Publications by authors named "Thuong Nguyen Van"

52 Publications

Kinetics of CD4 T Helper and CD8 Effector T Cell Responses in Acute Dengue Patients.

Front Immunol 2020 24;11:1980. Epub 2020 Sep 24.

Department of Immunogenetics, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki, Japan.

The protective or pathogenic role of T lymphocytes during the acute phase of dengue virus (DENV) infection has not been fully understood despite its importance in immunity and vaccine development. This study aimed to clarify the kinetics of T lymphocyte subsets during the clinical course of acute dengue patients. In this hospital-based cohort study, 59 eligible Vietnamese dengue patients were recruited and admitted. They were investigated and monitored for T cell subsets and a panel of clinical and laboratory parameters every day until discharged and at post-discharge from the hospital. We described for the first time the kinetics of T cell response during the clinical course of DENV infection. Severe cases showed significantly lower levels of effector CD8 T cells compared to mild cases at day -1 ( = 0.017) and day 0 ( = 0.033) of defervescence. After defervescence, these cell counts in severe cases increased rapidly to equalize with the levels of mild cases. Our results also showed a decline in total CD4 T, Th1, Th1/17 cells during febrile phase of dengue patients compared to normal controls or convalescent phase. On the other hand, Th2 cells increased during DENV infection until convalescent phase. Cytokines such as interferon-γ, IL-12p70, IL-5, IL-23, IL-17A showed tendency to decrease on day 0 and 1 compared with convalescence and only IL-5 showed significance indicating the production during acute phase was not systemic. With a rigorous study design, we uncovered the kinetics of T cells in natural DENV infection. Decreased number of effector CD8 T cells in the early phase of infection and subsequent increment after defervescence day probably associated with the T cell migration in DENV infection.
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http://dx.doi.org/10.3389/fimmu.2020.01980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7542683PMC
April 2021

A Mathematical Model for the Signal of Death and Emergence of Mind Out of Brain in Izhikevich Neuron Model.

Open Access Maced J Med Sci 2019 Sep 11;7(18):3121-3126. Epub 2019 Sep 11.

Department of Dermatology, University of G. Marconi, Rome, Italy.

Aim: In this paper, using a mathematical model, we will show that for special exchanged photons, the Hamiltonian of a collection of neurons tends to a constant number and all activities is stopped. These photons could be called as the dead photons. To this aim, we use concepts of Bio-BIon in Izhikevich Neuron model.

Methods: In a neuron, there is a page of Dendrite, a page of axon's terminals and a tube of Schwann cells, axon and Myelin Sheath that connects them. These two pages and tube form a Bio-Bion. In a Bio-Bion, exchanging photons and some charged particles between terminals of dendrite and terminals of axon leads to the oscillation of neurons and transferring information. This Bion produces the Hamiltonian, wave equation and action potential of Izhikevich Neuron model. Also, this Bion determines the type of dependency of parameters of Izhikevich model on temperature and frequency and obtains the exact shape of membrane capacitance, resting membrane potential and instantaneous threshold potential.

Results: Under some conditions, waves of neurons in this BIon join to each other and potential shrinks to a delta function. Consequently, total Hamiltonian of the system tends to a constant number and system of neuron act like a dead system. Finally, this model indicates that all neurons have the ability to produce similar waves and signals like waves of the mind.

Conclusion: Generalizing this to biology, we can claim that neurons out of the brain can produce signals of minding and imaging and thus mind isn't confined to the brain.
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http://dx.doi.org/10.3889/oamjms.2019.774DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910805PMC
September 2019

Psychotherapy Role in Treatment of Chronic Spontaneous Urticaria in a 32 Years Old Female Patient.

Open Access Maced J Med Sci 2019 Sep 30;7(18):3118-3120. Epub 2019 Aug 30.

Department of Dermatology, University of G. Marconi, Rome, Italy.

As indicated by the latest scientific evidence, the lines between different fields of medicine gradually blur and overlap more and more. Psychiatry and dermatology have seen this trend in the last decade as an ever-increasing number of studies suggest the strong connection of many dermatological syndromes and diseases with psychiatric conditions and vice versa. It seems that the relationship is more intertwined than previously believed and the effects of different multidisciplinary approaches to diagnostic and treatment are being considered. The aim of this case report is to highlight the effect of psychotherapy on chronic spontaneous urticaria which is tightly related to the maladaptive stress response.
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http://dx.doi.org/10.3889/oamjms.2019.773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910793PMC
September 2019

Formation of Neural Circuits in an Expanded Version of Darwin's Theory: Effects of DNAs in Extra Dimensions and within the Earth's Core on Neural Networks.

Open Access Maced J Med Sci 2019 Sep 10;7(18):3113-3117. Epub 2019 Sep 10.

Department of Dermatology, University of G. Marconi, Rome, Italy.

Aim: In this paper, inspiring Darwin's theory, we propose a model which connects evolutions of neural circuits with evolutions of cosmos. In this model, in the beginning, there are some closed strings which decay into two groups of open strings.

Methods: First group couple to our universe from one side and produce matters like some genes of DNAs and couple to an anti-universe from another side with opposite sign and create anti-matters like some anti-genes of anti-DNAs. Second group couple to the star and planet's cores like the earth's core from one side and produce anti-matters like stringy black anti-DNA and couple to outer layers of stars and planets like the earth from other side and produce matters like some genes of DNAs on the earth. Each DNA or anti-DNA contains some genetic circuits which act like the circuits of receiver or sender of radio waves. To transfer waves of these circuits, some neurons emerge which some of them are related to genetic circuits of anti-DNAs in anti-universe, and some are related to genetic circuits of stringy black anti-DNA within the earth's core. A collection of these neural circuits forms the little brain on the heart at first and main brain after some time.

