Thomas Thum

Thomas Thum

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Living myocardial slices: a novel multicellular model for cardiac translational research.

Eur Heart J 2020 Jul;41(25):2405-2408

Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.

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http://dx.doi.org/10.1093/eurheartj/ehz779DOI Listing
July 2020

Cardiac endurance training alters plasma profiles of circular RNA MBOAT2.

Am J Physiol Heart Circ Physiol 2020 Jul 15;319(1):H13-H21. Epub 2020 May 15.

Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1152/ajpheart.00067.2020DOI Listing
July 2020

The ESC Working Group on Myocardial Function.

Authors:
Thomas Thum

Eur Heart J 2020 Jul;41(25):2346-2348

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http://dx.doi.org/10.1093/eurheartj/ehaa369DOI Listing
July 2020

Pleiotropic cardiac functions controlled by ischemia-induced lncRNA H19.

J Mol Cell Cardiol 2020 Jul 7. Epub 2020 Jul 7.

Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Hannover, Germany,; REBIRTH Excellence Cluster, Hannover Medical School, Hannover, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2020.07.001DOI Listing
July 2020

Comprehensive Bioinformatics Identifies Key microRNA Players in ATG7-Deficient Lung Fibroblasts.

Int J Mol Sci 2020 Jun 9;21(11). Epub 2020 Jun 9.

Chair of Medical Informatics, Friedrich-Alexander University of Erlangen-Nürnberg, 91058 Erlangen, Germany.

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http://dx.doi.org/10.3390/ijms21114126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312768PMC
June 2020

Non-coding RNAs: Regulators of valvular calcification.

J Mol Cell Cardiol 2020 May 2;142:14-23. Epub 2020 Apr 2.

Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1016/j.yjmcc.2020.03.015DOI Listing
May 2020

SARS-CoV-2 receptor ACE2 expression in the human heart: cause of a post-pandemic wave of heart failure?

Authors:
Thomas Thum

Eur Heart J 2020 05;41(19):1807-1809

Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1093/eurheartj/ehaa410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239191PMC
May 2020

TGF-β Inhibitor CILP as a Novel Biomarker for Cardiac Fibrosis.

JACC Basic Transl Sci 2020 May 25;5(5):444-446. Epub 2020 May 25.

Institute for Molecular and Translational Therapeutic Strategies, Hannover Medical School, Germany, Hannover, Germany.

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http://dx.doi.org/10.1016/j.jacbts.2020.03.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251223PMC
May 2020

miR-21, Mediator, and Potential Therapeutic Target in the Cardiorenal Syndrome.

Front Pharmacol 2020 15;11:726. Epub 2020 May 15.

Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.3389/fphar.2020.00726DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243366PMC
May 2020

The Long Non-coding RNA Cyrano Is Dispensable for Pluripotency of Murine and Human Pluripotent Stem Cells.

Stem Cell Reports 2020 May 29. Epub 2020 May 29.

Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Hannover, Germany; REBIRTH-Centre for Translational Regenerative Medicine, Hannover Medical School, Hannover, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2020.05.011DOI Listing
May 2020

The Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, Germany.

Eur Heart J 2020 Apr;41(15):1459-1461

Director of the IMTTS, Hannover Medical School, Carl-Neuberg-Str. 1, D-30625 Hannover (Germany).

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http://dx.doi.org/10.1093/eurheartj/ehaa113DOI Listing
April 2020

AntimiR-21 Prevents Myocardial Dysfunction in a Pig Model of Ischemia/Reperfusion Injury.

J Am Coll Cardiol 2020 Apr;75(15):1788-1800

DZHK (German Center for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany; Institut für Pharmakologie und Toxikologie, Technische Universität München, Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2020.02.041DOI Listing
April 2020

MiRNA-181a is a novel regulator of aldosterone-mineralocorticoid receptor-mediated cardiac remodelling.

Eur J Heart Fail 2020 Apr 18. Epub 2020 Apr 18.

Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1002/ejhf.1813DOI Listing
April 2020

Omics phenotyping in heart failure: the next frontier.

Eur Heart J 2020 Apr 26. Epub 2020 Apr 26.

Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1093/eurheartj/ehaa270DOI Listing
April 2020

SARS-CoV-2 receptor ACE2-dependent implications on the cardiovascular system: From basic science to clinical implications.

J Mol Cell Cardiol 2020 Apr 30;144:47-53. Epub 2020 Apr 30.

Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, Hannover, Germany; REBIRTH Center for Translational Regenerative Medicine, Hannover Medical School, Hannover, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2020.04.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191280PMC
April 2020

Pharmacokinetic Studies of Antisense Oligonucleotides Using MALDI-TOF Mass Spectrometry.

