Dr. Thomas W Klein, PhD - University of South Florida - Professor Emeritus

Dr. Thomas W Klein

PhD

University of South Florida

Professor Emeritus

Tampa, FL | United States

Main Specialties: Allergy & Immunology

Additional Specialties: Immunology, cytokines, bacteriology


Top Author

Dr. Thomas W Klein, PhD - University of South Florida - Professor Emeritus

Dr. Thomas W Klein

PhD

Introduction

Primary Affiliation: University of South Florida - Tampa, FL , United States

Specialties:

Additional Specialties:

Research Interests:


View Dr. Thomas W Klein’s Resume / CV

Education

Jan 1973
Creighton University
PhD
Medical Microbiology

Publications

33Publications

583Reads

790Profile Views

742PubMed Central Citations

Δ(9)-Tetrahydrocannabinol (THC) enhances lipopolysaccharide-stimulated tissue factor in human monocytes and monocyte-derived microvesicles.

J Inflamm (Lond) 2015 12;12:39. Epub 2015 Jun 12.

Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, 2033 Mowry Road, Gainesville, FL 32610-3663 USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12950-015-0084-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4469459PMC
June 2015
37 Reads
3 Citations
2.024 Impact Factor

Δ(9)-Tetrahydrocannabinol treatment during human monocyte differentiation reduces macrophage susceptibility to HIV-1 infection.

J Neuroimmune Pharmacol 2014 Jun 23;9(3):369-79. Epub 2014 Feb 23.

Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, 2033 Mowry Road, Campus Box 103633, Gainesville, FL, 32610-3663, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11481-014-9527-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019698PMC
June 2014
33 Reads
6 Citations
4.110 Impact Factor

Cannabinoid 2 (CB2) receptor involvement in the down-regulation but not up-regulation of serum IgE levels in immunized mice.

J Neuroimmune Pharmacol 2012 Sep 4;7(3):591-8. Epub 2012 May 4.

Department of Molecular Medicine, University of South Florida Tampa Bay, USF Health Morsani College of Medicine, School of Biomedical Sciences, 12901 Bruce Downs Blvd, Tampa, FL 33612, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11481-012-9361-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419805PMC
September 2012
25 Reads
5 Citations
4.110 Impact Factor

Identification of transcription start sites and preferential expression of select CB2 transcripts in mouse and human B lymphocytes.

J Neuroimmune Pharmacol 2009 Dec 16;4(4):476-88. Epub 2009 Sep 16.

Department of Molecular Medicine, School of Basic Biomedical Sciences, College of Medicine, University of South Florida, 12901 Bruce B Downs Blvd., Tampa, FL 33612, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11481-009-9169-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2843092PMC
December 2009
7 Reads
5 Citations
4.110 Impact Factor

CB(1) and CB(2) cannabinoid receptors mediate different aspects of delta-9-tetrahydrocannabinol (THC)-induced T helper cell shift following immune activation by Legionella pneumophila infection.

J Neuroimmune Pharmacol 2009 Mar 16;4(1):92-102. Epub 2008 Sep 16.

Department of Molecular Medicine, University of South Florida, Tampa, FL 33612, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11481-008-9126-2DOI Listing
March 2009
11 Reads
16 Citations
4.110 Impact Factor

In memory of Billy R. Martin (1943-2008).

J Neuroimmune Pharmacol 2008 Dec 22;3(4):201-2. Epub 2008 Aug 22.

Department of Molecular Medicine, University of South Florida, 12901 Bruce B. Downs Blvd, Box 07, Tampa, FL 33626, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11481-008-9122-6DOI Listing
December 2008
20 Reads
4.110 Impact Factor

Suppression of dendritic cell activation by anthrax lethal toxin and edema toxin depends on multiple factors including cell source, stimulus used, and function tested.

DNA Cell Biol 2008 Dec;27(12):637-48

Department of Molecular Medicine, University of South Florida College of Medicine, Tampa, Florida 33612, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/dna.2008.0760DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994424PMC
December 2008
17 Reads
10 Citations
2.060 Impact Factor

Cannabinoid receptor 2 (CB2) mediates immunoglobulin class switching from IgM to IgE in cultures of murine-purified B lymphocytes.

J Neuroimmune Pharmacol 2008 Mar 27;3(1):35-42. Epub 2007 Sep 27.

Department of Molecular Medicine, School of Biomedical Sciences, College of Medicine, University of South Florida, Tampa, FL 33612, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11481-007-9088-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2423231PMC
March 2008
10 Reads
20 Citations
4.110 Impact Factor

Therapeutic potential of cannabinoid-based drugs.

