Publications by authors named "Thomas U Ahearn"

27Publications

Germline HOXB13 mutations p.G84E and p.R217C do not confer an increased breast cancer risk.

Authors:
Jingjing Liu Wendy J C Prager-van der Smissen J Margriet Collée Manjeet K Bolla Qin Wang Kyriaki Michailidou Joe Dennis Thomas U Ahearn Kristiina Aittomäki Christine B Ambrosone Irene L Andrulis Hoda Anton-Culver Natalia N Antonenkova Volker Arndt Norbert Arnold Kristan J Aronson Annelie Augustinsson Päivi Auvinen Heiko Becher Matthias W Beckmann Sabine Behrens Marina Bermisheva Leslie Bernstein Natalia V Bogdanova Nadja Bogdanova-Markov Stig E Bojesen Hiltrud Brauch Hermann Brenner Ignacio Briceno Sara Y Brucker Thomas Brüning Barbara Burwinkel Qiuyin Cai Hui Cai Daniele Campa Federico Canzian Jose E Castelao Jenny Chang-Claude Stephen J Chanock Ji-Yeob Choi Melissa Christiaens Christine L Clarke Fergus J Couch Kamila Czene Mary B Daly Peter Devilee Isabel Dos-Santos-Silva Miriam Dwek Diana M Eccles A Heather Eliassen Peter A Fasching Jonine Figueroa Henrik Flyger Lin Fritschi Manuela Gago-Dominguez Susan M Gapstur Montserrat García-Closas José A García-Sáenz Mia M Gaudet Graham G Giles Mark S Goldberg David E Goldgar Pascal Guénel Christopher A Haiman Niclas Håkansson Per Hall Patricia A Harrington Steven N Hart Mikael Hartman Peter Hillemanns John L Hopper Ming-Feng Hou David J Hunter Dezheng Huo Hidemi Ito Motoki Iwasaki Milena Jakimovska Anna Jakubowska Esther M John Rudolf Kaaks Daehee Kang Renske Keeman Elza Khusnutdinova Sung-Won Kim Peter Kraft Vessela N Kristensen Allison W Kurian Loic Le Marchand Jingmei Li Annika Lindblom Artitaya Lophatananon Robert N Luben Jan Lubiński Arto Mannermaa Mehdi Manoochehri Siranoush Manoukian Sara Margolin Shivaani Mariapun Keitaro Matsuo Tabea Maurer Dimitrios Mavroudis Alfons Meindl Usha Menon Roger L Milne Kenneth Muir Anna Marie Mulligan Susan L Neuhausen Heli Nevanlinna Kenneth Offit Olufunmilayo I Olopade Janet E Olson Håkan Olsson Nick Orr Sue K Park Paolo Peterlongo Julian Peto Dijana Plaseska-Karanfilska Nadege Presneau Brigitte Rack Rohini Rau-Murthy Gad Rennert Hedy S Rennert Valerie Rhenius Atocha Romero Matthias Ruebner Emmanouil Saloustros Rita K Schmutzler Andreas Schneeweiss Christopher Scott Mitul Shah Chen-Yang Shen Xiao-Ou Shu Jacques Simard Christof Sohn Melissa C Southey John J Spinelli Rulla M Tamimi William J Tapper Soo H Teo Mary Beth Terry Diana Torres Thérèse Truong Michael Untch Celine M Vachon Christi J van Asperen Alicja Wolk Taiki Yamaji Wei Zheng Argyrios Ziogas Elad Ziv Gabriela Torres-Mejía Thilo Dörk Anthony J Swerdlow Ute Hamann Marjanka K Schmidt Alison M Dunning Paul D P Pharoah Douglas F Easton Maartje J Hooning John W M Martens Antoinette Hollestelle

Sci Rep 2020 06 16;10(1):9688. Epub 2020 Jun 16.

Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1038/s41598-020-65665-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297796PMC
June 2020

Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses.

