Publications by authors named "Thomas Wurdinger"

100Publications

isomiRs-Hidden Soldiers in the miRNA Regulatory Army, and How to Find Them?

Biomolecules 2020 Dec 30;11(1). Epub 2020 Dec 30.

Faculty of Biology, University of Plovdiv, Tzar Assen 24, 4000 Plovdiv, Bulgaria.

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December 2020

Circulating platelets as liquid biopsy sources for cancer detection.

Mol Oncol 2020 Nov 20. Epub 2020 Nov 20.

Department of Neurosurgery, Cancer Center Amsterdam, Amsterdam University Medical Centers, VU University Medical Center, Amsterdam, The Netherlands.

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November 2020

Blood platelet RNA enables the detection of multiple sclerosis.

Mult Scler J Exp Transl Clin 2020 Jul-Sep;6(3):2055217320946784. Epub 2020 Jul 30.

Department of Neurology, Neuroscience Amsterdam, VUmc MS Center Amsterdam, Amsterdam UMC, VU University Medical Center, Amsterdam, The Netherlands.

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July 2020

Extracellular Vesicles Induce Mesenchymal Transition and Therapeutic Resistance in Glioblastomas through NF-κB/STAT3 Signaling.

Adv Biosyst 2020 12 9;4(12):e1900312. Epub 2020 Jun 9.

Experimental Therapeutics and Molecular Imaging Laboratory, Department of Neurology, Neuro-Oncology Division, Massachusetts General Hospital, Boston, MA, 02129, USA.

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December 2020

Tumor-educated platelets for the earlier detection of hepatocellular carcinoma.

Clin Res Hepatol Gastroenterol 2020 11 22;44(6):794-795. Epub 2020 Apr 22.

Department of Neurosurgery, Brain Tumor Center Amsterdam, Cancer Center Amsterdam, Amsterdam UMC, VU University Medical Center, Amsterdam, The Netherlands.

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November 2020

Platelet RNA as Pan-Tumor Biomarker for Cancer Detection.

Cancer Res 2020 04 19;80(7):1371-1373. Epub 2020 Feb 19.

Brain Tumor Center Amsterdam, Amsterdam UMC, VU University Medical Center, Amsterdam, the Netherlands.

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April 2020

The Landscape of Atypical and Eukaryotic Protein Kinases.

Trends Pharmacol Sci 2019 11 31;40(11):818-832. Epub 2019 Oct 31.

Division of Medicinal Chemistry, Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands. Electronic address:

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November 2019

Patient-Derived Glioma Models: From Patients to Dish to Animals.

Cells 2019 09 30;8(10). Epub 2019 Sep 30.

Experimental Therapeutics and Molecular Imaging Laboratory, Department of Neurology, Neuro-Oncology Division, Massachusetts General Hospital, Boston, MA 02129, USA.

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September 2019

RNA sequencing and swarm intelligence-enhanced classification algorithm development for blood-based disease diagnostics using spliced blood platelet RNA.

Nat Protoc 2019 04 20;14(4):1206-1234. Epub 2019 Mar 20.

Department of Neurosurgery, Cancer Center Amsterdam, Amsterdam UMC, VU University Medical Center, Amsterdam, the Netherlands.

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April 2019

Tumor-educated platelets.

Blood 2019 05 4;133(22):2359-2364. Epub 2019 Mar 4.

Department of Neurosurgery, Cancer Center Amsterdam, Brain Tumor Center Amsterdam, Amsterdam UMC, VU University Medical Center, Amsterdam, The Netherlands.

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May 2019

An Experimenter's Guide to Glioblastoma Invasion Pathways.

Trends Mol Med 2018 09 30;24(9):763-780. Epub 2018 Jul 30.

Division of Pharmacology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands. Electronic address:

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September 2018

Tumor-Educated Platelets as a Noninvasive Biomarker Source for Cancer Detection and Progression Monitoring.

Cancer Res 2018 07 19;78(13):3407-3412. Epub 2018 Jun 19.

