Publications by authors named "Thor D Stein"

76Publications

Neurofilament light chain in the vitreous humor of the eye.

Alzheimers Res Ther 2020 Sep 17;12(1):111. Epub 2020 Sep 17.

Boston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, Boston, MA, USA.

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http://dx.doi.org/10.1186/s13195-020-00677-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7500015PMC
September 2020

Reply to "Chronic Traumatic Encephalopathy and Primary Age-Related Tauopathy".

Ann Neurol 2020 Aug 4. Epub 2020 Aug 4.

Boston University Alzheimer's Disease and CTE Centers, Boston University School of Medicine, Boston, MA, USA.

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http://dx.doi.org/10.1002/ana.25858DOI Listing
August 2020

Practical Considerations in the Diagnosis of Mild Chronic Traumatic Encephalopathy and Distinction From Age-Related Tau Astrogliopathy.

J Neuropathol Exp Neurol 2020 Aug;79(8):921-924

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1093/jnen/nlaa047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395709PMC
August 2020

Chronic Traumatic Encephalopathy and Neuropathological Comorbidities.

Semin Neurol 2020 Aug 30;40(4):384-393. Epub 2020 Jun 30.

Department of Pathology, Neuropathology Brain Bank & Research Core, Ronald M. Loeb Center for Alzheimer's Disease, Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York.

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http://dx.doi.org/10.1055/s-0040-1713628DOI Listing
August 2020

Late contributions of repetitive head impacts and TBI to depression symptoms and cognition.

Neurology 2020 08 26;95(7):e793-e804. Epub 2020 Jun 26.

From the Departments of Neurology (M.L.A., J.M., O.H., S.C., A.C.M., R.A.S.), Pathology & Laboratory Medicine (T.D.S., A.C.M.), Boston University Alzheimer's Disease Center and CTE Center (Y.T., B.M.), and Departments of Neurosurgery (R.A.S.) and Anatomy and Neurobiology (R.A.S.), Boston University School of Medicine; Department of Biostatistics (Y.T., Z.H.B.), Biostatistics and Epidemiology Data Analytics Center (B.M.), and Department of Environmental Health (M.M.), Boston University School of Public Health, MA; VA Boston Healthcare System (T.D.S., A.C.M.); Department of Veterans Affairs Medical Center (T.D.S., A.C.M.), Bedford, MA; Departments of Psychiatry (R.N., S.M., M.W.W.), Radiology (M.W.W.), Biomedical Imaging (M.W.W.), Medicine (M.W.W.), and Neurology (M.W.W.), University of California, San Francisco; and Department of Veterans Affairs Medical Center (R.N., S.M., M.W.W.), Center for Imaging and Neurodegenerative Diseases, San Francisco, CA.

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http://dx.doi.org/10.1212/WNL.0000000000010040DOI Listing
August 2020

A longitudinal examination of plasma neurofilament light and total tau for the clinical detection and monitoring of Alzheimer's disease.

Neurobiol Aging 2020 Oct 29;94:60-70. Epub 2020 May 29.

Boston University Alzheimer's Disease Center and CTE Center, Boston University School of Medicine, Boston, MA, USA; Department of Neurology, Boston University School of Medicine, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2020.05.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7484086PMC
October 2020

Evolution of neuronal and glial tau isoforms in chronic traumatic encephalopathy.

Brain Pathol 2020 Sep 2;30(5):913-925. Epub 2020 Jul 2.

Neuropathology Brain Bank & Research CoRE, Department of Pathology, Nash Family Department of Neuroscience, Ronald M. Loeb Center for Alzheimer's Disease, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY.

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http://dx.doi.org/10.1111/bpa.12867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7484331PMC
September 2020

Alterations of transcriptome signatures in head trauma-related neurodegenerative disorders.

Sci Rep 2020 06 1;10(1):8811. Epub 2020 Jun 1.

Gong-Wu Genomic Medicine Institute, Seoul National University Bundang Hospital, Seongnam, 13605, Republic of Korea.

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http://dx.doi.org/10.1038/s41598-020-65916-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264177PMC
June 2020

Upregulation of Lysyl Oxidase Expression in Vitreous of Diabetic Subjects: Implications for Diabetic Retinopathy.