Authors:
Haoyu Zhang Thomas U Ahearn Julie Lecarpentier Daniel Barnes Jonathan Beesley Guanghao Qi Xia Jiang Tracy A O'Mara Ni Zhao Manjeet K Bolla Alison M Dunning Joe Dennis Qin Wang Zumuruda Abu Ful Kristiina Aittomäki Irene L Andrulis Hoda Anton-Culver Volker Arndt Kristan J Aronson Banu K Arun Paul L Auer Jacopo Azzollini Daniel Barrowdale Heiko Becher Matthias W Beckmann Sabine Behrens Javier Benitez Marina Bermisheva Katarzyna Bialkowska Ana Blanco Carl Blomqvist Natalia V Bogdanova Stig E Bojesen Bernardo Bonanni Davide Bondavalli Ake Borg Hiltrud Brauch Hermann Brenner Ignacio Briceno Annegien Broeks Sara Y Brucker Thomas Brüning Barbara Burwinkel Saundra S Buys Helen Byers Trinidad Caldés Maria A Caligo Mariarosaria Calvello Daniele Campa Jose E Castelao Jenny Chang-Claude Stephen J Chanock Melissa Christiaens Hans Christiansen Wendy K Chung Kathleen B M Claes Christine L Clarke Sten Cornelissen Fergus J Couch Angela Cox Simon S Cross Kamila Czene Mary B Daly Peter Devilee Orland Diez Susan M Domchek Thilo Dörk Miriam Dwek Diana M Eccles Arif B Ekici D Gareth Evans Peter A Fasching Jonine Figueroa Lenka Foretova Florentia Fostira Eitan Friedman Debra Frost Manuela Gago-Dominguez Susan M Gapstur Judy Garber José A García-Sáenz Mia M Gaudet Simon A Gayther Graham G Giles Andrew K Godwin Mark S Goldberg David E Goldgar Anna González-Neira Mark H Greene Jacek Gronwald Pascal Guénel Lothar Häberle Eric Hahnen Christopher A Haiman Christopher R Hake Per Hall Ute Hamann Elaine F Harkness Bernadette A M Heemskerk-Gerritsen Peter Hillemanns Frans B L Hogervorst Bernd Holleczek Antoinette Hollestelle Maartje J Hooning Robert N Hoover John L Hopper Anthony Howell Hanna Huebner Peter J Hulick Evgeny N Imyanitov Claudine Isaacs Louise Izatt Agnes Jager Milena Jakimovska Anna Jakubowska Paul James Ramunas Janavicius Wolfgang Janni Esther M John Michael E Jones Audrey Jung Rudolf Kaaks Pooja Middha Kapoor Beth Y Karlan Renske Keeman Sofia Khan Elza Khusnutdinova Cari M Kitahara Yon-Dschun Ko Irene Konstantopoulou Linetta B Koppert Stella Koutros Vessela N Kristensen Anne-Vibeke Laenkholm Diether Lambrechts Susanna C Larsson Pierre Laurent-Puig Conxi Lazaro Emilija Lazarova Flavio Lejbkowicz Goska Leslie Fabienne Lesueur Annika Lindblom Jolanta Lissowska Wing-Yee Lo Jennifer T Loud Jan Lubinski Alicja Lukomska Robert J MacInnis Arto Mannermaa Mehdi Manoochehri Siranoush Manoukian Sara Margolin Maria Elena Martinez Laura Matricardi Lesley McGuffog Catriona McLean Noura Mebirouk Alfons Meindl Usha Menon Austin Miller Elvira Mingazheva Marco Montagna Anna Marie Mulligan Claire Mulot Taru A Muranen Katherine L Nathanson Susan L Neuhausen Heli Nevanlinna Patrick Neven William G Newman Finn C Nielsen Liene Nikitina-Zake Jesse Nodora Kenneth Offit Edith Olah Olufunmilayo I Olopade Håkan Olsson Nick Orr Laura Papi Janos Papp Tjoung-Won Park-Simon Michael T Parsons Bernard Peissel Ana Peixoto Beth Peshkin Paolo Peterlongo Julian Peto Kelly-Anne Phillips Marion Piedmonte Dijana Plaseska-Karanfilska Karolina Prajzendanc Ross Prentice Darya Prokofyeva Brigitte Rack Paolo Radice Susan J Ramus Johanna Rantala Muhammad U Rashid Gad Rennert Hedy S Rennert Harvey A Risch Atocha Romero Matti A Rookus Matthias Rübner Thomas Rüdiger Emmanouil Saloustros Sarah Sampson Dale P Sandler Elinor J Sawyer Maren T Scheuner Rita K Schmutzler Andreas Schneeweiss Minouk J Schoemaker Ben Schöttker Peter Schürmann Leigha Senter Priyanka Sharma Mark E Sherman Xiao-Ou Shu Christian F Singer Snezhana Smichkoska Penny Soucy Melissa C Southey John J Spinelli Jennifer Stone Dominique Stoppa-Lyonnet Anthony J Swerdlow Csilla I Szabo Rulla M Tamimi William J Tapper Jack A Taylor Manuel R Teixeira MaryBeth Terry Mads Thomassen Darcy L Thull Marc Tischkowitz Amanda E Toland Rob A E M Tollenaar Ian Tomlinson Diana Torres Melissa A Troester Thérèse Truong Nadine Tung Michael Untch Celine M Vachon Ans M W van den Ouweland Lizet E van der Kolk Elke M van Veen Elizabeth J vanRensburg Ana Vega Barbara Wappenschmidt Clarice R Weinberg Jeffrey N Weitzel Hans Wildiers Robert Winqvist Alicja Wolk Xiaohong R Yang Drakoulis Yannoukakos Wei Zheng Kristin K Zorn Roger L Milne Peter Kraft Jacques Simard Paul D P Pharoah Kyriaki Michailidou Antonis C Antoniou Marjanka K Schmidt Georgia Chenevix-Trench Douglas F Easton Nilanjan Chatterjee Montserrat García-Closas