Results: To examine the model, we remove effects of matters in outer layers of earth in the conditions of microgravity and consider radiated signals of neural circuits in a chick embryo. We observe that in microgravity, more signals are emitted by neural circuits respect to normal conditions. This is a signature of exchanged waves between neural circuits and structures within the earth's core.

Conclusion: These communications help some animals to predict the time and place of an earthquake.
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http://dx.doi.org/10.3889/oamjms.2019.769DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910808PMC
September 2019

Beta Blockers and Melanoma.

Open Access Maced J Med Sci 2019 Sep 30;7(18):3110-3112. Epub 2019 Aug 30.

Department of Dermatology, University of G. Marconi, Rome, Italy.

Understanding the mechanisms of cancer immune-tolerance is one of the most important challenges. Several studies have demonstrated the potential anticarcinogenic effects of beta-blockers, in patients with prostate cancer, breast cancer, and melanoma. At the other side variety of dermatoses may be caused or aggravated by β-blockers-psoriasis, lichen planus-like drug eruptions (LDE), acrocyanosis, alopecia etc. Beta-blockers have been shown to improve the prognosis of melanoma patients significantly. Propranolol inhibits melanoma by downregulating the tumour angiogenesis but also tumour cell proliferation, invasiveness and local immune suppression. Studies showed that only β3-but, not β2-adrenoceptors, were up-regulated under hypoxia in peripheral blood mononuclear cells and selectively expressed in immune cell sub-populations including Treg, MDSC, and NK. They increased NK and CD8 number and cytotoxicity. Catecholamines may retard melanoma progression and that β-blockers may have unrecognised potential as a therapeutic intervention for melanoma, in the prevention of the growth of melanoma in all stages and as adjuvant therapy with other targeted and immune therapies for melanoma.
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http://dx.doi.org/10.3889/oamjms.2019.781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910815PMC
September 2019

In Ovo Sexing of Chicken Eggs by Virus Spectroscopy.

Open Access Maced J Med Sci 2019 Sep 12;7(18):3106-3109. Epub 2019 Sep 12.

Department of Dermatology, University of G. Marconi, Rome, Italy.

Recently, some new methods for sexing of chicken eggs by fluorescence and Raman spectroscopy through the shell membrane have been proposed. On the other hand, in another investigation, a new virus medical imaging has been suggested. In this research, summing over these considerations, a new technique for sexing of chicken eggs by virus spectroscopy through the shell membrane is proposed. It is shown that viruses outside the shell of egg can communicate with materials inside it and determine the gender of chick embryo and it's evolutions.
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http://dx.doi.org/10.3889/oamjms.2019.768DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910803PMC
September 2019

The Effects of Magnesium - Melatonin - Vit B Complex Supplementation in Treatment of Insomnia.

Open Access Maced J Med Sci 2019 Sep 30;7(18):3101-3105. Epub 2019 Aug 30.

Department of Dermatology, G. Marconi University, Rome, Italy.

Insomnia means difficulty in falling asleep and/or stays asleep. Insomnia commonly leads to daytime sleepiness, lethargy, and a general feeling of being unwell. The most common treatment of insomnia includes GABAA receptor positive allosteric modulators or Melatonin agonists. Our study aimed to evaluate the efficacy of Magnesium- melatonin-vitamin B complex supplement in the treatment of insomnia. The study included 60 patients diagnosed with insomnia. The patients were randomly divided into study group (N = 30), and control group (N = 30), and study group was treated with Magnesium-melatonin-vitamin B complex (one dose contains 175 mg liposomal magnesium oxide, 10 mg Vit B6, 16 μg vit B12, melatonin 1 mg, Extrafolate-S 600 μg) once a day 1 hour before sleep, during the 3 months. The severity of insomnia symptoms was measured by self-reported Athens insomnia scale (AIS), with a cut-off score by Soldatos (AIS score ≥ 6). Mean AIS score at zero points was 14.93 ± 3.778 in the study group and 14.37 ± 4.081 in the control group (p = 0.476), indicating the compatibility of the groups, and both scores correspond to mild to moderate insomnia. Mean AIS score after 3 months of the Magnesium- melatonin- vitamin B complex supplementation was 10.50 ± 4.21 corresponding to mild insomnia, while median AIS score in the control group was 15.13 ± 3.76 which is referred to moderate insomnia, and difference among groups was significant (p = 0.000). Our founding's indicating that 3 months of the Magnesium- melatonin-vitamin B complex supplementation has a beneficial effect in the treatment of insomnia regardless of cause.
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http://dx.doi.org/10.3889/oamjms.2019.771DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910806PMC
September 2019

DNA Waves and Their Applications in Biology.

Open Access Maced J Med Sci 2019 Sep 11;7(18):3096-3100. Epub 2019 Sep 11.

Department of Dermatology, University of G. Marconi, Rome, Italy.

Aim: In this research, we show that DNA waves have many applications in biology. DNA is formed by the joining of quantum particles like electrons and charged atoms. DNA has different motions during transcription, translation, and replication, in which the charged particles move, accelerate, and emit waves. Thus, DNA could emit quantum waves.

Methods: Two methods are proposed to observe the effect of DNA waves. The first proposed method measures DNA waves emitted by bacteria suspended in the milk. The vessel of milk is placed in the interior of an inductor. One side of the vessel is connected to a generator and another side to a scope. By sending a current to the inductor, an input electromagnetic field is produced. Bacteria interact with the input field, change it and produce new output signals. Using the scope, the output signals are observed and compared with the input signals. The number of DNA waves produced also depends on temperature.

