Thorsten M Schlaeger

Thorsten M Schlaeger

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Thorsten M Schlaeger

Thorsten M Schlaeger

Publications by authors named "Thorsten M Schlaeger"

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43Publications

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Xeno-Free Reprogramming of Peripheral Blood Mononuclear Erythroblasts on Laminin-521.

Curr Protoc Stem Cell Biol 2020 Mar;52(1):e103

Stem Cell Core Facility, Boston Children's Hospital, Stem Cell Program, Boston, Massachusetts.

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http://dx.doi.org/10.1002/cpsc.103DOI Listing
March 2020

Morphological and Molecular Defects in Human Three-Dimensional Retinal Organoid Model of X-Linked Juvenile Retinoschisis.

Stem Cell Reports 2019 11 24;13(5):906-923. Epub 2019 Oct 24.

Department of Medical Research, Taipei Veterans General Hospital, Taipei 11217, Taiwan; Institute of Pharmacology, National Yang-Ming University, Taipei 11221, Taiwan; School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan; Department of Ophthalmology, Taipei Veterans General Hospital, Taipei 11217, Taiwan; Genomic Research Center, Academia Sinica, Taipei 11529, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2019.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895767PMC
November 2019

Author Correction: Epoxyeicosatrienoic acids enhance embryonic haematopoiesis and adult marrow engraftment.

Nature 2019 Sep;573(7772):E1

Stem Cell Program and Division of Haematology/Oncology, Boston Children's Hospital and Dana-Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1038/s41586-019-1489-4DOI Listing
September 2019

The Lin28/let-7 Pathway Regulates the Mammalian Caudal Body Axis Elongation Program.

Dev Cell 2019 02 17;48(3):396-405.e3. Epub 2019 Jan 17.

Division of Pediatric Hematology/Oncology, Children's Hospital Boston, Boston, MA 02115, USA; Howard Hughes Medical Institute, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2018.12.016DOI Listing
February 2019

Nonintegrating Human Somatic Cell Reprogramming Methods.

Adv Biochem Eng Biotechnol 2018;163:1-21

Stem Cell Program, Boston Children's Hospital, Karp RB09213, 1 Blackfan Circle, Boston, MA, 02446, USA.

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http://dx.doi.org/10.1007/10_2017_29DOI Listing
September 2018

Using CRISPR-Cas9 to Generate Gene-Corrected Autologous iPSCs for the Treatment of Inherited Retinal Degeneration.

Mol Ther 2017 09 12;25(9):1999-2013. Epub 2017 Jun 12.

Stephen A. Wynn Institute for Vision Research and Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City, IA 52241, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2017.05.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589061PMC
September 2017

Developmental Vitamin D Availability Impacts Hematopoietic Stem Cell Production.

Cell Rep 2016 10;17(2):458-468

Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.09.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338633PMC
October 2016

Epoxyeicosatrienoic acids enhance embryonic haematopoiesis and adult marrow engraftment.

Nature 2015 Jul;523(7561):468-71

1] Stem Cell Program and Division of Haematology/Oncology, Boston Children's Hospital and Dana-Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachuestts 02115, USA [2] Chemical Biology Program, Harvard University, Cambridge, Massachusetts 02138, USA.

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http://dx.doi.org/10.1038/nature14569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754787PMC
July 2015

Adenosine signaling promotes hematopoietic stem and progenitor cell emergence.

J Exp Med 2015 May 13;212(5):649-63. Epub 2015 Apr 13.

Stem Cell Program, Division of Hematology/Oncology, Boston Children's Hospital and Dana-Farber Cancer Institute, Boston, MA 02115 Harvard Stem Cell Institute, Howard Hughes Medical Institute, and Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138 Harvard Stem Cell Institute, Howard Hughes Medical Institute, and Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138 Harvard Stem Cell Institute, Howard Hughes Medical Institute, and Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138

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http://dx.doi.org/10.1084/jem.20141528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4419349PMC
May 2015

Flow-induced protein kinase A-CREB pathway acts via BMP signaling to promote HSC emergence.

J Exp Med 2015 May 13;212(5):633-48. Epub 2015 Apr 13.