Department of Neurosurgery, Cancer Center Amsterdam, VU University Medical Center, Amsterdam, the Netherlands.

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July 2018

Quantification and localization of oncogenic receptor tyrosine kinase variant transcripts using molecular inversion probes.

Sci Rep 2018 05 4;8(1):7072. Epub 2018 May 4.

Department of Biochemistry, Radboud Institute for Molecular Life Sciences, University Medical Centre, Nijmegen, 6525 GA, The Netherlands.

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May 2018

Trimethylation of H3K27 during human cerebellar development in relation to medulloblastoma.

Oncotarget 2017 Oct 8;8(45):78978-78988. Epub 2017 Sep 8.

Department of Pediatric Oncology/Hematology, VU University Medical Center, Amsterdam, The Netherlands.

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October 2017

Platelet RNA in Cancer Diagnostics.

Semin Thromb Hemost 2018 Mar 13;44(2):135-141. Epub 2017 Sep 13.

Department of Radiation Sciences, Oncology, Umea University, Umea, Sweden.

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March 2018

Ape1 guides DNA repair pathway choice that is associated with drug tolerance in glioblastoma.

Sci Rep 2017 08 29;7(1):9674. Epub 2017 Aug 29.

Molecular Neuro-Oncology Research Unit, Department of Pediatrics & Adolescent Medicine, Medical University of Vienna, A-1090, Vienna, Austria.

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August 2017

Swarm Intelligence-Enhanced Detection of Non-Small-Cell Lung Cancer Using Tumor-Educated Platelets.

Cancer Cell 2017 08;32(2):238-252.e9

Department of Neurosurgery, VU University Medical Center, Cancer Center Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Brain Tumor Center Amsterdam, VU University Medical Center, Cancer Center Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Department of Neurology, Massachusetts General Hospital and Neuroscience Program, Harvard Medical School, 149 13(th) Street, Charlestown, MA 02129, USA. Electronic address:

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August 2017

Platelet RNA signatures for the detection of cancer.

Cancer Metastasis Rev 2017 06;36(2):263-272

Brain Tumor Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.

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June 2017

The G2 checkpoint-a node-based molecular switch.

FEBS Open Bio 2017 04 4;7(4):439-455. Epub 2017 Mar 4.

Division of Pharmacology/Mouse Cancer Clinic The Netherlands Cancer Institute Amsterdam The Netherlands.

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April 2017

Systemically administered AAV9-sTRAIL combats invasive glioblastoma in a patient-derived orthotopic xenograft model.

Mol Ther Oncolytics 2016 22;3:16017. Epub 2016 Jun 22.

Experimental Therapeutics and Molecular Imaging Laboratory, Neuroscience Center, Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA; Program in Neuroscience, Harvard Medical School, Boston, Massachusetts, USA.

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July 2016

Re: a Word of Caution on New and Revolutionary Diagnostic Tests.

Cancer Cell 2016 Feb;29(2):143-4

Department of Neurosurgery, VU University Medical Center, Cancer Center Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Department of Neurology, Massachusetts General Hospital and Neuroscience Program, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA; thromboDx B.V., 1098 EA Amsterdam, the Netherlands. Electronic address:

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February 2016

Intracranial AAV-sTRAIL combined with lanatoside C prolongs survival in an orthotopic xenograft mouse model of invasive glioblastoma.

Mol Oncol 2016 Apr 11;10(4):625-34. Epub 2015 Dec 11.

Experimental Therapeutics and Molecular Imaging Laboratory, Neuroscience Center, Department of Neurology, Massachusetts General Hospital, Boston, MA, USA; Program in Neuroscience, Harvard Medical School, Boston, MA, USA. Electronic address:

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April 2016

RNA-Seq of Tumor-Educated Platelets Enables Blood-Based Pan-Cancer, Multiclass, and Molecular Pathway Cancer Diagnostics.

Cancer Cell 2015 Nov 29;28(5):666-676. Epub 2015 Oct 29.