Front Pharmacol 2020 25;11:220. Epub 2020 Mar 25.

Hannover Medical School, Institute for Toxicology - Core Unit Proteomics, Hanover, Germany.

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http://dx.doi.org/10.3389/fphar.2020.00220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109322PMC
March 2020

Preclinical and Clinical Development of Noncoding RNA Therapeutics for Cardiovascular Disease.

Circ Res 2020 Feb 27;126(5):663-678. Epub 2020 Feb 27.

From the Institute of Molecular and Translational Therapeutic Strategies (C.-K.H., S.K.-K., T.T.), Hannover Medical School, Germany.

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http://dx.doi.org/10.1161/CIRCRESAHA.119.315856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7043728PMC
February 2020

Senescence-induced inflammation: an important player and key therapeutic target in atherosclerosis.

Eur Heart J 2020 Jan 3. Epub 2020 Jan 3.

Department of Internal Medicine III, Cardiology, Angiology and Intensive Care Medicine, Martin-Luther-University Halle (Saale), Ernst-Grube-Strasse 40, 06120 Halle (Saale), Germany.

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http://dx.doi.org/10.1093/eurheartj/ehz919DOI Listing
January 2020

miR-21-KO Alleviates Alveolar Structural Remodeling and Inflammatory Signaling in Acute Lung Injury.

Int J Mol Sci 2020 Jan 27;21(3). Epub 2020 Jan 27.

Institute of Functional and Applied Anatomy, Hannover Medical School, 30625 Hannover, Germany.

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http://dx.doi.org/10.3390/ijms21030822DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037600PMC
January 2020

CircSlc8a1, breaking a vicious circle in cardiac hypertrophy.

Cardiovasc Res 2019 12;115(14):1946-1947

Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, Carl Neuberg Str-1, Hannover, Germany.

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http://dx.doi.org/10.1093/cvr/cvz147DOI Listing
December 2019

A new diastolic dysfunction disease-modelling platform.

Eur Heart J 2019 12;40(45):3696-3698

Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1093/eurheartj/ehz447DOI Listing
December 2019

Studying Interactions between 2'-O-Me-Modified Inhibitors and MicroRNAs Utilizing Microscale Thermophoresis.

Mol Ther Nucleic Acids 2019 Dec 28;18:259-268. Epub 2019 Aug 28.

Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School (MHH), Hannover, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.omtn.2019.08.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796726PMC
December 2019

Long Noncoding RNA-Enriched Vesicles Secreted by Hypoxic Cardiomyocytes Drive Cardiac Fibrosis.

Mol Ther Nucleic Acids 2019 Dec 13;18:363-374. Epub 2019 Sep 13.

Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Hannover, Germany; REBIRTH Excellence Cluster, Hannover Medical School, Hannover, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.omtn.2019.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6807307PMC
December 2019

Serum circular RNAs act as blood-based biomarkers for hypertrophic obstructive cardiomyopathy.

Sci Rep 2019 12 30;9(1):20350. Epub 2019 Dec 30.

Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1038/s41598-019-56617-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6937321PMC
December 2019

RNA-based diagnostic and therapeutic strategies for cardiovascular disease.

Nat Rev Cardiol 2019 11 11;16(11):661-674. Epub 2019 Jun 11.

Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1038/s41569-019-0218-xDOI Listing
November 2019

Elevated levels of miR-181c and miR-633 in the CSF of patients with MS: A validation study.

Neurol Neuroimmunol Neuroinflamm 2019 11 1;6(6):e623. Epub 2019 Oct 1.

From the Department of Neurology (S.K., A.D., J.K., B.G., R.G., Aiden Haghikia), St. Josef-Hospital, Ruhr-University Bochum; Department of Cardiology (Arash Haghikia), Campus Benjamin Franklin, Charité Universitätsmedizin-Berlin; Institute of Molecular and Translational Therapeutic Strategies (IMTTS) (C.B., K.S., A.P., T.T.), Hannover Medical School; and REBIRTH Excellence Cluster (T.T.), Hannover Medical School, Germany.

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http://dx.doi.org/10.1212/NXI.0000000000000623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6812730PMC
November 2019

Identification of miR-143 as a Major Contributor for Human Stenotic Aortic Valve Disease.

J Cardiovasc Transl Res 2019 10 6;12(5):447-458. Epub 2019 Mar 6.

Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.