Division of Pediatric Hematology/Oncology, Boston Children's Hospital and Dana Farber Cancer Institute; Howard Hughes Medical Institute, Harvard Stem Cell Institute; Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children's Hospital and Dana Farber Cancer Institute; and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115 Division of Pediatric Hematology/Oncology, Boston Children's Hospital and Dana Farber Cancer Institute; Howard Hughes Medical Institute, Harvard Stem Cell Institute; Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children's Hospital and Dana Farber Cancer Institute; and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115 Division of Pediatric Hematology/Oncology, Boston Children's Hospital and Dana Farber Cancer Institute; Howard Hughes Medical Institute, Harvard Stem Cell Institute; Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children's Hospital and Dana Farber Cancer Institute; and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115

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http://www.jem.org/lookup/doi/10.1084/jem.20141514
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http://dx.doi.org/10.1084/jem.20141514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4419355PMC
May 2015

Notch1 acts via Foxc2 to promote definitive hematopoiesis via effects on hemogenic endothelium.

Blood 2015 Feb 13;125(9):1418-26. Epub 2015 Jan 13.

Stem Cell Program and Division of Hematology/Oncology, Children's Hospital Boston and Dana-Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA; Stem Cell Transplantation Program, Manton Center for Orphan Disease Research, Children's Hospital Boston, Boston, MA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA; Harvard Stem Cell Institute, Boston, MA;

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http://dx.doi.org/10.1182/blood-2014-04-568170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342355PMC
February 2015

A comparison of non-integrating reprogramming methods.

Nat Biotechnol 2015 Jan 1;33(1):58-63. Epub 2014 Dec 1.

1] Division of Pediatric Hematology/Oncology, Boston Children's Hospital, Dana-Farber Cancer Institute, Boston, Massachusetts, USA. [2] Harvard Stem Cell Institute, Cambridge, Massachusetts, USA. [3] Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA. [4] Howard Hughes Medical Institute, Children's Hospital Boston and Dana Farber Cancer Institute, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nbt.3070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329913PMC
January 2015

Neurotrophin receptor TrkB promotes lung adenocarcinoma metastasis.

Proc Natl Acad Sci U S A 2014 Jul 30;111(28):10299-304. Epub 2014 Jun 30.

Stem Cell Program, Boston Children's Hospital, Boston MA 02115;Harvard Stem Cell Institute, Cambridge, MA 02138;Department of Genetics, Harvard Medical School, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.1404399111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104911PMC
July 2014

iPSC-derived neurons as a higher-throughput readout for autism: promises and pitfalls.

Trends Mol Med 2014 Feb 24;20(2):91-104. Epub 2013 Dec 24.

Center for Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2013.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117413PMC
February 2014

Pluripotent stem cell models of Shwachman-Diamond syndrome reveal a common mechanism for pancreatic and hematopoietic dysfunction.

Cell Stem Cell 2013 Jun 18;12(6):727-36. Epub 2013 Apr 18.

Division of Pediatric Hematology/Oncology, Boston Children's Hospital, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.stem.2013.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3755012PMC
June 2013

Induced pluripotent stem cells as a tool for gaining new insights into Fanconi anemia.

Cell Cycle 2012 Aug 24;11(16):2985-90. Epub 2012 Jul 24.

Division of Pediatric Hematology/Oncology, Boston Children's Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.4161/cc.21109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442908PMC
August 2012

Live-cell immunofluorescence staining of human pluripotent stem cells.

Curr Protoc Stem Cell Biol 2011 Dec;Chapter 1:Unit 1C.12

Children's Hospital Boston, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1002/9780470151808.sc01c12s19DOI Listing
December 2011

Generation of induced pluripotent stem cell lines from human fibroblasts via retroviral gene transfer.

Methods Mol Biol 2011 ;767:55-65

Dr. Lorenz Studer Laboratory, Developmental Biology Department, Gerstner Sloan-Kettering Graduate School, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1007/978-1-61779-201-4_5DOI Listing
November 2011

A call for standardized naming and reporting of human ESC and iPSC lines.

Cell Stem Cell 2011 Apr;8(4):357-9

International Stem Cell Registry, Department of Cell Biology, University of Massachusetts Medical School, Shrewsbury, MA 01545, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S193459091100112
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http://dx.doi.org/10.1016/j.stem.2011.03.002DOI Listing
April 2011

Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells.

Nat Genet 2010 Dec 7;42(12):1113-7. Epub 2010 Nov 7.

Stem Cell Transplantation Program, Division of Pediatric Hematology and Oncology, Manton Center for Orphan Disease Research, Children's Hospital Boston and Dana Farber Cancer Institute, Boston, Massachusetts, USA.

