Thu H Le

Thu H Le

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Thu H Le

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Extracellular vesicles as novel diagnostic and research tool for patients with HTN and Kidney disease.

Am J Physiol Renal Physiol 2019 Jul 17. Epub 2019 Jul 17.

Medicine, University of Rochester, United States.

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http://dx.doi.org/10.1152/ajprenal.00071.2019DOI Listing
July 2019

Loss of reticulocalbin 2 lowers blood pressure and restrains ANG II-induced hypertension in vivo.

Am J Physiol Renal Physiol 2019 Jun 3;316(6):F1141-F1150. Epub 2019 Apr 3.

Department of Radiology and Medical Imaging, University of Virginia , Charlottesville, Virginia.

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http://dx.doi.org/10.1152/ajprenal.00567.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620588PMC
June 2019

Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies.

Nat Commun 2019 01 3;10(1):29. Epub 2019 Jan 3.

Department of Epidemiology, University of North Carolina, Chapel Hill, NC, 27516-8050, USA.

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http://www.nature.com/articles/s41467-018-07867-7
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http://dx.doi.org/10.1038/s41467-018-07867-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318312PMC
January 2019

Vascular Smooth Muscle Remodeling in Conductive and Resistance Arteries in Hypertension.

Arterioscler Thromb Vasc Biol 2018 09;38(9):1969-1985

From the Robert M. Berne Cardiovascular Research Center (I.A.M.B., M.E.G., L.J.D., S.A.M., B.E.I.).

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http://dx.doi.org/10.1161/ATVBAHA.118.311229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205219PMC
September 2018

Correction: Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations.

PLoS Genet 2018 05 11;14(5):e1007345. Epub 2018 May 11.

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http://dx.doi.org/10.1371/journal.pgen.1007345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5947884PMC
May 2018

E1841K Mutation Augments Proteinuria and Podocyte Injury and Migration.

J Am Soc Nephrol 2018 01 9;29(1):155-167. Epub 2017 Oct 9.

Department of Medicine, University of Virginia, Charlottesville, Virginia;

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http://dx.doi.org/10.1681/ASN.2015060707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748898PMC
January 2018

The Loss of Associates with Kidney Failure and Heart Failure.

J Am Soc Nephrol 2017 Nov 18;28(11):3345-3352. Epub 2017 Jul 18.

Welch Center for Prevention, Epidemiology and Clinical Research, Baltimore, Maryland.

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http://dx.doi.org/10.1681/ASN.2017030228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661294PMC
November 2017

in the Kidney-Unraveling the Molecular Mechanism Underlying Renal Damage in Salt-Sensitive Hypertension.

J Am Soc Nephrol 2017 11 16;28(11):3131-3133. Epub 2017 Oct 16.

Department of Medicine, University of Virginia, Charlottesville, Virginia

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http://dx.doi.org/10.1681/ASN.2017080917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661301PMC
November 2017

Plasmonics-Nanofluidics Hydrid Metamaterial: An Ultrasensitive Platform for Infrared Absorption Spectroscopy and Quantitative Measurement of Molecules.

ACS Nano 2017 10 28;11(10):9780-9788. Epub 2017 Sep 28.

Innovative Photon Manipulation Research Team, RIKEN Center for Advanced Photonics , Wako, Saitama 351-0198, Japan.

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http://dx.doi.org/10.1021/acsnano.7b02743DOI Listing
October 2017

Testing the trajectory difference in a semi-parametric longitudinal model.

Stat Methods Med Res 2017 Jun 13;26(3):1519-1531. Epub 2015 May 13.

3 Division of Biostatistics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.

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http://dx.doi.org/10.1177/0962280215584109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644124PMC
June 2017

Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations.

PLoS Genet 2017 May 12;13(5):e1006728. Epub 2017 May 12.

Epidemiology, Gilling School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1006728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446189PMC
May 2017

ACE2 and the Homolog Collectrin in the Modulation of Nitric Oxide and Oxidative Stress in Blood Pressure Homeostasis and Vascular Injury.

Antioxid Redox Signal 2017 Apr 12;26(12):645-659. Epub 2017 Jan 12.

1 Department of Nephrology, Medical Faculty, Heinrich-Heine University Düsseldorf , Düsseldorf, Germany .

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http://dx.doi.org/10.1089/ars.2016.6950DOI Listing
April 2017

Cross-Presentation of Soluble and Cell-Associated Antigen by Murine Hepatocytes Is Enhanced by Collectrin Expression.

J Immunol 2017 03 3;198(6):2341-2351. Epub 2017 Feb 3.

Division of Nephrology, Department of Medicine, Center for Immunity, Inflammation, and Regenerative Medicine, University of Virginia, Charlottesville, VA 22908;

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http://dx.doi.org/10.4049/jimmunol.1502234DOI Listing
March 2017

Genome-wide association study for conformation traits in three Danish pig breeds.

Genet Sel Evol 2017 01 24;49(1):12. Epub 2017 Jan 24.