Results: At lower temperatures, bacterial replication is less, and fewer DNA waves are produced. Conversely, more bacteria are generated at higher temperatures, and more DNA waves are produced. The second proposed method acquires and images of DNA signals of chick embryos. In this method, a circuit is constructed that consists of a graphene or metal tube, generator, inductor, scope, DNA in the interior of eggs and DNA exterior to the eggs. Magnetic waves pass the interior and exterior DNA as well as the graphene. The DNA is excited and the exciting interior/exterior DNA exchanges waves. Some of these waves interact with electrons in the graphene tube, and a current is generated. Properties of the chick embryo DNA can be explored by analysing changes in the waves that emerge from the eggs.

Conclusion: It is concluded that DNA waves could be used extensively in imaging and provide for us the exact information about evolutions of DNAs interior of biological systems.
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http://dx.doi.org/10.3889/oamjms.2019.767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910796PMC
September 2019

New Trends in Cutaneous Melanoma Surgery.

Open Access Maced J Med Sci 2019 Sep 14;7(18):3090-3092. Epub 2019 Sep 14.

Department of Dermatology, University of G. Marconi, Rome, Italy.

The main surgical treatment for melanoma consists in wide surgical excision of the primary lesion and the sentinel node but in recent times management of melanoma is rapidly evolving with the introduction of new systemic therapies, like BRAF inhibitors, MEK inhibitors and antibodies anti-PD-1 that show good results in controlling even advanced stages of the disease. This review aims to present data for the optimal surgical management of patients with malignant melanoma.
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http://dx.doi.org/10.3889/oamjms.2019.828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910799PMC
September 2019

Recovery of Brain in Chick Embryos by Growing Second Heart and Brain.

Open Access Maced J Med Sci 2019 Sep 30;7(18):3085-3089. Epub 2019 Aug 30.

Department of Dermatology, University of G. Marconi, Rome, Italy.

To recover chick embryos damaged the brain, two methods are presented. In both of them, somatic cells of an embryo introduced into an egg cell and an embryo have emerged. In one method, injured a part of the brain in the head of an embryo is replaced with a healthy part of the brain. In the second method, the heart of brain embryo dead is transplanted with the embryo heart. In this mechanism, new blood cells are emerged in the bone marrow and transmit information of transplantation to subventricular zone (SVZ) of the brain through the circulatory system. Then, SVZ produces new neural stem cells by a subsequent dividing into neurons. These neurons produce new neural circuits within the brain and recover the injured brain. To examine the model, two hearts of two embryos are connected, and their effects on neural circuits are observed.
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http://dx.doi.org/10.3889/oamjms.2019.777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910787PMC
September 2019

A Black Hole at the Center of Earth Plays the Role of the Biggest System of Telecommunication for Connecting DNAs, Dark DNAs and Molecules of Water on 4+N- Dimensional Manifold.

Open Access Maced J Med Sci 2019 Sep 30;7(18):3073-3080. Epub 2019 Aug 30.

Department of Dermatology, University of G. Marconi, Rome, Italy.

Recently, some scientists from NASA have claimed that there may be a black hole like structure at the centre of the earth. We show that the existence of life on the earth may be a reason that this black hole like object is a black brane that has been formed from biological materials like DNA. Size of this DNA black brane is 109 times longer than the size of the earth's core and compacted interior it. By compacting this long object, a curved space-time emerges, and some properties of black holes emerge. This structure is the main cause of the emergence of the large temperature of the core, magnetic field around the earth and gravitational field for moving around the sun. Also, this structure produces some waves which act like topoisomerase in biology and read the information on DNAs. However, on the four-dimensional manifold, DNAs are contracted at least four times around various axis's and waves of earth couldn't read their information. While, by adding extra dimensions on 4 +n-dimensional manifold, the separation distance between particles increases and all of the information could be recovered by waves. For this reason, each DNA has two parts which one can be seen on the four-dimensional universe, and another one has existed in extra dimensions, and only it's e_ects is observed. This dark part of DNA called as a dark DNA in an extra dimension. These dark DNAs not only exchange information with DNAs but also are connected with some of the molecules of water and helps them to store information and have memory. Thus, the earth is the biggest system of telecommunication which connects DNAs, dark DNAs and molecules of water.
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http://dx.doi.org/10.3889/oamjms.2019.776DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910781PMC
September 2019

Clinical Applications of System Regulation Medicine.

Open Access Maced J Med Sci 2019 Sep 14;7(18):3053-3060. Epub 2019 Sep 14.

Department of Dermatology, University of G. Marconi, Rome, Italy.

Increasing incidence and poor outcome of chronic non-communicable diseases in western population would require a paradigm shift in the treatments. Guidelines-based medical approaches continue to be the standard rule in clinical practice, although only less than 15% of them are based on high-quality research. For each person who benefits from the 10 best-selling drugs in the USA, a number between 4 and 25 has no one beneficial effect. The reductionist linear medicine method does not offer solutions in the non-manifest preclinical stage of the disease when it would still be possible to reverse the pathological progression and the axiom "a drug, a target, a symptom" are still inconclusive. Needs additional tools to address these challenges. System Medicine considers the disease as a dysregulation of the biological networks that changes throughout the evolution of the pathological process and with the comorbidities development. The strength of the networks indicates their ability to withstand dysregulations during the perturbation phases, returning to the state of stability. The treatment of dysregulated networks before the symptomatological manifestation emerges offers the possibility of treating and preventing pathologies in the preclinical phase and potentially reversing the pathological process, stopping it or preventing comorbidities. Furthermore, treating shared networks instead of individual phenotypic symptoms can reduce drug use, offering a solution to the problem of ineffective drug use.
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http://dx.doi.org/10.3889/oamjms.2019.775DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910802PMC
September 2019

New System Delivering Microwaves Energy for Inducing Subcutaneous Fat Reduction: In - Vivo Histological and Ultrastructural Evidence.