Cells 2019 09 21;8(10). Epub 2019 Sep 21.

Department of Ophthalmology, Boston University School of Medicine, Boston, MA 02118, USA.

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http://dx.doi.org/10.3390/cells8101122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829411PMC
September 2019

Failure to detect an association between self-reported traumatic brain injury and Alzheimer's disease neuropathology and dementia.

Alzheimers Dement 2019 05 7;15(5):686-698. Epub 2019 Mar 7.

Boston University Alzheimer's Disease Center and CTE Center, Boston University School of Medicine, Boston, MA, USA; Department of Neurology, Boston University School of Medicine, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2018.12.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511462PMC
May 2019

Association of Chronic Low-grade Inflammation With Risk of Alzheimer Disease in ApoE4 Carriers.

JAMA Netw Open 2018 10 5;1(6):e183597. Epub 2018 Oct 5.

Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, Massachusetts.

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http://dx.doi.org/10.1001/jamanetworkopen.2018.3597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324596PMC
October 2018

Cortical degeneration in chronic traumatic encephalopathy and Alzheimer's disease neuropathologic change.

Neurol Sci 2019 Mar 18;40(3):529-533. Epub 2018 Dec 18.

Departments of Neurology and Pathology & Immunology, Washington University School of Medicine, Saint Louis, MO, 63110, USA.

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http://dx.doi.org/10.1007/s10072-018-3686-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433808PMC
March 2019

The neuropathology of chronic traumatic encephalopathy.

Handb Clin Neurol 2018 ;158:297-307

VA Boston Healthcare System, Boston, MA, United States; Departments of Neurology and Pathology, Boston University School of Medicine, and Boston University CTE Center, Boston, MA, United States.

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http://dx.doi.org/10.1016/B978-0-444-63954-7.00028-8DOI Listing
March 2019

Reduced interleukin 1A gene expression in the dorsolateral prefrontal cortex of individuals with PTSD and depression.

Neurosci Lett 2019 01 23;692:204-209. Epub 2018 Oct 23.

National Center for PTSD at VA Boston Healthcare System, United States; Pathology and Laboratory Medicine, VA Boston Healthcare System, United States; Department of Neurology, Boston University School of Medicine, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03043940183070
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http://dx.doi.org/10.1016/j.neulet.2018.10.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351202PMC
January 2019

Astrocytic degeneration in chronic traumatic encephalopathy.

Acta Neuropathol 2018 12 7;136(6):955-972. Epub 2018 Sep 7.

Department of Neurology, Washington University, St. Louis, MO, USA.

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http://dx.doi.org/10.1007/s00401-018-1902-3DOI Listing
December 2018

Cerebrospinal fluid tau, Aβ, and sTREM2 in Former National Football League Players: Modeling the relationship between repetitive head impacts, microglial activation, and neurodegeneration.

Alzheimers Dement 2018 09 23;14(9):1159-1170. Epub 2018 Jul 23.

Boston University Alzheimer's Disease Center and Boston University CTE Center, Boston University School of Medicine, Boston, MA, USA; Department of Neurology, Boston University School of Medicine, Boston, MA, USA; Department of Neurosurgery, Boston University School of Medicine, Boston, MA, USA; Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2018.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131058PMC
September 2018

Characterization of Detergent Insoluble Proteome in Chronic Traumatic Encephalopathy.

J Neuropathol Exp Neurol 2018 Jan;77(1):40-49

Boston University Alzheimer's Disease and CTE Center; Department of Neurology, Boston University School of Medicine, Boston, Massachusetts; Center for Neurodegenerative Disease, Emory University School of Medicine; Department of Biochemistry, Emory University School of Medicine; Department of Neurology, Emory University School of Medicine, Atlanta, Georgia; Department of Anatomy and Neurobiology; Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, Massachusetts; VA Boston Healthcare System, Boston, Massachusetts; and Department of Veterans Affairs Medical Center, Bedford, Massachusetts.

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http://dx.doi.org/10.1093/jnen/nlx100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939631PMC
January 2018

Clinicopathological Evaluation of Chronic Traumatic Encephalopathy in Players of American Football.

