Thomas Thatcher

Thomas Thatcher

UNVERIFIED PROFILE

Are you Thomas Thatcher?   Register this Author

Register author
Thomas Thatcher

Thomas Thatcher

Publications by authors named "Thomas Thatcher"

Are you Thomas Thatcher?   Register this Author

51Publications

1016Reads

26Profile Views

Quenching the fires: Pro-resolving mediators, air pollution, and smoking.

Pharmacol Ther 2019 May 10;197:212-224. Epub 2019 Feb 10.

Division of Pulmonary and Critical Care Medicine, University of Rochester School of Medicine and Dentistry Rochester, NY 14642, United States; Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, United States; Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, United States. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pharmthera.2019.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6537608PMC
May 2019

Lipoxin B Enhances Human Memory B Cell Antibody Production via Upregulating Cyclooxygenase-2 Expression.

J Immunol 2018 12 22;201(11):3343-3351. Epub 2018 Oct 22.

Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14642;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1700503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246818PMC
December 2018

Activated human T lymphocytes inhibit TGFβ-induced fibroblast to myofibroblast differentiation via prostaglandins D and E.

Am J Physiol Lung Cell Mol Physiol 2018 04 20;314(4):L569-L582. Epub 2017 Dec 20.

Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry , Rochester, New York.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajplung.00565.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966783PMC
April 2018

Cigarette smoke dampens antiviral signaling in small airway epithelial cells by disrupting TLR3 cleavage.

Am J Physiol Lung Cell Mol Physiol 2018 03 14;314(3):L505-L513. Epub 2017 Dec 14.

Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry , Rochester, New York.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajplung.00406.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5900359PMC
March 2018

Comparison of in vitro toxicological effects of biomass smoke from different sources of animal dung.

Toxicol In Vitro 2017 Sep 30;43:76-86. Epub 2017 May 30.

Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, United States; Division of Pulmonary and Critical Care Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, United States; Lung Biology and Disease Program, University of Rochester, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, United States. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tiv.2017.05.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736384PMC
September 2017

Dung biomass smoke activates inflammatory signaling pathways in human small airway epithelial cells.

Am J Physiol Lung Cell Mol Physiol 2016 Dec 11;311(6):L1222-L1233. Epub 2016 Nov 11.

Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajplung.00183.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206396PMC
December 2016

Human lung fibroblasts produce proresolving peroxisome proliferator-activated receptor-γ ligands in a cyclooxygenase-2-dependent manner.

Am J Physiol Lung Cell Mol Physiol 2016 Nov 9;311(5):L855-L867. Epub 2016 Sep 9.

Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajplung.00272.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5130533PMC
November 2016

Introduction to Department of Defense Research on Burn Pits, Biomarkers, and Health Outcomes Related to Deployment in Iraq and Afghanistan.

J Occup Environ Med 2016 08;58(8 Suppl 1):S3-S11

Professor, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814 (Dr Mallon); 779th Aerospace Medical Squadron, 79th Medical WingJoint Base Andrews, Maryland (Dr Rohrbeck); Bioenvironmental Engineering Flight Commander, 30th Medical Group, 338 South Dakota Ave, Vandenberg AFB, CA 93437 (Maj Haines); Clinical Biomarkers Laboratory, Division of Pulmonary, Allergy, and Critical Care Medicine, Atlanta, Georgia (Dr Jones, Mr Walker); Departments of Medicine and Environmental Medicine, University of Rochester Medical Center (Drs Utell, Phipps, Thatcher, Woeller); Center for Air Resources Engineering and Science, Institute for a Sustainable Environment, Clarkson University, Potsdam, New York (Dr Hopke); U.S Army Center for Public Health (Provisional), Aberdeen Proving Ground (Drs Baird, Gaydos); and Anatomy and Cell Biology, Uniformed Services University, Bethesda, Maryland (Drs Pollard, Dalgard).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/JOM.0000000000000775DOI Listing
August 2016

Detection of Serum microRNAs From Department of Defense Serum Repository: Correlation With Cotinine, Cytokine, and Polycyclic Aromatic Hydrocarbon Levels.

J Occup Environ Med 2016 08;58(8 Suppl 1):S62-71

Department of Environmental Medicine (Dr Woeller, Mr Pollock, Ms Croasdell, Ms Kim, Dr Utell, Dr Phipps), Department of Medicine (Drs Thatcher, Utell, and Phipps), Microbiology and Immunology, University of Rochester Medical Center (Mr Van Twisk, Drs Thakar and Phipps); Center for Air Resources Engineering and Science, Clarkson University, Potsdam, New York (Drs Hopke and Xia); and Professor, Department of Preventive Medicine and Biostatistics, Uniformed Services University, Bethesda, MD 20814 (Dr Mallon).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/JOM.0000000000000742DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661968PMC
August 2016

MicroRNAs as Novel Biomarkers of Deployment Status and Exposure to Polychlorinated Dibenzo-p-Dioxins/Dibenzofurans.

