Thomas Spangenberg

Thomas Spangenberg

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Thomas Spangenberg

Thomas Spangenberg

Publications by authors named "Thomas Spangenberg"

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Evaluation of the pharmacokinetic-pharmacodynamic relationship of praziquantel in the Schistosoma mansoni mouse model.

PLoS Negl Trop Dis 2017 Sep 21;11(9):e0005942. Epub 2017 Sep 21.

Merck Global Health Institute, Ares Trading S.A., a subsidiary of Merck KGaA (Darmstadt, Germany), Coinsins, Switzerland.

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http://dx.doi.org/10.1371/journal.pntd.0005942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626502PMC
September 2017

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.

Authors:
Wesley C Van Voorhis John H Adams Roberto Adelfio Vida Ahyong Myles H Akabas Pietro Alano Aintzane Alday Yesmalie Alemán Resto Aishah Alsibaee Ainhoa Alzualde Katherine T Andrews Simon V Avery Vicky M Avery Lawrence Ayong Mark Baker Stephen Baker Choukri Ben Mamoun Sangeeta Bhatia Quentin Bickle Lotfi Bounaadja Tana Bowling Jürgen Bosch Lauren E Boucher Fabrice F Boyom Jose Brea Marian Brennan Audrey Burton Conor R Caffrey Grazia Camarda Manuela Carrasquilla Dee Carter Maria Belen Cassera Ken Chih-Chien Cheng Worathad Chindaudomsate Anthony Chubb Beatrice L Colon Daisy D Colón-López Yolanda Corbett Gregory J Crowther Noemi Cowan Sarah D'Alessandro Na Le Dang Michael Delves Joseph L DeRisi Alan Y Du Sandra Duffy Shimaa Abd El-Salam El-Sayed Michael T Ferdig José A Fernández Robledo David A Fidock Isabelle Florent Patrick V T Fokou Ani Galstian Francisco Javier Gamo Suzanne Gokool Ben Gold Todd Golub Gregory M Goldgof Rajarshi Guha W Armand Guiguemde Nil Gural R Kiplin Guy Michael A E Hansen Kirsten K Hanson Andrew Hemphill Rob Hooft van Huijsduijnen Takaaki Horii Paul Horrocks Tyler B Hughes Christopher Huston Ikuo Igarashi Katrin Ingram-Sieber Maurice A Itoe Ajit Jadhav Amornrat Naranuntarat Jensen Laran T Jensen Rays H Y Jiang Annette Kaiser Jennifer Keiser Thomas Ketas Sebastien Kicka Sunyoung Kim Kiaran Kirk Vidya P Kumar Dennis E Kyle Maria Jose Lafuente Scott Landfear Nathan Lee Sukjun Lee Adele M Lehane Fengwu Li David Little Liqiong Liu Manuel Llinás Maria I Loza Aristea Lubar Leonardo Lucantoni Isabelle Lucet Louis Maes Dalu Mancama Nuha R Mansour Sandra March Sheena McGowan Iset Medina Vera Stephan Meister Luke Mercer Jordi Mestres Alvine N Mfopa Raj N Misra Seunghyun Moon John P Moore Francielly Morais Rodrigues da Costa Joachim Müller Arantza Muriana Stephen Nakazawa Hewitt Bakela Nare Carl Nathan Nathalie Narraidoo Sujeevi Nawaratna Kayode K Ojo Diana Ortiz Gordana Panic George Papadatos Silvia Parapini Kailash Patra Ngoc Pham Sarah Prats David M Plouffe Sally-Ann Poulsen Anupam Pradhan Celia Quevedo Ronald J Quinn Christopher A Rice Mohamed Abdo Rizk Andrea Ruecker Robert St Onge Rafaela Salgado Ferreira Jasmeet Samra Natalie G Robinett Ulrich Schlecht Marjorie Schmitt Filipe Silva Villela Francesco Silvestrini Robert Sinden Dennis A Smith Thierry Soldati Andreas Spitzmüller Serge Maximilian Stamm David J Sullivan William Sullivan Sundari Suresh Brian M Suzuki Yo Suzuki S Joshua Swamidass Donatella Taramelli Lauve R Y Tchokouaha Anjo Theron David Thomas Kathryn F Tonissen Simon Townson Abhai K Tripathi Valentin Trofimov Kenneth O Udenze Imran Ullah Cindy Vallieres Edgar Vigil Joseph M Vinetz Phat Voong Vinh Hoan Vu Nao-Aki Watanabe Kate Weatherby Pamela M White Andrew F Wilks Elizabeth A Winzeler Edward Wojcik Melanie Wree Wesley Wu Naoaki Yokoyama Paul H A Zollo Nada Abla Benjamin Blasco Jeremy Burrows Benoît Laleu Didier Leroy Thomas Spangenberg Timothy Wells Paul A Willis

