Publications by authors named "Tian Tian"

996 Publications

Determination of risk factors associated with acute kidney injury during delivery or the postpartum period.

Eur J Obstet Gynecol Reprod Biol 2021 Jul 26. Epub 2021 Jul 26.

Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, Beijing, People's Republic of China.

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http://dx.doi.org/10.1016/j.ejogrb.2021.07.031DOI Listing
July 2021

Overall Survival Analyses following Adjuvant Chemotherapy or Nonadjuvant Chemotherapy in Patients with Stage IB Non-Small-Cell Lung Cancer.

J Oncol 2021 17;2021:8052752. Epub 2021 Jul 17.

West China School of Nursing, Sichuan University, Chengdu 610041, Sichuan, China.

Background: Adjuvant chemotherapy (ACT) can improve prognosis for stages II-IIIA patients with non-small-cell lung cancer (NSCLC), but its implication in stage I patients is still an intractable puzzle. This study aims to seek ACT candidates for stage IB NSCLC and establish a nomogram to predict overall survival (OS) of specific patient for clinician's decision.

Method: We performed a retrospective study on 16,765 patients (ACT group:  = 2,187; non-ACT group:  = 14,578) from the Surveillance, Epidemiology, and End Results (SEER) database. Overall survival was assessed in two groups. We performed propensity-score matching for risk adjustment. The risk factors were identified and used to create nomogram. Concordance index (C-index), Hosmer-Lemeshow test, and calibration were applied to evaluate model performance. To further evaluate the influence of tumor size on the selection of potential ACT candidates for patients with stage IB NSCLC, subgroup analyses were executed.

Result: Survival analysis for the entire study cohort showed that ACT had better OS than non-ACT (HR = 0.800, CI: (0.751-0.851), < 0.0001). In matched cohort, ACT also presented better OS than non-ACT (HR = 0.775, CI: (0.704-0.853), < 0.0001). Univariate and multivariate Cox regression analysis revealed that eight prognostic factors, including gender, age, grade, pathological subtype, tumor size, visceral pleural invasion, surgical procedure, and the number of removed lymph nodes, were significantly correlated with OS. The nomogram was further constructed based on these prognostic factors. The C-index of nomogram was 0.639 (95%CI: 0.632-0.646). The Hosmer-Lemeshow test, and calibration presented good congruence between the predictions and actual observations. Subgroup analyses of tumor size group showed that ACT shared similar OS to non-ACT in NSCLC patients with tumor size ≤20 mm ( > 0.05). However, for NSCLC patients with 20 mm < size ≤30 mm (HR = 0.845, 95%CI (0.724-0.986), =0.032) and 30 mm < size ≤40 mm (HR = 0.912, 95%CI (0.833-1.000), =0.049), ACT associated with better OS.

Conclusion: In this study, we found that ACT had better OS than non-ACT in patients with stage IB NSCLC. The nomogram provided an individual prediction of OS for patients after surgical resection. Patients with tumor size >20 mm and ≤40 mm may be potential candidates for ACT.
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http://dx.doi.org/10.1155/2021/8052752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8313364PMC
July 2021

A Diagnostic Analysis Workflow to Optimal Multiple Tumor Markers to Predict the Nonmetastatic Breast Cancer from Breast Lumps.

J Oncol 2021 8;2021:5579373. Epub 2021 Jul 8.

The First Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China.

Objective: To assess the diagnostic performance of clinically common single markers and combinations to distinguish nonmetastatic breast cancer and benign breast tumor. A predictive model with a better diagnostic ability for nonmetastatic breast cancer was established by using the diagnostic process.

Methods: A total of 222 patients with nonmetastatic breast cancer and 265 patients with benign breast disease were enrolled in this study. CEA, Ca 15-3, Ca 125, Ca 72-4, CYFRA 21-1, FERR, AFP, and NSE were measured by an electrochemiluminescent immunoenzymometric assay on the Elecsys system. There are four key steps for our diagnostic workflow, that is, feature selection, algorithm selection, parameter optimization, and outer test data was used to validate the optimal algorithm and markers.

Results: CEA, Ca 15-3, CYFRA 21-1, AFP, and FERR were selected using the -test in our inner development set. The optimal algorithm among logical regression, decision tree, support vector machine, random forest, and gradient boost machine was selected by 10-fold cross-validation, and we found that random forest and logistic regression are the better classification. The outer test data was used to validate the best markers and classification. The random forest with CEA, Ca 15-3, CYFRA 21-1, AFP, and FERR showed the optimal combination for distinguishing breast cancer and benign breast disease. The AUC value was 0.888, the cut-off point was 0.484, and sensitivity and specificity were 78.9% and 90.1%.

Conclusions: No single marker of these eight markers was good at identifying nonmetastatic breast cancer from benign tumors. But a diagnostic analysis workflow was established to develop a predictive model with better diagnostic capability for nonmetastatic breast cancer. This workflow is also applicable to the optimization of other disease markers and diagnostic models. The predictive model showed good diagnostic performance, and it could be gradually incorporated as a support method for the diagnosis of nonmetastatic breast cancer.
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http://dx.doi.org/10.1155/2021/5579373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8289572PMC
July 2021

MRI study of changes in knee bone marrow edema-like signal in asymptomatic amateur marathon runners before and after half-marathon running.

Clin Imaging 2021 May 18;80:150-157. Epub 2021 May 18.

Department of Radiology, The Affiliated Hospital of Hangzhou Normal University, No. 126, Wenzhou Road, Gongshu District, Hangzhou 310000, Zhejiang, China.

Objective: To evaluate the incidence of knee bone marrow edema-like signal and its changes before and after running a half marathon running in asymptomatic amateur marathon runners to explore the impact of the half marathon on knee bone marrow edema-like signal.

Methods: 50 asymptomatic amateur marathon runners (30 males, 20 females) were recruited. T1-weighted imaging (T1WI), fat-suppressed protein density weighted imaging (fs-PDWI) and three-dimensional double-echo steady-state (3D-DESS) sequence on the right knee were performed before and within 3 h after a half-marathon running. 20 healthy volunteers were recruited as control. According to the whole-organ magnetic resonance imaging score (WORMS) system, the involvement of bone marrow edema-like signal in 15 regions of knee was graded from 0 to 3. The results were classified and Mann Whitney U test was used for comparison between groups.

