Thorsten Zenz

Thorsten Zenz

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Thorsten Zenz

Thorsten Zenz

Publications by authors named "Thorsten Zenz"

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Phase 1 first-in-human trial of the anti-CD37 antibody BI 836826 in relapsed/refractory chronic lymphocytic leukemia.

Leukemia 2019 Oct 14;33(10):2531-2535. Epub 2019 May 14.

Department of Medicine V, University Hospital Heidelberg, Department of Molecular Therapy in Haematology & Oncology, NCT/DKFZ, Heidelberg, Germany.

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http://dx.doi.org/10.1038/s41375-019-0475-zDOI Listing
October 2019

Lymphoma and Leukemia Cell Vulnerabilities and Resistance Identified by Compound Library Screens.

Methods Mol Biol 2019 ;1956:351-362

Department of Haematology, Center for Oncology and Haematology, University Hospital and University of Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1007/978-1-4939-9151-8_17DOI Listing
July 2019

Nuclear FOXO1 promotes lymphomagenesis in germinal center B cells.

Blood 2018 12 17;132(25):2670-2683. Epub 2018 Oct 17.

Immune Regulation and Cancer, Max Delbrück Center for Molecular Medicine in the Helmholtz Alliance, Berlin-Buch, Germany.

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http://www.bloodjournal.org/lookup/doi/10.1182/blood-2018-06
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http://dx.doi.org/10.1182/blood-2018-06-856203DOI Listing
December 2018

TRRAP is essential for regulating the accumulation of mutant and wild-type p53 in lymphoma.

Blood 2018 06 13;131(25):2789-2802. Epub 2018 Apr 13.

Molecular Therapy in Haematology and Oncology, Department of Translational Oncology, National Center for Tumor Diseases and German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1182/blood-2017-09-806679DOI Listing
June 2018

Multi-Omics Factor Analysis-a framework for unsupervised integration of multi-omics data sets.

Mol Syst Biol 2018 06 20;14(6):e8124. Epub 2018 Jun 20.

European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, Cambridge, UK

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010767PMC
http://dx.doi.org/10.15252/msb.20178124DOI Listing
June 2018

MED12 mutations and NOTCH signalling in chronic lymphocytic leukaemia.

Br J Haematol 2017 11 2;179(3):421-429. Epub 2017 Aug 2.

Molecular Therapy in Haematology and Oncology & Department of Translational Oncology, National Centre for Tumour Disease (NCT) and German Cancer Research Centre (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1111/bjh.14869DOI Listing
November 2017

Elucidation of tonic and activated B-cell receptor signaling in Burkitt's lymphoma provides insights into regulation of cell survival.

Proc Natl Acad Sci U S A 2016 May 6;113(20):5688-93. Epub 2016 May 6.

Hematology/Oncology, Department of Medicine, Johann Wolfgang Goethe University, 60590 Frankfurt, Germany; Department of Haematology, Cambridge Institute of Medical Research, University of Cambridge, Cambridge CB2 0XY, United Kingdom; German Cancer Consortium/German Cancer Research Center, 69120 Heidelberg, Germany;

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http://dx.doi.org/10.1073/pnas.1601053113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878517PMC
May 2016

Phenotypic differentiation does not affect tumorigenicity of primary human colon cancer initiating cells.

Cancer Lett 2016 Feb 8;371(2):326-33. Epub 2015 Dec 8.

Department of Translational Oncology, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), Im Neuenheimer Feld 460, 69120 Heidelberg, Germany; German Consortium for Translational Cancer Research (DKTK), Germany. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2015.11.037DOI Listing
February 2016

BRAF inhibitor therapy in HCL.

Best Pract Res Clin Haematol 2015 Dec 20;28(4):246-52. Epub 2015 Oct 20.

Department of Translational Oncology, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), Im Neuenheimer Feld 460, 69120 Heidelberg, Germany; Department of Medicine V, Heidelberg University Medical Center, Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.beha.2015.10.001DOI Listing
December 2015

Mutational landscape and complexity in CLL.

Blood 2015 Oct;126(18):2078-9

EUROPEAN MOLECULAR BIOLOGY LABORATORY.

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http://dx.doi.org/10.1182/blood-2015-09-667584DOI Listing
October 2015

Epigenetic silencing of miR-708 enhances NF-κB signaling in chronic lymphocytic leukemia.

Int J Cancer 2015 Sep 13;137(6):1352-61. Epub 2015 Mar 13.

Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1002/ijc.29491DOI Listing
September 2015

[Hairy cell leukemia].

Dtsch Med Wochenschr 2015 Jun 12;140(12):882-4. Epub 2015 Jun 12.

Abteilung Translationale Onkologie, Nationales Centrum für Tumorerkrankungen (NCT) und Deutsches Krebsforschungszentrum (dkfz), Heidelberg.