PLoS Pathog 2016 07 28;12(7):e1005763. Epub 2016 Jul 28.

Medicines for Malaria Venture, Geneva, Switzerland.

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http://dx.doi.org/10.1371/journal.ppat.1005763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965013PMC
July 2016

A Proposed Target Product Profile and Developmental Cascade for New Cryptosporidiosis Treatments.

PLoS Negl Trop Dis 2015 Oct 8;9(10):e0003987. Epub 2015 Oct 8.

Medicines for Malaria Venture, Geneva, Switzerland; Department of Medicine, University of Washington School of Medicine, Seattle, Washington, United States of America.

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http://dx.doi.org/10.1371/journal.pntd.0003987DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598153PMC
October 2015

Repurposing of the Open Access Malaria Box for Kinetoplastid Diseases Identifies Novel Active Scaffolds against Trypanosomatids.

J Biomol Screen 2015 Jun 17;20(5):634-45. Epub 2015 Feb 17.

Drugs for Neglected Diseases initiative, Geneva, Switzerland

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http://dx.doi.org/10.1177/1087057115569155DOI Listing
June 2015

Activities of N,N'-Diarylurea MMV665852 analogs against Schistosoma mansoni.

Antimicrob Agents Chemother 2015 Apr 12;59(4):1935-41. Epub 2015 Jan 12.

Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland University of Basel, Basel, Switzerland

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http://dx.doi.org/10.1128/AAC.04463-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356791PMC
April 2015

Repurposing the open access malaria box to discover potent inhibitors of Toxoplasma gondii and Entamoeba histolytica.

Antimicrob Agents Chemother 2014 Oct 21;58(10):5848-54. Epub 2014 Jul 21.

Antimicrobial Agents Unit, Laboratory for Phytobiochemistry and Medicinal Plants Studies, University of Yaoundé I, Yaoundé, Cameroon.

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http://dx.doi.org/10.1128/AAC.02541-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187973PMC
October 2014

Orally active antischistosomal early leads identified from the open access malaria box.

PLoS Negl Trop Dis 2014 9;8(1):e2610. Epub 2014 Jan 9.

Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland ; University of Basel, Basel, Switzerland.

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http://dx.doi.org/10.1371/journal.pntd.0002610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3886923PMC
September 2014

Identification of Cryptosporidium parvum active chemical series by Repurposing the open access malaria box.

Antimicrob Agents Chemother 2014 May 24;58(5):2731-9. Epub 2014 Feb 24.

Department of Microbiology and Molecular Genetics, University of Vermont, Burlington, Vermont, USA.

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http://dx.doi.org/10.1128/AAC.02641-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993250PMC
May 2014

Antimalarial drug discovery - the path towards eradication.

Parasitology 2014 Jan 17;141(1):128-39. Epub 2013 Jul 17.

Medicines for Malaria Venture, ICC, 20 Route de Pré-Bois - PO Box 1826, 1215 Geneva 15, Switzerland.