Results: The total incidence of bone marrow edema-like signal in amateur marathon group was 62%. Among them, the incidence of grade 1-3 was 48% (24/50), 12% (6/50), 2% (1/50), respectively, which was statistically significant compared with the controls (P = 0.007). There was no significant difference between gender before running (P = 0.172) and after running (P = 0.162). There was no significant difference before and after running (P > 0.05). However, 3 subjects showed new lesions, 8 subjects showed progression and 4 subjects showed decreased signal.

Conclusion: The occurrence of knee bone marrow edema-like signal in amateur marathon runners is more common. The lesions of bone marrow edema-like signal will show aggravation or improvement in a certain extent after the half marathon.
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http://dx.doi.org/10.1016/j.clinimag.2021.05.005DOI Listing
May 2021

Protective Effect of Jiang Tang Xiao Ke Granules against Skeletal Muscle IR via Activation of the AMPK/SIRT1/PGC-1 Signaling Pathway.

Oxid Med Cell Longev 2021 3;2021:5566053. Epub 2021 Jul 3.

College of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.

The Jiang Tang Xiao Ke (JTXK) granule is a classic Chinese herbal formula that has been put into clinical use in the treatment of type 2 diabetes mellitus for decades. However, whether its ability to ameliorate skeletal muscle insulin resistance (IR) is through modulation of the AMPK/SIRT1/PGC-1 signaling pathway remains unknown. Therefore, we aimed to investigate the effects of JTXK granules on IR in skeletal muscle of high-fat diet-induced diabetic mice and C2C12 cells and analyze the underlying mechanisms. In the present study, we showed that JTXK granules attenuated body weight gain, reduced body fat mass, improved body lean mass, and enhanced muscle performance of diabetic mice. JTXK granules also improved glucose metabolism and skeletal muscle insulin sensitivity and partially reversed abnormal serum lipid levels, which might be related to the regulation of the AMPK/SIRT1/PGC-1 pathway, both in skeletal muscle tissue of diabetic mice and in C2C12 cells. Furthermore, drug-containing serum of JTXK granules was capable of enhancing glucose uptake and mitochondrial respiration in C2C12 cells, and AMPK was proven to be closely involved in this process. Taken together, these results suggest that the JTXK granule ameliorates skeletal muscle IR through activation of the AMPK/SIRT1/PGC-1 signaling pathway, which offers a novel perspective of this formula to combat IR-related metabolic diseases.
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http://dx.doi.org/10.1155/2021/5566053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8277912PMC
July 2021

Processed Multiparameter Electroencephalogram-Guided General Anesthesia Management Can Reduce Postoperative Delirium Following Carotid Endarterectomy: A Randomized Clinical Trial.

Front Neurol 2021 12;12:666814. Epub 2021 Jul 12.

Department of Anesthesiology, Xuanwu Hospital, Capital Medical University, Beijing, China.

Patients undergoing carotid endarterectomy (CEA) for severe carotid stenosis are vulnerable to postoperative delirium, a complication frequently associated with poor outcome. This study investigated the impact of processed electroencephalogram (EEG)-guided anesthesia management on the incidence of postoperative delirium in patients undergoing CEA. This single-center, prospective, randomized clinical trial on 255 patients receiving CEA under general anesthesia compared the outcomes of patient state index (PSI) monitoring [SEDLine Brain Function Monitor (Masimo, Inc, Irvine, CA)] (standard group, = 128) with PSI combined with density spectral array(DSA) -guided monitoring (intervention group, = 127) to reduce the risk of intraoperative EEG burst suppression. All patients were monitored by continuous transcranial Doppler ultrasound (TCD) and near-infrared spectroscopy (NIRS) to avoid perioperative cerebral hypoperfusion or hyperperfusion. According to the surgical process, EEG suppression time was calculated separately for three stages: S (from anesthesia induction to carotid artery clamping), S (from clamping to declamping), and S (from declamping to the end of surgery). The primary outcome was incidence of postoperative delirium according to the Confusion Assessment Method algorithm during the first 3 days post-surgery, and secondary outcomes were other neurologic complications and length of hospital stay. There were no episodes of cerebral hypoperfusion or hyperperfusion according to TCD and NIRS monitoring in either group during surgery. The incidence of postoperative delirium within 3 days post-surgery was significantly lower in the intervention group than the standard group (7.87 . 28.91%, < 0.01). In the intervention group, the total EEG suppression time and the EEG suppression time during S2 and S3 were shorter (Total, 0 "0" . 0 "1.17" min, = 0.04; S, 0 "0" . 0 "0.1" min, < 0.01; S, 0 "0" . 0 "0" min, = 0.02). There were no group differences in incidence of neurologic complications and length of postoperative hospital stay. Processed electroencephalogram-guided general anesthesia management, consisting of PSI combined with DSA monitoring, can significantly reduce the risk of postoperative delirium in patients undergoing CEA. Patients, especially those exhibiting hemodynamic fluctuations or receiving surgical procedures that disrupt cerebral perfusion, may benefit from the monitoring of multiple EEG parameters during surgery. www.ClinicalTrials.gov, identifier: NCT03622515.
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http://dx.doi.org/10.3389/fneur.2021.666814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8311024PMC
July 2021

Association between Dietary Inflammatory Index and Type 2 diabetes mellitus in Xinjiang Uyghur autonomous region, China.

PeerJ 2021 16;9:e11159. Epub 2021 Jul 16.

Department of Epidemiology and Biostatistics, School of Public Health, Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region, China.

Background: Diet and inflammation have both been studied in relation to type 2 diabetes mellitus (T2DM). The aim of this cross-sectional study was to examine the association between the Dietary Inflammatory Index (DII®) and T2DM.

Methods: Subjects were adults enrolled in the baseline study of the Xinjiang multi-ethnic natural population cohort and health follow-up study from January to May 2019. The study involved 5,105 subjects (58.7% men) between 35 and 74 years of age. The DII score was calculated from a data obtained via a food frequency questionnaire consisting of 127 food items.