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http://dx.doi.org/10.1007/s12265-019-09880-7DOI Listing
October 2019

Therapeutic modulation of RNA-binding protein Rbm38 facilitates re-endothelialization after arterial injury.

Cardiovasc Res 2019 Oct;115(12):1804-1810

Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Carl-Neuberg-Strasse 1, Hannover, Germany.

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http://dx.doi.org/10.1093/cvr/cvz063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755352PMC
October 2019

A comprehensive method protocol for annotation and integrated functional understanding of lncRNAs.

Brief Bioinform 2019 Oct 3. Epub 2019 Oct 3.

Functional Genomics and Systems Biology Group, Department of Bioinformatics, University of Würzburg, Germany.

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http://dx.doi.org/10.1093/bib/bbz066DOI Listing
October 2019

Circulating microRNAs in Fabry Disease.

Sci Rep 2019 10 24;9(1):15277. Epub 2019 Oct 24.

Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1038/s41598-019-51805-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6813291PMC
October 2019

Remote vitals monitoring in rodents using video recordings.

Biomed Opt Express 2019 Sep 5;10(9):4422-4436. Epub 2019 Aug 5.

Department of Anesthesiology, RWTH Aachen University, Faculty of Medicine, Aachen, Germany.

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http://dx.doi.org/10.1364/BOE.10.004422DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6757452PMC
September 2019

Circular RNAs: A Novel Class of Functional RNA Molecules with a Therapeutic Perspective.

Mol Ther 2019 08 9;27(8):1350-1363. Epub 2019 Jul 9.

Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, Hannover, Germany; REBIRTH Cluster of Excellence, Hannover Medical School, Hannover, Germany; National Heart and Lung Institute, Imperial College London, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2019.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697450PMC
August 2019

Letter by Pinet et al Regarding Article, "Comparative Analysis of Circulating Noncoding RNAs Versus Protein Biomarkers in the Detection of Myocardial Injury".

Circ Res 2019 08 1;125(4):e20-e21. Epub 2019 Aug 1.

From the University Lille, CHU Lille, Inserm, U1167, Institut Pasteur de Lille, France (Florence Pinet, Christophe Bauters); and Institute of Molecular and Translational Therapeutic Strategies (IMTTS) (Christian Bär, Thomas Thum) and REBIRTH Excellence Cluster (Christian Bär, Thomas Thum), Hannover Medical School, Germany.

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http://dx.doi.org/10.1161/CIRCRESAHA.119.315530DOI Listing
August 2019

Non-coding RNAs: key players in cardiac disease.

J Physiol 2019 Jul 10. Epub 2019 Jul 10.

Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1113/JP278131DOI Listing
July 2019

Identification of cell and disease specific microRNAs in glomerular pathologies.

J Cell Mol Med 2019 06 4;23(6):3927-3939. Epub 2019 Apr 4.

Department of Medicine/Nephrology, Friedrich-Alexander University Erlangen, Erlangen, Germany.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jcmm.14270
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http://dx.doi.org/10.1111/jcmm.14270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533525PMC
June 2019

Circulating non-coding RNAs in biomarker-guided cardiovascular therapy: a novel tool for personalized medicine?

Eur Heart J 2019 05;40(20):1643-1650

Institute of Molecular and Translational Therapeutic Strategies (IMTTS), IFB-Tx, Hannover Medical School, Carl-Neuberg-Str. 1, Hannover, Germany.

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http://dx.doi.org/10.1093/eurheartj/ehy234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6528150PMC
May 2019

Circulating Long Noncoding RNA LIPCAR Predicts Heart Failure Outcomes in Patients Without Chronic Kidney Disease.

Hypertension 2019 04;73(4):820-828

Program of Cardiovascular Diseases, Centre for Applied Medical Research, University of Navarra, Pamplona, Spain (B.L., S.R., M.U.M., A.G., J.D.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12261DOI Listing
April 2019

Long non-coding RNAs: A crucial part of the vasculature puzzle.

Vascul Pharmacol 2019 03 24;114:131-138. Epub 2018 Feb 24.

Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Hannover, Germany; REBIRTH Excellence Cluster, Hannover Medical School, Hannover, Germany; National Heart and Lung Institute, Imperial College London, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.vph.2018.02.008DOI Listing
March 2019

Blood-based microRNA profiling in patients with cardiac amyloidosis.

PLoS One 2018 17;13(10):e0204235. Epub 2018 Oct 17.

Institute of Molecular and Translational Therapeutic Strategies (IMTTS), IFB-Tx, Hannover Medical School, Hannover, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0204235PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192556PMC
March 2019

The Janus Face of miR-148a in Cardiac Remodeling and Heart Failure.