Nat Genet 2020 06 18;52(6):572-581. Epub 2020 May 18.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health (NIH), Department of Health and Human Services, Bethesda, MD, USA.

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http://dx.doi.org/10.1038/s41588-020-0609-2DOI Listing
June 2020

A mixed-model approach for powerful testing of genetic associations with cancer risk incorporating tumor characteristics.

Biostatistics 2020 Feb 29. Epub 2020 Feb 29.

Department of Biostatistics, Johns Hopkins Bloomberg SPH, 615 N Wolfe St, Baltimore, MD 21205, USA; Department of Oncology, Johns Hopkins University School of Medicine SPH, 733 N Broadway, Baltimore, MD 21205, USA and Department of Epidemiology, Johns Hopkins Bloomberg SPH, 615 N Wolfe St, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1093/biostatistics/kxz065DOI Listing
February 2020

Detectible mosaic truncating PPM1D mutations, age and breast cancer risk.

J Hum Genet 2019 Jun 8;64(6):545-550. Epub 2019 Mar 8.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1038/s10038-019-0589-1DOI Listing
June 2019

A Prospective Study of Aspirin Use and Prostate Cancer Risk by Status.

Cancer Epidemiol Biomarkers Prev 2018 10 14;27(10):1231-1233. Epub 2018 Aug 14.

National Cancer Institute, Division of Cancer Epidemiology and Genetics, Epidemiology and Biostatistics Program, Bethesda, Maryland.

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http://dx.doi.org/10.1158/1055-9965.EPI-18-0510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170677PMC
October 2018

Weight change, obesity and risk of prostate cancer progression among men with clinically localized prostate cancer.

Int J Cancer 2017 09 8;141(5):933-944. Epub 2017 Jun 8.

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.

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http://dx.doi.org/10.1002/ijc.30803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518616PMC
September 2017

Circulating Antioxidant Levels and Risk of Prostate Cancer by TMPRSS2:ERG.

Prostate 2017 May 19;77(6):647-653. Epub 2017 Jan 19.

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.

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http://dx.doi.org/10.1002/pros.23312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354965PMC
May 2017

Calcium-Sensing Receptor Tumor Expression and Lethal Prostate Cancer Progression.

J Clin Endocrinol Metab 2016 06 26;101(6):2520-7. Epub 2016 Apr 26.

Departments of Epidemiology (T.U.A., K.M.W., E.N., H.D.S., E.G., L.A.M., I.M.S.) and Department of Nutrition (E.G.), Harvard T. H. Chan School of Public Health, Department of Medical Oncology (R.L., M.L.), Dana-Farber Cancer Institute, Divisions of Preventive Medicine (H.D.S.), and Channing Division of Network Medicine (K.M.W., E.G., L.A.M.), Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115; Department of Histopathology Research (N.T., S.F.), Trinity College, Dublin 8, Ireland; and Public Health Sciences Division (I.M.S.), Fred Hutchinson Cancer Research Center, Seattle, Washington 98109.

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http://dx.doi.org/10.1210/jc.2016-1082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891799PMC
June 2016

Pre-diagnostic circulating sex hormone levels and risk of prostate cancer by ERG tumour protein expression.

Br J Cancer 2016 Apr 17;114(8):939-44. Epub 2016 Mar 17.

Department of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA.

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http://dx.doi.org/10.1038/bjc.2016.61DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4984801PMC
April 2016

Overexpression of the Long Non-coding RNA SChLAP1 Independently Predicts Lethal Prostate Cancer.

Eur Urol 2016 10 24;70(4):549-552. Epub 2015 Dec 24.

Department of Pathology, University of Michigan Health System, Ann Arbor, MI, USA; Comprehensive Cancer Center, University of Michigan Health System, Ann Arbor, MI, USA; Michigan Center for Translational Pathology, Ann Arbor, MI, USA; Howard Hughes Medical Institute, Ann Arbor, MI, USA. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2015.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919276PMC
October 2016

A Prospective Investigation of PTEN Loss and ERG Expression in Lethal Prostate Cancer.

