Publications by authors named "Thorsten Heinzel"

44Publications

Biocompatible sulfated valproic acid-coupled polysaccharide-based nanocarriers with HDAC inhibitory activity.

J Control Release 2020 Oct 5. Epub 2020 Oct 5.

Institute of Biochemistry and Biophysics, Center for Molecular Biomedicine, Friedrich Schiller University Jena, Hans-Knöll-Straße 2, 07745 Jena, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2020.10.006DOI Listing
October 2020

Polysaccharide Nanoparticles Bearing HDAC Inhibitor as Nontoxic Nanocarrier for Drug Delivery.

Macromol Biosci 2020 06 6;20(6):e2000039. Epub 2020 Apr 6.

Friedrich Schiller University Jena, Humboldtstraße 10, Jena, 07743, Germany.

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http://dx.doi.org/10.1002/mabi.202000039DOI Listing
June 2020

Survivin antagonizes chemotherapy-induced cell death of colorectal cancer cells.

Oncotarget 2018 Jun 12;9(45):27835-27850. Epub 2018 Jun 12.

Department of Toxicology, University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany.

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http://www.oncotarget.com/fulltext/25600
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http://dx.doi.org/10.18632/oncotarget.25600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021236PMC
June 2018

HSP90 is necessary for the ACK1-dependent phosphorylation of STAT1 and STAT3.

Cell Signal 2017 11 21;39:9-17. Epub 2017 Jul 21.

Department of Toxicology, University Medical Center, Obere Zahlbacher Str. 67, 55131 Mainz, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cellsig.2017.07.014DOI Listing
November 2017

Class I histone deacetylases regulate p53/NF-κB crosstalk in cancer cells.

Cell Signal 2017 01 9;29:218-225. Epub 2016 Nov 9.

Department of Toxicology, University Medical Center of the Johannes Gutenberg University Mainz, Obere Zahlbacher Straße 67, 55131 Mainz, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cellsig.2016.11.002DOI Listing
January 2017

Analysis of Histone Deacetylases Sumoylation by Immunoprecipitation Techniques.

Methods Mol Biol 2017 ;1510:339-351

Department of Biochemistry, Institute of Biochemistry and Biophysics, CMB - Center for Molecular Biomedicine, Friedrich Schiller University Jena, Hans-Knöll-Str. 2, Jena, 07745, Germany.

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http://dx.doi.org/10.1007/978-1-4939-6527-4_25DOI Listing
January 2018

Assessment of HDACi-Induced Acetylation of Nonhistone Proteins by Mass Spectrometry.

Methods Mol Biol 2017 ;1510:313-327

Department of Biochemistry, Instituteof Biochemistry and Biophysics, CMB - Center for Molecular Biomedicine, Friedrich Schiller University Jena, Hans-Knöll-Str. 2, Jena, 07745, Germany.

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http://dx.doi.org/10.1007/978-1-4939-6527-4_23DOI Listing
January 2018

Histone deacetylase 2 controls p53 and is a critical factor in tumorigenesis.

Biochim Biophys Acta 2014 Dec 27;1846(2):524-38. Epub 2014 Jul 27.

Department of Toxicology, University Medical Center, Obere Zahlbacher Str. 67, 55131 Mainz, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbcan.2014.07.010DOI Listing
December 2014

Caspase-3 and caspase-6 cleave STAT1 in leukemic cells.

Oncotarget 2014 Apr;5(8):2305-17

Leibniz Institute for Age Research - Fritz Lipmann Institute, Beutenbergstrasse 11, 07745 Jena, Germany. Friedrich-Schiller-Universität Jena, Centre for Molecular Biomedicine (CMB), Institute for Biochemistry and Biophysics, Hans-Knöll-Str. 2, 07745 Jena, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039164PMC
http://dx.doi.org/10.18632/oncotarget.1911DOI Listing
April 2014

Arginine residues within the DNA binding domain of STAT3 promote intracellular shuttling and phosphorylation of STAT3.

Cell Signal 2014 Aug 8;26(8):1698-706. Epub 2014 Apr 8.

Department of Toxicology, University Medical Center, Obere Zahlbacher Str. 67, 55131 Mainz, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cellsig.2014.03.033DOI Listing
August 2014

Survivin and YM155: how faithful is the liaison?