Results: Logistic regression analyses were used to estimate the odds ratios (ORs) and 95% confidence intervals (95% CIs) of DII in relation to T2DM. After adjusting for potential confounders, compared to subjects in the 1st DII quintile, subjects in the 5th quintile (i.e., with the most pro-inflammatory diet) had higher odds of T2DM (OR = 3.27, 95%CI:2.38,4.50;  < 0.001).

Conclusions: Our results suggest that a pro-inflammatory diet is associated with a higher risk of T2DM in this population of Chinese adults.
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http://dx.doi.org/10.7717/peerj.11159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8288110PMC
July 2021

Assessing association between mean systemic filling pressure and acute kidney injury after cardiac surgery.

Acta Anaesthesiol Scand 2021 Jul 26. Epub 2021 Jul 26.

Department of Anaesthesiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

With a great interest we read the recent article by Neuman et al assessing the association between mean systemic filling pressure analogue (P ) and acute kidney injury (AKI) following cardiac surgery. They showed that Pmsa as a surrogate for renal venous pressure was more closely associated with AKI than central venous pressure. As AKI has been significantly associated with morbidity and mortality in after cardiac surgery, their findings have potential implication. Other than the limitations described by authors in discussion, however, we noted several issues in their article on which we invited the authors to comment.
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http://dx.doi.org/10.1111/aas.13963DOI Listing
July 2021

Serum Metabolic Profiling of Late-Pregnant Women With Antenatal Depressive Symptoms.

Front Psychiatry 2021 8;12:679451. Epub 2021 Jul 8.

Shanghai Key Laboratory of Forensic Medicine (Academy of Forensic Science), Shanghai, China.

Antenatal depression (AD) is a major public health issue worldwide and lacks objective laboratory-based tests to support its diagnosis. Recently, small metabolic molecules have been found to play a vital role in interpreting the pathogenesis of AD. Thus, non-target metabolomics was conducted in serum. Liquid chromatography-tandem mass spectrometry-based metabolomics platforms were used to conduct serum metabolic profiling of AD and non-antenatal depression (NAD). Orthogonal partial least squares discriminant analysis, the non-parametric Mann-Whitney test, and Benjamini-Hochberg correction were used to identify the differential metabolites between AD and NAD groups; Spearman's correlation between the key differential metabolites and Edinburgh Postnatal Depression Scale (EPDS) and the stepwise logistic regression analysis was used to identify potential biomarkers. In total, 79 significant differential metabolites between AD and NAD were identified. These metabolites mainly influence amino acid metabolism and glycerophospholipid metabolism. Then, PC (16:0/16:0) and betaine were significantly positively correlated with EPDS. The simplified biomarker panel consisting of these three metabolites [betaine, PC (16:0/16:0) and succinic acid] has excellent diagnostic performance (95% confidence interval = 0.911-1.000, specificity = 95%, sensitivity = 85%) in discriminating AD and NAD. The results suggested that betaine, PC (16:0/16:0), and succinic acid were potential biomarker panels, which significantly correlated with depression; and it could make for developing an objective method in future to diagnose AD.
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http://dx.doi.org/10.3389/fpsyt.2021.679451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8295540PMC
July 2021

A panel of differentially methylated regions enable prognosis prediction for colorectal cancer.

Genomics 2021 Jul 21;113(5):3285-3293. Epub 2021 Jul 21.

Department of Epidemiology, College of Public Health, Harbin Medical University, Harbin 150081, Heilongjiang Province, PR China. Electronic address:

We aim to identify a panel of differentially methylated regions (DMRs) for predicting survival outcomes for patients with CRC from the TCGA (n = 393). Four DMRs (MUC12, TBX20, CHN2, and B3GNT7) were selected as candidate prognostic markers for CRC. The prediction potential of selected DMRs was validated by the targeted bisulfite sequencing method in an independent cohort with 251 Chinese CRC patients. DMR methylation scores (DMSs) were constructed to evaluate the prognosis of CRC. Results of the validation cohort confirmed that higher DMSs were associated with poor overall survival (OS) of CRC, with hazard ratio (HR) value ranged from 1.445 to 2.698 in multivariable Cox models. Patients in the high prognostic index (high-PI) group showed a markedly unfavorable prognosis compared to the low-PI group in both TCGA discovery cohort (HR = 3.508, 95%CI: 2.196-5.604, P < 0.001) and independent validation cohort (HR = 1.912, 95%CI: 1.258-2.907, P = 0.002).
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http://dx.doi.org/10.1016/j.ygeno.2021.07.010DOI Listing
July 2021

Novel Ultrahigh-Performance ZnO-Based Varistor Ceramics.

ACS Appl Mater Interfaces 2021 Jul 23. Epub 2021 Jul 23.

CAS Key Laboratory of Inorganic Functional Materials and Devices, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 201899, China.

The nonlinear response of a material to an external stimulus is vital in fundamental science and technical applications. The power-law current-voltage relationship of a varistor is one such example. An excellent example of such behavior is the power-law current-voltage relationship exhibited by BiO-doped ZnO varistor ceramics, which are the cornerstone of commercial varistor materials for overvoltage protection. Here, we report on a sustainable, ZnO-based varistor ceramic, without the volatile BiO, that is based on CrO as the varistor former and oxides of Ca, Co, and Sb as the performance enhancers. The material has an ultrahigh α of up to 219, a low of less than 0.2 μA/cm, and a high of up to 925 V/mm, making it superior to state-of-the-art varistor ceramics. The results provide insights into the design of materials with specific characteristics by tailoring states at the grain boundaries. The discovery of this ZnO-CrO-type varistor ceramic represents a major breakthrough in the field of varistors for overvoltage protection and could drastically affect the world market for overvoltage protection.
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http://dx.doi.org/10.1021/acsami.1c07735DOI Listing
July 2021

Letter to the Editor Regarding Serratus Anterior Plane Block Combined with General Analgesia and Patient-Controlled Serratus Anterior Plane Block in Patients with Breast Cancer: A Randomized Control Trial.