Mol Ther 2019 03 15;27(3):489-490. Epub 2019 Feb 15.

Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Hannover, Germany; REBIRTH Cluster of Excellence, Hannover Medical School, Hannover, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2019.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402946PMC
March 2019

Circulating miRNAs as mediators in cell-to-cell communication.

Epigenomics 2019 02 14;11(2):111-113. Epub 2019 Jan 14.

Institute of Molecular & Translational Therapeutic Strategies (IMTTS), Hannover Medical School, 30625, Hannover, Germany.

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http://dx.doi.org/10.2217/epi-2018-0183DOI Listing
February 2019

Noncoding RNAs: potential regulators in cardioncology.

Am J Physiol Heart Circ Physiol 2019 01 9;316(1):H160-H168. Epub 2018 Nov 9.

Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School , Hannover , Germany.

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https://www.physiology.org/doi/10.1152/ajpheart.00418.2018
Publisher Site
http://dx.doi.org/10.1152/ajpheart.00418.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383355PMC
January 2019

miR-212/132 Cluster Modulation Prevents Doxorubicin-Mediated Atrophy and Cardiotoxicity.

Mol Ther 2019 01 13;27(1):17-28. Epub 2018 Nov 13.

Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Hannover, Germany; Cardior Pharmaceuticals GmbH, Hannover Medical School Campus, Hannover, Germany; Excellence Cluster REBIRTH, Hannover Medical School, Hannover, Germany; National Heart and Lung Institute, Imperial College London, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2018.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319305PMC
January 2019

Long Non-coding RNAs: At the Heart of Cardiac Dysfunction?

Front Physiol 2019 29;10:30. Epub 2019 Jan 29.

Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Hanover, Germany.

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https://www.frontiersin.org/article/10.3389/fphys.2019.00030
Publisher Site
http://dx.doi.org/10.3389/fphys.2019.00030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361744PMC
January 2019

Inflammatory cells and their non-coding RNAs as targets for treating myocardial infarction.

Basic Res Cardiol 2018 12 6;114(1). Epub 2018 Dec 6.

Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.

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http://link.springer.com/10.1007/s00395-018-0712-z
Publisher Site
http://dx.doi.org/10.1007/s00395-018-0712-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290728PMC
December 2018

Vascular Smooth Muscle Cell Remodeling.

Circ Res 2018 12;123(12):1261-1263

From the Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, Germany.

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http://dx.doi.org/10.1161/CIRCRESAHA.118.314184DOI Listing
December 2018

Circulating non-coding RNAs as biomarkers to predict and monitor the response to exercise: chances and hurdles.

Eur Heart J 2018 10;39(38):3552

Institute of Molecular and Translational Therapeutic Strategies (IMTTS), IFB-Tx, Hannover Medical School, Carl-Neuberg-Str. 1, Hannover, Germany.

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http://dx.doi.org/10.1093/eurheartj/ehy457DOI Listing
October 2018

Remote Welfare Monitoring of Rodents Using Thermal Imaging.

Sensors (Basel) 2018 Oct 28;18(11). Epub 2018 Oct 28.

Department of Anesthesiology, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany.

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http://dx.doi.org/10.3390/s18113653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263688PMC
October 2018

Non-coding RNAs in vascular disease - from basic science to clinical applications: scientific update from the Working Group of Myocardial Function of the European Society of Cardiology.

Cardiovasc Res 2018 08;114(10):1281-1286

Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Carl-Neuberg-Str.1, 30625 Hannover, Germany.

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http://dx.doi.org/10.1093/cvr/cvy121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054241PMC
August 2018

Translational Opportunities and Challenges of Long Noncoding RNAs in Cardiac Regeneration.

Authors:
Thomas Thum

J Am Coll Cardiol 2018 07 23;72(5):551-552. Epub 2018 Jun 23.

Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, Hannover, Germany; Excellence Cluster REBIRTH, Hannover Medical School, Hannover, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2018.05.039DOI Listing
July 2018

Leukocyte telomere length correlates with hypertrophic cardiomyopathy severity.

Sci Rep 2018 07 25;8(1):11227. Epub 2018 Jul 25.

Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1038/s41598-018-29072-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060137PMC
July 2018

Refractory angina revisited: stem cells for a growing unmet clinical need?

Authors:
Thomas Thum

Eur Heart J 2018 06;39(23):2217-2219

Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1093/eurheartj/ehx793DOI Listing
June 2018

Endogenous Tumor Suppressor microRNA-193b: Therapeutic and Prognostic Value in Acute Myeloid Leukemia.

