetrahydrofuran group were designed and synthesized, among which compound 16 bearing (dimethylamino)methyl)furan-2-yl)methyl)thio fragment was identified. Compound 16 exhibited significant cytotoxicity on ALK-positive Karpas299 and H2228 cells with IC values of 20 nM and 110 nM. Meanwhile, compound 16 turned out as the most potent entity superior to ceritinib with IC values of 2.8, 2.6, 3.8 and 2.3 nM against ALK, ALK, ALK and ROS1, respectively. Subsequently, western blot assay showed that compound 16 significantly suppressed ALK and its downstream protein expression in a dose-dependent manner. Alternatively, the Hoechst 33258 and AO/EB staining assays illustrated that compound 16 could induce H2228 cell apoptosis. Ultimately, the binding models of compound 16 with ALK, ALK as well as ROS1 clearly presented the essential interactions within the active site. Together, compound 16 was validated as a promising ALK/ROS1 dual inhibitor for ALK mutation correlated tumors.
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http://dx.doi.org/10.1016/j.ejmech.2021.113259DOI Listing
March 2021

Warnings regarding the potential coronavirus disease 2019 (COVID-19) transmission risk: Vaccination is not enough.

Infect Control Hosp Epidemiol 2021 Feb 10. Epub 2021 Feb 10.

Internal Medicine, AMITA Health Saint Joseph Hospital Chicago, Chicago, Illinois, United States.

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http://dx.doi.org/10.1017/ice.2021.63DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948099PMC
February 2021

Bright solid-state sources for single photons with orbital angular momentum.

Nat Nanotechnol 2021 Mar 11;16(3):302-307. Epub 2021 Jan 11.

State Key Laboratory of Optoelectronic Materials and Technologies, School of Physics, Sun Yat-sen University, Guangzhou, China.

Photons that have a helical phase front, that is, twisted photons, can carry a discrete, in principle, unlimited, but quantized amount of orbital angular momentum (OAM). Hence, twisted single photons constitute a high-dimensional quantum system with information-processing abilities beyond those of two-level single-photon qubits. To date, the generation of single photons carrying OAM has relied on a non-linear process in bulk crystals, for example, spontaneous parametric down-conversion, which limits both the efficiency and the scalability of the source. Here, we present a bright solid-state source of single photons in an OAM superposition state with a single-photon purity of g(0) = 0.115(1) and a collection efficiency of 23(4)%. The mode purity of the single-photon OAM states is further examined via projection measurements. Future developments of integrated quantum photonic devices with pure OAM states as an additional degree of freedom may enable high-dimensional quantum information processing.
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http://dx.doi.org/10.1038/s41565-020-00827-7DOI Listing
March 2021

Self-Powered Flexible Sour Sensor for Detecting Ascorbic Acid Concentration Based on Triboelectrification/Enzymatic-Reaction Coupling Effect.

Sensors (Basel) 2021 Jan 7;21(2). Epub 2021 Jan 7.

College of Sciences, Northeastern University, Shenyang 110819, China.

Artificial sensory substitution systems can mimic human sensory organs through replacing the sensing process of a defective sensory receptor and transmitting the sensing signal into the nervous system. Here, we report a self-powered flexible gustation sour sensor for detecting ascorbic acid concentration. The material system comprises of NaCO-Ppy with AAO modification, PDMS and Cu wire mesh. The working mechanism is contributed to the triboelectrification/enzymatic-reaction coupling effect, and the device can collect weak energy from body movements and directly output triboelectric current without any external power-units. The triboelectric output is affected by AA concentration, and the response is up to 34.82% against 15.625 mM/L of AA solution. Furthermore, a practical application in detecting ascorbic acid concentration of different drinks has been demonstrated. This work can encourage the development of wearable flexible electronics and this self-powered sour sensor has the potential that can be acted as a kind of gustatory receptors to build electronic tongues.
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http://dx.doi.org/10.3390/s21020373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7827105PMC
January 2021

Characteristics of sleep architecture in autism spectrum disorders: A meta-analysis based on polysomnographic research.

Psychiatry Res 2021 02 24;296:113677. Epub 2020 Dec 24.