Adv Ther 2021 Jul 18. Epub 2021 Jul 18.

Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, No. 95 Yong-An Road, Xi-Cheng District, Beijing, 100050, People's Republic of China.

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http://dx.doi.org/10.1007/s12325-021-01847-yDOI Listing
July 2021

A phosphatidic acid-binding lncRNA SNHG9 facilitates LATS1 liquid-liquid phase separation to promote oncogenic YAP signaling.

Cell Res 2021 Jul 15. Epub 2021 Jul 15.

MOE Laboratory of Biosystem Homeostasis and Protection, College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, China.

Long noncoding RNAs (lncRNAs) are emerging as a new class of important regulators of signal transduction in tissue homeostasis and cancer development. Liquid-liquid phase separation (LLPS) occurs in a wide range of biological processes, while its role in signal transduction remains largely undeciphered. In this study, we uncovered a lipid-associated lncRNA, small nucleolar RNA host gene 9 (SNHG9) as a tumor-promoting lncRNA driving liquid droplet formation of Large Tumor Suppressor Kinase 1 (LATS1) and inhibiting the Hippo pathway. Mechanistically, SNHG9 and its associated phosphatidic acids (PA) interact with the C-terminal domain of LATS1, promoting LATS1 phase separation and inhibiting LATS1-mediated YAP phosphorylation. Loss of SNHG9 suppresses xenograft breast tumor growth. Clinically, expression of SNHG9 positively correlates with YAP activity and breast cancer progression. Taken together, our results uncover a novel regulatory role of a tumor-promoting lncRNA (i.e., SNHG9) in signal transduction and cancer development by facilitating the LLPS of a signaling kinase (i.e., LATS1).
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http://dx.doi.org/10.1038/s41422-021-00530-9DOI Listing
July 2021

Effect of Combined Atropine and Patching vs Patching Alone for Treatment of Severe Amblyopia in Children Aged 3 to 12 Years: A Randomized Clinical Trial.

JAMA Ophthalmol 2021 Jul 15. Epub 2021 Jul 15.

Eye Institute, Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China.

Importance: Patching is often less effective for severe amblyopia because of poor adherence. For the treatment of severe amblyopia, although combined atropine and patching therapy (CAPT) has been found to be efficacious, it is currently unknown whether CAPT is more efficacious than patching alone.

Objective: To compare the efficacy of CAPT vs patching alone in children aged 3 to 12 years with severe amblyopia.

Design, Setting, And Participants: This single-center randomized clinical trial was conducted from November 2018 to May 2020. The visual acuity (VA) examiner was masked to the treatment groups. The follow-up visits were at 3 months and 6 months. Participants aged 3 to 12 years with severe amblyopia (20/100 to 20/500) resulting from strabismus, anisometropia, or both were randomly assigned to CAPT or patching therapy.

Interventions: CAPT or patching alone for 6 months.

Main Outcomes And Measures: Change of the amblyopic eye VA from baseline to 6 months.

Results: Among 108 participants, the mean (SD) age was 5.2 (1.8) years, and 54 (50%) were female. Overall, 53 participants (49%) were randomized to CAPT and 55 (51%) were randomized to patching therapy. At baseline, the mean (SD) amblyopic eye VA was 0.95 (0.22) logMAR (approximately 20/200 [2.2 lines]). At 6 months, the CAPT group's mean improvement in amblyopic eye VA was 0.72 logMAR (7.2 lines) compared with 0.58 logMAR (5.8 lines) in the patching alone group (difference, 0.14 logMAR [1.4 lines] greater in the CAPT group; 95% CI, 0.05-0.22 logMAR [0.5-2.2 lines]; P = .002). The amblyopic eye VA improvement in the CAPT group also was greater than that in the patching alone group at 3 months (difference in the means, 0.13 logMAR [1.3 lines]; 95% CI, 0.04-0.22 logMAR [0.4-2.2 lines]; P = .004). No participants were withdrawn because of adverse effects.

Conclusions And Relevance: CAPT resulted in more mean improvement of amblyopic eye VA than patching alone among participants enrolled in this trial, although the clinical relevance of this relatively small VA difference cannot be determined from this trial.

Trial Registration: Chinese Clinical Trial Registry Identifier: ChiCTR1800018663.
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http://dx.doi.org/10.1001/jamaophthalmol.2021.2413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8283662PMC
July 2021

Vitellogenin from planthopper oral secretion acts as a novel effector to impair plant defenses.

New Phytol 2021 Jul 14. Epub 2021 Jul 14.

Institute of Plant Protection, Jiangsu Academy of Agricultural Sciences, Jiangsu Key Laboratory for Food and Safety-State Key Laboratory Cultivation Base of Ministry of Science and Technology, Nanjing, 210014, China.

Vitellogenin (Vg) is a well-known nutritious protein involved in reproduction in nearly all oviparous animals, including insects. Recently, Vg has been detected in saliva proteomes of several piercing-sucking herbivorous arthropods, including the small brown planthopper (Laodelphax striatellus, SBPH). Its function, however, remains unexplored. We investigated the molecular mechanism underlying SBPH orally secreted Vg-mediated manipulation of plant-insect interaction by RNA interference, phytohormone and H O profiling, protein-protein interaction studies and herbivore bioassays. A C-terminal polypeptide of Vg (VgC) in SBPH, when secreted into rice plants, acted as a novel effector to attenuate host rice defenses, which in turn improved insect feeding performance. Silencing Vg reduced insect feeding and survival on rice. Vg-silenced SBPH nymphs consistently elicited higher H O production, a well-established defense mechanism in rice, whereas expression of VgC in planta significantly hindered H O accumulation and promoted insect performance. VgC directly interacted with the rice transcription factor OsWRKY71, a protein which is involved in induction of H O accumulation and plant resistance to SBPH. These findings indicate a novel effector function of Vg: When secreted into host rice plant, this protein effectively weakened H O -mediated plant defense through its association with a plant immunity regulator.
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http://dx.doi.org/10.1111/nph.17620DOI Listing
July 2021

Telomere-to-telomere assembly of a fish Y chromosome reveals the origin of a young sex chromosome pair.