J Clin Oncol 2018 04 12;36(10):1007-1016. Epub 2018 Feb 12.

Raj Bhayadia, Razan Jammal, Stephan Emmrich, Jan Fiedler, Adrian Schwarzer, Michael Heuser, Michelle Ng, Dirk Heckl, and Thomas Thum, Hannover Medical School, Hannover; Raj Bhayadia, Michelle Ng, and Jan-Henning Klusmann, University of Halle, Halle; Kathrin Krowiorz, Arefeh Rouhi, Konstanze Döhner, Hartmut Döhner, and Florian Kuchenbauer, University Hospital of Ulm, Ulm; Nadine Haetscher, Susanne Wingert, Sabrina Bothur, and Michael A. Rieger, Goethe University Frankfurt, Frankfurt; Sabrina Bothur and Michael A. Rieger, German Cancer Consortium, and German Cancer Research Center, Heidelberg; Dirk Reinhardt, University Hospital Essen, Essen, Germany; Askar Obulkasim, C. Michel Zwaan, and Maarten Fornerod, Erasmus MC/Sophia Children's Hospital, Rotterdam; Marry van den Heuvel Eibrink, Prinses Maxima Center for Pediatric Oncology, Utrecht, the Netherlands; Tobias Mätzig and R. Keith Humphries, Terry Fox Laboratory, Vancouver, Canada; and Thomas Thum, National Heart and Lung Institute, Imperial College London, London, United Kingdom.

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http://dx.doi.org/10.1200/JCO.2017.75.2204DOI Listing
April 2018

Epigenetic modulation of vascular diseases: Assessing the evidence and exploring the opportunities.

Vascul Pharmacol 2018 Mar 14. Epub 2018 Mar 14.

Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.vph.2018.02.009DOI Listing
March 2018

A large shRNA library approach identifies lncRNA Ntep as an essential regulator of cell proliferation.

Cell Death Differ 2018 02 3;25(2):307-318. Epub 2017 Nov 3.

Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1038/cdd.2017.158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762845PMC
February 2018

Circulating microRNA-132 levels improve risk prediction for heart failure hospitalization in patients with chronic heart failure.

Eur J Heart Fail 2018 01 12;20(1):78-85. Epub 2017 Oct 12.

Institute of Molecular and Translational Therapeutic Strategies and Excellence Cluster REBIRTH, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1002/ejhf.961DOI Listing
January 2018

A long way for microRNAs to become meaningful prognostic biomarkers.

Eur J Heart Fail 2018 01 17;20(1):76-77. Epub 2017 Oct 17.

Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1002/ejhf.1036DOI Listing
January 2018

Quaking Inhibits Doxorubicin-Mediated Cardiotoxicity Through Regulation of Cardiac Circular RNA Expression.

Circ Res 2018 01 13;122(2):246-254. Epub 2017 Nov 13.

From the Institute of Molecular and Translational Therapeutic Strategies (S.K.G., A.G., C.B., S.C., A.F., J.F., T.T.) and Excellence Cluster REBIRTH (T.T.), Hannover Medical School, Germany; Herz- und Diabeteszentrum NRW, Universitätsklinikum der Ruhr Universität Bochum, Erich und Hanna Klessmann-Institute for Cardiovascular Research and Development, Bad Oeynhausen, Germany (H.M.); Clinic for Cardiology and Pneumology, Stem Cell Laboratory, University Medical Center, Gottingen, Germany (K.S.-B.); DZHK (German Center for Cardiovascular Research) Partner site Göttingen, Germany (K.S.-B.); and National Heart and Lung Institute, Imperial College London, United Kingdom (T.T.).

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http://dx.doi.org/10.1161/CIRCRESAHA.117.311335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771684PMC
January 2018

Sonic hedgehog-dependent activation of adventitial fibroblasts promotes neointima formation.

Cardiovasc Res 2017 Nov;113(13):1653-1663

Vascular Remodeling and Regeneration Group, Department of Cardiology and Angiology, Hannover Medical School, Carl-Neuberg-Str. 1, D-30625 Hannover, Germany.

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http://dx.doi.org/10.1093/cvr/cvx158DOI Listing
November 2017

miRNome Profiling of Purified Endoderm and Mesoderm Differentiated from hESCs Reveals Functions of miR-483-3p and miR-1263 for Cell-Fate Decisions.

Stem Cell Reports 2017 11;9(5):1588-1603

Institute of Clinical Biochemistry, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2017.10.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688239PMC
November 2017