Open Access Maced J Med Sci 2019 Sep 30;7(18):2991-2997. Epub 2019 Aug 30.

Clinic for Psychiatric Disorders "Dr. Laza Lazarevic", Belgrade, Serbia.

Background: Recently, it has been developed a new technology for the reduction of subcutaneous adipose tissue through a non-invasive treatment by microwaves. The main objective of the present study is to demonstrate the feasibility of utilising a non-invasive, localised microwaves (MW) device to induce thermal modifications into subcutaneous adipose tissue only by a controlled electromagnetic field that heats up fat preferentially. This device is provided with a special handpiece appropriately cooled, directly contacting the cutaneous surface of the body, which provides a calibrated energy transfer by microwaves.

Aim: In this paper, microscopic and ultrastructural modifications of subcutaneous adipose tissue induced by microwaves irradiation are evaluated.

Methods: Our experimental plan was designed for collecting biopsy samples, for each skin region treated with a single irradiation session, 1) before treatment (control), 2) immediately after treatment, 3) after 6 hrs, 4) after 1 month, 5) after 2 months. Bioptic samples from each step were processed for light microscopy and transmission electron microscopy. At the same time, each region where biopsies were collected was subjected to ultrasound examination. Recorded images permitted to evaluate the thickness of different layers as epidermis, dermis, hypodermis, connective fasciae, until to muscle layer, and related modifications induced by treatment.

Results: In every biopsy collected at different time-steps, epidermis and superficial dermis appeared not modified compared to control. Differently, already in the short-term biopsies, in the deep dermis and superficial hypodermis, fibrillar connective tissue appeared modified, showing reduction and fragmentation of interlobular collagen septa. The most important adipose tissue modifications were detectable following 1 month from treatment, with a significant reduction of subcutaneous fat, participating both the lysis of many adipocytes and the related phagocytic action of monocytes/macrophages on residuals of compromised structures of adipocytes. In the samples collected two months following treatment, the remnants of adipose tissue appeared normal, and macrophages were completely absent.

Conclusions: Ultrasound, microscopic and ultrastructural evidence are supporting significant effectiveness of the new device treatment in the reduction of subcutaneous fat. In this paper, the possible mechanisms involved in the activation of the monocytes/macrophages system responsible for the removal of adipocytes residuals have also been discussed.
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http://dx.doi.org/10.3889/oamjms.2019.778DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910790PMC
September 2019

Botulin Toxin Use in Rosacea and Facial Flushing Treatment.

Open Access Maced J Med Sci 2019 Sep 30;7(18):2985-2987. Epub 2019 Aug 30.

Department of Dermatology, University of G. Marconi, Rome, Italy.

Botulinum toxin (BTX) is a neurotoxin derived from the Clostridium botulinum bacterium that inhibits the release of acetylcholine at the neuromuscular junction level whose effects has been used for many years to treat a variety of muscular/neuromuscular conditions and more recently also for cosmetic use. BTX has experimented in some dermatological conditions, which include Rosacea and facial flushing treatment with good results. The complex mechanism underlying those results is not completely understood but was proposed a release inhibition of acetylcholine from peripheral autonomic nerves of the cutaneous vasodilatory system combined with the blockade substance P and calcitonin gene-related peptide (CGRP) thus modulating blood vessel dilatation. We analysed the published data on BTX off label applications rosacea and flushing retrieved from PubMed.
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http://dx.doi.org/10.3889/oamjms.2019.784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910814PMC
September 2019

Botulin Toxin Use in Scars/Keloids Treatment.

Open Access Maced J Med Sci 2019 Sep 30;7(18):2979-2981. Epub 2019 Aug 30.

Department of Dermatology, University of G. Marconi, Rome, Italy.

Botulinum toxin (BTX) is a neurotoxin protein derived from the Clostridium botulinum bacterium that inhibits the release of acetylcholine at the neuromuscular junction level whose effects has been used for many years to treat a variety of muscular/neuromuscular conditions and more recently also for cosmetic use. BTX has experimented in some dermatological conditions which include scar prevention and treatment with good results The complex mechanism underlying those results is not completely understood but several mechanisms were proposed release inhibition of different substances like (TGF)-β, substance P, calcitonin gene-related peptide (CGRP) and glutamate thus modulating cutaneous inflammation and wound healing. We analysed the published data on BTX off label applications on scars and keloids retrieved from PubMed.
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http://dx.doi.org/10.3889/oamjms.2019.783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910812PMC
September 2019

Autologous Fat Graft: Not Only an Aesthetic Solution.

Open Access Maced J Med Sci 2019 Sep 30;7(18):2961-2963. Epub 2019 Aug 30.

Department of Dermatology, University of G. Marconi, Rome, Italy.

Subcutaneous adipose tissue was defined as the "perfect filler" as is soft and malleable and is usually enough present in the body for correcting volume defects and small remodelling purposes. The first attempts to implant autologous adipose tissue dates back to the end of the twentieth century, and with the refinement of harvesting, processing and replanting techniques today a uniform and predictable amount of survival rate were achieved. Those improvements have led to wider use of autologous fat grafts in many medical specialities not only in aesthetic or reconstructive treatments.
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http://dx.doi.org/10.3889/oamjms.2019.781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910800PMC
September 2019

Quality of Life in Psoriasis Vietnamese Patients Treated with Metformin in Combination with Methotrexate.