Adv Exp Med Biol 2007 ;601:395-413

University of South Florida, Department of Molecular Medicine, Tampa, FL, USA.

View Article

Download full-text PDF

Source
October 2007
25 Reads
9 Citations

Differential effects of Chlamydia pneumoniae infection on cytokine levels in human T lymphocyte- and monocyte-derived cell cultures.

Int J Med Microbiol 2007 Apr 5;297(2):109-15. Epub 2007 Feb 5.

Department of Molecular Medicine, University of South Florida, College of Medicine, Tampa, FL 33612-4742, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijmm.2006.11.004DOI Listing
April 2007
7 Reads
6 Citations
3.614 Impact Factor

Role of Toll-like receptor 9 in Legionella pneumophila-induced interleukin-12 p40 production in bone marrow-derived dendritic cells and macrophages from permissive and nonpermissive mice.

Infect Immun 2007 Jan 23;75(1):146-51. Epub 2006 Oct 23.

Department of Molecular Medicine, MDC Box 10, University of South Florida College of Medicine, 12901 Bruce B. Downs Boulevard, Tampa, FL 33612, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/IAI.01011-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1828406PMC
January 2007
30 Reads
15 Citations
3.731 Impact Factor

Cannabinoid treatment suppresses the T-helper cell-polarizing function of mouse dendritic cells stimulated with Legionella pneumophila infection.

J Pharmacol Exp Ther 2006 Oct 12;319(1):269-76. Epub 2006 Jul 12.

Department of Medical Microbiology and Immunology, MDC 10 University of South Florida College of Medicine, 12901 Bruce B. Downs Blvd., Tampa, Florida 33612, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/jpet.106.108381DOI Listing
October 2006
18 Reads
20 Citations
3.972 Impact Factor

Addictive drugs and their relationship with infectious diseases.

FEMS Immunol Med Microbiol 2006 Aug;47(3):330-42

Department of Medical Microbiology and Immunology, University of South Florida College of Medicine, Tampa, FL 33612-4799, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1574-695X.2006.00097.xDOI Listing
August 2006
16 Reads
36 Citations
3.080 Impact Factor

Cannabinoid-induced immune suppression and modulation of antigen-presenting cells.

J Neuroimmune Pharmacol 2006 Mar;1(1):50-64

Department of Medical Microbiology and Immunology, University of South Florida College of Medicine, MDC Box 10, 12901 Bruce Downs Boulevard, Tampa, FL 33612, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11481-005-9007-xDOI Listing
March 2006
47 Reads
34 Citations
4.110 Impact Factor

Role of cannabinoid receptors in Delta-9-tetrahydrocannabinol suppression of IL-12p40 in mouse bone marrow-derived dendritic cells infected with Legionella pneumophila.

Eur J Pharmacol 2006 Feb 27;532(1-2):170-7. Epub 2006 Jan 27.

Department of Medical Microbiology and Immunology, MDC 10 University of South Florida College of Medicine, 12901 Bruce B. Downs Blvd., Tampa, FL 33612, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejphar.2005.12.040DOI Listing
February 2006
12 Reads
14 Citations
2.532 Impact Factor

Epigallocatechin gallate modulates cytokine production by bone marrow-derived dendritic cells stimulated with lipopolysaccharide or muramyldipeptide, or infected with Legionella pneumophila.

Exp Biol Med (Maywood) 2005 Oct;230(9):645-51

Department of Medical Microbiology and Immunology, University of South Florida, Tampa, FL 33612, USA.

View Article

Download full-text PDF

Source
October 2005
9 Reads
10 Citations

Cannabinoid-based drugs as anti-inflammatory therapeutics.

Authors:
Thomas W Klein

Nat Rev Immunol 2005 May;5(5):400-11

Department of Medical Microbiology and Immunology, University of South Florida College of Medicine, Tampa, Florida 33612, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nri1602DOI Listing
May 2005
8 Reads
147 Citations
34.985 Impact Factor

Nicotine modulates cytokine production by Chlamydia pneumoniae infected human peripheral blood cells.

Int Immunopharmacol 2005 Apr;5(4):749-56

Department of Medical Microbiology and Immunology, University of South Florida, College of Medicine, Tampa, FL 33612, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.intimp.2004.12.010DOI Listing
April 2005
8 Reads
3 Citations
2.472 Impact Factor

The THC-induced suppression of Th1 polarization in response to Legionella pneumophila infection is not mediated by increases in corticosterone and PGE2.

J Leukoc Biol 2004 Oct 16;76(4):854-61. Epub 2004 Jul 16.