JAMA 2017 07;318(4):360-370

Boston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, Boston, Massachusetts2Department of Neurology, Boston University School of Medicine, Boston, Massachusetts4VA Boston Healthcare System, US Department of Veteran Affairs, Boston, Massachusetts5Department of Veterans Affairs Medical Center, Bedford, Massachusetts12Department of Pathology, Boston University School of Medicine, Boston, Massachusetts23Boston University School of Medicine, Boston, Massachusetts.

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http://dx.doi.org/10.1001/jama.2017.8334DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807097PMC
July 2017

Quantitative validation of a nonlinear histology-MRI coregistration method using generalized Q-sampling imaging in complex human cortical white matter.

Neuroimage 2017 06 30;153:152-167. Epub 2017 Mar 30.

Department of Biomedical Engineering, Washington University School of Medicine, St. Louis, MO, USA; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuroimage.2017.03.059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5497585PMC
June 2017

Amylin receptor ligands reduce the pathological cascade of Alzheimer's disease.

Neuropharmacology 2017 06 28;119:170-181. Epub 2017 Mar 28.

Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, USA; Alzheimer's Disease Center, Boston University School of Medicine, Boston, MA, USA; Department of Psychiatry, Boston University School of Medicine, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2017.03.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511375PMC
June 2017

The Role of Substance P in Pulmonary Clearance of Bacteria in Comparative Injury Models.

Am J Pathol 2016 12;186(12):3236-3245

Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2016.08.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225288PMC
December 2016

Cognitive Reserve as a Modifier of Clinical Expression in Chronic Traumatic Encephalopathy: A Preliminary Examination.

J Neuropsychiatry Clin Neurosci 2017 19;29(1):6-12. Epub 2016 Aug 19.

From Boston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, Boston (MLA, JM, NWK, TDS, LEG, RCC, TMS, PTK, LM, BA, DD, PHM, CJN, RAS, ACM); the Department of Neurology, Boston University School of Medicine, Boston (MLA, JM, NWK, TDS, LEG, DIK, TMS, PTK, LM, BA, DD, PHM, RAS, ACM); Internal Medicine Department, North Shore Medical Center (DD); the VA Boston Healthcare System, U.S. Department of Veteran Affairs, Boston (NWK, TDS, ACM); the Departments of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston (NWK, TDS, ACM); the Department of Veterans Affairs Medical Center, Bedford, Mass. (TDS, ACM); the Departments of Psychiatry and Ophthalmology, Boston University School of Medicine, Boston (LEG); the Departments of Biomedical, Electrical & Computer Engineering, Boston University College of Engineering, Boston (LEG); the Concussion Legacy Foundation (RCC, CJN); the Department of Neurosurgery, Boston University School of Medicine, Boston (RAS); the Department of Neurosurgery, Emerson Hospital, Concord, Mass. (RCC); Braintree Rehabilitation Hospital, Braintree, Mass. (DIK); and the Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston (PHM, RAS).

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http://dx.doi.org/10.1176/appi.neuropsych.16030043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288278PMC
April 2017

Potential Long-Term Consequences of Concussive and Subconcussive Injury.

Phys Med Rehabil Clin N Am 2016 05 2;27(2):503-11. Epub 2016 Feb 2.

VA Boston HealthCare System, 150 South Huntington Avenue, Boston, MA 02130, USA; Department of Neurology, Boston University School of Medicine, 72 East Concord Street, B-7800, Boston, MA 02118, USA; Chronic Traumatic Encephalopathy Program, Boston University School of Medicine, 72 East Concord Street, B-7800, Boston, MA 02118, USA; Department of Pathology, Boston University School of Medicine, 72 East Concord Street, B-7800, Boston, MA 02118, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10479651150012
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http://dx.doi.org/10.1016/j.pmr.2015.12.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866819PMC
May 2016

Pathologically Confirmed Chronic Traumatic Encephalopathy in a 25-Year-Old Former College Football Player.

JAMA Neurol 2016 Mar;73(3):353-5

Alzheimer's Disease Center, Chronic Traumatic Encephalopathy Program, Boston University School of Medicine, Boston, Massachusetts2Department of Neurology, Boston University School of Medicine, Boston, Massachusetts4US Department of Veterans Affairs, VA Bo.