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http://www.journals.cambridge.org/abstract_S0031182013000826
Publisher Site
http://dx.doi.org/10.1017/S0031182013000826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3884835PMC
January 2014

Malaria in South America: a drug discovery perspective.

Malar J 2013 May 24;12:168. Epub 2013 May 24.

Medicines for Malaria Venture, 20 route de Pré-Bois, Geneva, CH 1215, Switzerland.

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http://dx.doi.org/10.1186/1475-2875-12-168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665683PMC
May 2013

Synthesis and biological evaluation of desmethylveramiline, a micromolar Hedgehog inhibitor.

Bioorg Med Chem Lett 2011 Jun 29;21(12):3608-12. Epub 2011 Apr 29.

Laboratoire d'Innovation Thérapeutique, UMR 7200 CNRS-Université de Strasbourg Faculté de Pharmacie, Illkirch, France.

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http://dx.doi.org/10.1016/j.bmcl.2011.04.103DOI Listing
June 2011

Highly sensitive, operationally simple, cost/time effective detection of the mycolactones from the human pathogen Mycobacterium ulcerans.

Chem Commun (Camb) 2010 Mar 1;46(9):1410-2. Epub 2010 Feb 1.

Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.

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http://xlink.rsc.org/?DOI=b924896j
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http://dx.doi.org/10.1039/b924896jDOI Listing
March 2010

Synthesis and structure assignment of the minor metabolite arising from the frog pathogen Mycobacterium liflandii.

Tetrahedron Lett 2010 Mar;51(13):1782-1785

Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1016/j.tetlet.2010.01.105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2840265PMC
March 2010

Short access to (+)-lupinine and (+)-epiquinamide via double hydroformylation.

Org Lett 2010 Feb;12(3):528-31

Faculté de Pharmacie, UMR 7200, CNRS-Université de Strasbourg, Laboratoire d'Innovation Thérapeutique, 74 route du Rhin, F-67401 Illkirch, France.

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http://pubs.acs.org/doi/abs/10.1021/ol902718q
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http://dx.doi.org/10.1021/ol902718qDOI Listing
February 2010

A general approach to aza-heterocycles by means of domino sequences driven by hydroformylation.

Chemistry 2008 ;14(35):10938-48

Faculté de Pharmacie, Université Louis Pasteur de Strasbourg, Laboratoire de Pharmacochimie de la Communication Cellulaire UMR 7175/LC1, 74, route du Rhin, BP 60024, 67401 Illkirch, France.

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http://doi.wiley.com/10.1002/chem.200801795
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http://dx.doi.org/10.1002/chem.200801795DOI Listing
January 2009

Hydroformylation of homoallylic azides: a rapid approach toward alkaloids.

Org Lett 2009 Jan;11(2):261-4

Departement de Pharmacochimie de la Communication Cellulaire, UMR 7175-LC-1 ULP/CNRS, Faculte de Pharmacie, 74 route du Rhin BP 60024, F-67401 Illkirch, France.

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http://pubs.acs.org/doi/abs/10.1021/ol802314g
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http://dx.doi.org/10.1021/ol802314gDOI Listing
January 2009

A new method for the synthesis of chiral beta-branched alpha-amino acids.

Org Lett 2007 Sep 6;9(20):3881-4. Epub 2007 Sep 6.

Département de Pharmacochimie de la Communication Cellulaire UMR 7175-LC-1 ULP/CNRS, Faculté de Pharmacie 74 route du Rhin BP 60024, F-67401 Illkirch, France.

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http://dx.doi.org/10.1021/ol071305mDOI Listing
September 2007

2,6,8-trisubstituted 1-deazapurines as adenosine receptor antagonists.

J Med Chem 2007 Feb;50(4):828-34

Division of Medicinal Chemistry, Leiden/Amsterdam Center for Drug Research, Post Office Box 9502, 2300 RA Leiden, The Netherlands.

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http://dx.doi.org/10.1021/jm0607956DOI Listing
February 2007