Department of Neurosurgery, VU University Medical Center, Cancer Center Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Department of Neurology, Massachusetts General Hospital and Neuroscience Program, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA; thromboDx B.V., 1098 EA Amsterdam, the Netherlands. Electronic address:

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November 2015

Bioluminescence-mediated longitudinal monitoring of adipose-derived stem cells in a large mammal ex vivo organ culture.

Sci Rep 2015 Sep 9;5:13960. Epub 2015 Sep 9.

Department of Orthopedic Surgery, VU University Medical Center, MOVE Research Institute Amsterdam, Amsterdam, The Netherlands.

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September 2015

Liquid biopsies in patients with diffuse glioma.

Acta Neuropathol 2015 Jun 27;129(6):849-65. Epub 2015 Feb 27.

Neuro-oncology Research Group, VU University Medical Center, Cancer Center Amsterdam, CCA Room 3.20, Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.

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June 2015

Mechanisms of intimate and long-distance cross-talk between glioma and myeloid cells: how to break a vicious cycle.

Biochim Biophys Acta 2014 Dec 20;1846(2):560-75. Epub 2014 Oct 20.

Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands. Electronic address:

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December 2014

Nontemplated nucleotide additions distinguish the small RNA composition in cells from exosomes.

Cell Rep 2014 Sep 18;8(6):1649-1658. Epub 2014 Sep 18.

Department of Pathology, VU University Medical Center, 1007MB Amsterdam, the Netherlands; Exosomes Research Group, VU University Medical Center, 1007MB Amsterdam, the Netherlands. Electronic address:

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September 2014

Identification of temozolomide resistance factors in glioblastoma via integrative miRNA/mRNA regulatory network analysis.

Sci Rep 2014 Jun 11;4:5260. Epub 2014 Jun 11.

1] Department of Neurosurgery, VU University Medical Center, Amsterdam, The Netherlands [2] Neuro-oncology Research Group, Cancer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands [3] Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

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June 2014

ABCB1, ABCG2, and PTEN determine the response of glioblastoma to temozolomide and ABT-888 therapy.

Clin Cancer Res 2014 May 19;20(10):2703-13. Epub 2014 Mar 19.

Authors' Affiliations: General Clinical Lab/Mouse Cancer Clinic, The Netherlands Cancer Institute; Department of Pharmacy and Pharmacology, The Netherlands Cancer Institute/Slotervaart Hospital, Amsterdam; Division of Drug Toxicology, Faculty of Pharmacy; Utrecht University, Utrecht; Molecular Therapeutics/Drug Discovery Program, University of Pittsburgh Cancer Institute; Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, Pennsylvania; Neuro-oncology Research Group, Departments of Neurosurgery and Pediatric Oncology/Hematology, Cancer Center Amsterdam, VU University Medical Center, Amsterdam, the Netherlands; and Molecular Neurogenetics Unit, Departments of Neurology and Radiology, Massachusetts General Hospital, and Neuroscience Program, Harvard Medical School, Boston, Massachusetts

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May 2014

Role of CYB5A in pancreatic cancer prognosis and autophagy modulation.

J Natl Cancer Inst 2014 Jan 3;106(1):djt346. Epub 2013 Dec 3.

Affiliations of authors: Department of Medical Oncology (EG, AA, GJP) and Department of Neurosurgery (TL, VC, TW), VU University Medical Center, and Centre for Integrative Bioinformatics (AvdV), VU University, Amsterdam, the Netherlands; Department of Ricerca Traslazionale e delle Nuove Tecnologie in Medicina e Chirurgia, University of Pisa, Pisa, Italy (NF, UB, EV); Department of Neurology, Stanford University, Stanford, CA (VC); Department of Neurology, Massachusetts General Hospital and Neuroscience Program, Harvard Medical School, Boston, MA (TW); Medical Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD (QW, J-HL, YW, GG).

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January 2014

Multiplex functional bioluminescent reporters using Gaussia luciferase fused to epitope tags in an immunobinding assay.