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http://www.nature.com/articles/ng.710
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http://dx.doi.org/10.1038/ng.710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040650PMC
December 2010

Clump passaging and expansion of human embryonic and induced pluripotent stem cells on mouse embryonic fibroblast feeder cells.

Curr Protoc Stem Cell Biol 2010 Aug;Chapter 1:Unit 1C.10

Stem Cell Program, Children's Hospital Boston, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1002/9780470151808.sc01c10s14DOI Listing
August 2010

Knockdown of Fanconi anemia genes in human embryonic stem cells reveals early developmental defects in the hematopoietic lineage.

Blood 2010 Apr 20;115(17):3453-62. Epub 2010 Jan 20.

Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Children's Hospital Boston and Dana-Farber Cancer Institute, MA, USA.

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http://dx.doi.org/10.1182/blood-2009-10-246694DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2867260PMC
April 2010

Live cell imaging distinguishes bona fide human iPS cells from partially reprogrammed cells.

Nat Biotechnol 2009 Nov 11;27(11):1033-7. Epub 2009 Oct 11.

Division of Pediatric Hematology/Oncology, Children's Hospital Boston and Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nbt.1580DOI Listing
November 2009

Derivation and maintenance of human embryonic stem cells from poor-quality in vitro fertilization embryos.

Nat Protoc 2008 ;3(5):923-33

Division of Newborn Medicine, Brigham & Women's Hospital and Children's Hospital Boston, Karp Family Research Building 7214, 300 Longwood Avenue, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nprot.2008.60DOI Listing
August 2008

Inducible endothelial cell-specific gene expression in transgenic mouse embryos and adult mice.

Exp Cell Res 2008 Apr 15;314(6):1202-16. Epub 2008 Jan 15.

Theodor Kocher Institute, University of Bern, Bern, Switzerland.

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http://dx.doi.org/10.1016/j.yexcr.2007.12.026DOI Listing
April 2008

Enhanced plating efficiency of trypsin-adapted human embryonic stem cells is reversible and independent of trisomy 12/17.

Cloning Stem Cells 2008 Mar;10(1):107-18

Division of Hematology/Oncology, Children's Hospital, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1089/clo.2007.0064DOI Listing
March 2008

Pluripotent stem cells and their niches.

Stem Cell Rev 2006 ;2(3):185-201

Division of Hematology/Oncology, Children's Hospital Boston, Boston, MA 02115, USA.

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http://dx.doi.org/10.1007/s12015-006-0047-2DOI Listing
October 2007

Teratoma formation assays with human embryonic stem cells: a rationale for one type of human-animal chimera.

Cell Stem Cell 2007 Sep 23;1(3):253-8. Epub 2007 Aug 23.

Division of Hematology/Oncology, Children's Hospital Boston and Dana-Farber Cancer Institute, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.stem.2007.07.019DOI Listing
September 2007

Science aside: the trajectory of embryonic stem cell research in the USA.

Drug Discov Today 2007 Apr 1;12(7-8):269-71. Epub 2007 Mar 1.

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http://dx.doi.org/10.1016/j.drudis.2007.02.011DOI Listing
April 2007

Tie2Cre-mediated gene ablation defines the stem-cell leukemia gene (SCL/tal1)-dependent window during hematopoietic stem-cell development.

Blood 2005 May 27;105(10):3871-4. Epub 2005 Jan 27.

Division of Hematology-Oncology, Dana-Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA.

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http://dx.doi.org/10.1182/blood-2004-11-4467DOI Listing
May 2005

Decoding hematopoietic specificity in the helix-loop-helix domain of the transcription factor SCL/Tal-1.

Mol Cell Biol 2004 Sep;24(17):7491-502

Department of Hematology/Oncology, Children's Hospital and Dana Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1128/MCB.24.17.7491-7502.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC506978PMC
September 2004

Expression of CD41 marks the initiation of definitive hematopoiesis in the mouse embryo.

Blood 2003 Jan 19;101(2):508-16. Epub 2002 Sep 19.

Department of Hematology/Oncology, Children's Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1182/blood-2002-06-1699DOI Listing
January 2003

Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene.

Nature 2003 Jan 19;421(6922):547-51. Epub 2003 Jan 19.

Department of Pediatric Oncology, Children's Hospital and the Dana Farber Cancer Institute, Harvard Medical School and Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature01345DOI Listing
January 2003