Department of Molecular Biology and Genetics, Center for Quantitative Genetics and Genomics, Aarhus University, Tjele, Denmark.

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http://dx.doi.org/10.1186/s12711-017-0289-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5259967PMC
January 2017

Modulating Vascular Hemodynamics With an Alpha Globin Mimetic Peptide (HbαX).

Hypertension 2016 12 31;68(6):1494-1503. Epub 2016 Oct 31.

From the Department of Molecular Physiology and Biological Physics (T.C.S.K., C.M., M.C., M.P., M.Y., B.E.I.), Robert M. Berne Cardiovascular Research Center (T.C.S.K., J.T.B., G.B.B.-F., C.M., L.J.D., X.S., A.K.B., M.E.G., B.E.I.), Department of Pharmacology (L.J.D.), Division of Nephrology, Department of Medicine (S.C., T.H.L.), and Division of Endocrinology, Department of Medicine (E.B.), University of Virginia School of Medicine, Charlottesville; Department of Physiological Sciences, Federal University of Espirito Santa, Brazil (G.B.B.-F., A.S.P.); Departments of Pediatrics and Biochemistry, Washington University in Saint Louis, MO (S.R., A.D.); Department of Biomedical Engineering (B.N., S.M.P., S.H.) and Department of Chemistry (J.N.M., L.C.), University of Virginia, Charlottesville; and College of Pharmacy, Dalian Medical University, Dalian, China (X.S.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.116.08171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159279PMC
December 2016

Extracellular Vesicles in Renal Diseases: More than Novel Biomarkers?

J Am Soc Nephrol 2016 Jan 6;27(1):12-26. Epub 2015 Aug 6.

Department of Medicine, Division of Nephrology, University of Virginia Health System, Charlottesville, Virginia.

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http://dx.doi.org/10.1681/ASN.2015010074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696584PMC
January 2016

Epigenetics in Kidney Transplantation: Current Evidence, Predictions, and Future Research Directions.

Transplantation 2016 Jan;100(1):23-38

1 Translational Genomics Transplant Laboratory, Division of Transplant, Department of Surgery, University of Virginia, Charlottesville, VA. 2 Division of Nephrology, Department of Medicine, University of Virginia, Charlottesville, VA. 3 Transplant Surgery, Division of Transplant, Department of Surgery, University of Virginia, Charlottesville, VA.

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http://dx.doi.org/10.1097/TP.0000000000000878DOI Listing
January 2016

A molecular signature in the pannexin1 intracellular loop confers channel activation by the α1 adrenoreceptor in smooth muscle cells.

Sci Signal 2015 Feb 17;8(364):ra17. Epub 2015 Feb 17.

Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA. Department of Molecular Physiology and Biophysics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.

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http://dx.doi.org/10.1126/scisignal.2005824DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4358815PMC
February 2015

Hemoglobin α/eNOS coupling at myoendothelial junctions is required for nitric oxide scavenging during vasoconstriction.

Arterioscler Thromb Vasc Biol 2014 Dec 2;34(12):2594-600. Epub 2014 Oct 2.

From the Department of Pharmacology and Chemical Biology (A.C.S.) and Heart, Lung, Blood and Vascular Medicine Institute (A.C.S., A.T.N., M.P.M.), University of Pittsburgh, PA; Robert M. Berne Cardiovascular Research Center (J.T.B., M.B., S.M.M., T.J., A.K.B., B.E.I.), Department of Molecular Physiology and Biophysics (M.B., M.V.A., A.V.S., B.E.I.), Deparment of Pediatrics (L.A.P.), Department of Chemistry (L.C.), and Department of Medicine (T.H.L.), University of Virginia, Charlottesville.

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http://dx.doi.org/10.1161/ATVBAHA.114.303974DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4239174PMC
December 2014

Role of collectrin, an ACE2 homologue, in blood pressure homeostasis.

Curr Hypertens Rep 2014 Nov;16(11):490

University of Virginia Health System, Division of Nephrology, Department of Medicine, University of Virginia, PO Box 800133, Charlottesville, VA, 22908, USA.

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http://dx.doi.org/10.1007/s11906-014-0490-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164340PMC
November 2014

Genetics of hypertension: discoveries from the bench to human populations.

Am J Physiol Renal Physiol 2014 Jan 16;306(1):F1-F11. Epub 2013 Oct 16.

Univ. of Virginia, Box 800133, Charlottesville, VA 22908.

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http://www.physiology.org/doi/10.1152/ajprenal.00334.2013
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http://dx.doi.org/10.1152/ajprenal.00334.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921821PMC
January 2014

Loss of collectrin, an angiotensin-converting enzyme 2 homolog, uncouples endothelial nitric oxide synthase and causes hypertension and vascular dysfunction.

Circulation 2013 Oct 18;128(16):1770-80. Epub 2013 Sep 18.