Open Access Maced J Med Sci 2019 Jan 27;7(2):302-303. Epub 2019 Jan 27.

University of Rome G. Marconi, Rome, Italy.

A cross-sectional study was performed on 48 psoriasis Vietnamese patients treated with metformin as an add-on for methotrexate and 48 psoriasis patients treated methotrexate alone. The mean PASI scores were 5.25 ± 5.72. Total QOL scores had a slight difference between patients treated metformin combined with methotrexate and methotrexate alone (62.32 ± 18.1 vs 60.91 ± 19.63). Combined therapy with metformin and methotrexate contributes to significantly improve the quality of life for patients with psoriasis.
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http://dx.doi.org/10.3889/oamjms.2019.066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364721PMC
January 2019

Successful Treatment of Intralesional Bleomycin in Keloids of Vietnamese Population.

Open Access Maced J Med Sci 2019 Jan 29;7(2):298-299. Epub 2019 Jan 29.

University of Rome G. Marconi, Rome, Italy.

Background: Keloid is an overactive condition of the skin tissue to early lesions characterised by proliferation of fibroblasts, excessive collagen production in the lesion. Treatment of keloids is a big challenge because of the poor response rate and high risk of recurrence after treatment. We found that bleomycin offers promise in the treatment of keloids.

Aim: To evaluate the efficacy of bleomycin injected in the injury for keloids treatment.

Methods: The treatment was carried out in 55 patients having 120 keloids of different sizes and locations. Average treatments were 4 times.

Results: Complete flattening was 70.8%, highly significant flattening was 8.3%, no patient of minimal flattening. Systemic side-effects of bleomycin were not evaluated, but local side-effects were mainly pains (100%), blisters (78.3%), ulceration (5.8%), and hyperpigmentation (56.7%).

Conclusion: The percentage of patients recurring 6, 12, 15, 18 months after the last treatment were 3.8, 15.4, 45.5, 50%, respectively.
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http://dx.doi.org/10.3889/oamjms.2019.099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364735PMC
January 2019

Microneedling Therapy for Atrophic Acne Scar: Effectiveness and Safety in Vietnamese Patients.

Open Access Maced J Med Sci 2019 Jan 29;7(2):293-297. Epub 2019 Jan 29.

University of Rome G. Marconi, Rome, Italy.

Aim: To evaluate the effectiveness and safety of micro-needling therapy in atrophic acne scar treatment.

Method: A prospective, single centred study was implemented in a total of 31 patients suffering from atrophic acne scar grade 2 to 4 of Goodman and Baron scaring grading system was recruited. They were treated by microneedle derma roller every week in 3 months. The scars were evaluated by a magic system camera and by dermatologists clinically using Goodman and Baron scaring grading system, and Lipper and Perez score at baseline, at final treatment, 1 month and 2 months after the final treatment.

Results: The results showed improvement in all patients. The mean of Goodman and Barron's grade was decreased from 3.29 ± 0.59 at baseline, 2.23 ± 0.56 at final treatment, 1.93 ± 0.58 one month after the completion of therapy and to 1.77 ± 0.57 two months after the completion of therapy (with the p-value < 0.05). Similarly, Lipper and Perez score also dropped significantly from 36.48 ± 12.07 at baseline to 23.16 ± 15.01 at final treatment, to 17.83 ± 7.00 one month after the final treatment and to 16.37 ± 7.29 at two months after the final treatment (p-value < 0.05). Skin roughness and hyperpigmented spots got improved significantly. History of having nodular-cystic or vulgaris acne did not affect the effectiveness of the therapy. Side effects of the therapy were burning sensation, erythema but they were very mild and recovered in 1-2 days. No severe complication and post-inflammatory hyperpigmentation were noted. 83.3% of the patients satisfied after the completion of the therapy.

Conclusion: Skin needling is an effective and safe method for the treatment of atrophic acne scars.
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http://dx.doi.org/10.3889/oamjms.2019.098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364723PMC
January 2019

The Effectiveness of Oral Mini-Pulse Methylprednisolonein - the Treatment of Alopecia Areata in Vietnam.

Open Access Maced J Med Sci 2019 Jan 29;7(2):291-292. Epub 2019 Jan 29.

University of Rome G. Marconi, Rome, Italy.

Background: Systemic corticosteroid is used to treat alopecia areata, but it is associated with side effects. Mini-pulse therapy is thought to be effective but able to reduce side effects.

Aim: The study aimed to evaluate the effectiveness of oral mini-pulse methylprednisolone in the treatment of alopecia areata.

Methods: Patients received methylprednisolone 16 mg orally for 2 consecutive days every week.

Results: After 3 months, among patients, 40% recovered well, and 55.6% recovered fairly. After 6 months, 82.2% recovered well, 17.8% recovered fairly. No adverse events were detected, and the recurrence rate was low (2.2%).

Conclusion: Oral mini-pulse methylprednisolone therapy is an effective and safe therapeutic option for alopecia areata without side effects, and the time of the treatment is short.
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http://dx.doi.org/10.3889/oamjms.2019.097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364712PMC
January 2019

Successful Treatment of Freckles by Alex Trivantage Laser Wavelight 755 nm in Vietnamese Patients.

Open Access Maced J Med Sci 2019 Jan 29;7(2):287-290. Epub 2019 Jan 29.

University of Rome G. Marconi, Rome, Italy.

Objectives: This study aims to evaluate the effectiveness of Alex Trivantage laser wavelength 755 nm (ATL) in the treatment of freckles at Hanoi Hospital of Dermatology and Venereology, Vietnam.