Genome Biol 2021 Jul 12;22(1):203. Epub 2021 Jul 12.

Department of Neurosciences and Developmental Biology, University of Vienna, 1090, Vienna, Austria.

Background: The origin of sex chromosomes requires the establishment of recombination suppression between the proto-sex chromosomes. In many fish species, the sex chromosome pair is homomorphic with a recent origin, providing species for studying how and why recombination suppression evolved in the initial stages of sex chromosome differentiation, but this requires accurate sequence assembly of the X and Y (or Z and W) chromosomes, which may be difficult if they are recently diverged.

Results: Here we produce a haplotype-resolved genome assembly of zig-zag eel (Mastacembelus armatus), an aquaculture fish, at the chromosomal scale. The diploid assembly is nearly gap-free, and in most chromosomes, we resolve the centromeric and subtelomeric heterochromatic sequences. In particular, the Y chromosome, including its highly repetitive short arm, has zero gaps. Using resequencing data, we identify a ~7 Mb fully sex-linked region (SLR), spanning the sex chromosome centromere and almost entirely embedded in the pericentromeric heterochromatin. The SLRs on the X and Y chromosomes are almost identical in sequence and gene content, but both are repetitive and heterochromatic, consistent with zero or low recombination. We further identify an HMG-domain containing gene HMGN6 in the SLR as a candidate sex-determining gene that is expressed at the onset of testis development.

Conclusions: Our study supports the idea that preexisting regions of low recombination, such as pericentromeric regions, can give rise to SLR in the absence of structural variations between the proto-sex chromosomes.
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http://dx.doi.org/10.1186/s13059-021-02430-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8273981PMC
July 2021

Study of C-reactive protein, procalcitonin, and immunocyte ratios in 194 patients with sepsis.

BMC Emerg Med 2021 Jul 7;21(1):81. Epub 2021 Jul 7.

Department of Emergency Medicine, Beijing Chaoyang Hospital Jingxi Branch, Capital Medical University, No.5 Jingyuan Road, Shijingshan, Beijing, 100043, China.

Background: Evidence suggests that C-reactive protein (CRP), procalcitonin (PCT), and immune cells can predict sepsis severity in adult patients. However, the specific values of these indicators are not consistent in predicting prognosis.

Methods: A retrospective study analyzed the medical records of 194 patients based on the concept of sepsis in 2016 (Sepsis 3.0) from January 2017 to December 2019. A comparative analysis of inflammatory factors associated with patients in the sepsis survival and the non-survival group was performed. The concentrations of CRP and PCT, neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and platelet-to-lymphocyte ratio (PLR) were measured. ROC curve was used to assess the diagnosis and analysis of the selected indices of sepsis. According to each index's cut-off value of the ROC curve, the patients were divided into two groups, and the prognosis was calculated.

Results: Among the 194 patients, 32 died (16.49%), the median age of the patients was 79 (66.0, 83.3) years, and 118 were male (60.8%). Analysis of related inflammatory indicators showed that CRP, NLR, MLR, PLR, and CRP*PCT in the non-survival group were statistically higher than those in the survival group (all p values were < 0.05). Regression analysis showed that PCT, CRP, NLR, PLR, and CRP*PCT were all independent prognostic factors for patients. The ROC curve results showed that CRP*PCT had the best diagnostic value (AUC = 0.915). The cut-off values of PCT, CRP, NLR, PLR, MLR, and CRP*PCT were 0.25 ng/mL, 85.00 mg/L, 8.66, 275.51, 0.74%, and 5.85 (mg/L), respectively. Kaplan-Meier survival estimate showed that patient prognosis between the CRP, PCT, NLR, PLR, and CRP*PCT was statistically different (all values P < 0.05, respectively). However, there was no statistically significant difference in gender and MLR (all values P > 0.05, respectively), grouping based on diagnostic cut-off values.

Conclusions: In this study, inflammation-related markers PCT, CRP, NLR, MLR, PLR, and CRP*PCT can be used as independent risk factors affecting the prognosis of patients with sepsis. Furthermore, except for MRL, these indicators have cut-off values for predicting patient death.
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http://dx.doi.org/10.1186/s12873-021-00477-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8265098PMC
July 2021

[Revealing the mechanisms underlying the therapeutic effects of acupuncture on migraine using neuroimaging: a narrative review].

Sheng Li Xue Bao 2021 Jun;73(3):433-445

Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.

Migraine is a neurological disorder characterized by attacks of moderate or severe headache and various neurological symptoms. Acupuncture, as a commonly used non-pharmacological therapy, has the advantage of obvious therapeutic effect and few side effects in the prevention and treatment of migraine. But the underlying mechanism of acupuncture on migraine remains unclear. Recently, advances in neuroimaging technology have helped to objectively assess the effect of acupuncture on treating migraine and offered new opportunities to explore the central mechanism of acupuncture on treating migraine. In order to better understand the current status of neuroimaging studies on the therapeutic mechanism of acupuncture on migraine and shed light on future research, this review aims to overview the neuroimaging studies in recent 10 years from two aspects: (1) Central mechanism of acupuncture on treating acute migraine attack; (2) Central mechanism of acupuncture on preventing migraine attack.
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June 2021

Antioxidant Fusion Protein SOD1-Tat Increases the Engraftment Efficiency of Total Bone Marrow Cells in Irradiated Mice.

Molecules 2021 Jun 3;26(11). Epub 2021 Jun 3.

Guangdong Provincial Key Laboratory of Proteomics and State Key Laboratory of Organ Failure Research, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.

