Thorold W Theunissen

Thorold W Theunissen

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Thorold W Theunissen

Thorold W Theunissen

Publications by authors named "Thorold W Theunissen"

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Recent insights into the naïve state of human pluripotency and its applications.

Exp Cell Res 2019 Dec 1;385(1):111645. Epub 2019 Oct 1.

Department of Developmental Biology and Center of Regenerative Medicine, Washington University School of Medicine, St. Louis, MO, 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yexcr.2019.111645DOI Listing
December 2019

ZMYM2 inhibits NANOG-mediated reprogramming.

Wellcome Open Res 2019 6;4:88. Epub 2019 Jun 6.

Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, Cambridgeshire, CB2 1QR, UK.

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http://dx.doi.org/10.12688/wellcomeopenres.15250.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6640293PMC
June 2019

Hominoid-Specific Transposable Elements and KZFPs Facilitate Human Embryonic Genome Activation and Control Transcription in Naive Human ESCs.

Cell Stem Cell 2019 May 18;24(5):724-735.e5. Epub 2019 Apr 18.

School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2019.03.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509360PMC
May 2019

Mechanisms of gene regulation in human embryos and pluripotent stem cells.

Development 2017 12;144(24):4496-4509

Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA

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http://dx.doi.org/10.1242/dev.157404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769625PMC
December 2017

Human Naive Pluripotent Stem Cells Model X Chromosome Dampening and X Inactivation.

Cell Stem Cell 2017 01 15;20(1):87-101. Epub 2016 Dec 15.

Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Bioinformatics Interdepartmental Program, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2016.10.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5218861PMC
January 2017

Molecular Criteria for Defining the Naive Human Pluripotent State.

Cell Stem Cell 2016 10 14;19(4):502-515. Epub 2016 Jul 14.

Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2016.06.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5065525PMC
October 2016

Failure to replicate the STAP cell phenomenon.

Nature 2015 Sep;525(7570):E6-9

Stem Cell Transplantation Program, Division of Pediatric Hematology Oncology, Children's Hospital Boston, and Dana-Farber Cancer Institute, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature15513DOI Listing
September 2015

Molecular control of induced pluripotency.

Cell Stem Cell 2014 Jun;14(6):720-34

Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2014.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112734PMC
June 2014

Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system.

Cell Res 2013 Oct 27;23(10):1163-71. Epub 2013 Aug 27.

1] Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA [2] Computational and Systems Biology Program, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1038/cr.2013.122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790238PMC
October 2013

Matrix remodeling maintains embryonic stem cell self-renewal by activating Stat3.

Stem Cells 2013 Jun;31(6):1097-106

Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1002/stem.1360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3664106PMC
June 2013

A defined Oct4 level governs cell state transitions of pluripotency entry and differentiation into all embryonic lineages.

Nat Cell Biol 2013 Jun 30;15(6):579-90. Epub 2013 Apr 30.

Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute and Department of Biochemistry, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1038/ncb2742DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671976PMC
June 2013

NANOG-dependent function of TET1 and TET2 in establishment of pluripotency.

Nature 2013 Mar 10;495(7441):370-4. Epub 2013 Feb 10.

Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK.

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http://dx.doi.org/10.1038/nature11925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3606645PMC
March 2013

Reprogramming capacity of Nanog is functionally conserved in vertebrates and resides in a unique homeodomain.

Development 2011 Nov;138(22):4853-65

Wellcome Trust Centre for Stem Cell Research and Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK.

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http://dev.biologists.org/cgi/doi/10.1242/dev.068775
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http://dx.doi.org/10.1242/dev.068775DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201656PMC
November 2011

Switching on pluripotency: a perspective on the biological requirement of Nanog.

Philos Trans R Soc Lond B Biol Sci 2011 Aug;366(1575):2222-9

Wellcome Trust Centre for Stem Cell Research and Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK.

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http://rstb.royalsocietypublishing.org/cgi/doi/10.1098/rstb.
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http://dx.doi.org/10.1098/rstb.2011.0003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130412PMC
August 2011

Nanog overcomes reprogramming barriers and induces pluripotency in minimal conditions.

Curr Biol 2011 Jan 30;21(1):65-71. Epub 2010 Dec 30.

Wellcome Trust Centre for Stem Cell Research and Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S09609822100158
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http://dx.doi.org/10.1016/j.cub.2010.11.074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3025321PMC
January 2011

Prmt5 is essential for early mouse development and acts in the cytoplasm to maintain ES cell pluripotency.

Genes Dev 2010 Dec;24(24):2772-7

Wellcome Trust, Cancer Research UK, Gurdon Institute of Cancer and Developmental Biology, University of Cambridge, Cambridge CB2 1QN, United Kingdom.

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http://genesdev.cshlp.org/cgi/doi/10.1101/gad.606110
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http://dx.doi.org/10.1101/gad.606110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003195PMC
December 2010

Stat3 activation is limiting for reprogramming to ground state pluripotency.

Cell Stem Cell 2010 Sep;7(3):319-28

Wellcome Trust Centre for Stem Cell Research & Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QR, UK.

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http://dx.doi.org/10.1016/j.stem.2010.06.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459098PMC
September 2010

Promotion of reprogramming to ground state pluripotency by signal inhibition.

PLoS Biol 2008 Oct;6(10):e253

Wellcome Trust Centre for Stem Cell Research, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.1371/journal.pbio.0060253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570424PMC
October 2008

Site-directed, virus-free, and inducible RNAi in embryonic stem cells.

Proc Natl Acad Sci U S A 2007 Dec 18;104(52):20850-5. Epub 2007 Dec 18.

Division of Hematology-Oncology, Children's Hospital and Dana-Farber Cancer Institute, Harvard Stem Cell Institute, and Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.0710565105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409230PMC
December 2007

A protein interaction network for pluripotency of embryonic stem cells.

Nature 2006 Nov 8;444(7117):364-8. Epub 2006 Nov 8.

Division of Hematology-Oncology, Children's Hospital and Dana Farber Cancer Institute, Harvard Medical School, Harvard Stem Cell Institute, Boston, Massachusetts 02115, USA.

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http://www.nature.com/articles/nature05284
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http://dx.doi.org/10.1038/nature05284DOI Listing
November 2006