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http://dx.doi.org/10.1001/jamaneurol.2015.3998DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792748PMC
March 2016

Concussion in Chronic Traumatic Encephalopathy.

Curr Pain Headache Rep 2015 Oct;19(10):47

VA Boston Healthcare System, Boston, MA, 02130, USA,

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http://link.springer.com/10.1007/s11916-015-0522-z
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http://dx.doi.org/10.1007/s11916-015-0522-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633042PMC
October 2015

The neuropathology of chronic traumatic encephalopathy.

Brain Pathol 2015 May;25(3):350-64

VA Boston Healthcare System, Boston University, Boston, MA; Department of Pathology and Laboratory Science, Boston University School of Medicine, Boston University, Boston, MA; Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA; Boston University Alzheimer's Disease Center, Boston University, Boston, MA; Chronic Traumatic Encephalopathy Center Program, Boston University, Boston, MA.

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http://dx.doi.org/10.1111/bpa.12248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526170PMC
May 2015

Post-traumatic neurodegeneration and chronic traumatic encephalopathy.

Mol Cell Neurosci 2015 May 7;66(Pt B):81-90. Epub 2015 Mar 7.

Boston University Chronic Traumatic Encephalopathy Program, Boston University School of Medicine, 72 E. Concord St., Boston, MA 02118, USA; Boston University Alzheimer's Disease Center, Boston University School of Medicine, 72 E. Concord St., Boston, MA 02118, USA; Department of Neurology, Boston University School of Medicine, 72 E. Concord St., Boston, MA 02118, USA; Department of Pathology and Laboratory Medicine, Boston University School of Medicine, 72 E. Concord St., Boston, MA 02118, USA; VA Boston Healthcare System, 150 South Huntington Avenue, Jamaica Plain, MA 02130, USA.

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http://dx.doi.org/10.1016/j.mcn.2015.03.007DOI Listing
May 2015

Chronic traumatic encephalopathy: historical origins and current perspective.

Annu Rev Clin Psychol 2015 12;11:309-30. Epub 2015 Jan 12.

Chronic Traumatic Encephalopathy Center, Boston University School of Medicine, Boston, Massachusetts 02118; email: , ,

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http://dx.doi.org/10.1146/annurev-clinpsy-032814-112814DOI Listing
January 2016

Chronic traumatic encephalopathy: historical origins and current perspective.

Annu Rev Clin Psychol 2015 12;11:309-30. Epub 2015 Jan 12.

Chronic Traumatic Encephalopathy Center, Boston University School of Medicine, Boston, Massachusetts 02118; email: , ,

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http://dx.doi.org/10.1146/annurev-clinpsy-032814-112814DOI Listing
January 2016

The neuropathology of sport.

Acta Neuropathol 2014 Jan 24;127(1):29-51. Epub 2013 Dec 24.

VA Boston HealthCare System, 150 South Huntington Ave, Boston, MA, 02130, USA,

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http://dx.doi.org/10.1007/s00401-013-1230-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255282PMC
January 2014

A 34-year-old man with bitemporal hemianopsia.

Brain Pathol 2014 Jan;24(1):107-10

Massachusetts General Hospital, Harvard University, Boston.

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http://dx.doi.org/10.1111/bpa.12108DOI Listing
January 2014

Clinical presentation of chronic traumatic encephalopathy.

Neurology 2013 Sep 21;81(13):1122-9. Epub 2013 Aug 21.

From the Center for the Study of Traumatic Encephalopathy (R.A.S., D.H.D., C.M.B., D.R.S., P.H.M., D.O.R., N.G.F., J.M.S., C.A.R., T.D.S., V.E.A., C.J.N., R.C.C., A.C.M.), BU Alzheimer's Disease Center (R.A.S., T.D.S., L.E.G., A.E.B., N.W.K., A.C.M.), Departments of Neurology (R.A.S., C.M.B., D.R.S., V.E.A., A.E.B., N.W.K., A.C.M.), Neurosurgery (R.A.S., R.C.C.), and Pathology (T.D.S., N.W.K., A.C.M.), Molecular Genetics Core Facility (I.S.), Boston University School of Medicine; Sports Legacy Institute (L.M., C.J.N., R.C.C.), Waltham; VA Boston Healthcare System (T.D.S., V.E.A., A.E.B., N.W.K., A.C.M.); Departments of Psychiatry, Neurology, Pathology & Laboratory Medicine, Ophthalmology, Biomedical Engineering, and Electrical & Computer Engineering (L.E.G.), Boston University School of Medicine and College of Engineering; and Department of Neurosurgery (R.C.C.), Emerson Hospital, Concord, MA.