Department of Epidemiology and Health Statistics, School of Public Health Anhui Medical University, No. 81 Meishan Road, Hefei 230032, Anhui, PR China. Electronic address:

Eleven parameters recorded by polysomnography were used to evaluate the differences in sleep structure between individuals with autism spectrum disorders (ASDs) and typically developed individuals (TDs). Four databases (PubMed, Web of Science, Cochrane Library, and China National Knowledge Infrastructure (CNKI)) were searched for potentially relevant literature published before July 14, 2019. Data extraction was performed by two independent assessors. The Cohen's d effect sizes and their 95% confidence intervals (CIs) were calculated to assess the effectiveness with the random-effects model. The heterogeneity was estimated by Cochran's Q test. The research yielded 14 case-control studies, 11 of which were included in this meta-analysis. Synthesis of the differences in 11 sleep parameters between individuals with ASDs and TDs demonstrated the pooled effect size of Cohen'd was -0.52 (95% CI: (-0.97, -0.08)) for total sleep time (TST), -0.69 (95% CI: (-1.27, -0.11)) for sleep efficiency (SE%) and 0.93 (95% CI: (0.37, 1.48)) for stage 1 sleep (S1%), respectively. Our findings suggested that compared with TDs, individuals with ASDs tend to have a decreased TST and SE% and an increased S1%. Differences of characteristics of sleep architecture in other sleep parameters between individuals with ASDs and TDs were not found in this study.
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http://dx.doi.org/10.1016/j.psychres.2020.113677DOI Listing
February 2021

Therapeutic potential of bicyclol in liver diseases: Lessons from a synthetic drug based on herbal derivative in traditional Chinese medicine.

Int Immunopharmacol 2021 Feb 28;91:107308. Epub 2020 Dec 28.

Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Anshan Road 154, Heping District, Tianjin 300052, China; Tianjin Institute of Digestive Disease, Tianjin Medical University General Hospital, Anshan Road 154, Heping District, Tianjin 300052, China; Tianjin Key Laboratory of Digestive Disease, Tianjin Medical University General Hospital, Anshan Road 154, Heping District, Tianjin 300052, China; Department of Gastroenterology, Tianjin Medical University General Hospital Airport Hospital, East Street 6, Tianjin Airport Economic Area, Tianjin 300308, China. Electronic address:

Bicyclol, an innovative chemical drug with proprietary intellectual property rights in China, is based on derivative of traditional Chinese medicine (TCM) Schisandra chinensis (Wuweizi) of North. Mounting data has proved that bicyclol has therapeutic potential in various pathological conditions in liver. In this narrative review, we provide the first summary of pharmacological activities, pharmacokinetic characteristics and toxicity of bicyclol, and discuss future research perspectives. Our results imply that bicyclol has a wide spectrum of pharmacological properties, including anti-viral, anti-inflammatory, immuno-regulatory, anti-oxidative, antisteatotic, anti-fibrotic, antitumor, cell death regulatory effects and modulation of heat shock proteins. Pharmacokinetic studies have indicated that bicyclol is the main substrate of CYP3A/2E1. Additionally, no obvious drug interactions have been found when bicyclol is administered simultaneously with other prescriptions. Furthermore, the results of chronic toxicity have strongly addressed that bicyclol has no noticeable toxic effects on all biochemical indices and pathological examinations of the main organs. In view of good pharmacological actions and safety, bicyclol is anticipated to be a potential candidate for various liver diseases, including acute liver injury, fulminant hepatitis, non-alcoholic fatty liver disease, fibrosis and hepatocellular carcinoma. Further studies are therefore required to delineate its molecular mechanisms and targets to confer this well-designed drug a far greater potency. We hope that bicyclol-based therapeutics for liver diseases might be broadly used in clinical practice worldwide.
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http://dx.doi.org/10.1016/j.intimp.2020.107308DOI Listing
February 2021

Approach in Improving Potency and Selectivity of Kinase Inhibitors: Allosteric Kinase Inhibitors.

Mini Rev Med Chem 2021 ;21(8):991-1003

Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.

Allostery is an efficient and particular regulatory mechanism to regulate protein functions. Different from conserved orthosteric sites, allosteric sites have a distinctive functional mechanism to form the complex regulatory network. In drug discovery, kinase inhibitors targeting the allosteric pockets have received extensive attention for the advantages of high selectivity and low toxicity. The approval of trametinib as the first allosteric inhibitor validated that allosteric inhibitors could be used as effective therapeutic drugs for the treatment of diseases. To date, a wide range of allosteric inhibitors have been identified. In this perspective, we outline different binding modes and potential advantages of allosteric inhibitors. In the meantime, the research processes of typical and novel allosteric inhibitors are described briefly in terms of structure-activity relationships, ligand-protein interactions, and in vitro and in vivo activity. Additionally, challenges, as well as opportunities, are also presented.
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http://dx.doi.org/10.2174/1389557521666201222144355DOI Listing
August 2021

Is periodontal disease associated with increased risk of colorectal cancer? A meta-analysis.

Int J Dent Hyg 2021 Feb 12;19(1):50-61. Epub 2020 Dec 12.

AMITA Health Saint Joseph Hospital Chicago, Chicago, IL, USA.

Objective: Colorectal cancer (CRC) is a commonly diagnosed cancer. Previous studies investigating the relationship between periodontal disease (PD) and CRC showed controversial conclusions. This meta-analysis is to explore the association between PD and CRC.