Methods Mol Biol 2014 ;1098:231-47

Department of Neurosurgery, Cancer Center Amsterdam, Neuro-oncology Research Group, VU University Medical Center, Amsterdam, The Netherlands.

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May 2014

Multiplex blood reporters for simultaneous monitoring of cellular processes.

Anal Chem 2013 Nov 16;85(21):10205-10. Epub 2013 Oct 16.

Experimental Therapeutics and Molecular Imaging Laboratory, Neuroscience Center, Department of Neurology, Massachusetts General Hospital , Boston, Massachusetts 02129, United States.

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November 2013

Crizotinib inhibits metabolic inactivation of gemcitabine in c-Met-driven pancreatic carcinoma.

Cancer Res 2013 Nov 1;73(22):6745-56. Epub 2013 Oct 1.

Authors' Affiliations: Departments of Medical Oncology, Hematology, Neurosurgery and Pediatric Oncology/Hematology, Neuro-oncology Research Group, VU University Medical Center; Diagnostic Oncology Division, Netherlands Cancer Institute; VisualSonics, Amsterdam, the Netherlands; Departments of Neurology and Pediatrics, Stanford University School of Medicine, Stanford, California; Division of Surgical Pathology, Division of General and Transplant Surgery, University of Pisa, Pisa, Italy; and Molecular Neurogenetics Unit, Department of Neurology, Massachusetts General Hospital and Neuroscience Program, Harvard Medical School, Boston, Massachusetts.

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November 2013

WEE1 inhibition and genomic instability in cancer.

Biochim Biophys Acta 2013 Dec 31;1836(2):227-35. Epub 2013 May 31.

Neurosurgical Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands; Neuro-oncology Research Group, Cancer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands; Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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December 2013

Functional multiplex reporter assay using tagged Gaussia luciferase.

Sci Rep 2013 10;3:1046. Epub 2013 Jan 10.

Department of Neurosurgery, Cancer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.

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June 2013

Extracellular vesicles and their convergence with viral pathways.

Adv Virol 2012 25;2012:767694. Epub 2012 Jul 25.

Departments of Neurology and Radiology, Massachusetts General Hospital and Neuroscience Program, Harvard Medical School, Boston, MA 02129, USA.

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August 2012

EZH2-regulated DAB2IP is a medulloblastoma tumor suppressor and a positive marker for survival.

Clin Cancer Res 2012 Aug 13;18(15):4048-58. Epub 2012 Jun 13.

Neuro-oncology Research Group, Department of Neurosurgery, Cancer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.

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August 2012

Myc-associated zinc finger protein (MAZ) is regulated by miR-125b and mediates VEGF-induced angiogenesis in glioblastoma.

FASEB J 2012 Jun 13;26(6):2639-47. Epub 2012 Mar 13.

Neuro-oncology Research Group, Department of Neurosurgery, Vrije Universiteit Medical Center, Amsterdam, The Netherlands.

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June 2012

PARP inhibition sensitizes childhood high grade glioma, medulloblastoma and ependymoma to radiation.

Oncotarget 2011 Dec;2(12):984-96

Department of Pediatric Oncology / Hematology, Neuro-oncology Research Group, Cancer Center Amsterdam, VU University Medical Center, Amsterdam, the Netherlands.

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December 2011

Blood platelets contain tumor-derived RNA biomarkers.

Blood 2011 Sep 10;118(13):3680-3. Epub 2011 Aug 10.

Neuro-oncology Research Group, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, The Netherlands.

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September 2011

Lanatoside C sensitizes glioblastoma cells to tumor necrosis factor-related apoptosis-inducing ligand and induces an alternative cell death pathway.

Neuro Oncol 2011 Nov 13;13(11):1213-24. Epub 2011 Jul 13.

Neuroscience Center and Molecular Neurogenetics Unit, Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.

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November 2011

WEE1 inhibition sensitizes osteosarcoma to radiotherapy.

BMC Cancer 2011 Apr 29;11:156. Epub 2011 Apr 29.