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http://dx.doi.org/10.1055/s-0041-102418DOI Listing
June 2015

Stromal cell-mediated glycolytic switch in CLL cells involves Notch-c-Myc signaling.

Blood 2015 May 16;125(22):3432-6. Epub 2015 Mar 16.

Department of Internal Medicine 5, Hematology and Oncology, University of Erlangen-Nuremberg, Erlangen, Germany;

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http://dx.doi.org/10.1182/blood-2014-10-607036DOI Listing
May 2015

Improved synthesis of N-benzylaminoferrocene-based prodrugs and evaluation of their toxicity and antileukemic activity.

J Med Chem 2015 Feb 9;58(4):2015-24. Epub 2015 Feb 9.

Department of Chemistry and Pharmacy, Organic Chemistry II, Friedrich-Alexander-University of Erlangen-Nürnberg , Henkestraße 42, 91054 Erlangen, Germany.

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http://pubs.acs.org/doi/10.1021/jm5019548
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http://dx.doi.org/10.1021/jm5019548DOI Listing
February 2015

Assessment of TP53 functionality in chronic lymphocytic leukaemia by different assays; an ERIC-wide approach.

Br J Haematol 2014 Nov 30;167(4):565-9. Epub 2014 Jun 30.

Department of Haematology, Academic Medical Centre, Amsterdam, The Netherlands; Laboratory of Exp. Immunology, Academic Medical Centre, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1111/bjh.13006DOI Listing
November 2014

Evolution of DNA methylation is linked to genetic aberrations in chronic lymphocytic leukemia.

Cancer Discov 2014 Mar 19;4(3):348-61. Epub 2013 Dec 19.

Divisions of 1Epigenomics and Cancer Risk Factors, 2Theoretical Bioinformatics, 3Biostatistics, and 4Molecular Genetics; 5Department of Translational Oncology, National Center for Tumor Diseases (NCT), The German Cancer Research Center (DKFZ); 6Department of Medicine V, University of Heidelberg, Heidelberg; 7Department of Medicine, University of Freiburg Medical Center, Freiburg; 8Department of Internal Medicine III, University of Ulm, Ulm; 9The German Cancer Consortium, Germany; 10Department of Medicine, University of California at San Diego Moores Cancer Center, La Jolla, California; and 11Division of Hematology, The Ohio State University, Columbus, Ohio.

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http://dx.doi.org/10.1158/2159-8290.CD-13-0349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134522PMC
March 2014

Targeted resequencing for analysis of clonal composition of recurrent gene mutations in chronic lymphocytic leukaemia.

Br J Haematol 2013 Nov 27;163(4):496-500. Epub 2013 Aug 27.

Department of Translational Oncology, National Centre for Tumour Diseases (NCT) and German Cancer Research Centre (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1111/bjh.12539DOI Listing
November 2013

Aminoferrocene-based prodrugs and their effects on human normal and cancer cells as well as bacterial cells.

J Med Chem 2013 Sep 26;56(17):6935-44. Epub 2013 Aug 26.

Department of Chemistry and Pharmacy, Friedrich-Alexander-University of Erlangen-Nürnberg , Organic Chemistry II, Henkestr. 42, 91054 Erlangen, Germany.

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http://dx.doi.org/10.1021/jm400754cDOI Listing
September 2013

Targeting the BRAF V600E mutation in multiple myeloma.

Cancer Discov 2013 Aug 23;3(8):862-9. Epub 2013 Apr 23.

Department of General Pathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany.

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http://dx.doi.org/10.1158/2159-8290.CD-13-0014DOI Listing
August 2013

Next-generation sequencing of cancer consensus genes in lymphoma.

Leuk Lymphoma 2013 Aug 14;54(8):1831-5. Epub 2013 Jun 14.

Department of Translational Oncology, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.3109/10428194.2013.796053DOI Listing
August 2013

Extracellular vesicles in chronic lymphocytic leukemia.

Leuk Lymphoma 2013 Aug;54(8):1826-30

Department of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.3109/10428194.2013.796052DOI Listing
August 2013

BRAF mutations in chronic lymphocytic leukemia.

Leuk Lymphoma 2013 Jun 20;54(6):1177-82. Epub 2012 Nov 20.

Department of Internal Medicine III, University of Ulm, Ulm, Germany.

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http://dx.doi.org/10.3109/10428194.2012.742525DOI Listing
June 2013

Telomere length in mantle cell lymphoma.

Blood 2013 Feb 14;121(7):1184-7. Epub 2012 Dec 14.

Department of Internal Medicine III, University of Ulm, Ulm, Germany.

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http://dx.doi.org/10.1182/blood-2012-08-452649DOI Listing
February 2013

Exhausting T cells in CLL.

Authors:
Thorsten Zenz

Blood 2013 Feb;121(9):1485-6

NCT/DKFZ, University of Heidelberg.

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http://dx.doi.org/10.1182/blood-2013-01-475939DOI Listing
February 2013

Improving treatment for chronic lymphocytic leukemia by rational use of monoclonal antibodies.