Patients And Methods: A group of 30 patients with freckles were treated by ATL (Alex Trivantage-Candela Co America) with spots size 3 mm, wavelength 755 mm, and energy 5-6 j/cm. All the patients were treated 2 times with 4-weeks interval. The results were evaluated at 4, 8, and 12 weeks after treatment. The colour of the lesions was evaluated by using Von-Luchan's chromatic scale and Visia® complex analysis system. Brown spot index (BSI) was calculated by the VISA complexion analysis system devices. The data was analysed by SPSS 16.0.

Results: After 2 times of treatment, the lesion colour of all of the patients had been improved. The good and very good levels of improvement were noted in 63.3% of patients; there was 26.7% of them had partial improvement. Brown spots index was significantly improved (39.13 ± 20.66 before and 54.23 ± 16.78 after treatment; p < 0.001). Hyperpigmentation was noted in 6.7% of patients.

Conclusion: freckles have been improved by treatment with Alex trivantage laser wavelength 755 nm with safety.
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http://dx.doi.org/10.3889/oamjms.2019.096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364722PMC
January 2019

Successful Treatment of Vitiligo Vietnamese Patients with Vitilinex® Herbal Bio-Actives in Combination with Phototherapy.

Open Access Maced J Med Sci 2019 Jan 29;7(2):283-286. Epub 2019 Jan 29.

University of Rome G. Marconi, Rome, Italy.

Background: Vitiligo is an acquired pigmentary disease, that causes progressive loss of melanocytes, resulting in hypopigmented skin patches. Current treatments aim at stopping the disease progression and achieving repigmentation of the amelanotic areas. Corticosteroids, surgery, topical immunomodulators, total depigmentation of normal pigmented skin and phototherapy are current treatment options for vitiligo although phototherapy remains the treatment of choice. There is no documented evidence that herbal bio-active products may also be effective treatment options for vitiligo.

Aim: This study aimed to investigate the efficacy and safety of Vitilinex® (herbal bio- actives) alone and in combination with UVB narrowband (311 nm) phototherapy, in the treatment of localised stable or active forms of vitiligo.

Material And Methods: Sixty two subjects with mean age 34.5 years (range: 18-58 years) with mild to moderate vitiligo, consisting of 36 females and 26 males were randomly divided into three treatment groups - Group A (13 females, 10 males) treated with Vitilinex® alone; Group B (12 females, 11 males) were treated with Vitilinex® in combination with narrowband UVB (311 nm) phototherapy for 15 seconds, using a handheld lamp and Group C (8 females, 8 males) were treated with nbUVB (311 nm) phototherapy alone, for 15 seconds over a 12-week period.

Results: In Group A, 9 patients (39%) achieved outstanding improvement with a re-pigmentation rate higher than 75%, with 2 patients experiencing total repigmentation. 6 patients (26%) had marked improvement with a repigmentation rate between 50-75% while 5 patients (22%) showed a moderate response between 25-50% re-pigmentation rate. 3 patients (13%) had minimal or no improvement. In Group B, 16 patients (69.5%) achieved outstanding improvement with a re-pigmentation rate higher than 75%, with 12 patients experiencing total re-pigmentation. 4 patients (17.5 %) achieved a marked improvement with a re-pigmentation rate between 50-75%; 2 patients (8.7%) showed a moderate response with a re-pigmentation rate between 25-50%. 1 (4.3%) patient had minimal or no improvement. In Group C, 6 patients (37.5%) achieved a re-pigmentation rate higher than 75%, with 2 patients experiencing total re-pigmentation. 4 patients (25%) achieved marked improvement with a re-pigmentation rate between 50-75% while 3 patients (18.75%) had a re-pigmentation rate between 25-50%. 3 patients (18.75%) had minimal or no improvement.

Conclusion: Vitilinex® herbal bio-actives in combination with nbUVB is a more effective treatment option for vitiligo with 87% of the patients achieving a re-pigmentation rate higher than 50%, compared to Vitilinex® alone (65%) or nbUVB alone (62.5%).
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http://dx.doi.org/10.3889/oamjms.2019.095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364738PMC
January 2019

Successful Treatment of Intralesional Triamcilonon Acetonide Injection in Keloid Patients.

Open Access Maced J Med Sci 2019 Jan 28;7(2):275-278. Epub 2019 Jan 28.

University of Rome G. Marconi, Rome, Italy.

Aim: Evaluation the effect of intralesional corticosteroid injection on keloid, at the National Hospital of Dermatology and Venereology from 1/2009 to 12/2009.

Methods: A group of 65 patients with keloid were randomly assigned into three groups. In the studied group, 33 patients were intralesionally injected 7.5 mg/1 cm of TCA. In the control group, TAC 32 patients were intralesionally injected 15 mg/1 cm of TCA. The result was evaluated basing on the criteria of Henderson (1998) and El-Tonsy (1996).

Results: In comparison between 2 groups, good to excellent improvement in the studied group was statistically higher than the control group (90.7% versus 68.7%; p < 0.05). After each injection, the thickness of the scar was reduced 1.24 ± 0.53 mm in the studied group and 0.81 ± 0.39 mm in the control group. The disappearance of pain and itching after treatment were 86.6% and 95.5% in the studied group and 78.1% and 80% in the control group (p > 0.05). Ulceration, acne and troublesome with menstrual cycles were sometimes were noted more frequently in the control group than in the studied group.

Conclusion: Intralesional triamcinolone acetonide injection had a good result, and 7.5 mg/1 cm scar is the best dose for treatment of keloid.
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http://dx.doi.org/10.3889/oamjms.2019.093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364710PMC
January 2019

Efficacy of Azole Antifungal in Treatment of Pityriasis Versicolor.