Department of Medical Microbiology and Immunology, University of South Florida, College of Medicine, Tampa 33612, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1189/jlb.0304184DOI Listing
October 2004
11 Reads
5 Citations
4.290 Impact Factor

Delta-9 tetrahydrocannabinol (THC) inhibits lytic replication of gamma oncogenic herpesviruses in vitro.

BMC Med 2004 Sep 15;2:34. Epub 2004 Sep 15.

Department of Medical Microbiology and Immunology, MDC Box 10, University of South Florida, and the H. Lee Moffitt Cancer Center, 12901 Bruce B. Downs Blvd, Tampa, FL 33612-4799, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1741-7015-2-34DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC521080PMC
September 2004
9 Reads
4 Citations
7.250 Impact Factor

Cannabinoid receptors and T helper cells.

J Neuroimmunol 2004 Feb;147(1-2):91-4

Department of Medical Microbiology and Immunology, University of South Florida, 12901 Bruce Downs Boulevard, Tampa, FL 33612, USA.

View Article

Download full-text PDF

Source
February 2004
32 Reads
17 Citations
2.470 Impact Factor

Legionella pneumophila suppresses macrophage interleukin-12 production by activating the p42/44 mitogen-activated protein kinase cascade.

Infect Immun 2003 Nov;71(11):6672-5

Department of Medical Microbiology and Immunology, University of South Florida College of Medicine, Tampa, Florida 33612, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC219421PMC
November 2003
11 Reads
7 Citations
3.731 Impact Factor

The cannabinoid system and immune modulation.

J Leukoc Biol 2003 Oct 1;74(4):486-96. Epub 2003 Jul 1.

University of South Florida, College of Medicine, Department of Medical Microbiology and Immunology, Tampa 33612, USA.

View Article

Download full-text PDF

Source
http://cannakb.com/assets/articles/Vaporizer%20and%20Other/T
Web Search
http://www.jleukbio.org/cgi/doi/10.1189/jlb.0303101
Publisher Site
http://dx.doi.org/10.1189/jlb.0303101DOI Listing
October 2003
26 Reads
131 Citations
4.290 Impact Factor

Microbial infections, immunomodulation, and drugs of abuse.

Clin Microbiol Rev 2003 Apr;16(2):209-19

Department of Medical Microbiology and Immunology, College of Medicine, University of South Florida, Tampa, Florida 33612, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC153143PMC
April 2003
7 Reads
66 Citations
17.410 Impact Factor

Legionella pneumophila pathogenesis and immunity.

Semin Pediatr Infect Dis 2002 Oct;13(4):273-9

Department of Medical Microbiology and Immunology, University of South Florida College of Medicine, Tampa, FL 33612-4799, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/spid.2002.127206DOI Listing
October 2002
7 Reads
17 Citations

Induction of a potential paracrine angiogenic loop between human THP-1 macrophages and human microvascular endothelial cells during Bartonella henselae infection.

Infect Immun 2002 Aug;70(8):4564-70

University of South Florida, College of Medicine, Department of Medical Microbiology and Immunology, Tampa 33612, USA.

View Article

Download full-text PDF

Source
http://iai.asm.org/content/70/8/4564.full.pdf
Web Search
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC128175PMC
August 2002
10 Reads
23 Citations
3.731 Impact Factor

Epigallocatechin gallate, a potential immunomodulatory agent of tea components, diminishes cigarette smoke condensate-induced suppression of anti-Legionella pneumophila activity and cytokine responses of alveolar macrophages.

Clin Diagn Lab Immunol 2002 Jul;9(4):864-71

Department of Medical Microbiology and Immunology, University of South Florida College of Medicine, Tampa, Florida 33612-4799, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC120017PMC
July 2002
8 Reads
2 Citations

Altered cannabinoid receptor mRNA expression in peripheral blood mononuclear cells from marijuana smokers.

J Neuroimmunol 2002 Jun;127(1-2):169-76

Department of Medical Microbiology and Immunology, MDC Box 10, 12901 Bruce Downs Blvd., University of South Florida, Tampa, FL 33612, USA.

View Article

Download full-text PDF

Source
June 2002
12 Reads
13 Citations
2.470 Impact Factor

In vitro therapeutic effect of epigallocatechin gallate on nicotine-induced impairment of resistance to Legionella pneumophila infection of established MH-S alveolar macrophages.

J Infect Dis 2002 Jan 3;185(2):229-36. Epub 2002 Jan 3.

Department of Medical Microbiology and Immunology, University of South Florida College of Medicine, Tampa, FL 33612-4799, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1086/338449DOI Listing
January 2002
18 Reads
6 Citations
6.000 Impact Factor