Departments of Medicine (S.C., Q.Z., C.K.R., F.R.C., N.L.H., R.M.C., S.-S.J.S., T.H.L.), Molecular Physiology and Biophysics (M.B., S.M., A.C.S., B.E.I.), and Pediatrics (L.A.P.), University of Virginia, Charlottesville; Department of Medicine, Duke University and Durham VA Medical Centers, Durham, NC (L.C., R.G.); Department of Cardiovascular and Renal Research Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark (J.H., K.M., B.L.J.); and Department of Medicine, Salem Veterans Administration, Salem, VA (S.M.M.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.113.003301DOI Listing
October 2013

AT1A angiotensin receptors in the renal proximal tubule regulate blood pressure.

Cell Metab 2011 Apr;13(4):469-475

Division of Nephrology, Department of Medicine, Duke University and Durham, VA Medical Centers, Durham, NC 27710, USA; Cardiovascular and Metabolic Disorders Research Program, Duke-NUS Graduate Medical School, Singapore 169857. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2011.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070917PMC
April 2011

Cardiac phenotype and angiotensin II levels in AT1a, AT1b, and AT2 receptor single, double, and triple knockouts.

Cardiovasc Res 2010 Jun 12;86(3):401-9. Epub 2010 Jan 12.

Division of Pharmacology, Vascular and Metabolic Diseases, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1093/cvr/cvq004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2868177PMC
June 2010

Glutathione S-transferase-micro1 regulates vascular smooth muscle cell proliferation, migration, and oxidative stress.

Hypertension 2009 Dec 12;54(6):1360-8. Epub 2009 Oct 12.

University of Virginia, Box 800133, Charlottesville, VA 22908, USA.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.109.139428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783903PMC
December 2009

Cardiovascular phenotype of mice lacking all three subtypes of angiotensin II receptors.

FASEB J 2008 Aug 22;22(8):3068-77. Epub 2008 May 22.

Department of Cardiology, Charité Berlin, Campus Benjamin Franklin, Berlin, Germany.

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http://dx.doi.org/10.1096/fj.08-108316DOI Listing
August 2008

Targeting genes in the renin-angiotensin system.

Curr Opin Nephrol Hypertens 2008 Jan;17(1):57-63

Division of Nephrology and Department of Medicine, Duke University and Durham VA Medical Centers, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1097/MNH.0b013e3282f2fd39DOI Listing
January 2008

Aminoaciduria and altered renal expression of luminal amino acid transporters in mice lacking novel gene collectrin.

Am J Physiol Renal Physiol 2007 Feb 19;292(2):F533-44. Epub 2006 Sep 19.

Dept. of Medicine, Duke University, Durham, NC, USA.

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http://dx.doi.org/10.1152/ajprenal.00325.2006DOI Listing
February 2007

Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney.

Proc Natl Acad Sci U S A 2006 Nov 7;103(47):17985-90. Epub 2006 Nov 7.

Department of Medicine, Duke University Medical Center and Durham Veterans Affairs Medical Center, Durham, NC 27710, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0605545103
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http://dx.doi.org/10.1073/pnas.0605545103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1693859PMC
November 2006

Altered blood pressure responses and normal cardiac phenotype in ACE2-null mice.

J Clin Invest 2006 Aug 27;116(8):2218-25. Epub 2006 Jul 27.

Division of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, Durham, North Carolina 27705, USA.

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http://dx.doi.org/10.1172/JCI16980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1518789PMC
August 2006

A new cardiac MASTer switch for the renin-angiotensin system.

J Clin Invest 2006 Apr;116(4):866-9

Division of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, Durham, North Carolina, USA.

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http://dx.doi.org/10.1172/JCI28312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1421370PMC
April 2006

A gammaGT-AT1A receptor transgene protects renal cortical structure in AT1 receptor-deficient mice.

Physiol Genomics 2004 Aug 11;18(3):290-8. Epub 2004 Aug 11.

Department of Medicine, Duke University and Durham Veterans Affairs Medical Centers, Durham 27705, USA.

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http://dx.doi.org/10.1152/physiolgenomics.00120.2003DOI Listing
August 2004

Modifier locus on mouse chromosome 3 for renal vascular pathology in AT1A receptor-deficiency.

Hypertension 2004 Feb 12;43(2):445-51. Epub 2004 Jan 12.

Department of Medicine, Duke University and Durham VA Medical Centers, 508 Fulton Street, Building 6, Room 1100, Durham, NC 27705, USA.

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http://dx.doi.org/10.1161/01.HYP.0000112423.28987.00DOI Listing
February 2004

Physiological impact of increased expression of the AT1 angiotensin receptor.

Hypertension 2003 Oct 8;42(4):507-14. Epub 2003 Sep 8.

Department of Medicine, Duke University and Durham VA Medical Centers, Durham, NC 27705, USA.

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http://dx.doi.org/10.1161/01.HYP.0000092000.07559.57DOI Listing
October 2003

RGS2: a "turn-off" in hypertension.

J Clin Invest 2003 Feb;111(4):441-3

Division of Nephrology, Department of Medicine, Duke University and Durham Veterans Administration Medical Centers, Durham, North Carolina 27705, USA.

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http://dx.doi.org/10.1172/JCI17836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC151929PMC
February 2003