Department of Orthopaedic Surgery, VU University Medical Center, 1007 MB Amsterdam, the Netherlands.

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April 2011

Human glioma growth is controlled by microRNA-10b.

Cancer Res 2011 May 6;71(10):3563-72. Epub 2011 Apr 6.

Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

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May 2011

miR-101 is down-regulated in glioblastoma resulting in EZH2-induced proliferation, migration, and angiogenesis.

Oncotarget 2010 Dec;1(8):710-20

Neuro-oncology Research Group, Departments of Neurosurgery and Pediatric Oncology/Hematology, Cancer Center Amsterdam, VU University Medical Center, Amsterdam, the Netherlands.

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December 2010

Functional drug screening assay reveals potential glioma therapeutics.

Assay Drug Dev Technol 2011 Jun 27;9(3):281-9. Epub 2010 Dec 27.

Neuroscience Center, Department of Neurology, Massachusetts General Hospital, Boston, USA.

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June 2011

Functional delivery of viral miRNAs via exosomes.

Proc Natl Acad Sci U S A 2010 Apr 18;107(14):6328-33. Epub 2010 Mar 18.

Department of Pathology, Cancer Center Amsterdam, Vrije Universiteit University Medical Center, 1081HV Amsterdam, The Netherlands.

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April 2010

Microfluidic isolation and transcriptome analysis of serum microvesicles.

Lab Chip 2010 Feb 8;10(4):505-11. Epub 2009 Dec 8.

BioMEMS Resource Center, Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

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February 2010

Comparative protein profiling reveals minichromosome maintenance (MCM) proteins as novel potential tumor markers for meningiomas.

J Proteome Res 2010 Jan;9(1):485-94

Department of Neurology and Radiology, Massachusetts General Hospital, and Neuroscience Program, Harvard Medical School, Boston, Massachusetts, 02129, USA.

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January 2010

Real-time monitoring of nuclear factor kappaB activity in cultured cells and in animal models.

Mol Imaging 2009 Sep-Oct;8(5):278-90

Neuroscience Center, Department of Neurology, Massachusetts General Hospital, Charlestown, 02129, USA.

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January 2010

Glioma angiogenesis: Towards novel RNA therapeutics.

Cell Adh Migr 2009 Apr-Jun;3(2):230-5. Epub 2009 Apr 22.

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, USA.

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September 2009

Mutant sodium channel for tumor therapy.

Mol Ther 2009 May 3;17(5):810-9. Epub 2009 Mar 3.

Department of Neurology, Molecular Neurogenetics Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA.

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May 2009

Performance of the red-shifted fluorescent proteins in deep-tissue molecular imaging applications.

J Biomed Opt 2008 Jul-Aug;13(4):044008

Massachusetts General Hospital and Harvard Medical School, Center for Molecular Imaging Research, Laboratory for Bio-Optics and Molecular Imaging, Charlestown, Massachusetts 02139, USA.

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January 2009

miR-296 regulates growth factor receptor overexpression in angiogenic endothelial cells.

Cancer Cell 2008 Nov;14(5):382-93

Department of Neurology, Massachusetts General Hospital and Neuroscience Program, Harvard Medical School, Boston, MA 02115, USA.

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November 2008

MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators.

Mol Cell Biol 2008 Sep 30;28(17):5369-80. Epub 2008 Jun 30.

Center of Neurologic Diseases, Brigham and Women's Hospital, 4 Blackfan Circle, HIM 758, Boston, MA 02115, USA.

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September 2008

A secreted luciferase for ex vivo monitoring of in vivo processes.

Nat Methods 2008 Feb 20;5(2):171-3. Epub 2008 Jan 20.

Molecular Neurogenetics Unit, Department of Neurology, Harvard Medical School, 149 13th St., Charlestown, Massachusetts 02129, USA.

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February 2008

The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions.

J Exp Med 2007 Nov 19;204(12):3037-47. Epub 2007 Nov 19.

Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.

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November 2007