Open Access Maced J Med Sci 2019 Jan 28;7(2):272-274. Epub 2019 Jan 28.

Psoriasis Eczema Clinic, Melbourne, Australia.

Aim: Compare itraconazole alone, fluconazole combined with ketoconazole and ketoconazole in the treatment of patients with pityriasis versicolor.

Material And Methods: A group of 240 pityriasis versicolor patients (confirmed with KOH and culture) were classified into 3 groups: Fluconazole 300 mg a week and 2% ketoconazole foam twice a week for 2 weeks (Category I), Itraconazole 200 mg daily for one week (category II); Ketoconazole 2% foam daily for 2 weeks (Category 3). Clinical (colour of macule, scale, pruritus) and mycological assessment were done after 4 weeks of therapy.

Results: After 4 weeks of treatment, clinical cure was observed in 62.4% (Category I), 36.3% (Category II) and 37.5% (Category III).

Conclusion: It was reported in our study that the most effective regimen for PV patients is fluconazole 300 mg per week combined with ketoconazole 2% twice a week for 2 weeks.
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http://dx.doi.org/10.3889/oamjms.2019.092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364740PMC
January 2019

Efficacy of 10% Potassium Hydroxide Solution Versus 10% Salicylic Acid Ointment in Treatment of Molluscum Contagiosum - the Low - Cost Dermatologic Therapy in Vietnam.

Open Access Maced J Med Sci 2019 Jan 28;7(2):269-271. Epub 2019 Jan 28.

University of Rome G. Marconi, Rome, Italy.

Background: Molluscum contagiosum is a common viral disease primarily affecting children.

Aim: The objective is to compare the efficacy of 10% potassium hydroxide (KOH) solution versus 10% salicylic pomade in the treatment of molluscum contagiosum.

Methods: Clinical trials on 70 patients were randomised into 2 groups: 39 patients treated with 10% KOH solution and 31 patients treated with 10% salicylic pomade. The evaluation was based on the complete clearance of lesions, side effects and complications of the drug.

Results: The clearance of all lesions after 2, 4, 6, 8 weeks of treatment in both groups were 7.7%; 23.1%; 53.8%; 79.5% and 0%; 3.2%, 9.7% 22.6%, respectively (p < 0.05). Side effects were seen in both groups include burning (76.9% versus 19.4%; p < 0.05); redness (59% versus 14%; p < 0.01); desquamation (12.8% versus 19.3%; p < 0.05).

Conclusion: The efficacy of KOH solution in the treatment of MC was better than that of salicylic pomade and both products are safe, effective, and easy to apply at home.
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http://dx.doi.org/10.3889/oamjms.2019.090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364743PMC
January 2019

Efficacy of BAFF in Monitoring Treatment Response in Early Vietnamese Systemic Sclerosis Patients.

Open Access Maced J Med Sci 2019 Jan 28;7(2):264-268. Epub 2019 Jan 28.

University of Rome G. Marconi, Rome, Italy.

Background: B-cell activating factor (BAFF) is considered to have a role in the pathogenesis of systemic sclerosis (SSc).

Aim: We conducted a longitudinal study on early SSc patients to determine the change in BAFF serum level after treatment and its association with organ involvements.

Methods: A total of 46 patients (32 diffuse, 14 limited) were recruited, among which 35 patients (24 diffuse, 11 limited) completed 12-month follow-up.

Results: Higher pretreatment BAFF levels were observed in patients with positive anti-topoisomerase antibody (ATA) (2252.1 ± 899.7 pg/ml versus 1475.5 ± 697.6 pg/ml in ATA-negative patients; p = 0.01) and muscular involvement (2741.9 ± 1039.9 pg/ml versus 1897.2 ± 762.9 pg/ml in patients without muscular involvement; p = 0.005). Lower levels were observed in patients with interstitial lung disease (ILD) (1926.7 ± 757.9 pg/ml versus 2721.6 ± 1131.4 pg/ml in non-ILD patients; p = 0.01). After treatment, BAFF level reduced significantly in diffuse SSc patients (1652.2 ± 892.7 pg/ml versus 2147.6 ± 945.5 pg/ml before treatment; p = 0.03).

Conclusion: Patients with worsening outcome had the highest pretreatment BAFF level and was associated with increased BAFF level after treatment. BAFF can be used to predict and monitor patients' response to therapy.
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http://dx.doi.org/10.3889/oamjms.2019.070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364724PMC
January 2019

The Efficacy of a Two-Fold Increase of H1-Antihistamine in the Treatment of Chronic Urticaria - the Vietnamese Experience.

Open Access Maced J Med Sci 2019 Jan 28;7(2):259-263. Epub 2019 Jan 28.

University of Rome G. Marconi, Rome, Italy.

Background: Chronic urticaria, a mast cell-driven condition, is common, debilitating and hard to treat. H1-antihistamines are the first line treatment of chronic urticaria, but often patients do not get satisfactory relief with the recommended dose. European guidelines recommend increased antihistamine doses up to four-fold.

Aim: We conducted this study to evaluate the efficacy of increased H1-antihistamine doses up to two-fold in Vietnamese chronic urticaria patients.

Methods: One hundred and two patients with chronic urticaria were recruited for treatment with levocetirizine (n = 52) or fexofenadine (n = 50). Treatment started at the conventional daily dose of 5 mg levocetirizine or 180 mg fexofenadine for 2 weeks and then increased to 10 mg levocetirizine or 360 mg fexofenadine for 2 weeks if patients did not have an improvement in symptoms. At week 0, week 2 and week 4 wheal, pruritus, size of the wheal, total symptom scores, and associated side-effects were assessed.