Total body irradiation is a standard procedure of bone marrow transplantation (BMT) which causes a rapid increase in reactive oxygen species (ROS) in the bone marrow microenvironment during BMT. The increase in ROS reduces the engraftment ability of donor cells, thereby affecting the bone marrow recovery of recipients after BMT. In the early weeks following transplantation, recipients are at high risk of severe infection due to weakened hematopoiesis. Thus, it is imperative to improve engraftment capacity and accelerate bone marrow recovery in BMT recipients. In this study, we constructed recombinant copper/zinc superoxide dismutase 1 (SOD1) fused with the cell-penetrating peptide (CPP), the trans-activator of transcription (Tat), and showed that this fusion protein has penetrating ability and antioxidant activity in both RAW264.7 cells and bone marrow cells in vitro. Furthermore, irradiated mice transplanted with SOD1-Tat-treated total bone marrow donor cells showed an increase in total bone marrow engraftment capacity two weeks after transplantation. This study explored an innovative method for enhancing engraftment efficiency and highlights the potential of CPP-SOD1 in ROS manipulation during BMT.
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http://dx.doi.org/10.3390/molecules26113395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8200013PMC
June 2021

Development and Performance Evaluation of a High-Permeability and High-Bonding Fog-Sealing Adhesive Material.

Materials (Basel) 2021 Jun 28;14(13). Epub 2021 Jun 28.

Key Laboratory for Special Area Highway Engineering of Ministry of Education, Chang'an University, South 2nd Ring Rd., Middle Section, Xi'an 710064, China.

Herein, the effects of the contents of emulsified asphalt, waterborne epoxy resin emulsion, and curing agent on the permeability, bond shear strength, water stability, and aging resistance of epoxy-emulsified asphalt were studied. A formulation of epoxy-emulsified asphalt as a fog-sealing adhesive material was recommended, and a comparison between the fabricated adhesive material and a traditional Chinese fog-sealing adhesive material was conducted to verify the technical performance of the new material. In addition, the strength formation mechanism of the epoxy-emulsified asphalt was revealed via microcosmic analysis. Results show that the curing agent content mainly affects the permeability of epoxy-emulsified asphalt, and the emulsified asphalt content significantly affects the bond shear strength, water stability, and aging resistance. Moreover, the ratio of waterborne epoxy resin emulsion to the curing agent (epoxy ratio) has a certain effect on the bond shear strength. In the recommended formulation (a high-permeability and high-bonding fog-sealing adhesive material, which can be referred to simply as HPBFA), emulsified asphalt accounts for 80% of the total mass of the mixture, and the epoxy ratio is 2:1-3:1. It can improve air permeability, bond shear strength, water stability and aging resistance. The HPBFA-cured material exhibits a continuous three-dimensional network structure, hydrophobic surface, and large contact angle. Furthermore, the initial thermal weight loss temperature of the HPBFA-cured material is significantly higher than the environmental aging temperature. Additionally, the maximum temperature decomposition range is 0-160 °C, indicating improved strength, wear resistance, permeability, and aging resistance of the material.
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http://dx.doi.org/10.3390/ma14133599DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8269687PMC
June 2021

DOT1L complex regulates transcriptional initiation in human erythroleukemic cells.

Proc Natl Acad Sci U S A 2021 Jul;118(27)

Sheng Yushou Center of Cell Biology and Immunology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China;

DOT1L, the only H3K79 methyltransferase in human cells and a homolog of the yeast Dot1, normally forms a complex with AF10, AF17, and ENL or AF9, is dysregulated in most cases of mixed-lineage leukemia (MLLr), and has been believed to regulate transcriptional elongation on the basis of its colocalization with RNA polymerase II (Pol II), the sharing of subunits (AF9 and ENL) between the DOT1L and super elongation complexes, and the distribution of H3K79 methylation on both promoters and transcribed regions of active genes. Here we show that DOT1L depletion in erythroleukemic cells reduces its global occupancy without affecting the traveling ratio or the elongation rate (assessed by 4sUDRB-seq) of Pol II, suggesting that DOT1L does not play a major role in elongation in these cells. In contrast, analyses of transcription initiation factor binding reveal that DOT1L and ENL depletions each result in reduced TATA binding protein (TBP) occupancies on thousands of genes. More importantly, DOT1L and ENL depletions concomitantly reduce TBP and Pol II occupancies on a significant fraction of direct (DOT1L-bound) target genes, indicating a role for the DOT1L complex in transcription initiation. Mechanistically, proteomic and biochemical studies suggest that the DOT1L complex may regulate transcriptional initiation by facilitating the recruitment or stabilization of transcription factor IID, likely in a monoubiquitinated H2B (H2Bub1)-enhanced manner. Additional studies show that DOT1L enhances H2Bub1 levels by limiting recruitment of the Spt-Ada-Gcn5-acetyltransferase (SAGA) complex. These results advance our understanding of roles of the DOT1L complex in transcriptional regulation and have important implications for MLLr leukemias.
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http://dx.doi.org/10.1073/pnas.2106148118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8271641PMC
July 2021

Screening and ecological risk of 1200 organic micropollutants in Yangtze Estuary water.

Water Res 2021 Aug 7;201:117341. Epub 2021 Jun 7.

Institute of Environmental Science and Technology, The University of Kitakyushu, 1-1 Hibikino, Wakamatsu, Kitakyushu, Fukuoka 808-0135, Japan. Electronic address:

The Yangtze River, the third largest river in the world, has been polluted by various organic chemicals. In 2018, China decided to implement ecological restoration of the Yangtze River to protect the river. However, except for some conventional pollution indices such as COD (Chemical Oxygen Demand) and NH-N, the overall levels and risks of a wide variety of organic micropollutants (OMPs) in the Yangtze Estuary is not clear. Herein, results from a wide-range screening on levels and risks of OMPs in the Yangtze Estuary water were reported. 36 water samples were collected at 9 sites in the Yangtze Estuary in 2012 and 2013. Approximately 1200 OMPs were screened. A total of 131 OMPs were detected with total concentrations ranging from 1.8×10 to 9.7×10 ng/L. A tiered strategy was proposed to simplify the assessment of multi-substance ecological risks. Results showed that risk quotient (RQ) for 77% of the OMPs was less than 0.1. For 20 OMPs with RQ ≥ 0.1, joint probabilistic risks were assessed by species sensitivity distribution models. The joint risks as expressed by multi-substance potentially affected fractions are > 5%, and are not insignificant. The results may serve as a benchmark for protecting biodiversity in the Yangtze Estuary, as China motivated to have a fundamental improvement on the environmental quality by 2035.
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http://dx.doi.org/10.1016/j.watres.2021.117341DOI Listing
August 2021

All-in-one mitochondria-targeted NIR-II fluorophores for cancer therapy and imaging.