Methods: Observational studies that explore the association between CRC and PD were included in this meta-analysis. A comprehensive literature search in 7 electronic databases to identify all relevant studies published prior to February 2020. The Newcastle-Ottawa Quality Assessment Scale was used to evaluate the quality each study. The pooled relative risk (RR) and 95% confidence interval (CI) were used to estimate the association between the PD and CRC risk.

Results: A total of 838 articles were obtained from database searching and 4 articles were obtained from other sources, and 13 articles with 14 studies involving 634,744 participants were included. An association between PD and increased CRC incidence was found, periodontal disease patients were 21% (95%CI, [1.06, 1.38], I =83.9%) more likely to develop colorectal cancer than people with healthy oral cavity. But there is no significant association between PD and CRC mortality. The heterogeneity of this meta-analysis was relatively high, I was 83.9% (95%CI, [72.7%, 90.5%]), chi-squared of Q test was 62.18, but sensitivity analysis confirmed the stability of the result. Funnel plot, Egger's test and Begg's test found no publication bias of analysis.

Conclusion: The current meta-analysis demonstrates an association between PD and CRC, indicating that early CRC screening is necessary for people with poor oral health, and oral health improvement might be beneficial for reducing CRC risk.
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http://dx.doi.org/10.1111/idh.12483DOI Listing
February 2021

Interplay between endoplasmic reticulum stress and non-coding RNAs in cancer.

J Hematol Oncol 2020 12 2;13(1):163. Epub 2020 Dec 2.

Department of Hematology, The First Affiliated Hospital of Jinan University, Guangzhou, 510632, Guangdong, China.

To survive, cancer cells are subjected to various internal and external adverse factors, including genetic mutations, hypoxia, nutritional deficiencies, and drug toxicity. All of these factors result in the accumulation of unfolded proteins in the endoplasmic reticulum, which leads to a condition termed endoplasmic reticulum stress (ER stress) and triggers the unfolded protein response (UPR). UPR downstream components strictly control transcription and translation reprogramming to ensure selective gene expression, including that of non-coding RNA (ncRNAs), to adapt to adverse environments. NcRNAs, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), play important roles in regulating target gene expression and protein translation, and their aberrant expression is related to tumor development. Dysregulation of ncRNAs is involved in the regulation of various cellular characteristics of cancer cells, including growth, apoptosis, metastasis, angiogenesis, drug sensitivity, and tumor stem cell properties. Notably, ncRNAs and ER stress can regulate each other and collaborate to determine the fate of tumor cells. Therefore, investigating the interaction between ER stress and ncRNAs is crucial for developing effective cancer treatment and prevention strategies. In this review, we summarize the ER stress-triggered UPR signaling pathways involved in carcinogenesis followed by the mutual regulation of ER stress and ncRNAs in cancer, which provide further insights into the understanding of tumorigenesis and therapeutic strategies.
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http://dx.doi.org/10.1186/s13045-020-01002-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7709275PMC
December 2020

The relationship between psychological resilience and emotion regulation among preschool left-behind children in rural China.

Psychol Health Med 2021 06 18;26(5):595-606. Epub 2020 Nov 18.

Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, China.

To evaluate the relationship between resilience and emotion regulation among preschool left-behind children (LBC) in rural China. A total of 620 preschool LBC were enrolled from rural areas in Anhui province, China. Multivariate logistic regression was used to evaluate the associations between resilience and variables. The results showed that 20.2% of LBC had higher resilience. Emotion regulation was correlated with resilience among preschool LBC. Children with higher cognitive reconstruction (adjusted OR (AOR) = 0.349,95%CI:0.249-0.489), passive dealing (AOR = 0.577, 95%CI:0.411-0.810), alternative action (AOR = 0.369, 95%CI:0.267-0.510) and self-comforting (AOR = 0.441, 95%CI:0.315-0.619) would have lower risk of low resilience. Our findings suggest that strengthening emotion regulation could promote psychological resilience and prevent adverse developments in LBC.
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http://dx.doi.org/10.1080/13548506.2020.1849748DOI Listing
June 2021

A self-reported Frailty Index predicts long-term mortality in hospitalized patients with cirrhosis.

Ann Transl Med 2020 Oct;8(19):1217

Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Tianjin, China.

Background: Frailty is a syndrome that diminishes the potential for functional recovery in liver cirrhosis (LC). However, its utility is limited due to sole reliance on physical performance, especially in hospitalized patients. We investigate the predictive value of a modified self-reported Frailty Index in cirrhotics, and identify which health deficits play more important roles.

Methods: Consecutive LC patients were assessed by our frailty scale. Outcomes of interest were mortality for 90-day, 1-year and 2-year. Independent predictors were identified by multivariate Cox regression. Receiver operating characteristic curve (ROC) was performed to evaluate discriminative ability. We used a combination of stepwise selection, best subset selection, and Akaike information criteria (AIC) to identify pivotal frailty components.