J Occup Environ Med 2016 08;58(8 Suppl 1):S89-96

Department of Environmental Medicine (Dr Woeller, Mr Pollock, Ms Croasdell, Dr Sime, Dr Utell, and Dr Phipps), Department of Medicine (Dr Thatcher, Dr Sime, Dr Utell, and Dr Phipps), Microbiology and Immunology (Mr Van Twisk, Dr Thakar, and Dr Phipps), and Department of Biostatistics and Computational Biology (Mr Van Twisk, Dr Thakar), University of Rochester Medical Center; Center for Air Resources Engineering and Science, Clarkson University, Potsdam, New York (Dr Hopke, Dr Xia); and Professor, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814 (Dr Mallon).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/JOM.0000000000000769DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4978134PMC
August 2016

Normal Human Lung Epithelial Cells Inhibit Transforming Growth Factor-β Induced Myofibroblast Differentiation via Prostaglandin E2.

PLoS One 2015 6;10(8):e0135266. Epub 2015 Aug 6.

Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, United States of America; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, United States of America; Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, United States of America; Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester NY, 14642, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0135266PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527711PMC
May 2016

Resolvin D1 Dampens Pulmonary Inflammation and Promotes Clearance of Nontypeable Haemophilus influenzae.

J Immunol 2016 Mar 3;196(6):2742-52. Epub 2016 Feb 3.

Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642; Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642; and Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1502331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779746PMC
March 2016

Specialized proresolving mediators (SPMs) inhibit human B-cell IgE production.

Eur J Immunol 2016 Jan 2;46(1):81-91. Epub 2015 Nov 2.

Department of Microbiology and Immunology, University of Rochester, Rochester, NY, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/eji.201545673DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710564PMC
January 2016

Endogenous ligands of the aryl hydrocarbon receptor regulate lung dendritic cell function.

Immunology 2016 Jan 10;147(1):41-54. Epub 2015 Nov 10.

Division of Pulmonary and Critical Care Medicine, University of Rochester, Rochester, NY, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/imm.12540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693882PMC
January 2016

Pharmacologic inhibition of lactate production prevents myofibroblast differentiation.

Am J Physiol Lung Cell Mol Physiol 2015 Dec 25;309(11):L1305-12. Epub 2015 Sep 25.

University of Rochester Department of Medicine, Rochester, New York; University of Rochester Department of Environmental Medicine, Rochester, New York; and University of Rochester Lung Biology and Disease Program, Rochester, New York

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajplung.00058.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669339PMC
December 2015

Resolvin D1 Reduces Emphysema and Chronic Inflammation.

Am J Pathol 2015 Dec 24;185(12):3189-201. Epub 2015 Oct 24.

Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry, Rochester, New York; Division of Pulmonary and Critical Care Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York; Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajpath.2015.08.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729265PMC
December 2015

Resolvins attenuate inflammation and promote resolution in cigarette smoke-exposed human macrophages.

Am J Physiol Lung Cell Mol Physiol 2015 Oct 21;309(8):L888-901. Epub 2015 Aug 21.

Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York; Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry, Rochester, New York; Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York; and

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajplung.00125.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609942PMC
October 2015

Thy1 (CD90) controls adipogenesis by regulating activity of the Src family kinase, Fyn.

FASEB J 2015 Mar 21;29(3):920-31. Epub 2014 Nov 21.

*Department of Environmental Medicine and Flaum Eye Institute, School of Medicine and Dentistry, University of Rochester, Rochester, New York, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1096/fj.14-257121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422356PMC
March 2015

Resolvin D1 attenuates polyinosinic-polycytidylic acid-induced inflammatory signaling in human airway epithelial cells via TAK1.

J Immunol 2014 Nov 15;193(10):4980-7. Epub 2014 Oct 15.

Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642; and Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1400313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409010PMC
November 2014

Cigarette smoke exposure exacerbates lung inflammation and compromises immunity to bacterial infection.

J Immunol 2014 Jun 21;192(11):5226-35. Epub 2014 Apr 21.

Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1302584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066560PMC
June 2014

The triterpenoid CDDO-Me inhibits bleomycin-induced lung inflammation and fibrosis.

PLoS One 2013 31;8(5):e63798. Epub 2013 May 31.

The Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Rochester, Rochester, New York, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0063798PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669327PMC
February 2014

Attenuation of inflammatory mediator production by the NF-κB member RelB is mediated by microRNA-146a in lung fibroblasts.

Am J Physiol Lung Cell Mol Physiol 2013 Jun 5;304(11):L774-81. Epub 2013 Apr 5.

Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajplung.00352.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680764PMC
June 2013

Emerging PPARγ-Independent Role of PPARγ Ligands in Lung Diseases.

PPAR Res 2012 18;2012:705352. Epub 2012 Jun 18.

Division of Pulmonary and Critical Care, Department of Medicine, University of Rochester School of Medicine and Dentistry, Box 692, Rochester, NY 14642, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2012/705352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3385049PMC
August 2012

Spiruchostatin A inhibits proliferation and differentiation of fibroblasts from patients with pulmonary fibrosis.

Am J Respir Cell Mol Biol 2012 May 12;46(5):687-94. Epub 2012 Jan 12.

Sir Henry Wellcome Laboratories, Southampton General Hospital, South Block, Southampton, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1165/rcmb.2011-0040OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854311PMC
May 2012

Transglutaminase 2 and its role in pulmonary fibrosis.

Am J Respir Crit Care Med 2011 Sep 23;184(6):699-707. Epub 2011 Jun 23.

University of Rochester, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Rochester, NY 14642, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1164/rccm.201101-0013OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3208598PMC
September 2011

The Role of PPARs in Lung Fibrosis.

PPAR Res 2007 ;2007:71323

Department of Environmental Medicine, University of Rochester, Rochester, NY 14642, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2007/71323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1940051PMC
July 2011

Lung-targeted overexpression of the NF-κB member RelB inhibits cigarette smoke-induced inflammation.

Am J Pathol 2011 Jul 5;179(1):125-33. Epub 2011 May 5.

Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajpath.2011.03.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3123857PMC
July 2011

PPAR-γ ligands repress TGFβ-induced myofibroblast differentiation by targeting the PI3K/Akt pathway: implications for therapy of fibrosis.

PLoS One 2011 Jan 6;6(1):e15909. Epub 2011 Jan 6.

The Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0015909PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017065PMC
January 2011

The aryl hydrocarbon receptor attenuates tobacco smoke-induced cyclooxygenase-2 and prostaglandin production in lung fibroblasts through regulation of the NF-kappaB family member RelB.

J Biol Chem 2008 Oct 12;283(43):28944-57. Epub 2008 Aug 12.

Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M800685200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570856PMC
October 2008

High-dose but not low-dose mainstream cigarette smoke suppresses allergic airway inflammation by inhibiting T cell function.

Am J Physiol Lung Cell Mol Physiol 2008 Sep 20;295(3):L412-21. Epub 2008 Jun 20.

Department of Medicine, Univ. of Rochester, Rochester, NY 14642, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajplung.00392.2007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2536795PMC
September 2008

Oropharyngeal aspiration of a silica suspension produces a superior model of silicosis in the mouse when compared to intratracheal instillation.

Exp Lung Res 2006 May;32(5):181-99

Department of Environmental Medicine and Lung Biology and Disease Program, University of Rochester, Rochester, New York 14642, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/01902140600817465DOI Listing
May 2006

Topical imiquimod treatment prevents UV-light induced loss of contact hypersensitivity and immune tolerance.

J Invest Dermatol 2006 Apr;126(4):821-31

Division of Pulmonary and Critical Care Medicine, University of Rochester School of Medicine, Rochester, New York, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/sj.jid.5700167DOI Listing
April 2006

Sensitivity to bleomycin-induced lung injury is not moderated by an antigen-limited T-cell repertoire.

Exp Lung Res 2005 Sep;31(7):685-700

Department of Microbiology and Immunology, Division of Pulmonary and Critical Care Medicine, University of Rochester, Rochester, New York 14642, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/01902140591007218DOI Listing
September 2005

Crystalline and amorphous silica differentially regulate the cyclooxygenase-prostaglandin pathway in pulmonary fibroblasts: implications for pulmonary fibrosis.

Am J Physiol Lung Cell Mol Physiol 2005 Jun 21;288(6):L1010-6. Epub 2005 Jan 21.

Department of Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajplung.00024.2004DOI Listing
June 2005

PPARgamma agonists inhibit TGF-beta induced pulmonary myofibroblast differentiation and collagen production: implications for therapy of lung fibrosis.

Am J Physiol Lung Cell Mol Physiol 2005 Jun 25;288(6):L1146-53. Epub 2005 Feb 25.

Department of Environmental Medicine, Univ. of Rochester School of Medicine, 601 Elmwood Ave., Rochester, NY 14642, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajplung.00383.2004DOI Listing
June 2005

Bacterial protease treatment of natural rubber latex alters its primary immunogenicity in a mouse model of sensitization.

Clin Immunol 2002 Oct;105(1):9-16

Department of Dermatology, University of Maryland School of Medicine 21201.

View Article

Download full-text PDF

Source
October 2002