Biochim Biophys Acta 2014 Apr 16;1845(2):202-20. Epub 2014 Jan 16.

Department of Toxicology, University Medical Center, Obere Zahlbacher Str. 67, 55131 Mainz, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbcan.2014.01.003DOI Listing
April 2014

STAT5 acetylation: Mechanisms and consequences for immunological control and leukemogenesis.

JAKSTAT 2013 Oct 19;2(4):e26102. Epub 2013 Aug 19.

Center for Molecular Biomedicine (CMB); Institute of Biochemistry and Biophysics; University of Jena; Jena, Germany ; Institute of Toxicology; Medical Center of the University Mainz; Mainz, Germany.

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http://www.tandfonline.com/doi/abs/10.4161/jkst.26102
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http://dx.doi.org/10.4161/jkst.26102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876427PMC
October 2013

Novel insights into appropriate encapsulation methods for bioactive compounds into polymers: a study with peptides and HDAC inhibitors.

Macromol Biosci 2014 Jan 21;14(1):69-80. Epub 2013 Aug 21.

Center for Molecular Biomedicine, Institute of Biochemistry and Biophysics, Department of Biochemistry, Friedrich Schiller University Jena, Hans-Knöll-Str. 2, D-07745, Jena, Germany.

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http://dx.doi.org/10.1002/mabi.201300213DOI Listing
January 2014

Acetylation of endogenous STAT proteins.

Methods Mol Biol 2013 ;967:167-78

Center for Molecular Biomedicine (CMB), Department of Biochemistry, University of Jena, Jena, Germany.

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http://link.springer.com/10.1007/978-1-62703-242-1_12
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http://dx.doi.org/10.1007/978-1-62703-242-1_12DOI Listing
June 2013

Breakdown of the FLT3-ITD/STAT5 axis and synergistic apoptosis induction by the histone deacetylase inhibitor panobinostat and FLT3-specific inhibitors.

Mol Cancer Ther 2012 Nov 31;11(11):2373-83. Epub 2012 Aug 31.

Institute of Biochemistry and Biophysics, Center for Molecular Biomedicine, Friedrich-Schiller University, Hans-Knöll-Str. 2, Jena 07745, Germany.

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http://dx.doi.org/10.1158/1535-7163.MCT-12-0129DOI Listing
November 2012

Acetylation modulates the STAT signaling code.

Cytokine Growth Factor Rev 2012 Dec 13;23(6):293-305. Epub 2012 Jul 13.

Center for Molecular Biomedicine, Institute for Biochemistry and Biophysics, Department of Biochemistry, Friedrich Schiller University of Jena, Jena, Germany.

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http://dx.doi.org/10.1016/j.cytogfr.2012.06.005DOI Listing
December 2012

Dynamically regulated sumoylation of HDAC2 controls p53 deacetylation and restricts apoptosis following genotoxic stress.

J Mol Cell Biol 2012 Oct 5;4(5):284-93. Epub 2012 Apr 5.

Center for Molecular Biomedicine, Institute for Biochemistry and Biophysics, Department of Biochemistry, Friedrich Schiller University of Jena, Hans-Knöll-Straße 2, 07745 Jena, Germany.

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http://dx.doi.org/10.1093/jmcb/mjs013DOI Listing
October 2012

Differential regulation of PML-RARα stability by the ubiquitin ligases SIAH1/SIAH2 and TRIAD1.

Int J Biochem Cell Biol 2012 Jan 22;44(1):132-8. Epub 2011 Oct 22.

Institute of Biochemistry and Biophysics, Center for Molecular Biomedicine (CMB), Department of Biochemistry, University of Jena, Jena, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S13572725110028
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http://dx.doi.org/10.1016/j.biocel.2011.10.008DOI Listing
January 2012

Phosphorylation-acetylation switch in the regulation of STAT1 signaling.

Mol Cell Endocrinol 2010 Feb 29;315(1-2):40-8. Epub 2009 Oct 29.

Institute of Biochemistry and Biophysics, Center for Molecular Biomedicine (CMB), University of Jena, Hans-Knöll-Str. 2, 07743 Jena, Germany.

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http://dx.doi.org/10.1016/j.mce.2009.10.007DOI Listing
February 2010

HDACi--targets beyond chromatin.