Chem Sci 2020 Nov 27;12(5):1843-1850. Epub 2020 Nov 27.

Department of Hematology, Zhongnan Hospital of Wuhan University, State Key Laboratory of Virology, Wuhan University School of Pharmaceutical Sciences Wuhan 430071 China

Small-molecule subcellular organelle-targeting theranostic probes are crucial for early disease diagnosis and treatment. The imaging window of these molecules is mainly focused on the visible and near-infrared region (below ∼900 nm) which limits the tissue penetration depth and therapeutic effects. Herein, a novel NIR-II small-molecule probe with a thiopyrylium cation was synthesized. not only can quickly and effectively image mitochondria in acute myeloid leukemia (AML) cells, and induce G/G phase arrest by the intrinsic mitochondrial apoptosis pathway w/o irradiation, but also exhibit moderate cytotoxicity against AML cancer cells in a dose dependent-manner without laser irradiation. The THP-1 cells treated with upon NIR laser irradiation showed enhanced chemo- and photothermal therapy (CPTT) with 93.07% ± 6.43 apoptosis by Annexin V staining. Meanwhile, displayed high synergistic CPTT effects , as well as specific NIR-II tumor imaging in AML patient derived PDX mouse models for the first time. Our work lays down a solid foundation for designing small-molecule NIR-II mitochondria-selective theranostic probes.
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http://dx.doi.org/10.1039/d0sc04727aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179124PMC
November 2020

Interfacially Engineered [email protected] Hollow Nanospheres for Glutathione Depleting Photothermally Enhanced Chemodynamic Therapy.

ACS Nano 2021 Jun 21. Epub 2021 Jun 21.

Department of Oncology, the First Affiliated Hospital of Anhui Medical University, 218 Jixi Road, Hefei 230036, P. R. China.

Fenton-like reactions driven by manganese-based nanostructures have been widely applied in cancer treatment owing to the intrinsic physiochemical properties of these nanostructures and their improved sensitivity to the tumor microenvironment. In this work, [email protected] composites incorporating alloyed ZnMnS and polydopamine (PDA) were constructed, in which the Fenton-like reactions driven by Mn ions can be tuned by a controllable release of Mn ions and . As a result, the [email protected] exhibited good biocompatibility with normal cells but was specifically toxic to cancer cells. In addition, the shell thickness of PDA was carefully investigated to obtain excellent specific toxicity to cancer cells and promote synergistic chemodynamic and photothermal therapies. Overall, this work highlights an alternative strategy for fabricating high-performance, multifunctional composite nanostructures for a combined cancer treatment.
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http://dx.doi.org/10.1021/acsnano.1c01077DOI Listing
June 2021

The cytoprotective role of omentin against oxidative stress-induced PC12 apoptosis.

Artif Cells Nanomed Biotechnol 2021 Dec;49(1):483-492

Medical Research Center, Xi'an No.3 Hospital, The Affiliated Hospital of Northwest University, Xi'an, China.

Oxidative stress has been proven to play a critical role in the pathogenesis of neuronal injury. As a novel adipocytokine, omentin is produced by visceral adipose with insulin sensitizing effects and has been revealed to possess anti-inflammatory effects. However, the possible effect of omentin on oxidative stress remains unknown. The present study aimed to detect the potential protective effect of omentin against hydrogen peroxide (HO)-induced cytotoxicity of PC12 cells. The results showed that no cytotoxic effect was shown in PC12 cells co-cultured with omentin alone at a concentration of 50-1000 ng/mL. The CCK8 and TUNEL assays suggested that omentin could remarkably attenuate apoptosis induced by 100 μM HO. The PCR and western blotting showed that the expression levels of Bax was significantly inhibited by omentin the upregulation of miR-128-3p at its 3'-UTR. Taken together, these results indicated that omentin protects PC12 cells against HO-induced apoptosis, and further studies need to be conducted before utilization in the clinic for the treatment of neurodegenerative diseases.
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http://dx.doi.org/10.1080/21691401.2021.1892707DOI Listing
December 2021

Methylation of three genes encoded by X chromosome in blood leukocytes and colorectal cancer risk.

Cancer Med 2021 Jul 18;10(14):4964-4976. Epub 2021 Jun 18.

Department of Epidemiology, Public Health College, Harbin Medical University, Harbin, Heilongjiang, The People's Republic of China.

X chromosome change has been proved to be associated with carcinogenesis and related to gender differences in cancer risk. If aberrant methylation of genes encoded by X chromosome involve in the risk and prognosis of cancers, including colorectal cancer (CRC), remain unclear. We conducted a case-control study consisted of 432 CRC cases and 434 controls, detecting the methylation levels of FAM156B, PIH1D3, and PPP1R3F in the X chromosome in blood leukocytes using methylation-sensitive high-resolution melting (MS-HRM). We analyzed the relationship between the methylation levels and CRC susceptibility and then explored the interactions with environmental factors on CRC risk with logistics regression. Moreover, we conducted a follow-up study containing 225 CRC patients to explore the associations between the methylation of FAM156B, PPP1R3F, and PIH1D3 and CRC prognosis. The hypermethylation of FAM156B, PPP1R3F, and PIH1D3 was related to increased CRC risk (OR  = 2.932, 95% confidence interval [CI]: 2.029-4.237; OR  = 1.602, 95% CI: 1.078-2.382; OR  = 1.628, 95% CI: 1.065-2.490, respectively). In the multiple CpG site methylation (MCSM) analysis, compared with non-MCSM, a significant relationship between MCSM and increased CRC risk was found (OR  = 2.202, 95% CI: 1.512-3.208). We observed synergistic interaction between PPP1R3F hypermethylation and fried food consumption on CRC risk (OR  = 2.682, 95% CI: 1.321-5.446). However, there were no associations between the methylation of FAM156B, PPP1R3F, and PIH1D3 and CRC prognosis (p > 0.05). In conclusion, the methylation of FAM156B, PPP1R3F, and PIH1D3 genes in blood leukocytes is significantly related to CRC risk and may be potential biomarkers for CRC risk but not prognosis.
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http://dx.doi.org/10.1002/cam4.4056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8290255PMC
July 2021

In reference to intraoperative dexmedetomidine for prevention of postoperative delirium in elderly patients with mild cognitive impairment.