Results: The study cohort consisted of 158 patients, in which 37 expired during follow-up. Compared with non-frail groups, the frail group had higher 1- and 2-year mortality. The area under ROC of the Child-Turcotte-Pugh classification (CTP) and Frailty Index were 0.66 and 0.68, while 0.72 for CTP + Frailty Index (P=0.034), respectively. The optimal predictors comprised instrumental activities of daily living (IADL) limitation, falls and loss of weight (AIC =170, C-statistic =0.67).

Conclusions: It is plausible for incorporating Frailty Index to improve prognostication in cirrhotics. IADL limitation, falls and loss of weight play more crucial roles on mortality determination.
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http://dx.doi.org/10.21037/atm-20-943DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7607105PMC
October 2020

A Novel miRNA Restores the Chemosensitivity of AML Cells Through Targeting FosB.

Front Med (Lausanne) 2020 6;7:582923. Epub 2020 Oct 6.

Department of Hematology, The First Affiliated Hospital of Jinan University, Guangzhou, China.

The heterogeneous nature of acute myeloid leukemia (AML) and its poor prognosis necessitate therapeutic improvement. Current advances in AML research yield important insights regarding both AML genetics and epigenetics. MicroRNAs (miRNAs) play important roles in cell proliferation, differentiation, and survival and may be useful for AML diagnosis and prognosis. In this study, a novel miRNA, hsa-miR-12462, was identified in bone marrow (BM) samples from AML patients at diagnosis by small RNA sequencing. A significant higher level of hsa-miR-12462 was found in patients who achieve complete remission (AML-CR) after induction therapy compared with those who suffer relapse/refractory (AML-RR). FosB was predicted to be the target of hsa-miR-12462 through RNA sequencing, bioinformatics analysis, and protein-protein interaction (PPI) network analysis and then verified by luciferase activity assay. T-5224, the inhibitor of FosB, was administered to AML cell lines, which could inhibit cell proliferation, promote apoptosis, and restore the sensitivity of AML cells to cytarabine (Ara-C). In summary, a higher level of hsa-miR-12462 in AML cells is associated with increased sensitivity to Ara-C targeting FosB.
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http://dx.doi.org/10.3389/fmed.2020.582923DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7573296PMC
October 2020

Pyrroformyl-containing 2,4-diaminopyrimidine derivatives as a new optimization strategy of ALK inhibitors combating mutations.

Bioorg Med Chem 2020 10 20;28(20):115715. Epub 2020 Aug 20.

Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, PR China. Electronic address:

Aiming to identify new optimization strategy effective for ALK-mutations, two series of pyrroformyl-containing 2,4-diaminopyrimidine compounds (11a-o, 12a-o) were designed, synthesized and evaluated for their anti-proliferative activities against three cancer cell lines in vitro by MTT assay. The biological evaluations on cellular assay resulted in discovery of compound 11k, which performed considerable activity with IC value of 0.034 μM against H2228 cell. Meanwhile, 11k exhibited outstanding enzymatic inhibitory potency with IC values of 1.9 nM and 3.1 nM against ALK and ALK, respectively, surpassing the reference ceritinib (IC = 2.4 nM and 7.6 nM). Ultimately, the binding mode of 11k with ALK was established to explore the SARs. Overall, 11k was considered as a promising ALK inhibitor for mutation treatment.
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http://dx.doi.org/10.1016/j.bmc.2020.115715DOI Listing
October 2020

Fragment-based modification of 2,4-diarylaminopyrimidine derivatives as ALK and ROS1 dual inhibitors to overcome secondary mutants.

Bioorg Med Chem 2020 10 25;28(20):115719. Epub 2020 Aug 25.

Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, PR China. Electronic address:

In order to explore novel ALK and ROS1 dual inhibitors capable of overcoming crizotinib-resistant mutants, two series of 2,4-diarylaminopyrimidine derivatives were designed, synthesized and evaluated for their in vitro cytotoxic activity. In this work, we retained the 2,4-diarylaminopyrimidine scaffold and derivatize the DAAP scaffold with sulfonyl and acrylamide moieties to extend the structure-activity relationship (SAR) study. To our delight, some compounds exhibited excellent inhibitory activity with a double-digit nanomolar level in MTT assay. Four compounds were selected for enzymic assays further, the results led to the identification of a potent ALK and ROS1 dual inhibitor X-17, with IC values of 3.7 nM, 2.3 nM, 8.9 nM and 1.9 nM against ALK, ALK, ALK and ROS1, respectively. Ultimately, the molecular docking studies on X-17 clearly disclosed reasonable and optimal binding interactions with ALK.
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http://dx.doi.org/10.1016/j.bmc.2020.115719DOI Listing
October 2020
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