Results: With the conventional dose, the total symptom scores after week 2 decreased significantly in both groups compared to baseline figures, i.e. 7.4 vs 2.3 for levocetirizine group and 8.0 vs 2.6 for fexofenadine group (p < 0.05). However, there were still 26 patients in each group who did not have improvements. Of these 26 patients, after having a two-fold increase of the conventional dose, 11.5% and 38.5% became symptom-free at week 4 in levocetirizine group and fexofenadine group, respectively. At week 4 in both groups, the total symptom scores had significantly decreased when compared with those at week 2 (2.8 ± 1.5 versus 4.7 ± 1.6 in levocetirizine group; 2.1 ± 1.9 versus 5.1 ± 1.4 in fexofenadine group). In both groups, there was no difference in the rate of negative side effects between the conventional dose and the double dose.

Conclusion: This study showed that increasing the dosages of levocetirizine and fexofenadine by two-fold improved chronic urticaria symptoms without increasing the rate of negative side effects.
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http://dx.doi.org/10.3889/oamjms.2019.069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364734PMC
January 2019

The Decline of PUVA Therapy in Vietnam: Effective Treatment of Narrow Band UVB in Vietnamese Vitiligo Patients.

Open Access Maced J Med Sci 2019 Jan 28;7(2):256-258. Epub 2019 Jan 28.

University of Rome G. Marconi, Rome, Italy.

Aim: To examine the efficacy and safety of Narrowband ultraviolet B (NB-UVB) in Vietnamese vitiligo patients.

Methods: We recruited thirty-one patients (14 males, 17 females), aged from 7 to 67 years, with both segmental vitiligo (SV) and non-segmental vitiligo (NSV), treated three times weekly with NB-UVB. The starting dose for adults from 15 years old and children less than 15 years old was 200 mJ/cm and 150 mJ/cm, respectively, with 50 mJ/cm and 20 mJ/cm dose increments at each subsequent visit, respectively, until mild erythema lasting less than 24 hrs reported by patient, given for a period of 6 months. Response to therapy was assessed based on VASI score changes.

Results: Based upon our results, 38.7% (12/31) of patients achieved a very good response of more than 50% VASI changes, 41.9% (13/31) obtained a good response (VASI changed from 25 to 50%). Total good and very good response to therapy significantly increased with prolonged treatment, increasing from 19.4% to 64.5% and 80.6% after 2, 4 and 6 months, respectively. Localised NSV patients obtained good and very good response significantly more frequently than generalised NSV (55.6% versus 18.2%). Adverse effects were minimal, of which one case developed herpes simplex, and 4 cases reported mild photo burn reaction which completely disappeared after adjusting the dose.

Conclusion: NB-UVB therapy is an effective and safe tool in the management of Vietnamese vitiligo patients.
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http://dx.doi.org/10.3889/oamjms.2019.068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364711PMC
January 2019

Successful Psoriasis Treatment Using NB-UVB with Methotrexate: The Vietnamese Experience.

Open Access Maced J Med Sci 2019 Jan 27;7(2):253-255. Epub 2019 Jan 27.

University of Rome G. Marconi, Rome, Italy.

Aim: To compare the effectiveness of narrowband ultraviolet B (NBUVB) and oral methotrexate (MTX) to oral MTX alone in Vietnamese psoriasis patients, from May 2016 to May 2018.

Methods: We conducted a non-randomized trial on 70 patients with plaque-type psoriasis of moderate to severe. Thirty-five patients apply NBUVB once/day in 5 days/week for 4 weeks plus oral MTX 7.5 mg/week and 35 patients oral MTX 7.5 mg/week and both two groups treatment for 3 months. The extent of the lesion was assessed by the Psoriasis Area and Severity Index (PASI).

Results: The proportion of decreasing PASI was comparable (68.49% in NBUVB and MTX versus 57.62% in MTX alone); p < 0.05. Inside, good 28.58%, moderate 68.57% and poor 2.85% in NBUVB and MTX better than good 2.85%, moderate 71.4% and poor 25.72% in MTX alone; p < 0.05. The recurrence rate after 24 months of the NBUVB and MTX group (42.9%) was lower than the MTX alone group (71.4%); p < 0.05.

Conclusion: NBUVB and oral MTX have affected treatment with chronic plaque psoriasis better than oral MTX alone.
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http://dx.doi.org/10.3889/oamjms.2019.065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364742PMC
January 2019

Effectiveness, Safety and Tolerance of Methotrexate in Vietnamese Psoriatic Arthritis Patients.

Open Access Maced J Med Sci 2019 Jan 27;7(2):250-252. Epub 2019 Jan 27.

University of Rome G. Marconi, Rome, Italy.

Aim: To access the effectiveness, safety and tolerance of methotrexate (MTX) in psoriatic arthritis (PsA) treatment.

Methods: We recruit 37 patients, admitted at HCMC Hospital of Dermato-Venereology from 1/2016 to 3/2017, with MTX dosage ranging from 10 mg to 15 mg per week.

Results: Skin lesion response after 12 weeks improved PASI 50: 40.5%, PASI 75: 24.3%. Disease activity score decreased after 12 weeks with ∆DAS28 = -1.43 + 0.79, 37.8% PsA achieved complete remission. Nausea and vomiting were 8.1%. These symptoms were mild and transient. We did not stop MTX usage. The rate of elevating SGPT 2-3 times as much as the upper limit of the normal range was 2.7%.

Conclusion: We finally demonstrated that the rate of treatment response in Vietnam is the same as demonstrated by foreign authors in other countries.
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http://dx.doi.org/10.3889/oamjms.2019.063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364709PMC
January 2019