J Natl Cancer Inst 2016 Feb 27;108(2). Epub 2015 Nov 27.

Department of Epidemiology (TUA, AP, EME, TG, REG, KMW, JRR, HDS, ELG, MJS, LAM) and Department of Nutrition (ELG, MJS), Harvard T. H. Chan School of Public Health, Boston, MA; Clinical Epidemiology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden (AP); Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA (REG); Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD (CLM, JLH, AMDM, TLL); Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (JRR, ELG, MJS, LAM, KMW); Divisions of Preventive Medicine and Aging, Department of Medicine, Brigham and Women's Hospital, Boston, MA (HDS); Pathology Unit, Addarii Institute, S. Orsola-Malpighi Hospital, Bologna, Italy (MF); Department of Histopathology Research, Trinity College, Dublin, Ireland (RF, SF); Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA (ML); Department of Oncology (AMDM, TLL) and Department of Urology (ADMD), Johns Hopkins University School of Medicine, Baltimore, MD.

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http://dx.doi.org/10.1093/jnci/djv346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862436PMC
February 2016

The expanding role of body mass in active surveillance for prostate cancer.

Eur Urol 2014 Nov 15;66(5):849-50. Epub 2014 Jul 15.

Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA; Department of Nutrition, Harvard School of Public Health, Boston, MA, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2014.06.043DOI Listing
November 2014

Transforming growth factors and receptor as potential modifiable pre-neoplastic biomarkers of risk for colorectal neoplasms.

Mol Carcinog 2015 Sep 9;54(9):821-30. Epub 2014 Apr 9.

Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia.

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http://dx.doi.org/10.1002/mc.22152DOI Listing
September 2015

Effects of calcium and vitamin D3 on transforming growth factors in rectal mucosa of sporadic colorectal adenoma patients: a randomized controlled trial.

Mol Carcinog 2015 Apr 26;54(4):270-80. Epub 2013 Oct 26.

Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia; Molecules to Mankind Program, Laney Graduate School, Emory University, Atlanta, Georgia.

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http://dx.doi.org/10.1002/mc.22096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484733PMC
April 2015

Effects of calcium and vitamin D supplementation on crypt morphology in normal colon mucosa: A randomized clinical trial.

Mol Carcinog 2015 Mar 24;54(3):242-7. Epub 2013 Sep 24.

Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia.

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http://doi.wiley.com/10.1002/mc.22090
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http://dx.doi.org/10.1002/mc.22090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482111PMC
March 2015

A randomized clinical trial of the effects of supplemental calcium and vitamin D3 on the APC/β-catenin pathway in the normal mucosa of colorectal adenoma patients.

Cancer Prev Res (Phila) 2012 Oct 10;5(10):1247-56. Epub 2012 Sep 10.

Nutrition and Health Sciences Program, Graduate Division of Biological and Biomedical Sciences, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1158/1940-6207.CAPR-12-0292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466388PMC
October 2012

Markers of the APC/β-catenin signaling pathway as potential treatable, preneoplastic biomarkers of risk for colorectal neoplasms.

Cancer Epidemiol Biomarkers Prev 2012 Jun 26;21(6):969-79. Epub 2012 Apr 26.

Rollins School of Public Health, Emory University, Atlanta, GA, USA.

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http://dx.doi.org/10.1158/1055-9965.EPI-12-0126DOI Listing
June 2012

Effects of vitamin D3 and calcium supplementation on serum levels of tocopherols, retinol, and specific vitamin D metabolites.

Nutr Cancer 2012 9;64(1):57-64. Epub 2011 Dec 9.

Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, Hawaii 96822, USA.

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http://dx.doi.org/10.1080/01635581.2012.630552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731208PMC
July 2012

A randomized clinical trial of the effects of supplemental calcium and vitamin D3 on markers of their metabolism in normal mucosa of colorectal adenoma patients.

Cancer Res 2011 Jan 17;71(2):413-23. Epub 2010 Nov 17.

Nutrition and Health Sciences Program, Graduate Division of Biological and Biomedical Sciences, Winship Cancer Institute, Emory University, Department of Epidemiology, Rollins School of Public Health, Atlanta, Georgia 30322, USA.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-10-1560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064476PMC
January 2011

Detecting and quantifying biomarkers of risk for colorectal cancer using quantum dots and novel image analysis algorithms.

Conf Proc IEEE Eng Med Biol Soc 2006;2006:3313-6

Dept. of Epidemiology, Emory Univ., Atlanta, GA 30332, USA.

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http://dx.doi.org/10.1109/IEMBS.2006.259745DOI Listing
March 2008