Cancer Lett 2009 Aug 1;280(2):160-7. Epub 2009 Apr 1.

Center for Molecular Biomedicine, Institute for Biochemistry and Biophysics, Friedrich-Schiller-Universität Jena, Jena, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S03043835090013
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http://dx.doi.org/10.1016/j.canlet.2009.02.028DOI Listing
August 2009

Histone deacetylases: salesmen and customers in the post-translational modification market.

Biol Cell 2009 Apr;101(4):193-205

Friedrich-Schiller-University Jena, Center for Molecular Biomedicine, Institute of Biochemistry and Biophysics, Hans-Knöll-Str. 2, 07745 Jena, Germany.

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http://doi.wiley.com/10.1042/BC20080158
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http://dx.doi.org/10.1042/BC20080158DOI Listing
April 2009

A phosphorylation-acetylation switch regulates STAT1 signaling.

Genes Dev 2009 Jan;23(2):223-35

Institute of Biochemistry and Biophysics, Center for Molecular Biomedicine (CMB), University of Jena, 07743 Jena, Germany.

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http://dx.doi.org/10.1101/gad.479209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2648535PMC
January 2009

Acetylation of non-histone proteins modulates cellular signalling at multiple levels.

Int J Biochem Cell Biol 2009 Jan 2;41(1):185-98. Epub 2008 Sep 2.

Leibniz Institute for Age Research - Fritz Lipmann Institute, Beutenbergstrasse 11, 07745 Jena, Germany.

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http://dx.doi.org/10.1016/j.biocel.2008.08.027DOI Listing
January 2009

TSA downregulates Wilms tumor gene 1 (Wt1) expression at multiple levels.

Nucleic Acids Res 2008 Jul 4;36(12):4067-78. Epub 2008 Jun 4.

Leibniz Institute for Age Research - Fritz Lipmann Institute, Beutenbergstrasse 11, 07745 Jena, Germany.

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http://dx.doi.org/10.1093/nar/gkn356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2475629PMC
July 2008

Mechanism for ubiquitylation of the leukemia fusion proteins AML1-ETO and PML-RARalpha.

FASEB J 2008 May 11;22(5):1369-79. Epub 2007 Dec 11.

Institute of Biochemistry and Biophysics, University of Jena, Philosophenweg 12, D-07743 Jena, Germany.

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http://dx.doi.org/10.1096/fj.06-8050comDOI Listing
May 2008

Competition between glucocorticoid receptor and NFkappaB for control of the human FasL promoter.

FASEB J 2006 Jun;20(8):1074-81

Georg-Speyer-Haus, Institute for Biomedical Research, Frankfurt, Germany.

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http://dx.doi.org/10.1096/fj.05-5457comDOI Listing
June 2006

SUMOylation of the corepressor N-CoR modulates its capacity to repress transcription.

Mol Biol Cell 2006 Apr 18;17(4):1643-51. Epub 2006 Jan 18.

Institute for Biomedical Research Georg-Speyer-Haus, 60596 Frankfurt, Germany.

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http://dx.doi.org/10.1091/mbc.e05-07-0610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1415330PMC
April 2006

Glucocorticoids inhibit activation-induced cell death (AICD) via direct DNA-dependent repression of the CD95 ligand gene by a glucocorticoid receptor dimer.

Blood 2005 Jul 31;106(2):617-25. Epub 2005 Mar 31.

Tumor Immunology Program, Division of Immunogenetics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1182/blood-2004-11-4390DOI Listing
July 2005

Nuclear receptors: overview and classification.

Curr Drug Targets Inflamm Allergy 2004 Dec;3(4):335-46

Georg-Speyer-Haus, Institute for Biomedical Research, Paul-Ehrlich-Str. 42-44, D-60596 Frankfurt am Main, Germany.

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http://dx.doi.org/10.2174/1568010042634541DOI Listing
December 2004

RU486-induced glucocorticoid receptor agonism is controlled by the receptor N terminus and by corepressor binding.

J Biol Chem 2002 Jul 13;277(29):26238-43. Epub 2002 May 13.

Institute for Genetics, Justus-Liebig-University Giessen, Heinrich-Buff-Ring 58-62, D-35392 Giessen, Germany.

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http://dx.doi.org/10.1074/jbc.M203268200DOI Listing
July 2002