Leuk Lymphoma 2012 Nov 3;53(11):2101-2. Epub 2012 Sep 3.

Department of Translational Oncology, National Center for Tumor Diseases, Heidelberg, Germany.

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http://dx.doi.org/10.3109/10428194.2012.720980DOI Listing
November 2012

Exploiting biological diversity and genomic aberrations in chronic lymphocytic leukemia.

Leuk Lymphoma 2012 Jun 6;53(6):1023-31. Epub 2011 Dec 6.

Division of Molecular Genetics, German Cancer Research Center, Heidelberg, Germany.

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http://dx.doi.org/10.3109/10428194.2011.631638DOI Listing
June 2012

Risk categories and refractory CLL in the era of chemoimmunotherapy.

Blood 2012 May 6;119(18):4101-7. Epub 2012 Mar 6.

Department of Translational Oncology, National Center for Tumor Diseases and German Cancer Research Center, Im Neuenheimer Feld 460, Heidelberg, Germany.

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http://dx.doi.org/10.1182/blood-2011-11-312421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968336PMC
May 2012

Can prognostic factors be used to direct therapy in chronic lymphocytic leukemia?

Curr Hematol Malig Rep 2012 Mar;7(1):3-12

Department of Medicine V, University Hospital Heidelberg, Im Neuenheimer Feld 410, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s11899-011-0110-1DOI Listing
March 2012

Importance of genetics in chronic lymphocytic leukemia.

Blood Rev 2011 May 23;25(3):131-7. Epub 2011 Mar 23.

Department of Internal Medicine III, University of Ulm, Ulm, Germany.

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http://dx.doi.org/10.1016/j.blre.2011.02.002DOI Listing
May 2011

Understanding and managing ultra high-risk chronic lymphocytic leukemia.

Hematology Am Soc Hematol Educ Program 2010 ;2010:481-8

Department of Internal Medicine III, University of Ulm, Ulm, Germany.

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http://dx.doi.org/10.1182/asheducation-2010.1.481DOI Listing
April 2011

Inflammatory cytokines and signaling pathways are associated with survival of primary chronic lymphocytic leukemia cells in vitro: a dominant role of CCL2.

Haematologica 2011 Mar 6;96(3):408-16. Epub 2010 Dec 6.

German Cancer Research Center, Dept. for Molecular Genetics, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.3324/haematol.2010.031377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046272PMC
March 2011

CLL 17p deletion: more than 'miR'ly p53?

Blood 2010 Aug;116(6):859-60

University of Ulm.

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http://dx.doi.org/10.1182/blood-2010-04-281253DOI Listing
August 2010

MDM2 promotor polymorphism and disease characteristics in CLL.

Leuk Res 2010 May 25;34(5):578-9. Epub 2009 Aug 25.

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http://dx.doi.org/10.1016/j.leukres.2009.07.015DOI Listing
May 2010

Moving from prognostic to predictive factors in chronic lymphocytic leukaemia (CLL).

Best Pract Res Clin Haematol 2010 Mar;23(1):71-84

Department of Internal Medicine III, University of Ulm, Ulm, Germany.

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http://dx.doi.org/10.1016/j.beha.2009.12.003DOI Listing
March 2010

From pathogenesis to treatment of chronic lymphocytic leukaemia.

Nat Rev Cancer 2010 Jan 3;10(1):37-50. Epub 2009 Dec 3.

Department of Internal Medicine III, University of Ulm, Germany.

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http://dx.doi.org/10.1038/nrc2764DOI Listing
January 2010

More (on) prognostic factors in chronic lymphocytic leukemia.

Leuk Lymphoma 2010 Jan;51(1):5-6

Department of Internal Medicine III, Ulm University, Ulm, Germany.

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http://dx.doi.org/10.3109/10428190903470885DOI Listing
January 2010

Immunoglobulin heavy chain variable gene usage and (super)-antigen drive in chronic lymphocytic leukemia.

Clin Cancer Res 2010 Jan 12;16(2):373-5. Epub 2010 Jan 12.

University of Ulm, Department of Medicine III, Ulm, Germany.

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http://dx.doi.org/10.1158/1078-0432.CCR-09-2948DOI Listing
January 2010

BCL2-938C>A polymorphism and disease progression in chronic lymphocytic leukemia.

Leuk Lymphoma 2009 Nov;50(11):1837-42

Department of Hematology and Oncology, University Ulm, Ulm, Germany.

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http://dx.doi.org/10.3109/10428190903207530DOI Listing
November 2009

Therapy with the FCR regimen does not overcome chronic lymphocytic leukemia biology: aberrant p53 expression predicts response and survival.

Leuk Lymphoma 2009 Oct;50(10):1559-61

Department of Internal Medicine III, University of Ulm, Ulm, Germany.

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http://dx.doi.org/10.1080/10428190903159384DOI Listing
October 2009