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http://dx.doi.org/10.1212/WNL.0b013e3182a55f7fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795597PMC
September 2013

FOSMN syndrome: novel insight into disease pathophysiology.

Neurology 2012 Jul 20;79(1):73-9. Epub 2012 Jun 20.

Sydney Medical School Westmead (S.V.), University of Sydney, Sydney, Australia.

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http://www.neurology.org/cgi/doi/10.1212/WNL.0b013e31825dce1
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http://dx.doi.org/10.1212/WNL.0b013e31825dce13DOI Listing
July 2012

Case records of the Massachusetts General Hospital. Case 40-2011. A 52-year-old man with weakness, infections, and enlarged adrenal glands.

N Engl J Med 2011 Dec;365(26):2520-30

Neuroendocrine Unit, the Department of Medicine, Massachusetts General Hospital, and Harvard Medical School, Boston, USA.

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http://dx.doi.org/10.1056/NEJMcpc1100919DOI Listing
December 2011

Entorhinal verrucae geometry is coincident and correlates with Alzheimer's lesions: a combined neuropathology and high-resolution ex vivo MRI analysis.

Acta Neuropathol 2012 Jan 13;123(1):85-96. Epub 2011 Dec 13.

Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Building 149-13th St., Room 2301, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1007/s00401-011-0929-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278990PMC
January 2012

Pathological mechanism of lumbar disc herniation resulting in neurogenic muscle hypertrophy.

J Clin Neurosci 2011 Dec 8;18(12):1682-4. Epub 2011 Oct 8.

Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit St., White Building Room 502, Boston, MA 02114, USA.

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http://dx.doi.org/10.1016/j.jocn.2011.03.033DOI Listing
December 2011

Concomitant presentation of a glioblastoma multiforme with superimposed abscess.

World Neurosurg 2011 Jan;75(1):126-31; discussion 50-3

Neurosurgery Service, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1016/j.wneu.2010.09.014DOI Listing
January 2011

Nrf2, a multi-organ protector?

FASEB J 2005 Jul;19(9):1061-6

Molecular Neurogenetics Unit, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.

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http://www.fasebj.org/doi/10.1096/fj.04-2591hyp
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http://dx.doi.org/10.1096/fj.04-2591hypDOI Listing
July 2005

Genetic dissection of systemic autoimmune disease in Nrf2-deficient mice.

Physiol Genomics 2004 Aug 11;18(3):261-72. Epub 2004 Aug 11.

School of Pharmacy, University of Wisconsin, Madison 53705-2222, USA.

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http://dx.doi.org/10.1152/physiolgenomics.00209.2003DOI Listing
August 2004

Genetic programming by the proteolytic fragments of the amyloid precursor protein: somewhere between confusion and clarity.

Rev Neurosci 2003 ;14(4):317-41

Neuroscience Training Program, University of Wisconsin, Madison, WI 53705-2222, USA.

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http://dx.doi.org/10.1515/revneuro.2003.14.4.317DOI Listing
December 2003

Circulating autoantibodies recognize and bind dying neurons following injury to the brain.

J Neuropathol Exp Neurol 2002 Dec;61(12):1100-8

Neuroscience Training Program, University of Wisconsin, Madison, Wisconsin 53706, USA.

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http://dx.doi.org/10.1093/jnen/61.12.1100DOI Listing
December 2002

Microarray expression analysis of effects of exercise training: increase in atrial MLC-1 in rat ventricles.

Am J Physiol Heart Circ Physiol 2003 Mar 7;284(3):H830-7. Epub 2002 Nov 7.

Department of Kinesiology, University of Wisconsin, Madison, Wisconsin 53706, USA.

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http://dx.doi.org/10.1152/ajpheart.00761.2002DOI Listing
March 2003