Int J Geriatr Psychiatry 2021 Jun 18. Epub 2021 Jun 18.

Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

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http://dx.doi.org/10.1002/gps.5589DOI Listing
June 2021

Prognostic implications of pre-ablation stimulated Tg: a retrospective analysis of 2500 thyroid cancer patients.

J Clin Endocrinol Metab 2021 Jun 18. Epub 2021 Jun 18.

Department of Nuclear Medicine, West China Hospital, Sichuan University.

Context: The risk of persistent and recurrent disease in patients with differentiated thyroid cancer (DTC) is a continuum that ranges from very low to very high, even within the three primary risk categories. It is important to identify independent clinicopathological parameters to accurately predict clinical outcomes.

Objective: To examine the association between pre-ablation stimulated thyroglobulin (ps-Tg) and persistent and recurrent disease in DTC patients and investigate whether incorporation of ps-Tg could provide a more individualized estimate of clinical outcomes.

Design, Setting, And Participants: Medical records of 2524 DTC patients who underwent total thyroidectomy and radioiodine ablation between 2006 and 2018 were retrospectively reviewed.

Main Outcome Measure: Ps-Tg was measured under thyroid hormone withdrawal before remnant ablation. Association of ps-Tg and clinical outcomes.

Results: In multivariate analysis, age, ATA risk stratification, M1, ps-Tg and cumulative administered activities were the independent predictive factors for persistent/ recurrent disease. Receiver operating characteristic analysis identified ps-Tg cutoff (≤ 10.1 ng/mL) to predict disease free status with a negative predictive value of 95%, and validated for all ATA categories. Integration of ps-Tg into ATA risk categories indicated that the presence of ps-Tg ≤ 10.1 ng/mL was associated with a significantly decreased chance of having persistent/recurrent disease in intermediate- and high-risk patients (9.9 to 4.1% in intermediate-risk patients, and 33.1 to 8.5% in high-risk patients).

Conclusion: Ps-Tg (≤ 10.1 ng/mL) was a key predictor of clinical outcomes in DTC patients. Its incorporation as a variable in the ATA risk stratification system could more accurately predict clinical outcomes.
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http://dx.doi.org/10.1210/clinem/dgab445DOI Listing
June 2021

Prevalence of bovine tuberculosis in dairy cattle in China during 2010-2019: A systematic review and meta-analysis.

PLoS Negl Trop Dis 2021 Jun 17;15(6):e0009502. Epub 2021 Jun 17.

College of Veterinary Medicine, Qingdao Agricultural University, Qingdao, Shandong Province, PR China.

Background: Bovine tuberculosis (bTB), caused by members of the Mycobacterium tuberculosis complex bacteria, mainly Mycobacterium bovis (M. bovis), is a major threat to public health and economic development. There has been no systematic epidemiological assessment concerning bTB in dairy cattle in China.

Methodology/principal Findings: Literature related to bTB in China was retrieved from China National Knowledge Infrastructure (CNKI), PubMed, ScienceDirect, VIP Chinese Journals Database, and Wan Fang Database to build the first meta-analysis for estimating the prevalence and infection moderators of bTB in dairy cattle in China. A total of 100 relevant studies published from 2010 to 2019 were included. We estimated the overall prevalence of bTB was 2.4% (95% CI: 2.1-2.8) during this decade. In the sampling year subgroup, the prevalence was lowest in 2017 or later at 0.8% (95% CI: 0.3-1.5). The lowest prevalence was 0.7% (95% CI: 0.5-1.0) in Northwestern China. The lowest prevalence was 2.1% (95% CI: 1.8-2.5) using SIT test. Heifer cows had the highest prevalence, which was 27.1% (95% CI: 9.7-49.2). The prevalence in scale farming was 3.7% (95% CI: 3.1-4.3), significantly higher than that in free-range farming (1.7%, 95% CI: 1.1-2.4). The prevalence of bTB was highest in summer at 4.0% (95% CI: 1.7-7.0). In addition, the influence of different geographical factors (altitude, longitude, latitude, precipitation, temperature, humidity) on the prevalence was analyzed.

Conclusions/significance: The results showed that bTB was widespread in China but has been gradually reduced through concerted national intervention. It is suggested that different countries should formulate corresponding prevention and control measures according to the epidemic situation in its cattle industry. Enhanced monitoring of warm and humid areas may play an important role in reducing the incidence of bTB. In addition, when large-scale breeding is promoted, attention should be paid to standardizing breeding management and improving animal welfare to reduce the prevalence of bTB in cattle.
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http://dx.doi.org/10.1371/journal.pntd.0009502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8241035PMC
June 2021

CsZnSnS: A Sulfide Compound Realizes a Large Birefringence by Modulating the Dimensional Structure.

Inorg Chem 2021 Jul 16;60(13):9248-9253. Epub 2021 Jun 16.

College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620, China.

Birefringence, an important optical performance parameter for optoelectronic functional materials, is mainly influenced by the types of anion groups and their spatial arrangement. Inspired by the relationship between the structure and properties of chalcogenides, combined with the dimensional transformation, we successfully synthesized a sulfide compound (CsZnSnS) with a two-dimensional layered structure and a large birefringence. The experimental results showed that, compared with RbZnSnS, CsZnSnS achieved the structural transition from a zero-dimensional arrangement to a two-dimensional lamellar arrangement and achieved a breakthrough of birefringence from 0 to 0.12, which was determined by both experiments and first-principles calculations. These findings demonstrated that CsZnSnS was a potential birefringent material and provided instructions for the study of the synthesis of birefringent materials.
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http://dx.doi.org/10.1021/acs.inorgchem.1c01024DOI Listing
July 2021
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